Drug resistance and toxicity constitute challenging hurdles for cancer therapy. The application of nanotechnology for anticancer drug delivery is expected to address these issues and bring new hope ...for cancer treatment. In this context, we established an original nanomicellar drug delivery system based on an amphiphilic dendrimer (AmDM), which could generate supramolecular micelles to effectively encapsulate the anticancer drug doxorubicin (DOX) with high drug-loading capacity (>40%), thanks to the unique dendritic structure creating large void space for drug accommodation. The resulting AmDM/DOX nanomicelles were able to enhance drug potency and combat doxorubicin resistance in breast cancer models by significantly enhancing cellular uptake while considerably decreasing efflux of the drug. In addition, the AmDM/DOX nanoparticles abolished significantly the toxicity related to the free drug. Collectively, our studies demonstrate that the drug delivery system based on nanomicelles formed with the self-assembling amphiphilic dendrimer constitutes a promising and effective drug carrier in cancer therapy.
Significance Nanotechnology-based drug delivery is expected to bring new hope for cancer treatment by enhancing anticancer drug efficacy, overcoming drug resistance, and reducing drug toxicity. In this respect, we developed an innovative drug delivery system based on a self-assembling amphiphilic dendrimer, which can generate supramolecular nanomicelles with large void space in their core to encapsulate anticancer drugs with high loading capacity. The resulting drug-encapsulated nanomicelles can effectively enhance drug potency and combat drug resistance by promoting cellular uptake and decreasing efflux of the anticancer drug. Moreover, this drug delivery system can significantly reduce the systemic toxicity of the free drug. The present study illustrates a successful example of how advances in dendrimer nanotechnology can be advantageously implemented to foster therapeutic perspectives.
Progress on development of the new FDIRC PID detector Va'vra, J.; Arnaud, N.; Barnyakov, A.Yu ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
08/2013, Letnik:
718
Journal Article
Recenzirano
Odprti dostop
We present a progress status of a new concept of PID detector called FDIRC, intended to be used at the SuperB experiment, which requires π/K separation up to a few GeV/c. The new photon camera is ...made of the solid fused-silica optics with a volume 25× smaller and speed increased by a factor of 10 compared to the BaBar DIRC, and therefore will be much less sensitive to electromagnetic and neutron background.
Study of H-8500 MaPMT for the FDIRC detector at SuperB Gargano, F.; Arnaud, N.; Barnyakov, A.Yu ...
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment,
08/2013, Letnik:
718
Journal Article, Conference Proceeding
Recenzirano
An overview of ongoing studies on the Hamamatsu H-8500 Multi-Anode Photomultiplier (MaPMT) is presented. This device will be used for the FDIRC Particle Identification Detector (PID) of the SuperB ...experiment. The H-8500 MaPMT has been chosen for its excellent single photon timing capabilities and its highly pixilated design. Results on timing studies, gain uniformity, single photoelectron detection efficiency uniformity and cross-talk are presented.
A search is presented for the four-body decay B0→ppp¯p¯ in a sample of 471 million BB¯ pairs collected with the BABAR detector, operated at the SLAC PEP-II asymmetric-energy e+e− collider. The ...center-of-mass energy is 10.58 GeV. From a fit to the distribution of the energy-substituted mass mES, the branching fraction B(B0→ppp¯p¯)=(1.1±0.5±0.2)×10−7 is extracted, where the first uncertainty is statistical and the second is systematic. The significance of the signal, including the systematic uncertainty, is 2.9 standard deviations. The upper limit on the branching fraction is determined to be 2.0×10−7 at 90% confidence level.
The existing muon detectors for high-energy physics experiments are mainly made of gas chambers such as Resistive Plate Chambers, Limited Streamer Tubes or Multi Wire Proportional Chambers. With the ...increasing luminosity of the new accelerators and the increment in dimensions of the experiments the development of a new detection technique, which is robust, cheap and capable to sustain high particle rate, is mandatory. We present the technology proposed for the Super B muon system. The detector is based on MINOS style extruded scintillators coupled to wavelength shifting fibers. The light readout is done by means of Silicon Photomultiplier devices. We report the R&D results on prototypes that can be operated either with binary readout, measuring only one coordinate, or with a TDC readout that can measure both the coordinate at the same time with adequate precision. Efficiency and time resolution will be discussed for different prototype geometry as well as the main operational issues related to the photodetectors, like stability, noise rate and neutron damage. A full-scale prototype with the same geometry designed for the SuperB experiment is under construction in our lab and it will be tested with a muon/pion beam at FNAL next fall. The structure optimization has been studied using a GEANT4 Monte Carlo simulation and the expected muon identification performances have been evaluated with a neural network algorithm, we present preliminary results of the optimization and its implication for the SuperB muon system.
We report on the first search for electron-muon lepton flavor violation (LFV) in the decay of a b quark and b antiquark bound state. We look for the LFV decay Υ(3S)→e±μ∓ in a sample of 118 million ...Υ(3S) mesons from 27 fb-1 of data collected with the BABAR detector at the SLAC PEP-II e+e- collider operating with a 10.36 GeV center-of-mass energy. No evidence for a signal is found, and we set a limit on the branching fraction BΥ(3S)→e±μ∓<3.6×10-7 at 90% C. L. This result can be interpreted as a limit ΛNP/gNP2>80 TeV on the energy scale ΛNP divided by the coupling-squared gNP2 of relevant new physics (NP).
A study of the two-body decays B^{±}→X_{ccover ¯}K^{±}, where X_{ccover ¯} refers to one charmonium state, is reported by the BABAR Collaboration using a data sample of 424 fb^{-1}. The absolute ...determination of branching fractions for these decays are significantly improved compared to previous BABAR measurements. Evidence is found for the decay B^{+}→X(3872)K^{+} at the 3σ level. The absolute branching fraction BB^{+}→X(3872)K^{+}=2.1±0.6(stat)±0.3(syst)×10^{-4} is measured for the first time. It follows that BX(3872)→J/ψπ^{+}π^{-}=(4.1±1.3)%, supporting the hypothesis of a molecular component for this resonance.
The DIRC-like time-of-flight detector (FTOF) is a ring imaging Cherenkov counter designed to improve the charged particle identification on the forward side of SuperB. Here we review the main ...characteristics of this device, summarize the results of a prototype test done last year in the SLAC Cosmic Ray Telescope and present the future steps needed to build the FTOF.
We present a search for nine lepton-number-violating and three lepton-flavor-violating neutral charm decays of the type D^{0}→h^{'-}h^{-}ℓ^{'+}ℓ^{+} and D^{0}→h^{'-}h^{+}ℓ^{'±}ℓ^{∓}, where h and ...h^{'} represent a K or π meson and ℓ and ℓ^{'} an electron or muon. The analysis is based on 468 fb^{-1} of e^{+}e^{-} annihilation data collected at or close to the ϒ(4S) resonance with the BABAR detector at the SLAC National Accelerator Laboratory. No significant signal is observed for any of the twelve modes, and we establish 90% confidence level upper limits on the branching fractions in the range (1.0-30.6)×10^{-7}. The limits are between 1 and 3 orders of magnitude more stringent than previous measurements.
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