A series of solid supramolecules based on acrylamide–phenylpyridium copolymers with various substituent groups (P−R: R=−CN, −CO2Et, −Me, −CF3) and cucurbit7uril (CB7) are constructed to exhibit ...tunable second‐level (from 0.9 s to 2.2 s) room‐temperature phosphorescence (RTP) in the amorphous state. Compared with other solid supramolecules P−R/CB7 (R=−CN, −CO2Et, −Me), P−CF3/CB7 displays the longest lifetime (2.2 s), which is probably attributed to the fluorophilic interaction of cucurbiturils leading to a uncommon host–guest interaction between 4‐phenylpyridium with −CF3 and CB7. Furthermore, the RTP solid supramolecular assembly (donors) can further react with organic dyes Eosin Y or SR101 (acceptors) to form ternary supramolecular systems featuring ultralong phosphorescence energy transfer (PpET) and visible delayed fluorescence (yellow for EY at 568 nm and red for SR101 at 620 nm). Significantly, the ultralong multicolor PpET supramolecular assembly can be further applied in fields of anti‐counterfeiting and information encryption and painting.
Solid supramolecules based on acrylamide–phenylpyridium copolymers with various substituent groups and cucurbit7uril not only exhibit tunable ultralong phosphorescence with lifetimes varying from 0.9 s to 2.2 s, but also co‐assemble with organic dyes Eosin Y or SR101 to display high‐performance phosphorescence energy transfer with multicolor delayed fluorescence properties.
Herein, synergistically confining anthracene‐phenylpyridium derivatives (1’ and 1) as dual‐rotor luminogens through macrocyclic cucurbit8uril (CB8) and hyaluronic acid (HA) mediated supramolecular ...secondary reassembly is reported to give bright fluorescence emission. The non‐emissive dual‐rotor molecule 1 first assembles with CB8 to form non‐emissive supramolecular nanotubes, which are further reconstructed to be nanoparticles with a diameter of 83 nm by HA induced secondary reassembly through electrostatic interaction. Intriguingly, the secondary reassembly not only transforms the topological morphology, but also acts as a switch to activate the robust fluorescence of dual‐rotor molecule, accompanying emission at 600 nm with large Stokes shift (150 nm). This activation is mainly attributed to sufficient suppression of intramolecular rotation and promotion of intramolecular charge transfer of dual‐rotor molecule after reassembly. Benefiting from multiple components synergistic stimuli‐responsiveness and the targeted ability of HA to tumor cells, the secondary reassembly constructed dual‐rotor luminescence system is successfully applied in triplet encryption information security and targeted cancer cell imaging.
The dual‐rotor molecules 1 and 1’ can be activated to generate fluorescence and morphological changes by synergistic effect based on cucurbit8uril mediated host–guest interaction and hyaluronic acid induced supramolecular secondary reassembly through electrostatic interaction, which is successfully applied in aspects of triplet encryption information security and bioimaging in cancer cells.
Ischemic brain injury (IBI) can cause nerve injury and is a leading cause of morbidity and mortality worldwide. The neuroprotective effects of propofol against IBI have been previously demonstrated. ...However, the neuroprotective effects of propofol on hippocampal neurons are not yet entirely clear. In the present study, models of IBI were established in hypoxia-exposed hippocampal neuronal cells. Cell viability assay and apoptosis assay were performed to examine the neuroprotective effects of propofol on hippocampal neurons in IBI. A significant decrease in cell viability and a significant increase in cell apoptosis were observed in the IBI group compared with the control group, accompanied by a decrease in glial glutamate transporter-1 (GLT‑1) expression as determined by RT-qPCR and western blot analysis. The effects of IBI were reversed by propofol treatment. The siRNA-mediated knockdown of GLT‑1 in the hypoxia-exposed hippocampal neuronal cells led to an increase in cell apoptosis, Jun N-terminal kinase (JNK) activation and N-methyl-D‑aspartate (NMDA) receptor (NR1 and NR2B) activation, as well as to a decrease in cell viability and a decrease in Akt activation. The effects of RNA interference-mediated GLT‑1 gene silencing on cell viability, JNK activation, NMDAR activation, cell apoptosis and Akt activation in the hippocampal neuronal cells were slightly reversed by propofol treatment. The JNK agonist, anisomycin, and the Akt inhibitor, LY294002, both significantly blocked the effects of propofol on hippocampal neuronal cell viability and apoptosis in IBI. The decrease in JNK activation and the increase in Akt activation caused by GLT‑1 overexpression were reversed by NMDA. Collectively, our findings suggest that propofol treatment protects hippocampal neurons against IBI by enhancing GLT‑1 expression and inhibiting the activation of NMDAR via the JNK/Akt signaling pathway.
