There is no agreed-upon, unique concept of spirituality; its dimensions and characteristics depend on the approach used. Spirituality appears in management studies from three main perspectives: ...individual spirituality, spirituality in the workplace, and organizational spirituality. Spirituality can also be considered from a religious perspective. This article identifies a comprehensive concept of organizational spirituality based on the terms and concepts used in the literature. A systematic review of the literature was made using the Web of Science and Scopus databases; the articles were then subjected to bibliometric analysis using VOSviewer software. The results included two clusters: organizational spirituality and workplace spirituality. Cluster analysis suggested that there is scope for research on workplace spirituality and a gap in organizational spirituality studies. The proposed concept for organizational spirituality is an organizational identity resulting from its values, practices, and discourse that is composed of workplace and individual spirituality guided by the leader and other members and influenced by the environment, organizational culture, and knowledge management. This spirituality generates value and social good that is visible in the organization’s image, mission, vision, and organizational values. This article contributes to the literature by the categorization and systematization of the existing literature and proposing a unified concept—a mental and linguistic representation of organizational spirituality—that represents its essence and confers the qualities and attributes inherent to this phenomenon.
Zinc Dynamics and Action at Excitatory Synapses Vergnano, Angela Maria; Rebola, Nelson; Savtchenko, Leonid P. ...
Neuron (Cambridge, Mass.),
06/2014, Letnik:
82, Številka:
5
Journal Article
Recenzirano
Odprti dostop
Decades after the discovery that ionic zinc is present at high levels in glutamatergic synaptic vesicles, where, when, and how much zinc is released during synaptic activity remains highly ...controversial. Here we provide a quantitative assessment of zinc dynamics in the synaptic cleft and clarify its role in the regulation of excitatory neurotransmission by combining synaptic recordings from mice deficient for zinc signaling with Monte Carlo simulations. Ambient extracellular zinc levels are too low for tonic occupation of the GluN2A-specific nanomolar zinc sites on NMDA receptors (NMDARs). However, following short trains of physiologically relevant synaptic stimuli, zinc transiently rises in the cleft and selectively inhibits postsynaptic GluN2A-NMDARs, causing changes in synaptic integration and plasticity. Our work establishes the rules of zinc action and reveals that zinc modulation extends beyond hippocampal mossy fibers to excitatory SC-CA1 synapses. By specifically moderating GluN2A-NMDAR signaling, zinc acts as a widespread activity-dependent regulator of neuronal circuits.
•Ambient zinc levels are low (<10 nM), insufficient to occupy GluN2A-NMDA receptors•Repetitive synaptic stimuli are required for zinc modulation of NMDA-EPSCs•By targeting GluN2A-NMDARs, zinc controls synaptic integration and plasticity•Zinc action is prominent at both hippocampal mossy fibers and SC-CA1 synapses
Zinc has long been known to concentrate in synaptic vesicles of a subset of glutamatergic synapses. Vergnano et al. reveal the dynamics and function of synaptic zinc in regulating synaptic transmission, integration, and plasticity at hippocampal synapses.
Cancer Statistics for Hispanics/Latinos, 2018 Miller, Kimberly D.; Goding Sauer, Ann; Ortiz, Ana P. ...
