Mutual funds are becoming increasingly popular with the emergence of Internet finance. Clear profiling of a fund's investment style is crucial for fund managers to evaluate their investment ...strategies, and for investors to understand their investment. However, it is challenging to profile a fund's investment style as it requires a comprehensive analysis of complex multi‐dimensional temporal data. In addition, different fund managers and investors have different focuses when analysing a fund's investment style. To address the issue, we propose iFUNDit, an interactive visual analytic system for fund investment style analysis. The system decomposes a fund's critical features into performance attributes and investment style factors, and visualizes them in a set of coupled views: a fund and manager view, to delineate the distribution of funds' and managers' critical attributes on the market; a cluster view, to show the similarity of investment styles between different funds; and a detail view, to analyse the evolution of fund investment style. The system provides a holistic overview of fund data and facilitates a streamlined analysis of investment style at both the fund and the manager level. The effectiveness and usability of the system are demonstrated through domain expert interviews and case studies by using a real mutual fund dataset.
iFUNDit is an interactive visual analytics system for fund investment style analysis. Itdecomposes a fund's critical features into performance attributes and investment stylefactors, and visualizes them in a set of coupled views: the Fund View and Manager View, todelineate the distribution of funds' and managers' critical attributes on the market; the Cluster view, to show the similarity of investment styles between different funds; and theDetail View, to analyze the evolution of fund investment style. The system provides a holisticoverview of fund data and facilitates streamlined analysis of investment style at both thefund and the manager level. The effectiveness and usability of the system are demonstrated through domain expert interviews and case studies by using a real mutual fund dataset.
Summary
Background
The current global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown limited responses to medical ...treatments.
Aims
To observe the effect of combination treatment of giammonium glycyrrhizinate and vitamin C (DV) on the prognoses of patients with COVID-19.
Methods
This retrospective observational study recruited 207 COVID-19 patients from Tongji Hospital, patients were assigned to DV and non-DV groups on the basis of the DV treatment. To make the results more credible, a propensity score matching (PSM) approach was adopted at a 1:3 ratio to determine the participants. Logistic analysis was used to assess the effect of DV therapy in the progress of COVID-19.
Results
In the DV group, the new-onset incidence rate of acute respiratory distress syndrome (ARDS) after admission was clearly lower than that in the non-DV group (DV vs. non-DV groups, 15.2% vs. 35.7%; P = 0.002). Compared with the non-DV group, the DV group showed fewer new onset of complications (such as ARDS, acute liver injury and acute myocardial injury) (DV vs. non-DV groups, 19.6% vs. 46.1%; P = 0.000). Moreover, DG+VC may help to recover the count of NK cells and decrease the level of sIL-2R.
Conclusions
DG+VC might be a promising candidate for preventing the deterioration of COVID-19 patients, which is worthy to be studied in large and perspective cohort.
Purpose
To determine the association between serum periostin and the presence of diabetic retinopathy (DR).
Methods
Serum periostin was detected in 114 healthy subjects, 122 patients with type 2 ...diabetes mellitus (T2DM) and 159 patients with DR and compared among groups. Clinical data and other laboratory measurements such as glycated hemoglobin (HbA1c), lipid profiles, serum creatinine (Cr) and high-sensitivity CRP (hsCRP) were also collected and compared among groups. For subgroup analysis, patients with DR were divided into a non-proliferated diabetic retinopathy (NPDR) group and a proliferated diabetic retinopathy (PDR) group. Multivariate analysis was performed using logistic regression models.
Results
The serum periostin level was significantly higher in patients with diabetic retinopathy compared with healthy subjects and patients with T2DM (both
P
< 0.001, respectively). Also, the periostin level was significantly higher in the PDR group compared to the NPDR group (
P
= 0.044). Multivariate logistic regression revealed that serum periostin was independently associated with the presence of DR in patients with T2DM (
P
< 0.001). The receiver operating characteristic (ROC) curves for DR development using serum periostin showed that the area under the receiver operating characteristic curves (AUC) was 0.838 (
P
< 0.001).
