In this work, we present a new, high performance algorithm for background rejection in imaging atmospheric Cherenkov telescopes. We build on the already popular machine-learning techniques used in ...gamma-ray astronomy by the application of the latest techniques in machine learning, namely recurrent and convolutional neural networks, to the background rejection problem. Use of these machine-learning techniques addresses some of the key challenges encountered in the currently implemented algorithms and helps to significantly increase the background rejection performance between 100 GeV and 100 TeV energies. We apply these machine learning techniques to the H.E.S.S. telescope array, first testing their performance on simulated data and then applying the analysis to two well known gamma-ray sources. With real observational data we find significantly improved performance over the current standard methods, with a 20–25% reduction in the background rate when applying the recurrent neural network analysis. Importantly, we also find that the convolutional neural network results are strongly dependent on the sky brightness in the source region which has important implications for the future implementation of this method in Cherenkov telescope analyses.
ABSTRACT
The use of acoustic Doppler current profilers (ADCP) for discharge measurements and three‐dimensional flow mapping has increased rapidly in recent years and has been primarily driven by ...advances in acoustic technology and signal processing. Recent research has developed a variety of methods for processing data obtained from a range of ADCP deployments and this paper builds on this progress by describing new software for processing and visualizing ADCP data collected along transects in rivers or other bodies of water. The new utility, the Velocity Mapping Toolbox (VMT), allows rapid processing (vector rotation, projection, averaging and smoothing), visualization (planform and cross‐section vector and contouring), and analysis of a range of ADCP‐derived datasets. The paper documents the data processing routines in the toolbox and presents a set of diverse examples that demonstrate its capabilities. The toolbox is applicable to the analysis of ADCP data collected in a wide range of aquatic environments and is made available as open‐source code along with this publication. Published 2012. This article is a U.S. Government work and is in the public domain in the USA.
We present a high-performance event reconstruction algorithm: an Image Pixel-wise fit for Atmospheric Cherenkov Telescopes (ImPACT). The reconstruction algorithm is based around the likelihood ...fitting of camera pixel amplitudes to an expected image template. A maximum likelihood fit is performed to find the best-fit shower parameters. A related reconstruction algorithm has already been shown to provide significant improvements over traditional reconstruction for both the CAT and H.E.S.S. experiments. We demonstrate a significant improvement to the template generation step of the procedure, by the use of a full Monte Carlo air shower simulation in combination with a ray-tracing optics simulation to more accurately model the expected camera images. This reconstruction step is combined with an MVA-based background rejection.
Examples are shown of the performance of the ImPACT analysis on both simulated and measured (from a strong VHE source) gamma-ray data from the H.E.S.S. array, demonstrating an improvement in sensitivity of more than a factor two in observation time over traditional image moments-fitting methods, with comparable performance to previous likelihood fitting analyses. ImPACT is a particularly promising approach for future large arrays such as the Cherenkov Telescope Array (CTA) due to its improved high-energy performance and suitability for arrays of mixed telescope types.
The discovery of extended TeV emission around the Geminga and PSR B0656+14 pulsars, with properties consistent with free particle propagation in the interstellar medium (ISM), has led to the ...suggestion of “TeV halos” as a separate source class, which is distinct from pulsar wind nebulae. This has sparked considerable discussion on the possible presence of such halos in other systems. In defining halos as regions where the pulsar no longer dominates the dynamics of the interstellar medium, yet where an over-density of relativistic electrons is present, we make an assessment of the current TeV source population associated with energetic pulsars in terms of size and estimated energy density. Based on two alternative estimators, we conclude that a large majority of the known TeV sources have emission originating in the zone that is energetically and dynamically dominated by the pulsar (i.e. the pulsar wind nebula), rather than from a surrounding halo of escaped particles diffusing into the ISM. Furthermore, whilst the number of established halos will surely increase in the future since there is a known large population of older, less energetic pulsars, we find that it is unlikely that such halos contribute significantly to the total TeV
γ
-ray luminosity from electrons accelerated in pulsar wind nebulae due to their lower intrinsic surface brightness.
ABSTRACT
HiPERCAM is a portable, quintuple-beam optical imager that saw first light on the 10.4-m Gran Telescopio Canarias (GTC) in 2018. The instrument uses re-imaging optics and four dichroic ...beamsplitters to record $u_{\rm s}\, g_{\rm s}\, r_{\rm s}\, i_{\rm s}\, z_{\rm s}$ (320–1060 nm) images simultaneously on its five CCD cameras, each of 3.1-arcmin (diagonal) field of view. The detectors in HiPERCAM are frame-transfer devices cooled thermo-electrically to 183 K, thereby allowing both long-exposure, deep imaging of faint targets, as well as high-speed (over 1000 windowed frames per second) imaging of rapidly varying targets. A comparison-star pick-off system in the telescope focal plane increases the effective field of view to 6.7 arcmin for differential photometry. Combining HiPERCAM with the world’s largest optical telescope enables the detection of astronomical sources to gs ∼ 23 in 1 s and gs ∼ 28 in 1 h. In this paper, we describe the scientific motivation behind HiPERCAM, present its design, report on its measured performance, and outline some planned enhancements.
