The first observation of the decays B_{(s)}^{0}→J/ψppover ¯ is reported, using proton-proton collision data corresponding to an integrated luminosity of 5.2 fb^{-1}, collected with the LHCb ...detector. These decays are suppressed due to limited available phase space, as well as due to Okubo-Zweig-Iizuka or Cabibbo suppression. The measured branching fractions are B(B^{0}→J/ψppover ¯)=4.51±0.40(stat)±0.44(syst)×10^{-7}, B(B_{s}^{0}→J/ψppover ¯)=3.58±0.19(stat)±0.39(syst)×10^{-6}. For the B_{s}^{0} meson, the result is much higher than the expected value of O(10^{-9}). The small available phase space in these decays also allows for the most precise single measurement of both the B^{0} mass as 5279.74±0.30(stat)±0.10(syst) MeV and the B_{s}^{0} mass as 5366.85±0.19(stat)±0.13(syst) MeV.
These final results from DELPHI searches for the Standard Model (SM) Higgs boson, together with benchmark scans of the Minimal Supersymmetric Standard Model (MSSM) neutral Higgs bosons, used data ...taken at centre-of-mass energies between 200 and 209 GeV with a total integrated luminosity of 224 pb-1. The data from 192 to 202 GeV are reanalysed with improved b-tagging for MSSM final states decaying to four b-quarks. The 95% confidence level lower mass bound on the Standard Model Higgs boson is 114.1 GeV/c2. Limits are also given on the lightest scalar and pseudo-scalar Higgs bosons of the MSSM.
Summary
background There is experimental evidence that leptin is required for the development of T helper 1 (Th1)‐mediated autoimmune diseases. However, to our knowledge, there are no studies ...demonstrating such a role in human autoimmune thyroid disease.
objective In the present study we have retrospectively examined patients developing postpartum thyroiditis (PPT), as a model of autoimmune disease, for changes in serum leptin levels during the postpartum period.
materials and methods The study group included 61 women in the first month postpartum who were positive for thyroid peroxidase antibodies (TPOAb+ve). Twenty TPOAb‐negative (–ve), age and body mass index (BMI)‐matched, postpartum women were enrolled as the control group. All subjects were evaluated for BMI, serum leptin values, thyroid function serum free‐triiodiothyronine (FT3), free‐thyroxine (FT4), thyrotropin (TSH) and autoimmunity TPOAb levels and complement activity index (C3 index) at 4, 12, 16, 20 and 24 weeks’ postpartum. During the postpartum period, 32 of 61 TPOAb+ve women (52·4%) showed one or more episodes of thyroid dysfunction (PPTD group), whereas the remaining 29 TPOAb+ve women remained euthyroid throughout the study period (PPTE group). None of the control group developed thyroid dysfunction.
results Four weeks postpartum, TPOAb+ve women showed higher serum leptin values than TPOAb–ve women, despite comparable BMI. At this time, PPTE and PPTD patients showed no significant differences in leptin levels or leptin/BMI ratio. Throughout the postpartum period, PPTD patients maintained significantly higher leptin values and leptin/BMI ratio compared to the healthy women. In PPTE women, however, a significant reduction in leptin levels and leptin/BMI ratio was seen at 12 weeks’ postpartum. This decrease was transient and correlated negatively with the variation in C3 index at the same time. No significant correlation was found between serum leptin variations and FT4 or TSH levels.
conclusions This study has demonstrated that women developing postpartum thyroiditis have higher leptin values compared to the healthy women. The higher levels were maintained for 6 months postpartum. This result would suggest an involvement of leptin in the pathogenesis of postpartum thyroid disease, although further studies are needed to characterize the reciprocal effects of leptin, immune system and thyroid hormones during the course of this disease.
An analysis of $B^{\pm}\to DK^{\pm}$ and $B^{\pm}\to D\pi^{\pm}$ decays is presented where the $D$ meson is reconstructed in the four-body final state $K^{\pm}\pi^{\mp} \pi^+ \pi^-$. Using LHCb data ...corresponding to an integrated luminosity of $1.0{\rm \,fb}^{-1}$, first observations are made of the suppressed ADS modes $B^{\pm}\to \pi^{\pm} K^{\mp}\pi^+\pi^-_D K^{\pm}$ and $B^{\pm}\to \pi^{\pm} K^{\mp} \pi^+\pi^- _D\pi^{\pm}$ with a significance of $5.1\sigma$ and greater than $10\sigma$, respectively. Measurements of CP asymmetries and CP-conserving ratios of partial widths from this family of decays are also performed. The magnitude of the ratio between the suppressed and favoured $B^{\pm}\to DK^{\pm}$ amplitudes is determined to be $r^K_B = 0.097 \pm{0.011}$.
The determination of the differential branching fraction and the first angular analysis of the decay $B_s^0\to\phi\mu^{+}\mu^{-}$ are presented using data, corresponding to an integrated luminosity ...of $1.0\,{\rm fb}^{-1}$, collected by the LHCb experiment at $\sqrt{s}=7\,{\rm TeV}$. The differential branching fraction is determined in bins of $q^{2}$, the invariant dimuon mass squared. Integration over the full $q^{2}$ range yields a total branching fraction of ${\cal B}(B_s^0\to\phi\mu^{+}\mu^{-}) = (7.07\,^{+0.64}_{-0.59}\pm 0.17 \pm 0.71)\times 10^{-7}$, where the first uncertainty is statistical, the second systematic, and the third originates from the branching fraction of the normalisation channel. An angular analysis is performed to determine the angular observables $F_{\rm L}$, $S_3$, $A_6$, and $A_9$. The observables are consistent with Standard Model expectations.
The production of J/psi and Upsilon mesons in pp collisions at sqrt(s) = 8 TeV is studied with the LHCb detector. The J/psi and Upsilon mesons are reconstructed in the mu+mu- decay mode and the ...signal yields are determined with a fit to the mu+mu- invariant mass distributions. The analysis is performed in the rapidity range 2.0
Nature Communications 7 Article number: 12342 (2016); Published 9 August 2016; Updated 13 September 2016 The HTML version of this Article incorrectly listed the authors of the UK IBD Genetics ...Consortium and the NIDDK IBD Genetics Consortium individually in the main author list. This has now been corrected in the HTML; the PDF version of the paper was correct from the time of publication.
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