Kinetic Alfvén waves (KAWs) are ubiquitous throughout the plasma universe. Although they are broadly believed to provide a potential approach for energy exchange between electromagnetic fields and ...plasma particles, neither the detail nor the efficiency of the interactions has been well-determined yet. The primary difficulty has been the paucity of knowledge of KAWs' spatial structure in observation. Here, we apply a particle-sounding technique to Magnetospheric Multiscale mission data to quantitatively determine the perpendicular wavelength of KAWs from ion gyrophase-distribution observations. Our results show that KAWs' perpendicular wavelength is statistically 2.4Formula: see text times proton thermal gyro-radius. This observation yields an upper bound of the energy the majority proton population can reach in coherent interactions with KAWs, that is, roughly 5.76 times proton perpendicular thermal energy. Therefore, the method and results shown here provide a basis for unraveling the effects of KAWs in dissipating energy and accelerating particles in a number of astrophysical systems, e.g., planetary magnetosphere, astrophysical shocks, stellar corona and wind, and the interstellar medium.
Studies of solar wind turbulence traditionally employ high-resolution magnetic field data, but high-resolution measurements of ion and electron moments have been possible only recently. We report the ...first turbulence studies of ion and electron velocity moments accumulated in pristine solar wind by the Fast Plasma Investigation (FPI) instrument on board the Magnetospheric Multiscale Mission. Use of these data is made possible by a novel implementation of a frequency domain Hampel filter, described herein. After presenting procedures for processing of the data, we discuss statistical properties of solar wind turbulence extending into the kinetic range. Magnetic field fluctuations dominate electron and ion-velocity fluctuation spectra throughout the energy-containing and inertial ranges. However, a multispacecraft analysis indicates that at scales shorter than the ion inertial length, electron velocity fluctuations become larger than ion-velocity and magnetic field fluctuations. The kurtosis of ion-velocity peaks around a few ion inertial lengths and returns to a near Gaussian value at sub-ion scales.
We report Magnetospheric Multiscale observations of electron pressure gradient electric fields near a magnetic reconnection diffusion region using a new technique for extracting 7.5 ms electron ...moments from the Fast Plasma Investigation. We find that the deviation of the perpendicular electron bulk velocity from E × B drift in the interval where the out-of-plane current density is increasing can be explained by the diamagnetic drift. In the interval where the out-of-plane current is transitioning to in-plane current, the electron momentum equation is not satisfied at 7.5 ms resolution.
Spatial and high-time-resolution properties of the velocities, magnetic field, and 3-D electric field within plasma turbulence are examined observationally using data from the Magnetospheric ...Multiscale mission. Observations from a Kelvin-Helmholtz instability (KHI) on the Earth's magnetopause are examined, which both provides a series of repeatable intervals to analyze, giving better statistics, and provides a first look at the properties of turbulence in the KHI. For the first time direct observations of both the high-frequency ion and electron velocity spectra are examined, showing differing ion and electron behavior at kinetic scales. Temporal spectra exhibit power law behavior with changes in slope near the ion gyrofrequency and lower hybrid frequency. The work provides the first observational evidence for turbulent intermittency and anisotropy consistent with quasi two-dimensional turbulence in association with the KHI. The behavior of kinetic-scale intermittency is found to have differences from previous studies of solar wind turbulence, leading to novel insights on the turbulent dynamics in the KHI.