Conclusions
The current study demonstrated that serum periostin is significantly associated with the presence of DR in patients with T2DM and is an independent risk factor of DR.
Abstract
The turbulent transport properties and dynamics of zonal flows (ZFs) in the presence of fast ions (FIs) are investigated for a typical internal transport barrier (ITB) plasma based on the ...gyrokinetic approach, focusing on the role of FI temperature and the effects of the toroidal rotation, including the
E
×
B
rotational shear, parallel velocity gradient (PVG) as well as the rotation velocity itself. Linear GENE simulations have shown that the core ITB plasma on HL-2A is dominated by ion temperature gradient (ITG) modes and trapped electron modes (TEMs), where the former is stabilized by FIs whereas destabilized by the PVG. Neither of the FIs or the PVG has observable effect on TEMs. The ion heat transport generally decreases at large FI temperature due to the nonlinear electromagnetic stabilization of turbulence with increased total plasma
β
until electromagnetic modes are excited. The transport fluxes peak around a certain FI temperature and the ZF shearing rate is significantly higher at such value compared with that in the absence of FIs, and the heat flux reduction is a result of the synergistic interaction between turbulence, ZFs and the external rotational shear. The
E
×
B
shear stabilizing and PVG destabilizing is not obvious at low normalized ITG
R
/
L
Ti
, indicating they are less important in determining the stiffness level in the relatively low density and rotation scenarios regarding the HL-2A ITB discharges. The turbulence suppression is predominated by the nonlinear stabilization of ITG turbulence as well as enhanced ZFs simultaneously in the presence of FIs. These results have also provided the possible way to reduce the turbulence transport through increasing the FI temperature in the off-axis neutral beam heated plasmas such as in HL-2A.
Acute myeloblastic leukemia (AML) is characterized by the accumulation of abnormal myeloblasts (mainly granulocyte or monocyte precursors) in the bone marrow and blood. Though great progress has been ...made for improvement in clinical treatment during the past decades, only minority with AML achieve long-term survival. Therefore, further understanding mechanisms of leukemogenesis and exploring novel therapeutic strategies are still crucial for improving disease outcome. MicroRNA-100 (miR-100), a small non-coding RNA molecule, has been reported as a frequent event aberrantly expressed in patients with AML; however, the molecular basis for this phenotype and the statuses of its downstream targets have not yet been elucidated. In the present study, we found that the expression level of miR-100 in vivo was related to the stage of the maturation block underlying the subtypes of myeloid leukemia. In vitro experiments further demonstrated that miR-100 was required to promote the cell proliferation of promyelocytic blasts and arrest them differentiated to granulocyte/monocyte lineages. Significantly, we identified RBSP3, a phosphatase-like tumor suppressor, as a bona fide target of miR-100 and validated that RBSP3 was involved in cell differentiation and survival in AML. Moreover, we revealed a new pathway that miR-100 regulates G1/S transition and S-phase entry and blocks the terminal differentiation by targeting RBSP3, which partly in turn modulates the cell cycle effectors pRB/E2F1 in AML. These events promoted cell proliferation and blocked granulocyte/monocyte differentiation. Our data highlight an important role of miR-100 in the molecular etiology of AML, and implicate the potential application of miR-100 in cancer therapy.
The results demonstrated that pancreatic ductal carcinoma (PDAC) of the body/tail was associated with more transcriptional and genomic changes, and correlated with worse prognosis, than PDAC of the ...pancreatic head. The different mutation types and gene expression of tumour locations provide deep insight into the carcinogenesis or metastasis of PDAC, and suggest different early diagnostic and therapeutic strategies. SNV, single-nucleotide variations; NLS, Nuclear localization sequence; MB, million base-pairs; UTR, untranslated region.
Context.
