This document summarises the talks and discussions happened during the VBSCan Mid-Term Scientific Meeting workshop. The VBSCan COST action is dedicated to the coordinated study of vector boson ...scattering (VBS) from the phenomenological and experimental point of view, for the best exploitation of the data that will be delivered by existing and future particle colliders.
Sveučilište u Splitu, kao član CMS kolaboracije, sudjeluje u razvoju olovno/scintilacijskog elektromagnetskog kalorimetra ”sandwich”-tipa (shashlik), u okviru RD36 projekta. Tijekom 1994. provedeni ...su detaljni eksperimentalni testovi svojstava prototip-tornjeva shashlik kalorimetra, kao jednog od kandidata za elektromagnetski kalorimetar u CMS detektoru na LHC-u. Izmjereno energijsko razlučivanja određeno je stohastičkim članom iznosa 8.5%/ √ E, šumom iznosa 0.33/E, te konstantnim članom iznosa 0.5% (E u GeV). Razmatrana je reproducibilnost proizvodnje tornjeva jednakih svojstava, uniformnost odziva kalorimetra na površini 25 cm ×25 cm, te kutno razlučivanje. Procijenjen je i utjecaj radijacijskih oštećenja na shashlik tornjeve.
The minimal SU(5) theory augmented by the fermionic adjoint representation restores the coupling constant unification and gives realistic neutrino masses and mixing through the hybrid Type I and Type ...III seesaw. The crucial prediction of the theory is an SU(2) lepton triplet with the mass below TeV. We study the signature of these heavy leptons and propose the strategy to test this mechanism at the hadron and lepton colliders. The smoking gun evidence of the theory is Delta L=2 lepton number violation through events of a pair of like-sign leptons plus four jets without significant missing energy at hadron colliders. We find that via this unique channel, the heavy lepton can be searched for up to a mass of 200 GeV at the Tevatron with 8 fb^-1, and up to 450 (700) GeV at the LHC of 14 TeV C.M.energy with 10 (100) fb^-1. The signal rate at the 10 TeV LHC is reduced to 60-35% for a mass of 200-700 GeV. We also comment on how to distinguish this theory from other models with similar heavy leptons. Finally, we compare the production rates and angular distributions of heavy leptons in e+e- collisions for various models.
•VDR expression is increased in cytoplasm, nuclei and membranes of DRG neurons in diabetes mellitus.•VDR expression occurs in all neurons, although is more prominent in small somata.•VDR signaling ...system could be a potential therapeutic target for diabetic neuropathy.
The effects of vitamin D on the nervous system have been studied extensively. In spite of accumulating data about the substantial changes in the vitamin D receptor (VDR) signaling system, during different types of neuroinflammatory diseases, its role in diabetic neuropathy has not been investigated in detail. To assess the role of VDR signaling in diabetic neuropathy, we examined expression of VDRs in dorsal root ganglia (DRG) neurons in a rat model of streptozotocin-induced diabetes mellitus type 1. Diabetes mellitus (DM) type 1 was induced with streptozotocin in male Sprague-Dawley rats. After two months, expression of VDRs was analyzed immunohistochemically in the cytoplasm of L4 and L5 DRG neurons of diabetic rats. Semi-quantitative analysis for the determination of staining in nuclei and plasma-membranes of DRG neurons was performed. A significant increase in VDR expression was observed in DRG neurons of diabetic rats. Expression of VDRs was increased in the cytoplasm, nuclei and in cell membranes of neurons. An increase in VDR expression occurred in all neurons, but the greatest increase of fluorescence intensity in cytoplasm was observed in neurons of small diameter. Results of the present study indicate that the VDR signaling system could be a potential therapeutic target for diabetic neuropathy.
Rats with experimentally-induced acute myocardial infarction (AMI) have proven to be a clinically relevant model for visceral pain. As there are no behavioral data available on rats in the ...postinfarction period, we aimed to identify specific pain-related behavioral changes following AMI to increase the validity of the model. AMI was induced by left coronary artery ligation and pain-related behavior was analyzed using the open fi eld test (OFT) and elevated plus maze (EPM). Morphine was applied following AMI induction to differentiate pain-related changes from those related to nonspecific global changes in responsiveness. AMI was histologically confi rmed. Hypolocomotion was consistently evident in all behavioral tests for both the infarcted group and sham group. In the OFT, both AMI and sham rats exhibited less exploratory behavior and less activity. A similar pattern of behavior was observed in EPM, where both surgical groups showed fewer entries to the open arms and spent less time in the open arms. The sham group with an intact pericardium showed the same pattern of activity as control rats. The reduction in activity and rearing observed following AMI was successfully reversed following morphine injection. This effect was abolished after naloxone application allowing us to attribute observed changes specifically to pain. This study demonstrates that pain-related behavior in the acute postinfarction period is generally characterized by reduced mobility and explorative behavior. Our results showed that cardiac ischemia as a consequence of experimentally-induced infarction is a less important source of pain behavior than manipulation of the pericardium.
Diabetes mellitus (DM) is a metabolic disorder associated with serious liver complications. As a metabolic chronic disease, DM is very common in the elderly. Recent studies suggest ameliorating ...effects of vitamin D on metabolic and oxidative stress in the liver tissue in an experimental model of DM. The aim of this study was to investigate the expression of vitamin D receptors (VDRs) and 1α-hydroxylase, the key enzyme for the production of active vitamin D form (calcitriol) in the liver during long-term diabetes mellitus type 1 (DM1) in aging rats. We performed immunohistochemical analysis of liver expression of 1α-hydroxylase and VDRs during aging in long-term streptozotocin-induced DM1. 1α-Hydroxylase was identified in the monocyte/macrophage system of the liver. In addition to the nuclear expression, we also observed the expression of VDR in membranes of lipid droplets within hepatocytes. Aging and long-term DM1 resulted in significant increases in the number of 1α-hydroxylase immunoreactive cells, as well as the percentage of strongly positive VDR hepatocytes. In conclusion, the liver has the capacity for active vitamin D synthesis in its monocyte/macrophage system that is substantially increased in aging and long-term diabetes mellitus. These conditions are also characterized by significant increases in vitamin D receptor expression in hepatocytes. The present study suggests that VDR signaling system could be a potential target in prevention of liver complications caused by diabetes and aging.
•1α-Hydroxylase (1α-OHase) is highly expressed by liver monocyte/macrophage system.•Aging and long-term DM increase the number of 1α-OHase immunoreactive cells in the liver.•Aging and long-term DM increase the expression of VDR in hepatocytes.•VDR is strongly expressed in lipid droplets of hepatocytes.
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