To test Eastern Tibet crustal thickening modes, we compare 2‐D numerical models of two emblematic end‐member models, with either an obstacle in the low viscosity lower crust or a thrust embedded in ...the high viscosity one. We show that the obstacle halts the viscous lower crustal flow potentially initiated by the weight of the high Central Tibet, generating a smooth exhumation gradient at the edge of the plateau, not observed in Eastern Tibet. On the contrary, including a low viscosity discontinuity in the upper crust, mimicking a shallow steep listric fault as inferred in the region, reproduces a sharper exhumation profile, as constrained from thermo‐kinematic inversions of thermochronological data, and the lack of foreland basin, as observed in the field. Moreover, such fault drives deformation throughout the entire crust, suggesting a deep crustal ductile shear zone limiting the more ductile deformation in the lower crust although no discontinuity is imposed.
Plain Language Summary
The role of thrusting in crustal thickening during the formation of Tibet, the world's largest and highest orogenic plateau, constitutes one of the main controversies in earth sciences. In Eastern Tibet in particular, two end‐members based on two contrasting controversial hypotheses can be tested: the thickening is dominated either by the flow of the lower Tibetan crust halted by the hard Sichuan craton, or by thrusting of the Tibetan upper crust. Here, we present 2‐D crustal numerical models of a shallow steep listric thrust (as inferred in the region) embedded in the high viscosity upper crust, and we show that such model reproduces the exhumation profile constrained from thermochronological data and the lack of foreland basin observed in the field. Interestingly, we also show that such upper crustal thrust drives upward the more ductile lower crust albeit no discontinuity is imposed. On the contrary, by using a model driven by an overpressure in the lower crust, we show that the obstacle halts the viscous lower crustal flow and generates a smooth exhumation gradient at the edge of the plateau, not observed in Eastern Tibet.
Key Points
2‐D numerical models of thrusts embedded in the high viscosity upper crust, to test thermo‐kinematic models based on thermochronology data
accommodation in the lower crust by ductile flow of the deformation induced by the high angle thrust in the upper crust
predicting exhumation rates and subsidence patterns that are compatible with the measured ones in Eastern Tibet
Thrusting implication in the crustal thickening history of eastern Tibet is highly debated. The ∼250 km‐long Muli thrust of the Yalong thrust belt in SE Tibet is a major Miocene structure with a ...pronounced topographic step (∼2,000 m). Using thermo‐kinematic modeling based on thermochronology data, we constrain the crustal geometry of the thrust as being steep (>70°) at the surface, in agreement with field observations, and flattening at depth (≥20 km) on an intra‐crustal décollement. Thrusting motion on the fault shows a velocity of 0.2 ± 0.06 km/Ma since 50 Ma, followed by an acceleration at a rate of 0.6 ± 0.08 km/Ma starting at 12.5 ± 1 Ma, yielding a total of ∼15 km of exhumed crust. Deeper, deformation may be localized through a ductile shear zone, and be related to the ∼15 km Moho step and shear wave velocity contrast imaged by tomography beneath the Yalong thrust belt.
Plain Language Summary
The India‐Eurasia collision (∼50 million years ago Ma) led to the formation of the Tibetan Plateau, the world's largest and highest orogenic plateau. The formation and evolution of such a unique geological feature has been one of the main controversies in Earth Sciences for decades, especially regarding the role of faulting in the thickening of the crust. Here, we present 3D thermo‐kinematic models of thermochronology data allowing to constrain the exhumation history of the Muli thrust fault, a ∼250 km‐long major structure of the SE Tibetan margin, linked to significant steps in surface topography and in crustal boundary at depth (Moho). We constrain a steep fault (>70°) within the upper crust, consistent with field observations, that flattens at depth (≥20 km). The Muli thrust presents rapid thrusting motion (0.6 ± 0.08 km/Ma) that initiated at ∼12.5 Ma, following a slower phase (0.2 ± 0.06 km/Ma) since 50 Ma, with total rock exhumation of ∼15 km. This underlines the important role of thrust faulting in the thickening of the SE Tibetan crust.
Key Points
Thermo‐kinematic modeling of Muli thrust, a major thrust fault of SE Tibetan Plateau
15 km crust exhumation in 50 Ma on a high‐angle (>70°) ramp—décollement fault linked to thickening of SE Tibetan crust
Fault related to significant Moho step and shear wave velocity contrast in deep crust suggests entire crust implication
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Provider: - Institution: - Data provided by Europeana Collections- Appartient à l’ensemble documentaire : BNormand1- Avec mode texte- All metadata published by Europeana are available free of ...restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
We show that the dynamics of kinetically constrained models of glass formers takes place at a first-order coexistence line between active and inactive dynamical phases. We prove this by computing the ...large-deviation functions of suitable space-time observables, such as the number of configuration changes in a trajectory. We present analytic results for dynamic facilitated models in a mean-field approximation, and numerical results for the Fredrickson-Andersen model, the East model, and constrained lattice gases, in various dimensions. This dynamical first-order transition is generic in kinetically constrained models, and we expect it to be present in systems with fully jammed states.
