Letters to the Editor Boisture, James B; Pushkarev, Sergei; Brainerd, Gretchen S
The Russian review (Stanford),
07/1974, Letnik:
33, Številka:
3
Journal Article
Adsorbed chemical influenza vaccine is a standard preparation. It meets with the WHO requirements with respect to the content of hemagglutinin, ovalbumin, protein nitrogen. For the dosage of the ...vaccine by the hemagglutinin content in weight units (microgram) in the process of manufacture, the development of the national standard of this antigen is necessary. After the treatment of virus suspension with ether the number of intact virions remains stable, constituting 3-4%.
The median molecular-weight peptides (MMP), detected in blood of patients with burns and in that of experimental animals with burns, were shown to affect various systems in vivo. The MMP from the ...blood of intact dogs and of the animals with burns exhibited the modifying effect on proteolysis within acid and neutral pH ranges in liver and brain tissues of mouse. The MMP appears to be involved in the regulation of proteolysis both in normal state and in burns.
The authors substantiate the employment of radiocardiography for the examination of the cardiohemodynamics in patients with obesity of the III and IV grades. On the basis of a study of the main ...hemodynamic indices in patients with extreme obesity a trial is made to evaluate the pathogenesis of cardiac insufficiency in these patients.
The authors present the results of the determination of the effective renal blood flow (ERB), the effective renal plasma flow (ERP) and the rate of glomerular filtration (GRF) by sequential ...administration of 131I-hippuran and 169Yb-DTPK assessing the contribution of each radionuclide in blood plasma specimens with the help of a multichannel pulse analyzer. The mean values of ERB (738.4 +/- 27.3 ml/min), ERP (391 +/- 22.4 ml/min) and GRF (128.9 ml/min) were in full accord with the literature data. The difference between GRF values calculated in the presence of 131I in plasma and after its decomposition, did not exceed 5% (6.4 +/- 1.8 ml/min), and the ratio of correlation between them was 0.948, p less than 0.01. A possibility of simultaneous determination of ERB and GRF under clinical conditions was shown.
The authors present the results of comparative analysis of 7 radionuclide clearance methods for the determination of glomerular filtration rate (GFR), based on single administration of 169Yb-DTPC. A ...reference method was based on the determination of GFR by a curve of a decrease in plasma concentrations with subsequent biexponential analysis on a DVK-2M computer. Methods of the determination of GFR based on 2 blood drawing tests after achieving a uniform distribution of the indicator in its volume of dilution (1) and extracorporal labeling of gamma radiation by a precordial detector (2) showed the highest degree of correlation with the reference method (r = 0.918, p less than 0.001 and r = 0.920, p less than 0.001, respectively). The use of both methods based on a single-chamber model of renal clearance, led to good results, provided the measurements were to start not earlier than 1.5 h after administration of the indicator.
