Dentine of permanent mandibular incisors from nine individuals was hydrolysed and the amino acid composition determined by ion-exchange chromatography against a standard calibrant of 41 amino acids. ...Nineteen amino acids were detected, including small quantities of 1-methylhistidine and asparagine, two amino acids whose existence had apparently not been recorded before in human dentine. The total content of hydroxylysine plus lysine varied between 2.6 and 3.3 residues per 100 (SD, 0.74) in different teeth, which therefore did not support previous studies that had proposed a constant total value. This and other quantifiable differences between present and previous findings may be the result of the different methods and the influence of dietary and other regional factors on dentinogenesis.
Melatonin and sperm motility Pitout, M J; van Vuuren, R J; van Aswegen, C H ...
South African medical journal,
06/1991, Letnik:
79, Številka:
11
Journal Article
Good sperm motility in normozoospermic men was associated with high bound and total sialic acid (SA) and pyruvate concentrations in the seminal plasma, as well as high endogenous (sperm) pyruvate ...concentrations. The presence of sialidase in the seminal plasma was also demonstrated for the first time. The results suggest that SA is metabolized to pyruvate by a JV-acetylneuraminic acid (NANA)-aldolase in the seminal plasma and that pyruvate subsequently serves as an energy source for sperm.
Plasma carcinoembryonic antigen (CEA) levels were performed by radioimmunoassay in 234 patients with histologically proved breast cancer: 181 with advanced metastatic disease and 53 without distant ...metastases but nodal involvement at time of mastectomy. Four hundred and thirty‐four assays were done and correlated with the clinical status of the patients. Values above 2.5 ng/ml were taken as abnormal. Active disease was associated with elevated plasma CEA levels. Very high values were not recorded in 109 patients when they were considered to be in complete remission, while only 22 patients out of 63 patients with progressive disease had normal values. In 16 of these, values remained normal despite progression of disease. In 6 patients clinical relapse preceded CEA elevation by 2–5 months. Tumor burden and abnormal serial CEA values showed positive correlation in 38 patients. In 30 patients, change in clinical status and CEA values occurred simultaneously. In only 2 patients an increase in CEA value occurred 2–3 months before clinical documentation of relapse.
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