Iron(II)- and 2-oxoglutarate-dependent (Fe/2OG) oxygenases generate iron(IV)-oxo (ferryl) intermediates that can abstract hydrogen from aliphatic carbons (R–H). Hydroxylation proceeds by coupling ...of the resultant substrate radical (R•) and oxygen of the Fe(III)-OH complex (“oxygen rebound”). Nonhydroxylation outcomes result from different fates of the Fe(III)-OH/R• state; for example, halogenation results from R• coupling to a halogen ligand cis to the hydroxide. We previously suggested that halogenases control substrate-cofactor disposition to disfavor oxygen rebound and permit halogen coupling to prevail. Here, we explored the general implication that, when a ferryl intermediate can ambiguously target two substrate carbons for different outcomes, rebound to the site capable of the alternative outcome should be slower than to the adjacent, solely hydroxylated site. We evaluated this prediction for (i) the halogenase SyrB2, which exclusively hydroxylates C5 of norvaline appended to its carrier protein but can either chlorinate or hydroxylate C4 and (ii) two bifunctional enzymes that normally hydroxylate one carbon before coupling that oxygen to a second carbon (producing an oxacycle) but can, upon encountering deuterium at the first site, hydroxylate the second site instead. In all three cases, substrate hydroxylation incorporates a greater fraction of solvent-derived oxygen at the site that can also undergo the alternative outcome than at the other site, most likely reflecting an increased exchange of the initially O2-derived oxygen ligand in the longer-lived Fe(III)-OH/R• states. Suppression of rebound may thus be generally important for nonhydroxylation outcomes by these enzymes.
Kinetic‐size magnetic holes (KSMHs) in the turbulent magnetosheath are statistically investigated using high time resolution data from the Magnetospheric Multiscale mission. The KSMHs with short ...duration (i.e., <0.5 s) have their cross section smaller than the ion gyroradius. Superposed epoch analysis of all events reveals that an increase in the electron density and total temperature significantly increases (resp. decrease) the electron perpendicular (resp. parallel) temperature and an electron vortex inside KSMHs. Electron fluxes at ~90° pitch angles with selective energies increase in the KSMHs are trapped inside KSMHs and form the electron vortex due to their collective motion. All these features are consistent with the electron vortex magnetic holes obtained in 2‐D and 3‐D particle‐in‐cell simulations, indicating that the observed KSMHs seem to be best explained as electron vortex magnetic holes. It is furthermore shown that KSMHs are likely to heat and accelerate the electrons.
Key Points
Kinetic‐size magnetic holes are statistical investigated by MMS
Observed kinetic‐size magnetic holes seem to be best explained as electron vortex magnetic holes
Kinetic‐size magnetic holes are likely to heat and accelerate the electrons
Plain Language Summary
A nonlinear energy cascade in magnetized turbulent plasmas leads to the formation of different coherent structures which are thought to play an important role in dissipating energy and transporting particles. This study statistically investigate one new type of coherent structure, named electron vortex magnetic hole, used by Magnetospheric Multiscale data. It reveals the common features of this structure, including an increase in the electron density and total temperature, significantly increase (resp. decrease) the electron perpendicular (resp. parallel) temperature and an electron vortex inside these holes. The increase of electron temperature inside the holes indicates that these holes are likely to heat and accelerate the electrons. This gives new clue for energy dissipation in turbulent plasmas.
Observations of a current sheet as thin as the electron scale are extremely rare in the near‐Earth magnetotail. By measurement from the novel Magnetospheric Multiscale mission in the near‐Earth ...magnetotail, we identified such an electron‐scale current sheet and determined its detailed properties. The electron current sheet was bifurcated, with a half‐thickness of nine electron inertial lengths, and was sandwiched between the Hall field. Because of the strong Hall electric field, the super‐Alfvénic electron bulk flows were created mainly by the electric field drift, leading to the generation of the strong electron current. Inevitably, a bifurcated current sheet was formed since the Hall electric field was close to zero at the center of the current sheet. Inside the electron current sheet, the electrons were significantly heated while the ion temperature showed no change. The ions kept moving at a low speed, which was not affected by this electron current sheet. The energy dissipation was negligible inside the current sheet. The observations indicate that a thin current sheet, even as thin as electron scale, is not the sufficient condition for triggering bursty reconnection.
Plain Language Summary
Magnetic reconnection plays a key role for many explosive phenomena in space, astrophysical, and laboratorial plasmas. It is widely accepted that reconnection will be triggered once the current sheet thins down to ion scale. In this letter, however, an electron‐scale current sheet, much thinner than ion scale, was observed without any bursty reconnection signatures. The observations indicate that a thin current sheet, even as thin as electron scale, is not the sufficient condition for triggering reconnection.
