Abstract
The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) Stellar Library (MaStar) is a large collection of high-quality empirical stellar spectra designed to cover all spectral types ...and ideal for use in the stellar population analysis of galaxies observed in the MaNGA survey. The library contains 59,266 spectra of 24,130 unique stars with spectral resolution
R
∼ 1800 and covering a wavelength range of 3622–10,354 Å. In this work, we derive five physical parameters for each spectrum in the library: effective temperature (
T
eff
), surface gravity (
log
g
), metallicity (Fe/H), microturbulent velocity (
log
(
v
micro
)
), and alpha-element abundance (
α
/Fe). These parameters are derived with a flexible data-driven algorithm that uses a neural network model. We train a neural network using the subset of 1675 MaStar targets that have also been observed in the Apache Point Observatory Galactic Evolution Experiment (APOGEE), adopting the independently-derived APOGEE Stellar Parameter and Chemical Abundance Pipeline parameters for this reference set. For the regions of parameter space not well represented by the APOGEE training set (7000 ≤
T
≤ 30,000 K), we supplement with theoretical model spectra. We present our derived parameters along with an analysis of the uncertainties and comparisons to other analyses from the literature.
The assessment and management of neonatal pain is crucial for the development and wellbeing of vulnerable infants. Specifically, neonatal pain is associated with adverse health outcomes but is often ...under-identified and therefore under-treated. Neonatal stress may be misinterpreted as pain and may therefore be treated inappropriately. The assessment of neonatal pain is complicated by the non-verbal status of patients, age-dependent variation in pain responses, limited education on identifying pain in premature infants, and the clinical utility of existing tools.
We review research surrounding neonatal pain assessment scales currently in use to assess neonatal pain in the neonatal intensive care unit.
We performed a systematic review of original research using PRISMA guidelines for literature published between 2016 and 2021 using the key words "neonatal pain assessment" in the databases Web of Science, PubMed, and CINAHL. Fifteen articles remained after review, duplicate, irrelevant, or low-quality articles were eliminated.
We found research evaluating 13 neonatal pain scales. Important measurement categories include behavioral parameters, physiological parameters, continuous pain, acute pain, chronic pain, and the ability to distinguish between pain and stress. Provider education, inter-rater reliability and ease of use are important factors that contribute to an assessment tool's success. Each scale studied had strengths and limitations that aided or hindered its use for measuring neonatal pain in the neonatal intensive care unit, but no scale excelled in all areas identified as important for reliably identifying and measuring pain in this vulnerable population.
A more comprehensive neonatal pain assessment tool and more provider education on differences in pain signals in premature neonates may be needed to increase the clinical utility of pain scales that address the different aspects of neonatal pain.
ABSTRACT
We study the nature of the faint radio source population detected in the MeerKAT International GHz Tiered Extragalactic Exploration (MIGHTEE) Early Science data in the COSMOS field, focusing ...on the properties of the radio-loud active galactic nuclei (AGNs). Using the extensive multiwavelength data available in the field, we are able to classify 88 per cent of the 5223 radio sources in the field with host galaxy identifications as AGNs (35 per cent) or star-forming galaxies (54 per cent). We select a sample of radio-loud AGNs with redshifts out to z ∼ 6 and radio luminosities 1020 < L1.4 GHz/W Hz−1 < 1027 and classify them as high-excitation and low-excitation radio galaxies (HERGs and LERGs). The classification catalogue is released with this work. We find no significant difference in the host galaxy properties of the HERGs and LERGs in our sample. In contrast to previous work, we find that the HERGs and LERGs have very similar Eddington-scaled accretion rates; in particular we identify a population of very slowly accreting AGNs that are formally classified as HERGs at these low radio luminosities, where separating into HERGs and LERGs possibly becomes redundant. We investigate how black hole mass affects jet power, and find that a black hole mass ≳ 107.8 M⊙ is required to power a jet with mechanical power greater than the radiative luminosity of the AGN (Lmech/Lbol > 1). We discuss that both a high black hole mass and black hole spin may be necessary to launch and sustain a dominant radio jet.
The participation of 5-lipoxygenase (5-LO) in the development of atherosclerosis has been suggested by recent studies. However, a role for 5-LO as a modulator of atherosclerotic plaque instability ...has not been previously reported in humans. Thus, the aims of this study was to analyze the expression of 5-LO in human carotid plaques and to investigate the mechanism by which this enzyme could lead to plaque instability and rupture.
