Urotensin II (UII) is a vasoactive peptide secreted by endothelial cells. Increased plasma UII concentration was observed in patients with heart failure, liver cirrhosis, diabetic nephropathy and ...renal insufficiency. In patients with myocardial infarction both increased and decreased plasma UII concentrations were demonstrated. The aim of this study was to analyze whether plasma UII concentration reflects the severity of acute coronary syndrome (ACS).
One hundred and forty-nine consecutive patients with ACS, without age limit, were enrolled in the study. In all patients plasma concentration of creatinine, creatine kinase isoenzyme MB (CK-MB), troponin C, N-terminal prohormone of brain natriuretic peptide (NT-pro BNP), and UII were assessed, and echocardiography was performed in order to assess the degree of left ventricular hypertrophy, ejection fraction (EF) and mass (LVM).
In patients with the highest risk (TIMI 5-7) plasma UII concentration was significantly lower than in those with low risk (TIMI 1-2): 2.61±1.47 ng/ml vs. 3.60±2.20 ng/ml. Significantly lower plasma UII concentration was found in patients with increased concentration of troponin C (2.60±1.52 ng/ml vs. 3.41±2.09 ng/ml). There was a significant negative correlation between plasma UII concentration and TIMI score or concentration of troponin C, but not CK-MB. Borderline correlation between plasma UII and ejection fraction (R = 0.157; p=0.063) or NT-proBNP (R = - 0.156; p=0.058) was found.
Decreased plasma urotensin II concentration in patients with ACS could be associated with more severe injury of myocardium.
Introduction: Urotensin II (UII) is a vasoactive peptide secreted by endothelial cells. Increased plasma UII concentration was observed in patients with heart failure, liver cirrhosis, diabetic ...nephropathy and renal insufficiency. In patients with myocardial infarction both increased and decreased plasma UII concentrations were demonstrated. The aim of this study was to analyze whether plasma UII concentration reflects the severity of acute coronary syndrome (ACS). Material and methods: One hundred and forty-nine consecutive patients with ACS, without age limit, were enrolled in the study. In all patients plasma concentration of creatinine, creatine kinase isoenzyme MB (CK-MB), troponin C, N-terminal prohormone of brain natriuretic peptide (NT-pro BNP), and UII were assessed, and echocardiography was performed in order to assess the degree of left ventricular hypertrophy, ejection fraction (EF) and mass (LVM). Results: In patients with the highest risk (TIMI 5-7) plasma UII concentration was significantly lower than in those with low risk (TIMI 1-2): 2.61 ±1.47 ng/ml vs. 3.60 ±2.20 ng/ml. Significantly lower plasma UII concentration was found in patients with increased concentration of troponin C (2.60 ±1.52 ng/ml vs. 3.41 ±2.09 ng/ml). There was a significant negative correlation between plasma UII concentration and TIMI score or concentration of troponin C, but not CK-MB. Borderline correlation between plasma UII and ejection fraction (R = 0.157; p = 0.063) or NT-proBNP (R = -0.156; p = 0.058) was found. Conclusions: Decreased plasma urotensin II concentration in patients with ACS could be associated with more severe injury of myocardium.
Slow ventricular tachycardia (VT), which is below the detection rate of implantable cardioverter-defibrillator may cause haemodynamical instability, when pharmacological agents or antitachycardia ...pacing are unsuccessful, electrical cardioversion is necessary. We present another method of termination of slow VT by ICD, in which transcutaneous pacing mimics faster VT and triggers ICD discharge.
We describe a case of a 19-year-old pregnant woman with paroxysmal atrio-ventricular reentrant tachycardia (AVNRT). Transoesophageal atrial pacing (TAP) successfully terminated the arrhythmia, ...however, AVNRT restarted after 20 min and was initiated by ventricular ectopy. Intravenous metoprolol effectively suppressed ventricular ectopy and AVNRT did not recur. A modification of the ESC algorithm, with the inclusion of pacing techniques to terminate AVNRT, is proposed.
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