•We conducted a longitudinal study with a population of high school students.•We examined potential predictors of academic motivation and high school dropout.•Teacher support for basic needs ...predicted only academic motivation.•Parent support for basic needs and reciprocal friendships predicted both outcomes.
The purpose of this study was to examine whether parent and teacher support for basic psychological needs (i.e., autonomy, competence and relatedness), students' reciprocal friendships, and academic motivation assessed in Grade 10 (N = 624) could predict dropping out of high school two years later in Grade 12. Results revealed that reciprocal friendships contributed to the prediction of dropping out of high school, above and beyond the effects of academic motivation, or parent and teacher support for basic psychological needs. Although parent support for basic psychological needs appeared to be the most significant predictor of academic motivation and dropping out of high school, results suggested that reciprocal friendships represented an important factor that affect both motivation and persistence. Most specifically, our findings demonstrated that a lack of reciprocal friendships had detrimental effects on these aforementioned processes, whereas having reciprocal friendships lead to favorable outcomes.
Self-determination Theory differentiates various types of motivation, each of which have different consequences for well-being and behavior. Despite broad agreement concerning the nature of different ...types of motivation, numerous scoring methods, each of which rely on different assumptions, are commonly practiced. These practices range from a relative autonomy index that collapses all types of motivation into a single index, higher-order models grouping subscales into a two-factor solution, to multi-factorial approaches examining all motivation types as separate constructs. Existing evidence has not empirically compared these methods or clearly favored the use of one over another. We review each method and further investigate the advantages and disadvantages of each approach by directly comparing a range of commonly utilized scoring methods, as well as recently developed methods across six independent samples from various life domains to determine their effectiveness. Results generally favor multidimensional methods (e.g., exploratory structural equation modeling, B-ESEM, and CFA) as more comprehensive scoring practices as they maximize construct relevant information. However, selection of an ideal method will rely on theoretical congruence between methodology and research questions.
Is dehydroepiandrosterone a hormone? Labrie, F; Luu-The, V; Bélanger, A ...
Journal of endocrinology,
11/2005, Letnik:
187, Številka:
2
Journal Article
Recenzirano
Odprti dostop
Dehydroepiandrosterone (DHEA) is not a hormone but it is a very important prohormone secreted in large amounts by the adrenals in humans and other primates, but not in lower species. It is secreted ...in larger quantities than cortisol and is present in the blood at concentrations only second to cholesterol. All the enzymes required to transform DHEA into androgens and/or estrogens are expressed in a cell-specific manner in a large series of peripheral target tissues, thus permitting all androgen-sensitive and estrogen-sensitive tissues to make locally and control the intracellular levels of sex steroids according to local needs. This new field of endocrinology has been called intracrinology. In women, after menopause, all estrogens and almost all androgens are made locally in peripheral tissues from DHEA which indirectly exerts effects, among others, on bone formation, adiposity, muscle, insulin and glucose metabolism, skin, libido and well-being. In men, where the secretion of androgens by the testicles continues for life, the contribution of DHEA to androgens has been best evaluated in the prostate where about 50% of androgens are made locally from DHEA. Such knowledge has led to the development of combined androgen blockade (CAB), a treatment which adds a pure anti-androgen to medical (GnRH agonist) or surgical castration in order to block the access of the androgens made locally to the androgen receptor. In fact, CAB has been the first treatment demonstrated to prolong life in advanced prostate cancer while recent data indicate that it can permit long-term control and probably cure in at least 90% of cases of localized prostate cancer. The new field of intracrinology or local formation of sex steroids from DHEA in target tissues has permitted major advances in the treatment of the two most frequent cancers, namely breast and prostate cancer, while its potential use as a physiological HRT could well provide a physiological balance of androgens and estrogens, thus offering exciting possibilities for women's health at menopause.
There is now evidence that estrogens and androgens are exerting their effects in different tissues throughout the body. In order to determine the sites of action of these steroids, studies have been ...performed to identify at the cellular level the localization of androgen receptor (AR) and the two estrogen receptor (ER) subtypes, ERalpha and ERbeta, specially in the rat, monkey and human. In the prostate, AR was observed in the secretory and stromal cells. In the testis, Sertoli, Leydig and myoid cells were labelled. In the epididymis and seminal vesicles, both epithelial and stromal cells contained AR. In the ovary, AR was detected in granulosa and interstitial cells. In the uterus, epithelial, stromal and muscle cells were all immunopositive for AR. In the central nervous system, AR-containing neurons were found to be widely distributed throughout the brain. In the mammary gland, epithelial cells in acini and ducts and stromal cells were demonstrated to express AR. In the skin, AR was detected in keratinocytes, sebaceous and sweat glands, and hair follicles. In addition, AR was also found in anterior pituitary, thyroid, adrenal cortex, liver, kidney tubules, urinary bladder, cardiac and striated muscle, and bone. The ER subtypes are in general differentially expressed. While ERalpha has been predominantly found in anterior pituitary, uterus, vagina, testis, liver and kidney, ERbeta is predominant in thyroid, ovary, prostate, skin, bladder, lungs, gastro-intestinal tract, cartilage and bone. In tissues which contain both receptor subtypes, such as ovary, testis and various regions of the brain, a cell-specific localization for each ER subtype has been generally observed. Altogether, the recent results on the cellular localization of sex steroid receptors will certainly contribute to a better understanding of the specific role of these steroids in different target organs.
Although the Sport Motivation Scale (SMS), published in 1995, has demonstrated validity and reliability in multiple studies, the scale has received some criticisms leading to revisions herein ...described. The objective of the present studies was to examine the construct validity and reliability of a revised scale sport motivation scale (SMS-II).
