The mechanisms by which administration of a formalin-inactivated respiratory syncytial virus vaccine resulted in enhanced disease among children after they later became naturally infected with the ...virus remains largely undefined. After immunization and live virus challenge, the cotton rat demonstrated the histopathologic marker of the enhanced disease, polymorphonuclear leukocyte infiltration of lung alveolar spaces. We now report that immunization with formalin-inactivated vaccine formulated with the adjuvant, 3-deacylated monophosphoryl lipid A, dramatically reduces or eliminates the polymorphonuclear leukocyte infiltration within the alveoli of cotton rats post-challenge. We suggest, that this or similar adjuvants may be beneficial components of candidate non-replicating respiratory syncytial virus vaccines, whose development has been hampered by safety concerns.
The rate of nuclear muon capture by the proton has been measured using a new technique based on a time projection chamber operating in ultraclean, deuterium-depleted hydrogen gas, which is key to ...avoiding uncertainties from muonic molecule formation. The capture rate from the hyperfine singlet ground state of the {mu}p atom was obtained from the difference between the {mu}{sup -} disappearance rate in hydrogen and the world average for the {mu}{sup +} decay rate, yielding {lambda}{sub S}=725.0{+-}17.4 s{sup -1}, from which the induced pseudoscalar coupling of the nucleon, g{sub P}(q{sup 2}=-0.88m{sub {mu}}{sup 2})=7.3{+-}1.1, is extracted.
Elemental analysis of light constituents in thin plastic films El Masri, Y.; Heitz, Ch; Keutgen, Th ...
Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms,
04/2009, Letnik:
267, Številka:
7
Journal Article
Recenzirano
Experiments with 1–3
MeV
4He beams and 2.2–3.2
MeV proton beams have been performed in order to develop a precise and highly sensitive method for the detection and analysis of light elements in ...threat or drug materials using simultaneously the RBS and ERDA techniques. Commercially available plastic films have been used as samples. The 1
MeV
4He beam has been found to be inadequate owing to the rapid destruction of the targets. Best results have been obtained using proton beams with energies higher than 3
MeV. For 3.2
MeV proton beams, ERDA has been used for the analysis of the hydrogen constituent.
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