Survey data from 409 second-year medical students in the US, 1988-1992, reveal that while most students were sexually active, a significant minority (13.5%) were sexually inexperienced. Most ...respondents had been sexually involved with 2-5 partners over their lifetime, although 16% of male (M) students reported sexual involvement with 11+ sexual partners. Major gender differences included a significantly lower rate of masturbation, fewer lifetime sexual partners, greater difficulty in achieving orgasm, & increased frequency of both prepubertal & postpubertal sexual victimization among females (Fs). Fs were also more tolerant of abortion & homosexuality, but had less positive attitudes toward pornography than their M counterparts. Only two sexual attitudes showed significant change over the course of the study: attitudes toward homosexuality became more positive, whereas endorsement of premarital sexual intercourse declined. 4 Tables, 15 References. Adapted from the source document.
We compared the effects of nonpharmacologic therapy, propranolol monotherapy, and placebo on blood pressure, metabolic, exercise, and quality of life variables in a 12-week, randomized, ...placebo-controlled trial of 79 male patients with hypertension. A significant reduction in diastolic blood pressure was observed with both nondrug therapy (-8.0 +/- 1.08 mm Hg) and propranolol (-9.5 +/- 1.46 mm Hg) compared to placebo (-0.1 +/- 2.01 mm Hg). However, only patients receiving nonpharmacologic therapy showed a reduced body mass index, lower total and low-density lipoprotein serum cholesterol levels, and increased exercise tolerance compared to both propranolol and placebo. Patients receiving propranolol felt less anxious and unsure but showed a significant decrement in nocturnal penile tumescence compared to both placebo and nondrug therapy. Patients receiving nondrug therapy felt more energetic and reported improved sexual arousal and greater sexual satisfaction after treatment. Reductions in blood pressure in the nondrug treatment group were related to both weight reduction and improved fitness. We conclude that nondrug therapy is effective in controlling blood pressure in men with mild hypertension and is associated with improvements in weight, lipoprotein levels, and exercise tolerance compared to both propranolol and placebo. Quality of life assessments further support the use of nondrug therapy in this context.
A consensus guidelines model was developed for managing erectile dysfunction (ED) by urology nurses and other health care clinicians. The model emphasizes identification of ED in all males older than ...40, education and counseling as keys to intervention, and inclusion of partners whenever possible. These guidelines are intended to provide a comprehensive care model for ED patients and their partners, which would be optimally cost effective and clinically relevant. If successful, this new model will allow quality sexual health care to be provided to increasing numbers of patients and their partners.
A study was conducted to examine tolerability and pharmacodynamics of single doses of yohimbine in healthy volunteers using measures of mood, heart rate, blood pressure, and serum catecholamine ...levels. Participants were given single oral doses of yohimbine hydrochloride as high as 21.6 mg. Plasma concentrations of yohimbine, epinephrine, norepinephrine, and MHPG (3-methoxy-4-hydroxyphenylethylene-glycol) were quantified by means of high-performance liquid chromatography with electrochemical detection. Mood was assessed by visual analogue scale (VAS), the Profile of Mood States, and the Spielberger State Anxiety Index. Yohimbine was well tolerated and rapidly absorbed and eliminated. Dose-related increases in area under the concentration-time curve (AUC) were observed. Administration of yohimbine in the presence of a high fat meal diminished both the rate and extent of drug absorption. Significant intersubject variability in the pharmacokinetic parameters of yohimbine was observed, with some individuals exhibiting greatly increased oral bioavailability of yohimbine. Increases in blood pressure, respiratory rate, plasma catecholamine levels, and total VAS score were observed in participants with elevated AUC values. The AUC of yohimbine had the largest effect on total VAS score. The results indicate that higher doses of yohimbine are both well tolerated and produce dose-related increases in AUC, which are associated with more pronounced autonomic effects. Increases in respiratory rate and plasma MHPG appear to be the most reliable pharmacodynamic measures for single oral doses of yohimbine. Individual differences in the pharmacokinetics of yohimbine are important in determining pharmacodynamic effects and should be considered in evaluations of its clinical effectiveness.
Woundtable discussion: Tadalafil study group KLONER, Robert A; BRINDIS, Ralph G; CHEITLIN, Melvin D ...
The American journal of cardiology,
2003, Letnik:
92, Številka:
9A
Conference Proceeding
The increasing emphasis on surgical, pharmacological, and mechanical solutions to erectile failure in the past decade has led to a relative neglect of the importance of couples dynamics in both the ...genesis and maintenance of erectile failure. Yet ignoring such issues compromises the success of sex therapy. Systemic approaches, family-of-origin issues, transferential projections, and cognitive-behavioral interventions may all have a place in treatment. These conceptual approaches are reviewed and four key relationship variables, namely, status and dominance, sexual attraction and sexual "chemistry," intimacy and trust, and sexual scripts, are highlighted as being of special importance in the evaluation and treatment of erectile problems.
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