The increasing demand for meat and milk has stimulated interest in the development and recovery of pastures. Although humic acids (HAs) have been shown to have a biostimulating effect on plant ...growth, their use in pastures remains relatively unknown. This study aimed to evaluate the growth of 'Brachiaria decumbens' at different HAs concentrations and application times. This study was conducted in a greenhouse with pots containing 1.5 L of soil collected in a degraded pasture. A trial was carried out in a randomized block design in which five HAs concentrations (0, 7.5, 15, 30 and 60 mg L-1 C) and four application times were used as follows: leaf spray 15 days after emergence (LS 15 DAE); LS 45 DAE; LS 60 DAE; and successive leaf sprays (15, 45 and 60 DAE). Stem height, diameter, forage production and root development were evaluated. Height and stem diameter measurements were performed weekly. At 45 and 90 DAE, a cut was made at a height of 10 cm to simulate grazing and to measure forage production. At 90 DAE, the root mass was assessed. The HAs used at the concentration of 60 mg L-1 C applied at 15 DAE promoted increases of 44% in plant height and 196% in forage mass. After the cut, the optimum concentration was approximately 40 mg L-1 C. Although the use of HAs promoted root development, successive applications had deleterious effects on the plant. HAs could improve pasture biomass production at a low cost if applied at the ideal concentration.
Objetivo: Revisar a literatura sobre transtornos mentais relacionados à cirurgia bariátrica. Métodos: Trata-se de uma revisão integrativa da literatura. O levantamento electrónico foi realizado nas ...bases de dados LILACS, Pubmed, Scielo, BVS e portal de periódicos CAPES. Os descritores em ciências da saúde (DeC) “cirurgia bariátrica” e “transtornos mentais” foram aplicados como termos de busca. Resultados: foram selecionados 9 estudos para análise qualitativa, sendo 6 da plataforma Pubmed, 2 da Scielo e 1 da plataforma LILACS. Observou-se que pacientes candidatos à cirurgia bariátrica apresentam alta prevalência de distúrbios psicológicos, como depressão, ansiedade e transtorno da compulsão alimentar periódica, principalmente quando associados à recuperação de peso pós-cirúrgica. Também tem sido discutido que a cirurgia bariátrica é uma técnica eficaz para promover melhora dos sintomas de ansiedade e compulsão alimentar. Considerações Finais: Foi encontrada forte correlação entre o desenvolvimento de transtornos de depressão e ansiedade e o ganho de peso após a cirurgia. O tratamento psicológico de pacientes obesos com distúrbios psicológicos pode ser realizado com terapias cognitivas e comportamentais, com maior taxa de sucesso se iniciadas após a cirurgia, antes do ganho de peso.
Extracorporeal Membrane Oxygenation in the COVID-19 Pandemic Assunção, Letícia Almeida de; Santos, Anderson Lineu Siqueira dos; Oliveira, Tatyellen Natasha da Costa ...
International Journal of Advanced Engineering Research and Science,
2021, Letnik:
8, Številka:
7
Journal Article
The resonance assignments of the human NLRP7 PYD domain have been determined based on triple-resonance experiments using uniformly (13)C,(15)N-labeled protein. This assignment is the first step ...towards the 3D structure determination of the NLRP7 PYD domain.
The resonance assignments of the human NLRP7 PYD domain have been determined based on triple-resonance experiments using uniformly ¹³C,¹⁵N-labeled protein. This assignment is the first step towards ...the 3D structure determination of the NLRP7 PYD domain.
•Paraquat and rotenone bind to aS via solvent effects rather than through specific interactions.•The effects of paraquat and rotenone on aS fibrillation kinetics depend on NaCl ...concentration.•Paraquat interacts with the C-terminal domain of the disordered aS monomer, which is markedly reduced in the presence of NaCl.•The effects of these agrochemicals on PD cannot be explained via direct interactions with aS.
Epidemiological data have suggested that exposure to environmental toxins might be associated with the etiology of Parkinson's disease (PD). In this context, certain agrochemicals are able to induce Parkinsonism in different animal models via the inhibition of mitochondrial complex I, which leads to an increase in both oxidative stress and the death of nigrostriatal neurons. Additionally, in vitro experiments have indicated that pesticides are capable of accelerating the fibrillation of the presynaptic protein α-synuclein (aS) by binding directly to the protein. However, the molecular details of these interactions are poorly understood. In the present work we demonstrate that paraquat and rotenone, two agrochemicals that lead to a Parkinsonian phenotype in vivo, bind to aS via solvent effects rather than through specific interactions. In fact, these compounds produced no significant effects on aS fibrillation under physiological concentrations of NaCl. NMR data suggest that paraquat interacts with the C-terminal domain of the disordered aS monomer. This interaction was markedly reduced in the presence of NaCl, presumably due to the disruption of electrostatic interactions between the protein and paraquat. Interestingly, the effects produced by short-term incubation of paraquat with aS on the protein conformation resembled those produced by incubating the protein with NaCl alone. Taken together, our data indicate that the effects of these agrochemicals on PD cannot be explained via direct interactions with aS, reinforcing the idea that the role of these compounds in PD is limited to the inhibition of mitochondrial complex I and/or the up-regulation of aS.
