In the last few years, many reports have confirmed the presence of WU, KI and Merkel cell (MC) polyomaviruses (PyV) in respiratory samples wordwide, but their pathogenic role in patients with ...underlying conditions such as cystic fibrosis is still debated. To determine the prevalence of MCPyV, WUPyV and KIPyV, we conducted a 1-year-long microbiological testing of respiratory specimens from 93 patients with cystic fibrosis in Brescia, Italy. We detected PyV DNA in 94 out of 337 analysed specimens. KIPyV was the most common virus detected (12.1%), followed by WUPyV (8.9%) and MCPyV (6.8%). We found an intriguing association between the presence of MCPyV and the concurrent isolation of Pseudomonas aeruginosa, as well as with the patient status, classified as chronically colonized with P. aeruginosa. Our study adds perspective on the prevalence and the potential pathogenic role of PyV infections.
Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS) is a hereditary autoinflammatory syndrome characterized by recurrent episodes of fever and localized inflammation. Clinical ...presentation can be very variable in terms of duration of fever attacks, periodicity, and accompanying manifestations. One of the most characteristic symptoms is the occurrence of migrating skin rash with myalgia that is sustained by monocytic inflammation.
We herein present the case of a family suffering from TRAPS who had been misdiagnosed for a long period of time and whose main symptom was migrating angioedema. Skin biopsy from one of the patients documented a monocytic panniculitis. All the living patients responded dramatically to anakinra treatment.
The classic symptom of migratory angioedema with myalgia in TRAPS can be produced by monocytic panniculitis.This manifestation is so characteristic of TRAPS that its occurrence, even in the absence of other manifestations, should prompt genetic analysis. Our patient's condition responded promptly to anakinra treatment.
In the last few years, many reports have confirmed the presence of WU, KI and Merkel cell (MC) polyomaviruses (PyV) in respiratory samples wordwide, but their pathogenic role in patients with ...underlying conditions such as cystic fibrosis is still debated. To determine the prevalence of MCPyV, WUPyV and KIPyV, we conducted a 1-year-long microbiological testing of respiratory specimens from 93 patients with cystic fibrosis in Brescia, Italy. We detected PyV DNA in 94 out of 337 analysed specimens. KIPyV was the most common virus detected (12.1%), followed by WUPyV (8.9%) and MCPyV (6.8%). We found an intriguing association between the presence of MCPyV and the concurrent isolation of Pseudomonas aeruginosa, as well as with the patient status, classified as chronically colonized with P. aeruginosa. Our study adds perspective on the prevalence and the potential pathogenic role of PyV infections.
Data acquisition and monitoring for the KLOE detector Aloisio, A.; Ambrosino, F.; Antonelli, M. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
01/2004, Letnik:
516, Številka:
2
Journal Article
Recenzirano
The Data Acquisition system for the KLOE experiment, presently running at the Laboratori Nazionali di Frascati DAΦNE collider, has been designed to sustain an acquisition throughput of
50
Mbyte/
s
...for an event rate of
10
kHz
. Its two major components are the front end data readout, based on custom buses, and a complex network of computers and storage devices hosting a set of distributed processes. The end result is a seamless data transport from the readout system to the storage library, accompanied by concurrent on line calibrations and data quality control.
We present a new measurement of the K
L-K
S mass difference (
Δm) using semileptonic decays of neutral kaons. The measurement yields
Δm = (0.5274 ± 0.0029
stat. ± 0.0005
syst.) × 10
10ħ/s.
The time-dependent rate asymmetry of initial K
0 and
K
0 decaying into
π
+
π
−
π
0 was measured in order to reveal the CP-violating amplitude of the K
S →
π
+
π
−
π
0 decay. For the real and the ...imaginary parts of
η
+−0, we find Re(η
+−0) = (6 ± 13
stat. ± 1
syst.) × 10
−3 and Im(η
+−0) = (−2 ± 18
stat. ± 3
syst.) × 10
−3 which correspond to |
η
+−0| < 0.037 with CL.
The interference between CP-conserving Ks and K
L →
π
+
π
−
π
0 decay amplitudes was observed by studying the decay rate asymmetries between initial K
0 and
K
0 separately for the phase space regions
...E
CM(
π
+) >
E
CM(
π
−) and
E
CM(
π
+) <
E
CM(
π
−). For the parameter λ we found Re(λ) = 0.036 ± 0.010(stat.)
−0.003
+0.002(syst.) and Im(λ) consistent with zero, leading to a branching ratio B = 4.1
−1.9
+2.5(stat.)
−0.6
+0.5(syst.) × 10
−7 for the CP-conserving K
S →
π
+
π
−
π
0 decay.
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