The purpose of this study was to control the fabrication of new labile supramolecular assemblies by formulating associations of DNA molecules with inorganic layered double hydroxides (LDHs). The ...results show that LDH/DNA hybrids synthesized by a coprecipitation route involving the in situ formation of LDHs around DNA molecules acting as templates were characterized by a lamellar organization, with DNA molecules sandwiched between hydroxide layers, exhibiting a regular spacing of 1.96 nm. Our results indicate that labile complexes resulting from the association of nucleic acids and inorganic materials can be obtained not only by anion exchange but also by a direct self-assembly route.
Dopamine transmission is involved in reward processing and motor control, and its impairment plays a central role in numerous neurological disorders. Despite its strong pathophysiological relevance, ...the molecular and structural organization of the dopaminergic synapse remains to be established. Here, we used targeted labelling and fluorescence activated sorting to purify striatal dopaminergic synaptosomes. We provide the proteome of dopaminergic synapses with 57 proteins specifically enriched. Beyond canonical markers of dopamine neurotransmission such as dopamine biosynthetic enzymes and cognate receptors, we validated 6 proteins not previously described as enriched. Moreover, our data reveal the adhesion of dopaminergic synapses to glutamatergic, GABAergic or cholinergic synapses in structures we named "dopamine hub synapses". At glutamatergic synapses, pre- and postsynaptic markers are significantly increased upon association with dopamine synapses. Dopamine hub synapses may thus support local dopaminergic signalling, complementing volume transmission thought to be the major mechanism by which monoamines modulate network activity.
The voltage-gated KCNQ1 potassium channel regulates key physiological functions in a number of tissues. In the heart, KCNQ1 alpha-subunits assemble with KCNE1 beta-subunits forming a channel complex ...constituting the delayed rectifier current I(Ks). In epithelia, KCNQ1 channels participate in controlling body electrolyte homeostasis. Several regulatory mechanisms of the KCNQ1 channel complexes have been reported, including protein kinase A (PKA)-phosphorylation and beta-subunit interactions. However, the mechanisms controlling the membrane density of KCNQ1 channels have attracted less attention.
Here we demonstrate that KCNQ1 proteins expressed in HEK293 cells are down-regulated by Nedd4/Nedd4-like ubiquitin-protein ligases. KCNQ1 and KCNQ1/KCNE1 currents were reduced upon co-expression of Nedd4-2, the isoform among the nine members of the Nedd4/Nedd4-like family displaying the highest expression level in human heart. In vivo expression of a catalytically inactive form of Nedd4-2, able to antagonize endogenous Nedd4-2 in guinea-pig cardiomyocytes, increased I(Ks) significantly, but did not modify I(K1). Concomitant with the reduction in current induced by Nedd4-2, an increased ubiquitylation as well as a decreased total level of KCNQ1 proteins were observed in HEK293 cells. Pull-down and co-immunoprecipitation experiments showed that Nedd4-2 interacts with the C-terminal part of KCNQ1. The Nedd4/Nedd4-like-mediated regulation of the KCNQ1 channel complexes is strictly dependent on a PY motif located in the distal part of the C-terminal domain. When this motif was mutated, the current and ubiquitylation levels were unaffected by Nedd4-2, and Nedd4-2 proteins were neither pulled-down nor co-immunoprecipitated.
These results suggest that KCNQ1 internalization and stability is physiologically regulated by its Nedd4/Nedd4-like-dependent ubiquitylation. This mechanism may thereby be important in regulating the surface density of the KCNQ1 channels in cardiomyocytes and other cell types.
Abstract Systemic gene delivery systems are needed for therapeutic application to organs that are inaccessible by percutaneous injection. Currently, the main objective is the development of a stable ...and non-toxic vector that can encapsulate and deliver foreign genetic material to target cells. To this end, DNA, complexed with cationic lipids i.e. DOTAP/DOPE, was encapsulated into lipid nanocapsules (LNCs) leading to the formation of stable nanocarriers (DNA LNCs) with a size inferior to 130 nm. Amphiphilic and flexible poly (ethylene glycol) (PEG) polymer coatings PEG lipid derivative (DSPE-mPEG2000 ) or F108 poloxamer at different concentrations were selected to make DNA LNCs stealthy. Some of these coated lipid nanocapsules were able to inhibit complement activation and were not phagocytised in vitro by macrophagic THP-1 cells whereas uncoated DNA LNCs accumulated in the vacuolar compartment of THP-1 cells. These results correlated with a significant increase of in vivo circulation time in mice especially for DSPE-mPEG2000 10 m m and an early half-life time ( t1/2 of distribution) 5-fold greater than for non-coated DNA LNCs (7.1 h vs 1.4 h). Finally, a tumor accumulation assessed by in vivo fluorescence imaging system was evidenced for these coated LNCs as a passive targeting without causing any hepatic damage.
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