<正>Objective:To observe the effects of sevoflurane treatment on lung inflammation in rats with lipopolysaccharide-induced acute lung injury(ALI).Methods:The rat model of ALI was established by ...intratracheal instillation of lipopolysaccharide(LPS).45 infantile SD ratsbody weight(272±15) gwere randomly divided into 3 groups(n=15):control group,LPS group, sevoflurane group.NS(1 mL/kg) was instillated in rats’airways of control group;LPS(5 mg/ kg) was instillated in rats’airways of LPS group.Sevoflurane group rats received sevoflurane (2.4%) inhalation for a hour after LPS was instillated in rats’airways.Six hours after NS or LPS instillation,all rats were exsanguinated.Lung tissues were examined by HE staining.Expressions of TNF-αand ICAM1 mRNA were detected by semiquantitative RT-PCR techniques.The protein level of TNF-αand ICAM1 were assessed by western blot techniques.Results:In LPS group the permeability of lung tissues increased,organizational structure severely damaged and the alveolar wall turned thick,with interstitial edema and Europhiles infiltrated increasingly.The LPS group had higher mRNA expressions of TNF-αand ICAM1 than control group and sevoflurane group (P<0.05),and LPS group had higher protein level of TNF-αand ICAMI than control group and sevoflurane group(P<0.05).Conclusions:Sevoflurane treatment can attenuate lung inflammation in rats with lipopolysaccharide-induced acute lung injury.
Transversus abdominis plane block (TAPB) is a block of the abdominal afferent nerve fibers between the internal oblique muscle and the transverse abdominal muscle achieved with local anesthetics. It ...can effectively block the conduction of the anterior nerve of the abdominal wall and exert a good analgesic effect. However, the effect of combining the block with remimazolam on anesthesia in patients undergoing gastrointestinal tumor surgery is still unclear.
To examine the effects of combining TAPB with remimazolam on the stress response and postoperative recovery of gastrointestinal tumor surgery patients.
A retrospective analysis was conducted on the clinical data of 102 individuals diagnosed with gastrointestinal malignancies who underwent laparoscopic surgery under general anesthesia between April 2020 and June 2023. The patients were categorized into a control group (
= 51), receiving remimazolam for general anesthesia, and an observation group (
= 51), receiving TAPB combined with remimazolam for general anesthesia. A comparison was made between both groups in terms of hemodynamic parameters, stress markers, pain levels, recovery quality, analgesic effects, and adverse reactions during the perioperative period.
The observation group had significantly higher heart rates at time points 1 min after induction and upon leaving the operating room than the control group (
< 0.05). The mean arterial pressure at time point T1 in the observation group was significantly higher than that in the control group (
< 0.05). Five minutes after extubation, the levels of the hormones adrenaline and noradrenaline in the observation group were considerably lower than those in the control group (
< 0.05). At 12 h, 24 h, and 48 h following surgery, the visual analog scale scores of the observation group were considerably lower than those of the control group (
< 0.05). The observation group had shorter awakening and extubation times and lower Riker sedation-agitation scale scores than the control group (
< 0.05). The observation group exhibited considerably fewer effective pump presses, lower fentanyl dosages, and lower incidences of rescue analgesia within 24 h following surgery than the control group (
< 0.05).
The application effect of TAPB combined with remimazolam general anesthesia in anesthesia of patients undergoing gastrointestinal tumor surgery is good, which is helpful to promote faster recovery after operation.
