Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary cause for hysterectomy, leading to considerable morbidity and high economic burden. Here we conduct ...a GWAS meta-analysis in 35,474 cases and 267,505 female controls of European ancestry, identifying eight novel genome-wide significant (P < 5 × 10
) loci, in addition to confirming 21 previously reported loci, including multiple independent signals at 10 loci. Phenotypic stratification of UL by heavy menstrual bleeding in 3409 cases and 199,171 female controls reveals genome-wide significant associations at three of the 29 UL loci: 5p15.33 (TERT), 5q35.2 (FGFR4) and 11q22.3 (ATM). Four loci identified in the meta-analysis are also associated with endometriosis risk; an epidemiological meta-analysis across 402,868 women suggests at least a doubling of risk for UL diagnosis among those with a history of endometriosis. These findings increase our understanding of genetic contribution and biology underlying UL development, and suggest overlapping genetic origins with endometriosis.
Fine sand soils important to Florida agriculture have volumetric soil water content values (theta(v)) of < 0.10 cm(3) cm(-3) after drainage due to gravity has ceased. Small changes in theta(v), in ...the range of 0.02 to 0.08 cm(3) cm(-3) can greatly affect plant available water and, therefore, good calibration of soil water content sensors is necessary. The Enviro-SCAN (Sentek Pty. Ltd., South Australia) is a multiple sensor capacitance probe capable of continuous measurement of soil water content by volume (theta(v)). Many fine sand soils in Florida have plant available theta(v), values of less than or equal to 0.08 cm(3) cm(-3). The manufacturer's calibration curve has very few data points < 0.10 cm(3) cm(-3) theta(v) and no data in the 0.02 to 0.04 cm(3) cm(-3) theta(v) range. Because of the lack of data in this range, a calibration curve from 0.02 to 0.08 cm(3) cm(-3) theta(v) was developed for Candler fine sand (hyperthermic, uncoated Typic Quartzipsamments), Apopka fine sand (loamy, siliceous, hyperthermic Grossarenic Paleudults), and Immokalee fine sand (sandy, siliceous, hyperthermic Arenic Alaquods) in two locations in Florida. Since calibration curves for the three soils did not differ significantly, data from the three soils were combined. An exponential calibration curve was developed (RMSE = 0.0085, R(2) = 0.83). This equation provides substantially different estimates of water content in the 0.02 to 0.08 range than values obtained from the manufacturer's calibration. This improved calibration extends the useful range of the EnviroSCAN to include an important group of soils with very low water holding capacity.
Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which have progressively increased in number with increasing ...sample sizes of the respective studies. Here, we conduct a genome-wide association study in 322,580 UK Biobank participants for three depression-related phenotypes: broad depression, probable major depressive disorder (MDD), and International Classification of Diseases (ICD, version 9 or 10)-coded MDD. We identify 17 independent loci that are significantly associated (P < 5 × 10
) across the three phenotypes. The direction of effect of these loci is consistently replicated in an independent sample, with 14 loci likely representing novel findings. Gene sets are enriched in excitatory neurotransmission, mechanosensory behaviour, post synapse, neuron spine and dendrite functions. Our findings suggest that broad depression is the most tractable UK Biobank phenotype for discovering genes and gene sets that further our understanding of the biological pathways underlying depression.
The Muon g − 2 Experiment at Fermi National Accelerator Laboratory (FNAL) has measured the muon anomalous precession frequency ωam to an uncertainty of 434 parts per billion (ppb), statistical, and ...56 ppb, systematic, with data collected in four storage ring configurations during its first physics run in 2018. When combined with a precision measurement of the magnetic field of the experiment's muon storage ring, the precession frequency measurement determines a muon magnetic anomaly of aμ ( FNAL ) = 116 592 040 ( 54 ) × 10−11 (0.46 ppm). This article describes the multiple techniques employed in the reconstruction, analysis, and fitting of the data to measure the precession frequency. It also presents the averaging of the results from the 11 separate determinations of ωam, and the systematic uncertainties on the result.
We present the first results of the Fermilab National Accelerator Laboratory (FNAL) Muon g-2 Experiment for the positive muon magnetic anomaly a_{μ}≡(g_{μ}-2)/2. The anomaly is determined from the ...precision measurements of two angular frequencies. Intensity variation of high-energy positrons from muon decays directly encodes the difference frequency ω_{a} between the spin-precession and cyclotron frequencies for polarized muons in a magnetic storage ring. The storage ring magnetic field is measured using nuclear magnetic resonance probes calibrated in terms of the equivalent proton spin precession frequency ωover ˜_{p}^{'} in a spherical water sample at 34.7 °C. The ratio ω_{a}/ωover ˜_{p}^{'}, together with known fundamental constants, determines a_{μ}(FNAL)=116 592 040(54)×10^{-11} (0.46 ppm). The result is 3.3 standard deviations greater than the standard model prediction and is in excellent agreement with the previous Brookhaven National Laboratory (BNL) E821 measurement. After combination with previous measurements of both μ^{+} and μ^{-}, the new experimental average of a_{μ}(Exp)=116 592 061(41)×10^{-11} (0.35 ppm) increases the tension between experiment and theory to 4.2 standard deviations.
This paper presents the beam dynamics systematic corrections and their uncertainties for the Run-1 dataset of the Fermilab Muong−2Experiment. Two corrections to the measured muon precession ...frequencyωamare associated with well-known effects owing to the use of electrostatic quadrupole (ESQ) vertical focusing in the storage ring. An average vertically oriented motional magnetic field is felt by relativistic muons passing transversely through the radial electric field components created by the ESQ system. The correction depends on the stored momentum distribution and the tunes of the ring, which has relatively weak vertical focusing. Vertical betatron motions imply that the muons do not orbit the ring in a plane exactly orthogonal to the vertical magnetic field direction. A correction is necessary to account for an average pitch angle associated with their trajectories. A third small correction is necessary, because muons that escape the ring during the storage time are slightly biased in initial spin phase compared to the parent distribution. Finally, because two high-voltage resistors in the ESQ network had longer than designedRCtime constants, the vertical and horizontal centroids and envelopes of the stored muon beam drifted slightly, but coherently, during each storage ring fill. This led to the discovery of an important phase-acceptance relationship that requires a correction. The sum of the corrections toωamis0.50±0.09ppm; the uncertainty is small compared to the 0.43 ppm statistical precision ofωam.
CDF Central Outer Tracker Affolder, T; Allspach, D; Ambrose, D ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
07/2004, Letnik:
526, Številka:
3
Journal Article
Recenzirano
The Central Outer Tracker is a large cylindrical drift chamber constructed to replace Collider Detector at Fermilab's original central drift chamber for the higher luminosity expected for Run 2 at ...the Fermilab Tevatron. The chamber's drift properties are described in the context of meeting the operating requirements for Run 2. The design and construction of the chamber, the front-end readout electronics, and the high-voltage system are described in detail. Wire aging considerations are also discussed.
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