CA: a cancer journal for clinicians,
November/December 2018, Letnik:
68, Številka:
6
Journal Article
Recenzirano
Odprti dostop
Cancer is the leading cause of death among Hispanics/Latinos, who represent the largest racial/ethnic minority group in the United States, accounting for 17.8% (57.5 million) of the total population ...in the continental United States and Hawaii in 2016. In addition, more than 3 million Hispanic Americans live in the US territory of Puerto Rico. Every 3 years, the American Cancer Society reports on cancer occurrence, risk factors, and screening for Hispanics in the United States based on data from the National Cancer Institute, the North American Association of Central Cancer Registries, and the Centers for Disease Control and Prevention. For the first time, contemporary incidence and mortality rates for Puerto Rico, which has a 99% Hispanic population, are also presented. An estimated 149,100 new cancer cases and 42,700 cancer deaths will occur among Hispanics in the continental United States and Hawaii in 2018. For all cancers combined, Hispanics have 25% lower incidence and 30% lower mortality compared with non‐Hispanic whites, although rates of infection‐related cancers, such as liver, are up to twice as high in Hispanics. However, these aggregated data mask substantial heterogeneity within the Hispanic population because of variable cancer risk, as exemplified by the substantial differences in the cancer burden between island Puerto Ricans and other US Hispanics. For example, during 2011 to 2015, prostate cancer incidence rates in Puerto Rico (146.6 per 100,000) were 60% higher than those in other US Hispanics combined (91.6 per 100,000) and 44% higher than those in non‐Hispanic whites (101.7 per 100,000). Prostate cancer is also the leading cause of cancer death among men in Puerto Rico, accounting for nearly 1 in 6 cancer deaths during 2011‐2015, whereas lung cancer is the leading cause of cancer death among other US Hispanic men combined. Variations in cancer risk are driven by differences in exposure to cancer‐causing infectious agents and behavioral risk factors as well as the prevalence of screening. Strategies for reducing cancer risk in Hispanic populations include targeted, culturally appropriate interventions for increasing the uptake of preventive services and reducing cancer risk factor prevalence, as well as additional funding for Puerto Rico‐specific and subgroup‐specific cancer research and surveillance.
First Anecdotal uses of the Term “Health Literacy” It has become part of the health literacy narrative to attribute the first appearance of the phrase “health literacy” to an article published in ...1974 (Peerson & Saunders, 2009; Pleasant, 2013; Ratzan, 2001; Tones, 2002). According to Tones (2002), Simonds argues a case for health education with the intention that students might become as literate in health as in other curricular topics. ...health literacy is seen as an outcome of health education meeting minimal standards for all grade levels (Ratzan, 2001). According to the EU-HLS definition, health literacy “is linked to literacy and entails people's knowledge, motivation and competences to access, understand, appraise, and apply health information in order to make judgments and take decisions in everyday life concerning healthcare, disease prevention and health promotion to maintain or improve quality of life during the life course” (Sørensen et al., 2012, p 3). ...they question the uniqueness of a health literacy construct, argue in favor of construct redundancy and construct proliferation, and conclude that measures of health literacy rather reflect domain-specific contextualized measures of basic
Cancer statistics for Hispanics/Latinos, 2015 Siegel, Rebecca L.; Fedewa, Stacey A.; Miller, Kimberly D. ...
CA: a cancer journal for clinicians,
November/December 2015, Letnik:
65, Številka:
6
Journal Article
Neutrinos are massless in the Standard Model. The most popular mechanism to generate neutrino masses are the type I and type II seesaw, where right-handed neutrinos and a scalar triplet are augmented ...to the Standard Model, respectively. In this work, we discuss a model where a type I + II seesaw mechanism naturally arises via spontaneous symmetry breaking of an enlarged gauge group. Lepton flavor violation is a common feature in such setup and for this reason, we compute the model contribution to the
μ
→
e
γ
and
μ
→
3
e
decays. Moreover, we explore the connection between the neutrino mass ordering and lepton flavor violation in perspective with the LHC, HL-LHC and HE-LHC sensitivities to the doubly charged scalar stemming from the Higgs triplet. Our results explicitly show the importance of searching for signs of lepton flavor violation in collider and muon decays. The conclusion about which probe yields stronger bounds depends strongly on the mass ordering adopted, the absolute neutrino masses and which much decay one considers. In the 1–5 TeV mass region of the doubly charged scalar, lepton flavor violation experiments and colliders offer orthogonal and complementary probes. Thus if a signal is observed in one of the two new physics searches, the other will be able to assess whether it stems from a seesaw framework.
An historical overview covering the field of electroanalytical metal cations speciation in freshwaters is presented here, detailing both the notable experimental and theoretical developments. Then, a ...critical review of the progress in the last five years is given, underlining in particular the improvements in electrochemical setups and methodologies dedicated to field surveys. Given these recent achievements, a road map to carry out on-site dynamic metal speciation measurements is then proposed, and the key future developments are discussed. This review shows that electroanalytical stripping techniques provide a unique framework for quantitatively assessing metals at trace levels while offering access to both thermodynamic and dynamic features of metal complexation with natural colloidal and particulate ligands.
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