A series of solid supramolecules based on acrylamide–phenylpyridium copolymers with various substituent groups (P−R: R=−CN, −CO2Et, −Me, −CF3) and cucurbit7uril (CB7) are constructed to exhibit ...tunable second‐level (from 0.9 s to 2.2 s) room‐temperature phosphorescence (RTP) in the amorphous state. Compared with other solid supramolecules P−R/CB7 (R=−CN, −CO2Et, −Me), P−CF3/CB7 displays the longest lifetime (2.2 s), which is probably attributed to the fluorophilic interaction of cucurbiturils leading to a uncommon host–guest interaction between 4‐phenylpyridium with −CF3 and CB7. Furthermore, the RTP solid supramolecular assembly (donors) can further react with organic dyes Eosin Y or SR101 (acceptors) to form ternary supramolecular systems featuring ultralong phosphorescence energy transfer (PpET) and visible delayed fluorescence (yellow for EY at 568 nm and red for SR101 at 620 nm). Significantly, the ultralong multicolor PpET supramolecular assembly can be further applied in fields of anti‐counterfeiting and information encryption and painting.
A series of solid supramolecules based on acrylamide–phenylpyridium copolymers with various substituent groups (P−R: R=−CN, −CO2Et, −Me, −CF3) and cucurbit7uril (CB7) are constructed to exhibit ...tunable second‐level (from 0.9 s to 2.2 s) room‐temperature phosphorescence (RTP) in the amorphous state. Compared with other solid supramolecules P−R/CB7 (R=−CN, −CO2Et, −Me), P−CF3/CB7 displays the longest lifetime (2.2 s), which is probably attributed to the fluorophilic interaction of cucurbiturils leading to a uncommon host–guest interaction between 4‐phenylpyridium with −CF3 and CB7. Furthermore, the RTP solid supramolecular assembly (donors) can further react with organic dyes Eosin Y or SR101 (acceptors) to form ternary supramolecular systems featuring ultralong phosphorescence energy transfer (PpET) and visible delayed fluorescence (yellow for EY at 568 nm and red for SR101 at 620 nm). Significantly, the ultralong multicolor PpET supramolecular assembly can be further applied in fields of anti‐counterfeiting and information encryption and painting.
Solid supramolecules based on acrylamide–phenylpyridium copolymers with various substituent groups and cucurbit7uril not only exhibit tunable ultralong phosphorescence with lifetimes varying from 0.9 s to 2.2 s, but also co‐assemble with organic dyes Eosin Y or SR101 to display high‐performance phosphorescence energy transfer with multicolor delayed fluorescence properties.
A series of solid supramolecules based on acrylamide–phenylpyridium copolymers with various substituent groups (P−R: R=−CN, −CO2Et, −Me, −CF3) and cucurbit7uril (CB7) are constructed to exhibit ...tunable second‐level (from 0.9 s to 2.2 s) room‐temperature phosphorescence (RTP) in the amorphous state. Compared with other solid supramolecules P−R/CB7 (R=−CN, −CO2Et, −Me), P−CF3/CB7 displays the longest lifetime (2.2 s), which is probably attributed to the fluorophilic interaction of cucurbiturils leading to a uncommon host–guest interaction between 4‐phenylpyridium with −CF3 and CB7. Furthermore, the RTP solid supramolecular assembly (donors) can further react with organic dyes Eosin Y or SR101 (acceptors) to form ternary supramolecular systems featuring ultralong phosphorescence energy transfer (PpET) and visible delayed fluorescence (yellow for EY at 568 nm and red for SR101 at 620 nm). Significantly, the ultralong multicolor PpET supramolecular assembly can be further applied in fields of anti‐counterfeiting and information encryption and painting.
The aim of this study was to investigate clinical application of remifentanil in local anesthesia for resection of tumors in functional brain area.
Twenty-four patients were randomly divided into two ...groups: control group and remifentanil group. In remifentanil group remifentanil was infused intravenously with micro pump in 0.05-0.1 µg·kg-1·min-1. The hemodynamic changes and complications during operation were monitored.
The satisfactory degree for surgical procedure was evaluated. The surgery of two groups could be completed in a conscious state. Mean artery pressure (MAP), heart rate (HR) in remifentanil group during opening or closing skull or intra- cranial period were significantly lower than control group (p < 0.05). There were no conspicuous complications in two groups such as respiratory depression, nausea, vomitting and dysphoria. Satisfaction rate of remifentanyl group was significantly higher than control group (p < 0.05).
Awake brain tumor surgery could be completed in rational use of remifentanil on the base of good local anesthesia, and hemodynamics were stable and the patients were well tolerated.
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