To observe the treatment effect and toxicity of nonmyeloablative allogeneic stem cell transplantation (NST) for hematologic diseases.
A total of 243 hematologic diseases patients received ...HLA-identical NST were enrolled in this study from 9 transplant centers of NST Cooperative Group in China. Nonmyeloablative conditioning regimen was based on fludarabine (Flud), rabbit anti-human thymocyte globulin (ATG), cyclophosphamide (CTX) (FAC), and plus cytarabine or busulfan (BU) etc. Graft-versus-host disease (GVHD) prophylaxis included cyclosporin A (CsA) and mycophenolate mofetil (MMF).
Among the 243 patients, 219 (90.1%) achieved full donor chimerism (FDC), 2(0.8%) engraftment failure. 78 (32.1%) had mixture chimerism (MC) at 4 weeks after NST, out of which 56 switched to FDC, 16 remained MC and 6 (2.5%) developed graft rejection. The incidence of acute GVHD was 34.2%, including 6.6% of grade III-IV acute GVHD. Chronic GVHD developed in 78 (32.1%) patients. The follow-up durations were 3 - 99 months, 162 (66.7%)
To verify the application and effectiveness of monthly deworming for all dogs in the control of Echinococcus granulosus infection.
Baited praziquantel was used to treat all registered dogs monthly by ...hydatid disease control officers at village level and all stray (unowned) dogs were eliminated in the counties of Hutubi and Wensu in 1987-1990 and 1990-1994 respectively. Prevalence of echinococcosis in dogs and sheep was recorded yearly.
The infection rate in dogs decreased from 18.5% and 14.7% before implementation of the control measure to zero in 3-4 years in Hutubi and Wensu Counties respectively. Prevalence of hydatid disease in new born sheep was reduced by more than 85% in comparison to the same age sheep before the control program in both counties.
"Monthly drug administration to all dogs" is an effective way to the control of echinococcosis in dogs and of hydatid disease in sheep.
To study the clinical significance of formation and conversion of hematopoietic mixed chimerism in nonmyeloablative allogeneic hematopoietic stem cell transplantation (NAST) in treatment of ...hematological diseases.
Nonmyeloablative pretreatment was given to 42 patients with hematological diseases, 26 males and 16 females with the median age of 37, that were matched with the donors in terms of HLA, such as CD3 monoclonal antibody, cyclosporine A, cyclophosphamide (CTX) and cytarabine for patients with leukemia among which 6 were given fludarabine in addition, and CTX and antilymphocyte globulin for patients with myeloproliferative disease and aplastic anemia, thus practicing nonmyeloablative allogeneic stem cell transplantation (NAST). The incidence of graft-versus-host disease (GVHD) and survival were observed.
Donor-recipient hematopoietic cell chimerism was formed in 42 patients, with 18 cases of full donor chimerism (FDC) and 24 cases of mixed chimerism (MC). Of the 42 patients, 10 (23.8%) developed acute G
To investigate the therapeutic effect of conditioning regimen containing fludarabine in nonmyeloablative allogeneic peripheral blood stem cells transplantation (NAST) in the treatment of ...hematological diseases.
Thirty-six patients with acute leukaemia, severe aplastic anaemia, MDS and myelofibrosis received NAST from HLA matched donors' G-CSF mobilized peripheral blood stem cells after nonmyeloabalative conditioning. The conditioning regimen consisted of CTX, Ara-C, CsA, anti-CD(3) antibody or anti-thymocyte globulin and with or without fludarabine. GVHD prophylaxis was performed with cyclosporine combined methotrexate (no MMF group, n = 5) or mycophenolate mofetil (MMF group, n = 31).
All of the treatment was generally well tolerated and all cases achieved engrafted of the donor cells. In fludarabine group, engraftment was observed in 87.5% (14/16) patients with complete donor chimerism, graft failure was 12.5% (2/16) and in no fludarabine group, 80% (16/20) and 20% (4/20), respectively. The incidence of acu
To explore the significance of nonmyeloablative allogeneic peripheral blood hematopoietic stem cell transplantation in the treatment of hematological diseases.
A nonmyeloablative conditioning regimen ...consisted of CD(3) monoclonal antibody, cyclosporine A, cyclophosphamide and cytarabine was used for allogeneic stem cell transplantation in 33 patients with hematological diseases. Of them, 11 were acute leukemia (AL) in first complete remission (CR(1)), 4 AL-CR(2) approximately 3, 3 refractory AL, 4 severe aplastic anemia (SAA), 7 chronic myeloid leukemia (CML), 2 myelodysplastic syndrome, 1 each of chronic lymphocytic leukemia (CLL) and myelofibrosis.
All 33 patients passed the hematopoietic suppression stage smoothly and achieved engraftment of the donor cells. There were 24 cases of full donor chimerism (13 cases converted from mixed chimerism), 4 mixed chimerism (MC) and 5 developed graft rejection. Of the 33 cases, 7 (21.2%) developed acute GVHD and chronic GVHD, 25 (75.8%) still live and 8 (24.2%) died.
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The purpose of this research is to analysis on cell morphology of PC (Polycarbonate) foam in different processing parameters. In this study, foamed PC was produced using a dynamic simulation foaming ...setup designed by ourselves. Cell morphology was compared as different temperatures, pressures, gas saturation time, pressure drop rates and different shear rates were used. Cell morphology of foamed samples was measured by using scanning electron microscopy（SEM）. It was found that foamed samples with better morphology could be obtained as pressure, pressure drop rate and gas saturation time increased.
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