Two studies were conducted using distinct samples of athletes. Study 1 examined adult athletes participating in a variety of sports and Study 2 examined youth basketball players and swimmers.
In Study 1 the SMS-II was introduced and featured various item content changes, a reduced number of items per subscale, the addition of an integrated regulation subscale, and the introduction of a single intrinsic motivation subscale to replace the three intrinsic motivation subscales in the SMS. Relations of SMS-II subscales with each other and with expected outcomes supported the new scale's validity. In Study 2, the structure of the SMS-II and its relations with outcomes were further examined.
Results of factor analyses, tests for internal consistency, and correlations among the different subscales and between the subscales and several outcomes of interest, supported the validity of the SMS-II.
Discussion focuses on the need for measurement improvement, and potential future directions for SMS-II research.
► A revised version of the sport motivation scale (SMS-II) is proposed. ► A shorter scale with 1 measure of intrinsic motivation and an integrated subscale. ► Validated with two distinct samples: adult athletes and youth athletes. ► Factor analyses, reliabilities, and correlations support scale structure. ► Results support the creation of the SMS-II.
Recent media reports commented about a possible issue of the misuse of antidiabetics related to molecules promoted as a weight-loss treatment in non-obese people. We evaluated here available ...pharmacovigilance misuse/abuse signals related to
, a glucagon-like peptide-1 (GLP-1) analogue, in comparison to other GLP-1 receptor agonists (
,
,
,
,
, and
) and the
-
combination. To acheieve that aim, we analyzed the Food and Drug Administration's FDA Adverse Events Reporting System (FAERS) dataset, performing a descriptive analysis of adverse event reports (AERs) and calculating related pharmacovigilance measures, including the reporting odds ratio (ROR) and the proportional reporting ratio (PRR). During January 2018-December 2022, a total of 31,542 AERs involving the selected molecules were submitted to FAERS; most involved dulaglutide (n = 11,858; 37.6%) and semaglutide (n = 8249; 26.1%). In comparing semaglutide vs. the remaining molecules, the respective PRR values of the AERs 'drug abuse', 'drug withdrawal syndrome', 'prescription drug used without a prescription', and 'intentional product use issue' were 4.05, 4.05, 3.60, and 1.80 (all < 0.01). The same comparisons of semaglutide vs. the phentermine-topiramate combination were not associated with any significant differences. To the best of our knowledge, this is the first study documenting the misuse/abuse potential of semaglutide in comparison with other GLP1 analogues and the phentermine-topiramate combination. The current findings will need to be confirmed by further empirical investigations to fully understand the safety profile of those molecules.
Glucagon-like peptide-1 (GLP-1) is involved in a range of central and peripheral pathways related to appetitive behavior. Hence, this study explored the effects of glucagon-like peptide-1 receptor ...agonists (GLP-1 RAs) on substance and behavioral addictions, including alcohol, caffeine, nicotine, cannabis, psychostimulants, compulsive shopping, and sex drive/libido. Data were collected from various social platforms. Keywords related to GLP-1 RAs and substance/behavioral addiction were used to extract relevant comments. The study employed a mixed-methods approach to analyze online discussions posted from December 2019 to June 2023 and collected using a specialized web application. Reddit entries were the focus here due to limited data from other platforms, such as TikTok and YouTube. A total of 5859 threads and related comments were extracted from six subreddits, which included threads about GLP-1 RAs drugs and associated brand names. To obtain relevant posts, keywords related to potential substance use and compulsive behavior were selected. Further analysis involved two main steps: (1) manually coding posts based on users’ references to the potential impact of GLP-1 RAs on substance use and non-substance habits, excluding irrelevant or unclear comments; (2) performing a thematic analysis on the dataset of keywords, using AI-assisted techniques followed by the manual revision of the generated themes. Second, a thematic analysis was performed on the keyword-related dataset, using AI-assisted techniques followed by the manual revision of the generated themes. In total, 29.75% of alcohol-related; 22.22% of caffeine-related; and 23.08% of nicotine-related comments clearly stated a cessation of the intake of these substances following the start of GLP-1 RAs prescription. Conversely, mixed results were found for cannabis intake, and only limited, anecdotal data were made available for cocaine, entactogens, and dissociative drugs’ misuse. Regarding behavioral addictions, 21.35% of comments reported a compulsive shopping interruption, whilst the sexual drive/libido elements reportedly increased in several users. The current mixed-methods approach appeared to be a useful tool in gaining insight into complex topics such as the effects of GLP-1 RAs on substance and non-substance addiction-related disorders; some GLP-1 RA-related mental health benefits could also be inferred from here. Overall, it appeared that GLP-1 RAs may show the potential to target both substance craving and maladaptive/addictive behaviors, although further empirical research is needed.
This research examined changes in intrinsic and extrinsic motivation during the transition from junior to senior high school as well as the impact of motivational changes on various educational ...consequences (i.e., dropout intentions, absenteeism, homework frequency, and educational aspirations). A total of 646 participants completed a questionnaire in 8th, 9th, and 10th grade. Using the true intraindividual change modeling technique (
R. Steyer, I. Partchev, & M. J. Shanahan, 2000
), the authors reached results revealing that students' intrinsic motivation and extrinsic motivation decreased gradually from 8th to 10th grade. Furthermore, less educational adjustment was observed for students experiencing a decline in external regulation during the transitional year and students experiencing a decline in intrinsic motivation and identified regulation during the year after the transition.
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