Present-day galaxies are surrounded by cool and enriched halo gas extending for hundreds of kiloparsecs. This halo gas is thought to be the dominant reservoir of material available to fuel future ...star formation, but direct constraints on its mass and physical properties have been difficult to obtain. We report the detection of a fast radio burst (FRB 181112), localized with arcsecond precision, that passes through the halo of a foreground galaxy. Analysis of the burst shows that the halo gas has low net magnetization and turbulence. Our results imply predominantly diffuse gas in massive galactic halos, even those hosting active supermassive black holes, contrary to some previous results.
Extracorporeal membrane oxygenation is a life-sustaining therapy for severe respiratory failure. Extracorporeal membrane oxygenation circuits require systemic anticoagulation that creates a delicate ...balance between circuit-related thrombosis and bleeding-related complications. Although unfractionated heparin is most widely used anticoagulant, alternative agents such as bivalirudin have been used. We sought to compare extracorporeal membrane oxygenation circuit thrombosis and bleeding-related outcomes in respiratory failure patients receiving either unfractionated heparin or bivalirudin for anticoagulation on venovenous extracorporeal membrane oxygenation support.
Retrospective cohort study.
Single-center, cardiothoracic ICU.
Consecutive patients requiring venovenous extracorporeal membrane oxygenation who were maintained on anticoagulation between 2013 and 2020.
IV bivalirudin or IV unfractionated heparin.
Primary outcomes were the presence of extracorporeal membrane oxygenation in-circuit-related thrombotic complications and volume of blood products administered during extracorporeal membrane oxygenation duration. One hundred sixty-two patients receiving unfractionated heparin were compared with 133 patients receiving bivalirudin for anticoagulation on venovenous extracorporeal membrane oxygenation. In patients receiving bivalirudin, there was an overall decrease in the number of extracorporeal membrane oxygenation circuit thrombotic complications (p < 0.005) and a significant increase in time to circuit thrombosis (p = 0.007). Multivariable Cox regression found that heparin was associated with a significant increase in risk of clots (ExpB = 2.31, p = 0.001). Patients who received bivalirudin received significantly less volume of packed RBCs, fresh frozen plasma, and platelet transfusion (p < 0.001 for each). There was a significant decrease in the number major bleeding events in patients receiving bivalirudin, 40.7% versus 11.7%, p < 0.001.
Patients receiving bivalirudin for systemic anticoagulation on venovenous extracorporeal membrane oxygenation experienced a decrease in the number of extracorporeal membrane oxygenation circuit-related thrombotic events as well as a significant decrease in volume of blood products administered.
We have developed a new coherent dedispersion mode to study the emission of fast radio bursts (FRBs) that trigger the voltage capture capability of the Australian SKA Pathfinder (ASKAP) ...interferometer. In principle the mode can probe emission timescales down to 3 ns with full polarimetric information preserved. Enabled by the new capability, here we present a spectropolarimetric analysis of FRB 181112 detected by ASKAP, localized to a galaxy at redshift 0.47. At microsecond time resolution the burst is resolved into four narrow pulses with a rise time of just 15 s for the brightest. The pulses have a diversity of morphology, but do not show evidence for temporal broadening by turbulent plasma along the line of sight, nor is there any evidence for periodicity in their arrival times. The pulses are highly polarized (up to 95%), with the polarization position angle varying both between and within pulses. The pulses have apparent rotation measures that vary by and apparent dispersion measures that vary by . Conversion between linear and circular polarization is observed across the brightest pulse. We conclude that the FRB 181112 pulses are most consistent with being a direct manifestation of the emission process or the result of propagation through a relativistic plasma close to the source. This demonstrates that our method, which facilitates high-time-resolution polarimetric observations of FRBs, can be used to study not only burst emission processes, but also a diversity of propagation effects present on the gigaparsec paths they traverse.
The lower rate of primary outcome events in the intensive treatment group in SPRINT (Systolic Pressure Intervention Trial) was associated with increased clinically significant serious adverse events ...(SAEs). In 2017, the American College of Cardiology/American Heart Association issued risk-based blood pressure treatment guidelines. The authors hypothesized that stratification of the SPRINT population by degree of future cardiovascular disease (CVD) risk might identify a group which could benefit the most from intensive treatment.
This study investigated the effect of baseline 10-year CVD risk on primary outcome events and all-cause SAEs in SPRINT.
Stratifying by quartiles of baseline 10-year CVD risk, Cox proportional hazards models were used to examine the associations of treatment group with the primary outcome events and SAEs. Using multiplicative Poisson regression, a predictive model was developed to determine the benefit-to-harm ratio as a function of CVD risk.
Within each quartile, there was a lower rate of primary outcome events and no significant differences in all-cause SAEs for the intensive treatment group compared to the standard treatment group. From the first to fourth quartiles, the number needed to treat to prevent primary outcomes decreased from 91 to 38. The number needed to harm for all-cause SAEs increased from 62 to 250. The predictive model demonstrated significantly increasing benefit-to-harm ratios (± SE) of 0.50 ± 0.15, 0.78 ± 0.26, 2.13 ± 0.73, and 4.80 ± 1.86, for the first, second, third, and fourth quartile, respectively (p for trend <0.001). All possible pairwise comparisons of between-quartile mean values of benefit-to-harm ratios were significantly different (p < 0.001).
In SPRINT, those with lower baseline CVD risk had more harm than benefit from intensive treatment, whereas those with higher risk had more benefit. With the 2017 American College of Cardiology/American Heart Association blood pressure treatment guidelines, this analysis may help providers and patients make decisions regarding the intensity of blood pressure treatment.