Key Points
An electron‐scale current sheet was observed in the near‐Earth tail
The electron‐scale current sheet was observed without any bursty reconnection signatures
The Hall electric field drift of electrons accounts for the formation of the electron‐scale current sheet
Abstract
Identifying how energy transfer proceeds from macroscales down to microscales in collisionless plasmas is at the forefront of astrophysics and space physics. It provides information on the ...evolution of involved plasma systems and the generation of high-energy particles in the universe. Here we report two cross-scale energy-transfer events observed by NASA’s Magnetospheric Multiscale spacecraft in Earth’s magnetosphere. In these events, hot ions simultaneously undergo interactions with macroscale (~
$${10}^{5}$$
10
5
km) ultra-low-frequency waves and microscale (
$$\sim {10}^{3}$$
~
10
3
km) electromagnetic-ion-cyclotron (EMIC) waves. The cross-scale interactions cause energy to directly transfer from macroscales to microscales, and finally dissipate at microscales via EMIC-wave-induced ion energization. The direct measurements of the energy transfer rate in the second event confirm the efficiency of this cross-scale transfer process, whose timescale is estimated to be roughly ten EMIC-wave periods about (1 min). Therefore, these observations experimentally demonstrate that simultaneous macroscale and microscale wave-ion interactions provide an efficient mechanism for cross-scale energy transfer and plasma energization in astrophysical and space plasmas.
Background: Acute hepatic failure secondary to paracetamol poisoning is associated with high mortality. C-jun (NH2) terminal kinase (JNK) is a member of the mitogen-activated protein kinase family ...and is a key intracellular signalling molecule involved in controlling the fate of cells. Aim: To examine the role of JNK in paracetamol-induced acute liver failure (ALF). Methods: A previously developed mouse model of paracetamol poisoning was used to examine the role of JNK in paracetamol-induced ALF. Results: Paracetamol-induced hepatic JNK activation both in human and murine paracetamol hepatotoxicity and in our murine model preceded the onset of hepatocyte death. JNK inhibition in vivo (using two JNK inhibitors with different mechanisms of action) markedly reduced mortality in murine paracetamol hepatotoxicity, with a significant reduction in hepatic necrosis and apoptosis. In addition, delayed administration of the JNK inhibitor was more effective than N-acetylcysteine after paracetamol poisoning in mice. JNK inhibition was not protective in acute carbon tetrachloride-mediated or anti-Fas antibody-mediated hepatic injury, suggesting specificity for the role of JNK in paracetamol hepatotoxicity. Furthermore, disruption of the JNK1 or JNK2 genes did not protect against paracetamol-induced hepatic damage. Pharmacological JNK inhibition had no effect on paracetamol metabolism, but markedly inhibited hepatic tumour necrosis foctor α (TNF α) production after paracetamol poisoning. Conclusions: These data demonstrated a central role for JNK in the pathogenesis of paracetamol-induced liver failure, thereby identifying JNK as an important therapeutic target in the treatment of paracetamol hepatotoxicity.
A series of endohedral and exohedral amine-functionalized ligands were synthesized and used in the construction of supramolecular D 2h rhomboids and a D 6h hexagon. These supramolecular polygons were ...obtained via self-assembly of 120° dipyridyl donors with 180° or 120° diplatinum precursors when combined in 1:1 ratios. Steady-state absorption and emission spectra were collected for each ligand and metallacycle. Density functional theory (DFT) and time-dependent DFT calculations were employed to probe the nature of the observed optical transitions for the rhomboids. The emissive properties of these bis(phosphine) organoplatinum metallacycles arise from ligand-centered transitions involving π-type molecular orbitals with modest contributions from metal-based atomic orbitals. The D 2h rhomboid self-assembled from 2,6-bis(4-pyridylethynyl)aniline and a 60° organoplatinum(II) acceptor has a low-energy excited state in the visible region and emits above 500 nm, properties which greatly differ from those of the parent 2,6-bis(4-pyridylethynyl)aniline ligand.
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