Chang’e-4 (CE-4) provides unprecedented information about lunar materials exposed by the South Pole-Aitken (SPA) basin. Diverse results have been obtained from previous interpretations of ...CE-4 visible and near-infrared (VNIR) spectra. Some studies suggest that materials at the CE-4 landing site are dominated by olivine and orthopyroxene, but others argue that only a small amount of olivine should be exposed at the CE-4 landing site.
Aims.
Laboratory spectroscopy studies using the Engineering Model of CE-4 Visible and Near-infrared Imaging Spectrometer (VNIS) are critical in constraining the accurate mineral proportions and composition of soils and boulders at the CE-4 landing site.
Methods.
VNIR spectra of nine lunar analogs – prepared by mixing orthopyroxene (OPX), clinopyroxene (CPX), olivine (OL), and plagioclase – were acquired using the CE-4 VNIS Engineering Model. The spectral indices model and modified Gaussian model were developed to estimate CPX/(CPX+OPX) and OL/(OL+CPX+OPX) and are applicable to the in situ spectra acquired by the Yutu-2 VNIS spectrometer.
Results.
The lunar rocks and regolith at the CE-4 landing site excavated by the Finsen impact are CPX-rich with limited OL (CPX:OPX:OL = 56:29:17). The mineral chemistries of the four lunar rocks show Mid-Ca, Fe pyroxene, and Mid-Mg OL (
Fo
60−79
), providing critical constraints for mineral compositions in the SPA compositional anomaly. These rocks exhibit high M1 intensity ratios, indicating that they were crystallized at a high temperature (980–1300 °C) and a rapid-cooling magmatic system produced by impact melt differentiation or volcanic resurfacing events.
Host-microbiota interactions describe a co-evolution and mutualistic symbiosis. Gut microbial communities are important for diverse host functions. However, in birds, the relationship between the ...composition of the intestinal microbiota and the genetic variation of the host is not clearly understood. To dissect these interactions, a Chinese yellow broiler line (genetically selected for a high growth rate) and Huiyang Beard chickens (low growth rate) were crossed, generating an F2 population. The population structures of the gut microbes in the phenotypically high and low 91-d body weight individuals of both sexes in the F2 population were studied. Interestingly, a non-metric multidimensional scaling analysis revealed that the microbiota of the high-weight and low-weight females was clearly separated into 2 clusters. A β-diversity analysis showed that the locus rs16775833 within the doublesex and mab-3-related transcription factor (DMRT) gene cluster accounted for approximately 21% of the variation in the population structure of the gut microbiota. Furthermore, the 2 genetic loci rs15142709 and rs15142674 were significantly associated with specific species of Methanobacterium. These loci are located in the pleiomorphic adenoma gene 1 (PLAG1) and lck/yes-related novel tyrosine kinase (LYN) genes, which are involved in cell differentiation and growth. This finding suggests evidence for the influence of the host genetics on the composition of the gut microbiota in birds and the importance and utility of the host-microbe status to better understand its effect on the potential growth of birds.
To investigate the value of transanal multipoint full-layer puncture biopsy (TMFP) in predicting pathological complete response (pCR) after neoadjuvant radiotherapy and chemotherapy (nCRT) in ...patients with locally advanced rectal cancer (LARC) and to establish a predictive model for providing clinical guidance regarding the treatment of LARC.
In this multicenter, prospective, cohort study, we collected data on 110 LARC patients from four hospitals between April 2020 and March 2023: Beijing Chaoyang Hospital of Capital Medical University (50 patients), Beijing Friendship Hospital of Capital Medical University (41 patients), Qilu Hospital of Shandong University (16 patients), and Zhongnan Hospital of Wuhan University (three patients). The patients had all received TMFP after completing standard nCRT. The variables studied included (1) clinicopathological characteristics; (2) clinical complete remission (cCR) and efficacy of TMFP in determining pCR after NCRT in LARC patients; and (3) hospital attended, sex, age
Highlights • Forced limb-use enhanced neurogenesis in the aged rats. • Forced limb-use suppressed apoptosis in the aged rats. • Forced limb-use is effective in behavioral recovery after stroke in the ...aged rats.
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