Short cervical length measured during the second trimester of pregnancy is an important risk factor for spontaneous preterm birth (sPTB). The aim of this study is to identify the association between ...mid-pregnancy cervical length (CL) and gestational age at birth in asymptomatic singleton pregnant women.
This is a prospective cohort study involving singleton pregnant women who participated in the screening phase of a Brazilian multicenter randomized controlled trial (P5 trial) between July 2015 and March 2019. Transvaginal ultrasound to measure CL was performed from 18 to 22 + 6 weeks. Women with CL ≤ 30 mm received vaginal progesterone (200 mg/day) until 36 weeks' gestation. For this analysis we considered all women with CL ≤ 30 mm receiving progesterone and a random selection of women with CL > 30 mm, keeping the populational distribution of CL. We obtained prognostic effectiveness data (area under receive operating characteristic curve (AUC), sensitivity and specificity and estimated Kaplan-Meier curves for preterm birth using different CL cutoff points.
We report on 3139 women and identified a negative association between cervical length and sPTB. CL ≤ 25 mm was associated with sPTB < 28, sPTB < 34 and sPTB < 37 weeks, whereas a CL 25-30 mm was directly associated with late sPTB. CL by transvaginal ultrasound presented an AUC of 0.82 to predict sPTB < 28 weeks and 0.67 for sPTB < 34 weeks. Almost half of the sPTB occurred in nulliparous women and CL ≤ 30 mm was associated with sPTB at < 37 weeks (OR = 7.84; 95%CI = 5.5-11.1). The number needed to screen to detect one sPTB < 34 weeks in women with CL ≤ 25 mm is 121 and we estimated that 248 screening tests are necessary to prevent one sPTB < 34 weeks using progesterone prophylaxis.
CL measured by transvaginal ultrasound should be used to predict sPTB < 34 weeks. Women with CL ≤ 30 mm are at increased risk for late sPTB.
Since there are populational differences and risk factors that influence the cervical length, the aim of the study was to construct a populational curve with measurements of the uterine cervix of ...pregnant women in the second trimester of pregnancy and to evaluate which variables were related to cervical length (CL) less than or equal to25 mm. This was a multicenter cross-sectional study performed at 17 hospitals in several regions of Brazil. From 2015 to 2019, transvaginal ultrasound scan was performed in women with singleton pregnancies at 18 0/7 to 22 6/7 weeks of gestation to measure the CL. We analyzed CL regarding its distribution and the risk factors for CL less than or equal to25 mm using logistic regression. The percentage of CL less than or equal to 25mm was 6.67%. Shorter cervices, when measured using both straight and curve techniques, showed similar results: range 21.0-25.0 mm in straight versus 22.6-26.0 mm in curve measurement for the 5.sup.th percentile. However, the difference between the two techniques became more pronounced after the 75.sup.th percentile (range 41.0-42.0 mm straight x 43.6-45.0 mm in curve measurement). The risk factors identified for short cervix were low body mass index (BMI) (OR: 1.81 CI: 1.16-2.82), higher education (OR: 1.39 CI: 1.10-1.75) and personal history (one prior miscarriage OR: 1.41 CI: 1.11-1.78 and greater than or equal to2 prior miscarriages OR: 1.67 CI: 1.24-2.25, preterm birth OR: 1.70 CI: 1.12-2.59, previous low birth weight <2500 g OR: 1.70 CI: 1.15-2.50, cervical surgery OR: 4.33 CI: 2.58-7.27). By contrast, obesity (OR: 0.64 CI: 0.51-0.82), living with a partner (OR: 0.76 CI: 0.61-0.95) and previous pregnancy (OR: 0.46 CI: 0.37-0.57) decreased the risk of short cervix. The CL distribution showed a relatively low percentage of cervix less than or equal to25 mm. There may be populational differences in the CL distribution and this as well as the risk factors for short CL need to be considered when adopting a screening strategy for short cervix.
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