The study investigates esophageal motor function and esophageal clearance immediately after surgical induction of reflux in piglets and 8 weeks later after peptic esophagitis has developed.
...Twenty-four sedated, nonintubated piglets were divided into three groups: sham (laparotomy only), reflux (distal esophageal myotomy), and reflux + esophagitis (8 weeks after myotomy). All animals underwent stationary manometry of the esophagus with a four-lumen perfused assembly after injection of 1-, 2-, and 3-mL boluses of saline and acid into the proximal esophagus. Simultaneous pH monitoring allowed assessment of acid clearance. Wave features and clearance times after saline and acid were compared among groups.
There were minor changes in peristaltic activity of the esophagus after saline boluses in animals with reflux. Acid clearance time was prolonged, especially the time to re-establish resting esophageal pH, in animals with esophagitis. These changes, which were volume-dependent, were related to the loss of peristaltic organization of the esophageal waves. The esophageal wave frequency, amplitude, and duration were only slightly changed by the induction of reflux and by esophagitis.
The esophagus affected by acid reflux, with or without esophagitis, was capable of near-normal motor responses after boluses of saline. Reflux impaired the peristaltic response to acid, and the effect was more pronounced when reflux and esophagitis were both present. The acid clearance time was also strikingly prolonged in the presence of reflux and esophagitis. The results suggest that long episodes of reflux seen on pH tracings from individuals with esophagitis might be secondary both to acid-related motor dysfunction and large volumes of refluxate.
Biliary Cystadenocarcinoma Ramia, José M; de la Plaza, Roberto; Pérez Mies, Belén ...
Cirugia española (English ed.),
June-July 2015, Letnik:
93, Številka:
6
Journal Article
AbstractThe “fibromatosis like” phenotype is a rare tumor and represents just 1% of breast carcinomas. It is classified into a large group of heterogeneous metaplastic carcinomas. Due to its innocent ...and harmless histology it is often obscured and represents a considerable diagnostic challenge, especially in fine needle biopsy. “Fibromatosis like” variant shows a subtle proliferation of spindled cells with scanty nuclear atypia an eosinophilic cytoplasm.Besides this mesenchymal proliferation it's feasible to find a second “epithelial type” element (squamous, glandular) that grants the metaplastic nature of the lesion. In many cases the neoplasia mimics breast benign fibromatous changes or reactive spindle cells post puncture that may be misleading to a misdiagnosis.There are many hypothesis concerning the possible relationship between the papillary lesions and the development of metaplastic carcinoma, however the scientific opinion is inconsistent.
Intraductal papillary mucinous neoplasm Ramia-Ángel, José Manuel; Plaza Llamas, Roberto de la; Sánchez-Tembleque, María Dolores ...
Revista española de enfermedades digestivas,
09/2011, Letnik:
103, Številka:
9
Journal Article
Intraductal papillary mucinous neoplasm Ramia-Ángel, José Manuel; Plaza Llamas, Roberto de la; Sánchez-Tembleque, María Dolores ...
Revista española de enfermedades digestivas
103, Številka:
9
Journal Article
To present our experience with mesothelial cysts with excretory system involvement.
3 cases of mesothelial cyst are presented; two of them caused obstructive uropathy.
Cases 1 and 2 were treated by ...surgery, while case 3 was managed conservatively. All cases are currently asymptomatic.
Mesothelial cysts are an uncommon cause of obstructive uropathy. Treatment is by surgery for the symptomatic cases and conservative management is a valid alternative for the asymptomatic cases.
We report two new cases of this rare and aggressive tumour; one case appeared in the earliest age reported in the literature (case #2). We also review etiological, diagnostic and therapeutic ...features.
Despite aggressive surgery and adjuvant chemotherapy it has a very poor prognosis, with disease progression within 6 months in both cases.
Sarcomatoid renal cell carcinoma is an infrequent entity, extremely aggressive and requires radical surgery at the time of diagnosis due to its advanced stage, although results are poor. It can also appear in young people with the same aggressiveness than in adult age.
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