Sildenafil citrate (Viagra) is the first effective, orally administered agent for the management of erectile dysfunction (ED). It is a potent and selective inhibitor of phosphodiesterase type 5 ...(PDE5), the predominant isoform found in human corporal smooth muscle. Sexual stimulation releases, in the penis, the neurotransmitter nitric oxide, which in turn increases cyclic GMP (cGMP) within the smooth muscle cell. Cyclic GMP produces penile smooth muscle relaxation, which increases blood inflow and entrapment within the penis. The inhibition of PDE5 by sildenafil increases the duration and activity of cGMP and thus amplifies the effect of sexual stimulation. Sildenafil has demonstrated significant efficacy (57-83%) regardless of the etiology (organic, psychogenic, mixed), age, or baseline severity of the ED. The adverse events related to sildenafil include headaches, flushing, dyspepsia, and nasal stuffiness. In over 50 million patient administrations in the field since FDA approval, sildenafil has maintained this safety and efficacy profile. It has dramatically impacted the field of sexual health care, not only medically but also societally and economically.
Urology Padma-Nathan, Harin
The Western journal of medicine,
08/1987, Letnik:
147, Številka:
2
Journal Article
Recenzirano
The Scientific Board of the California Medical Association presents the following inventory of items of progress in urology. Each item, in the judgment of a panel of knowledgeable physicians, has ...recently become reasonably firmly established, both as to scientific fact and important clinical significance. The items are presented in simple epitome and an authoritative reference, both to the item itself and to the subject as a whole, is generally given for those who may be unfamiliar with a particular item. The purpose is to assist busy practitioners, students, research workers or scholars to stay abreast of these items of progress in urology that have recently achieved a substantial degree of authoritative acceptance, whether in their own field of special interest or another. The items of progress listed below were selected by the Advisory Panel to the Section on Urology of the California Medical Association and the summaries were prepared under its direction.
The Scientific Board of the California Medical Association presents the following inventory of items of progress in urology. Each item, in the judgment of a panel of knowledgeable physicians, has ...recently become reasonably firmly established, both as to scientific fact and important clinical significance. The items are presented in simple epitome and an authoritative reference, both to the item itself and to the subject as a whole, is generally given for those who may be unfamiliar with a particular item. The purpose is to assist busy practitioners, students, research workers or scholars to stay abreast of these items of progress in urology that have recently achieved a substantial degree of authoritative acceptance, whether in their own field of special interest or another.The items of progress listed below were selected by the Advisory Panel to the Section on Urology of the California Medical Association and the summaries were prepared under its direction.
Intracavernosal self-injection of smooth muscle relaxants, primarily papaverine admixed with phentolamine, have been used to treat impotence in over 300 patients. The program is effective in a large ...fraction of this group. Selection of patients, adjustment of dose, methods for monitoring, clinical efficacy, and complications are discussed.
