The role of aerosols and clouds is one of the largest sources of uncertainty in understanding climate change. The primary scientific goal of this thesis is to improve the understanding of ...cloud-aerosol interactions by applying inverse modeling using Markov Chain Monte Carlo (MCMC) simulation. Through a set of synthetic tests using a pseudo-adiabatic cloud parcel model, it is shown that a self adaptive MCMC algorithm can efficiently find the correct optimal values of meteorological and aerosol physiochemical parameters for a specified droplet size distribution and determine the global sensitivity of these parameters. For an updraft velocity of 0.3 m s-1, a shift towards an increase in the relative importance of chemistry compared to the accumulation mode number concentration is shown to exist somewhere between marine (~75 cm-3) and rural continental (~450 cm-3) aerosol regimes. Examination of in-situ measurements from the Marine Stratus/Stratocumulus Experiment (MASE II) shows that for air masses with higher number concentrations of accumulation mode (Dp = 60-120 nm) particles (~450 cm-3), an accurate simulation of the measured droplet size distribution requires an accurate representation of the particle chemistry. The chemistry is relatively more important than the accumulation mode particle number concentration, and similar in importance to the particle mean radius. This result is somewhat at odds with current theory that suggests chemistry can be ignored in all except for the most polluted environments. Under anthropogenic influence, we must consider particle chemistry also in marine environments that may be deemed relatively clean. The MCMC algorithm can successfully reproduce the observed marine stratocumulus droplet size distributions. However, optimising towards the broadness of the measured droplet size distribution resulted in a discrepancy between the updraft velocity, and mean radius/geometric standard deviation of the accumulation mode. This suggests that we are missing a dynamical process in the pseudo-adiabatic cloud parcel model.
At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 3: Submitted. Paper 4: Manuscript.
The true role of the lawyer in society is the furnishing of helpful services, Mr. Partridge declares. And, he adds, the successful lawyer is the man who has helped the most people and has thereby ...created a practice of loyal and trusting clients. But this won't happen if you let the dollar ride you.
In this article, Mr. Partridge, the Chairman of the Section of Real Property, Probate and Trust Law's Committee on Simplification of Security Transfers by Fiduciaries, asks for support of the Uniform ...Act for Simplification of Security Transfers—a matter, he notes, that is at least as important as D-Day. Mr. Partridge's vigorous style makes his article entertaining as well as informative.
The economic and social development of nations relies on their population having physical access to services and employment opportunities. For the vast majority of the 3.4 billion people living in ...rural locations, this largely depends on their access to urban centers of different sizes. Similarly, urban centers depend on their rural hinterlands. Building on the literature on functional areas/territories and the rural-urban continuum as well as insights from central place theory, this review paper advances the notion of catchment areas differentiated along an urban-to-rural continuum to capture these urban-rural interconnections. It further shows how a new, publicly available data set operationalizing this concept can shed new light on policy making across a series of development fields, including institutions and governance, urbanization and food systems, welfare and poverty, and access to health and education services. Together the insights support a more geographically nuanced perspective on development.
Most human transcription factors bind a small subset of potential genomic sites and often use different subsets in different cell types. To identify mechanisms that govern cell-type-specific ...transcription factor binding, we used an integrative approach to study estrogen receptor α (ER). We found that ER exhibits two distinct modes of binding. Shared sites, bound in multiple cell types, are characterized by high-affinity estrogen response elements (EREs), inaccessible chromatin, and a lack of DNA methylation, while cell-specific sites are characterized by a lack of EREs, co-occurrence with other transcription factors, and cell-type-specific chromatin accessibility and DNA methylation. These observations enabled accurate quantitative models of ER binding that suggest tethering of ER to one-third of cell-specific sites. The distinct properties of cell-specific binding were also observed with glucocorticoid receptor and for ER in primary mouse tissues, representing an elegant genomic encoding scheme for generating cell-type-specific gene regulation.
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•Two types of estrogen receptor α binding sites: shared and cell specific•Shared sites are encoded in the genome as high-affinity estrogen response elements•Cell-specific sites rely on interacting factors and depend on genomic context•Cell-specific binding is predicted from DNA sequence and chromatin accessibility
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