We obtained atherosclerotic plaques from 60 patients undergoing carotid endarterectomy. We divided the plaques into symptomatic and symptomatic according to clinical evidence of plaque instability. Clinical evidence of plaque instability was provided by the assessment of recent ischemic symptoms attributable to the stenosis and by the presence of ipsilateral cerebral lesion(s) determined by computed tomography. Plaques were analyzed for CD68+ macrophages, CD3+ T cells, alpha-actin+ smooth muscle cells, 5-LO, cyclooxygenase 2, matrix metalloproteinase (MMP)-2, and MMP-9 by immunohistochemical, immunoblotting, and densitometric analyses. MMP activity was assessed by zymography. Leukotriene (LT) B4 and collagen were quantified by ELISA and Sirius red polarization, respectively. The percentage of macrophage-rich and T-cell-rich areas was larger in symptomatic compared with asymptomatic patients (25+/-6% versus 8+/-4%, P<0.0001, and 74+/-17 versus 18+/-4 cell/mm2, P<0.003). 5-LO expression was higher in symptomatic compared with asymptomatic plaques (24+/-4% versus 6+/-3%, P<0.0001) and was associated with increased MMP-2 and MMP-9 expression (27+/-4% versus 7+/-3%, P<0.0001, and 29+/-5% versus 8+/-2%, P<0.0001) and activity and with decreased collagen content (6.9+/-2.4% versus 17.8+/-3.1%, P<0.01). Immunofluorescence showed that 5-LO and MMPs colocalize in activated macrophages. Notably, higher 5-LO in symptomatic plaques correlated with increased LTB4 production (18.15+/-3.56 versus 11.27+/-3.04 ng/g tissue, P<0.0001).
The expression of 5-LO is elevated in symptomatic compared with asymptomatic plaques and is associated with acute ischemic syndromes, possibly through the generation of LTB4, subsequent MMP biosynthesis, and plaque rupture.
Transcriptional interference between genes and the regulatory elements of simple eukaryotes such as Saccharomyces cerevisiae is an unavoidable consequence of their compressed genetic arrangement. We ...have shown previously that with the tandem arranged genes GAL10 and GAL7, inefficient transcriptional termination of the upstream gene inhibits initiation of transcription on the downstream gene. We now show that transcriptional interference can occur also with S. cerevisiae RNA polymerase II genes arranged convergently. We demonstrate that when the GAL10 and GAL7 genes are rearranged in a convergent orientation, transcriptional initiation occurs at full levels. However, as soon as the two transcripts begin to overlap, elongation is restricted, resulting in a severe reduction in steady-state mRNA accumulation. This effect is observed only in cis arrangement, arguing against RNA-interference effects acting on the potential generation of antisense transcripts. These data reinforce the necessity of separating adjacent RNA polymerase II transcription units by efficient termination signals.
Measurements of the low-z Hα luminosity function, Φ, have a large dispersion in the local number density of sources (∼0.5-1 Mpc−3 dex−1), and correspondingly in the star formation rate density ...(SFRD). The possible causes for these discrepancies include limited volume sampling, biases arising from survey sample selection, different methods of correcting for dust obscuration and active galactic nucleus contamination. The Galaxy And Mass Assembly (GAMA) survey and Sloan Digital Sky Survey (SDSS) provide deep spectroscopic observations over a wide sky area enabling detection of a large sample of star-forming galaxies spanning 0.001 < SFRHα (M yr− 1) < 100 with which to robustly measure the evolution of the SFRD in the low-z Universe. The large number of high-SFR galaxies present in our sample allow an improved measurement of the bright end of the luminosity function, indicating that the decrease in Φ at bright luminosities is best described by a Saunders functional form rather than the traditional Schechter function. This result is consistent with other published luminosity functions in the far-infrared and radio. For GAMA and SDSS, we find the r-band apparent magnitude limit, combined with the subsequent requirement for Hα detection leads to an incompleteness due to missing bright Hα sources with faint r-band magnitudes.