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ABSTRACT
Combining high time and frequency resolution full-polarization spectra of fast radio bursts (FRBs) with knowledge of their host galaxy properties provides an opportunity to study both the ...emission mechanism generating them and the impact of their propagation through their local environment, host galaxy, and the intergalactic medium. The Australian Square Kilometre Array Pathfinder (ASKAP) telescope has provided the first ensemble of bursts with this information. In this paper, we present the high time and spectral resolution, full polarization observations of five localized FRBs to complement the results published for the previously studied ASKAP FRB 181112. We find that every FRB is highly polarized, with polarization fractions ranging from 80 to 100 per cent, and that they are generally dominated by linear polarization. While some FRBs in our sample exhibit properties associated with an emerging archetype (i.e. repeating or apparently non-repeating), others exhibit characteristic features of both, implying the existence of a continuum of FRB properties. When examined at high time resolution, we find that all FRBs in our sample have evidence for multiple subcomponents and for scattering at a level greater than expected from the Milky Way. We find no correlation between the diverse range of FRB properties (e.g. scattering time, intrinsic width, and rotation measure) and any global property of their host galaxy. The most heavily scattered bursts reside in the outskirts of their host galaxies, suggesting that the source-local environment rather than the host interstellar medium is likely the dominant origin of the scattering in our sample.
Abstract
We present a systematic study of the most luminous (
M
IR
Vega magnitudes brighter than −14) infrared (IR) transients discovered by the
SPitzer
InfraRed Intensive Transients Survey (SPIRITS) ...between 2014 and 2018 in nearby galaxies (
D
< 35 Mpc). The sample consists of nine events that span peak IR luminosities of
M
4.5,peak
between −14 and −18.2, show IR colors between 0.2 < (3.6–4.5) < 3.0, and fade on timescales between 55 days <
t
fade
< 480 days. The two reddest events (
A
V
> 12) show multiple, luminous IR outbursts over several years and have directly detected, massive progenitors in archival imaging. With analyses of extensive, multiwavelength follow-up, we suggest the following possible classifications: five obscured core-collapse supernovae (CCSNe), two erupting massive stars, one luminous red nova, and one intermediate-luminosity red transient. We define a control sample of all optically discovered transients recovered in SPIRITS galaxies and satisfying the same selection criteria. The control sample consists of eight CCSNe and one Type Iax SN. We find that 7 of the 13 CCSNe in the SPIRITS sample have lower bounds on their extinction of 2 <
A
V
< 8. We estimate a nominal fraction of CCSNe in nearby galaxies that are missed by optical surveys as high as
(90% confidence). This study suggests that a significant fraction of CCSNe may be heavily obscured by dust and therefore undercounted in the census of nearby CCSNe from optical searches.
We present a new fast radio burst (FRB) at 920 MHz discovered during commensal observations conducted with the Australian Square Kilometre Array Pathfinder (ASKAP) as part of the Commensal Real-time ...ASKAP Fast Transients (CRAFT) survey. FRB 191001 was detected at a dispersion measure (DM) of 506.92(4) pc cm−3 and its measured fluence of 143(15) Jy ms is the highest of the bursts localized to host galaxies by ASKAP to date. The subarcsecond localization of the FRB provided by ASKAP reveals that the burst originated in the outskirts of a highly star-forming spiral in a galaxy pair at redshift z = 0.2340(1). Radio observations show no evidence for a compact persistent radio source associated with the FRB 191001 above a flux density of 15 Jy. However, we detect diffuse synchrotron radio emission from the disk of the host galaxy that we ascribe to ongoing star formation. FRB 191001 was also detected as an image-plane transient in a single 10 s snapshot with a flux density of 19.3 mJy in the low-time-resolution visibilities obtained simultaneously with CRAFT data. The commensal observation facilitated a search for repeating and slowly varying radio emissions 8 hr before and 1 hr after the burst. We found no variable radio emission on timescales ranging from 1 ms to 1.4 hr. We report our upper limits and briefly review FRB progenitor theories in the literature that predict radio afterglows. Our data are still only weakly constraining of any afterglows at the redshift of the FRB. Future commensal observations of more nearby and bright FRBs will potentially provide stronger constraints.
Quantifying neural activity in natural conditions (i.e. conditions comparable to the standard clinical patient experience) during the administration of psychedelics may further our scientific ...understanding of the effects and mechanisms of action. This data may facilitate the discovery of novel biomarkers enabling more personalized treatments and improved patient outcomes. In this single-blind, placebo-controlled study with a non-randomized design, we use time-domain functional near-infrared spectroscopy (TD-fNIRS) to measure acute brain dynamics after intramuscular subanesthetic ketamine (0.75 mg/kg) and placebo (saline) administration in healthy participants (n = 15, 8 females, 7 males, age 32.4 ± 7.5 years) in a clinical setting. We found that the ketamine administration caused an altered state of consciousness and changes in systemic physiology (e.g. increase in pulse rate and electrodermal activity). Furthermore, ketamine led to a brain-wide reduction in the fractional amplitude of low frequency fluctuations, and a decrease in the global brain connectivity of the prefrontal region. Lastly, we provide preliminary evidence that a combination of neural and physiological metrics may serve as predictors of subjective mystical experiences and reductions in depressive symptomatology. Overall, our study demonstrated the successful application of fNIRS neuroimaging to study the physiological effects of the psychoactive substance ketamine in humans, and can be regarded as an important step toward larger scale clinical fNIRS studies that can quantify the impact of psychedelics on the brain in standard clinical settings.
Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that functions as a regulator of transcription. Significant advances have been ...made recently in our understanding of how p53 function is regulated and the mechanisms by which p53 mediates its effects.
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