In the sub-TeV regime, the most widely used hadronic interaction models disagree significantly in their predictions for post-first interaction and ground-level particle spectra from cosmic ray ...induced air showers. These differences generate an important source of systematic uncertainty in their experimental use. We investigate the nature and impact of model uncertainties through a simultaneous analysis of ground level particles and first interaction scenarios. We focus on air shower primaries with energies close to the transition between high and low energy hadronic interaction models, where the dissimilarities have been shown to be the largest and well within the range of accelerator measurements. Interaction models are shown to diverge as several shower scenarios are compared, reflecting intrinsic differences in the model theoretical frameworks. Finally, we discuss the importance of interactions in the energy regime where the switching between models occurs (
<
1
TeV) and the effect of the choice of model on the number of hadronic interactions within cosmic ray induced air showers of higher energies.
Introduction
Specific patterns of blood test results are associated with COVID-19 infection. The aim of this study was to identify which blood tests could be used to assist in diagnosing COVID-19.
...Method
A retrospective review was performed on consecutive patients referred to hospital with a clinical suspicion of COVID-19 over a period of four weeks. The patient’s clinical presentation and severe acute respiratory syndrome coronavirus 2 reverse-transcription polymerase chain reaction (SARS-CoV-2 RT-PCR) were recorded. The patients were divided by diagnosis into COVID (COVID-19 infection) or CONTROL (an alternate diagnosis). A retrospective review of consecutive patients over a further two-week period was used for the purposes of validation.
Results
Overall, 399 patients (53% COVID, 47% CONTROL) were analysed. White cell count, neutrophils and lymphocytes were significantly lower, while lactate dehydrogenase and ferritin were significantly higher, in the COVID group in comparison to CONTROL. Combining the white cell count, lymphocytes and ferritin results into a COVID Combined Blood Test (CCBT) had an area under the curve of 0.79. Using a threshold CCBT of –0.8 resulted in a sensitivity of 0.85 and a specificity of 0.63. Analysing this against a further retrospective review of 181 suspected COVID-19 patients, using the same CCBT threshold, resulted in a sensitivity of 0.73 and a specificity of 0.75. The sensitivity was comparable to the SARS-CoV-2 RT PCR.
Discussion
Mathematically combining the blood tests has the potential to assist clinical acumen allowing for rapid streaming and more accurate patient flow pending definitive diagnosis. This may be of particular use in low-resource settings.
Cosmic ray electrons and positrons are tracers of particle propagation in the interstellar medium (ISM). A recent measurement performed using the High Energy Stereoscopic System extends the ...all-electron (electron+positron) spectrum up to 20 TeV, probing very local sources and transport due to the ∼10 kyr cooling time of these particles. An additional key local measurement was the recent estimation of the ISM diffusion coefficient around Geminga performed using the High-Altitude Water Cherenkov Observatory. The inferred diffusion coefficient is much lower than typically assumed values. It has been argued that if this diffusion coefficient is representative of the local ISM, pulsars would not be able to account for the all-electron spectrum measured at Earth. Here we show that a low diffusion coefficient in the local ISM is compatible with a pulsar wind nebula origin of the highest energy electrons, if a so-far-undiscovered pulsar with spin-down power ∼10^{33-34} erg/s exists within 30-80 pc of Earth. The existence of such a pulsar is broadly consistent with the known population and may be detected in near future survey observations.
Abstract The DNA Commission of the International Society of Forensic Genetics (ISFG) regularly publishes guidelines and recommendations concerning the application of DNA polymorphisms to the question ...of human identification. Previous recommendations published in 2000 addressed the analysis and interpretation of mitochondrial DNA (mtDNA) in forensic casework. While the foundations set forth in the earlier recommendations still apply, new approaches to the quality control, alignment and nomenclature of mitochondrial sequences, as well as the establishment of mtDNA reference population databases, have been developed. Here, we describe these developments and discuss their application to both mtDNA casework and mtDNA reference population databasing applications. While the generation of mtDNA for forensic casework has always been guided by specific standards, it is now well-established that data of the same quality are required for the mtDNA reference population data used to assess the statistical weight of the evidence. As a result, we introduce guidelines regarding sequence generation, as well as quality control measures based on the known worldwide mtDNA phylogeny, that can be applied to ensure the highest quality population data possible. For both casework and reference population databasing applications, the alignment and nomenclature of haplotypes is revised here and the phylogenetic alignment proffered as acceptable standard. In addition, the interpretation of heteroplasmy in the forensic context is updated, and the utility of alignment-free database searches for unbiased probability estimates is highlighted. Finally, we discuss statistical issues and define minimal standards for mtDNA database searches.