Cyclooxygenase-2 (COX-2) is up-regulated in many cancers and is a rate-limiting step in colon carcinogenesis. Nonsteroidal antiinflammatory drugs, which inhibit COX-2, prevent colon cancer and cause ...apoptosis. The mechanism for this response is not clear, but it might result from an accumulation of the substrate, arachidonic acid, an absence of a prostaglandin product, or diversion of the substrate into another pathway. We found that colon adenocarcinomas overexpress another arachidonic acid-utilizing enzyme, fatty acid-CoA ligase (FACL) 4, in addition to COX-2. Exogenous arachidonic acid caused apoptosis in colon cancer and other cell lines, as did triacsin C, a FACL inhibitor. In addition, indomethacin and sulindac significantly enhanced the apoptosis-inducing effect of triacsin C. These findings suggested that unesterified arachidonic acid in cells is a signal for induction of apoptosis. To test this hypothesis, we engineered cells with inducible overexpression of COX-2 and FACL4 as "sinks" for unesterified arachidonic acid. Activation of the enzymatic sinks blocked apoptosis, and the reduction of cell death was inversely correlated with the cellular level of arachidonic acid. Inhibition of the COX-2 component by nonsteroidal antiinflammatory drugs restored the apoptotic response. Cell death caused by exposure to tumor necrosis factor α or to calcium ionophore also was prevented by removal of unesterified arachidonic acid. We conclude that the cellular level of unesterified arachidonic acid is a general mechanism by which apoptosis is regulated and that COX-2 and FACL4 promote carcinogenesis by lowering this level.
We use 10 387 galaxies from the Herschel Astrophysical TeraHertz Large Area Survey (H-ATLAS) to probe the far-infrared radio correlation (FIRC) of star-forming galaxies as a function of redshift, ...wavelength, and effective dust temperature. All of the sources in our 250 μm-selected sample have spectroscopic redshifts, as well as 1.4 GHz flux density estimates measured from the Faint Images of the Radio Sky at Twenty centimetres (FIRST) survey. This enables us to study not only individual sources, but also the average properties of the 250 μm-selected population using median stacking techniques. We find that individual sources detected at ≥5σ in both the H-ATLAS and FIRST data have logarithmic flux ratios (i.e. FIRC q
λ parameters) consistent with previous studies of the FIRC. In contrast, the stacked values show larger q
λ, suggesting excess far-IR flux density/luminosity in 250 μm-selected sources above what has been seen in previous analyses. In addition, we find evidence that 250 μm sources with warm dust spectral energy distributions have a larger 1.4 GHz luminosity than the cooler sources in our sample. Though we find no evidence for redshift evolution of the monochromatic FIRC, our analysis reveals significant temperature dependence. Whilst the FIRC is reasonably constant with temperature at 100 μm, we find increasing inverse correlation with temperature as we probe longer PACS and SPIRE wavelengths. These results may have important implications for the use of monochromatic dust luminosity as a star formation rate indicator in star-forming galaxies, and in the future, for using radio data to determine galaxy star formation rates.
We describe the spectroscopic target selection for the Galaxy And Mass Assembly (GAMA) survey. The input catalogue is drawn from the Sloan Digital Sky Survey (SDSS) and UKIRT Infrared Deep Sky Survey ...(UKIDSS). The initial aim is to measure redshifts for galaxies in three 4°× 12° regions at 9, 12 and 14.5 h, on the celestial equator, with magnitude selections r < 19.4, z < 18.2 and KAB < 17.6 over all three regions, and r < 19.8 in the 12-h region. The target density is 1080 deg−2 in the 12-h region and 720 deg−2 in the other regions. The average GAMA target density and area are compared with completed and ongoing galaxy redshift surveys. The GAMA survey implements a highly complete star–galaxy separation that jointly uses an intensity-profile separator (Δsg=rpsf−rmodel as per the SDSS) and a colour separator. The colour separator is defined as Δsg,jk=J−K−f(g−i), where f(g−i) is a quadratic fit to the J−K colour of the stellar locus over the range 0.3 < g−i < 2.3. All galaxy populations investigated are well separated with Δsg,jk > 0.2. From 2 yr out of a 3-yr AAOmega program on the Anglo-Australian Telescope, we have obtained 79 599 unique galaxy redshifts. Previously known redshifts in the GAMA region bring the total up to 98 497. The median galaxy redshift is 0.2 with 99 per cent at z < 0.5. We present some of the global statistical properties of the survey, including K-band galaxy counts, colour–redshift relations and preliminary n(z).
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