PURPOSE: To present revised criteria for the diagnosis of Vogt-Koyanagi-Harada disease, a chronic, bilateral, granulomatous ocular and multisystem inflammatory condition of unknown cause.
METHODS: ...Diagnostic criteria and nomenclature were subjects of discussion at the First International Workshop on Vogt-Koyanagi-Harada Disease on October 19–21, 1999, at the University of California, Los Angeles, Conference Center, Lake Arrowhead, California. A committee appointed by the workshop participants was charged with drafting revised criteria for Vogt-Koyanagi-Harada disease, based on discussions held during the conference. This article is the consensus committee report.
RESULTS: New criteria, taking into account the multisystem nature of Vogt-Koyanagi-Harada disease, with allowance for the different ocular findings present in the early and late stages of the disease, were formulated and agreed upon by the committee. These criteria are based on additional knowledge and experience of experts in the field and are believed to reflect disease features more fully than previously published criteria.
CONCLUSIONS: The revised definition of Vogt-Koyanagi-Harada disease, with expanded diagnostic criteria, will facilitate performance of studies involving homogeneous populations of patients, at various stages of disease, that address unanswered questions regarding treatment and disease mechanisms.
The Large Hadron Collider (LHC), operating at the international CERN Laboratory in Geneva, Switzerland, is leading Big Data driven scientific explorations. Experiments at the LHC explore the ...fundamental nature of matter and the basic forces that shape our universe, and were recently credited for the discovery of a Higgs boson. ATLAS and ALICE are the largest collaborations ever assembled in the sciences and are at the forefront of research at the LHC. To address an unprecedented multi-petabyte data processing challenge, both experiments rely on a heterogeneous distributed computational infrastructure. The ATLAS experiment uses PanDA (Production and Data Analysis) Workload Management System (WMS) for managing the workflow for all data processing on hundreds of data centers. Through PanDA, ATLAS physicists see a single computing facility that enables rapid scientific breakthroughs for the experiment, even though the data centers are physically scattered all over the world. The scale is demonstrated by the following numbers: PanDA manages O(102) sites, O(105) cores, O(108) jobs per year, O(103) users, and ATLAS data volume is O(1017) bytes. In 2013 we started an ambitious program to expand PanDA to all available computing resources, including opportunistic use of commercial and academic clouds and Leadership Computing Facilities (LCF). The project titled 'Next Generation Workload Management and Analysis System for Big Data' (BigPanDA) is funded by DOE ASCR and HEP. Extending PanDA to clouds and LCF presents new challenges in managing heterogeneity and supporting workflow. The BigPanDA project is underway to setup and tailor PanDA at the Oak Ridge Leadership Computing Facility (OLCF) and at the National Research Center "Kurchatov Institute" together with ALICE distributed computing and ORNL computing professionals. Our approach to integration of HPC platforms at the OLCF and elsewhere is to reuse, as much as possible, existing components of the PanDA system. We will present our current accomplishments with running the PanDA WMS at OLCF and other supercomputers and demonstrate our ability to use PanDA as a portal independent of the computing facilities infrastructure for High Energy and Nuclear Physics as well as other data-intensive science applications.
The study design included a multidisciplinary examination of the mineral phase of ovine intervertebral disc calcifications. The objective of the study was to investigate the mineral phase and its ...mechanisms of formation/association with degeneration in a naturally occurring animal model of disc calcification. The aetiology of dystrophic disc calcification in adult humans is unknown, but occurs as a well-described clinical disorder with hydroxyapatite as the single mineral phase. Comparable but age-related pathology in the sheep could serve as a model for the human disorder. Lumbar intervertebral discs (
n
= 134) of adult sheep of age 6 years (
n
= 4), 8 years (
n
= 12) and 11 years (
n
= 2) were evaluated using radiography, morphology, scanning and transmission electron microscopy, energy dispersive X-ray spectroscopy, X-ray powder diffraction, histology, immunohistology and proteoglycan analysis. Half of the 6-year, 84% of the 8-year and 86% of the 11-year-old discs had calcific deposits. These were not well delineated by plain radiography. They were either: (a) punctate deposits in the outer annulus, (b) diffuse deposits in the transitional zone or inner annulus fibrosus with occasional deposits in the nucleus, or (c) large deposits in the transitional zone extending variably into the nucleus. Their maximal incidence was in the lower lumbar discs (L4/5–L6/7) with no calcification seen in the lumbosacral or lower thoracic discs. All deposits were hydroxyapatite with large crystallite sizes (800–1,300 Å) compared to cortical bone (300–600 Å). No type X-collagen, osteopontin or osteonectin were detected in calcific deposits, although positive staining for bone sialoprotein was evident. Calcified discs had less proteoglycan of smaller hydrodynamic size than non-calcified discs. Disc calcification in ageing sheep is due to hydroxyapatite deposition. The variable, but large, crystal size and lack of protein markers indicate that this does not occur by an endochondral ossification-like process. The decrease in disc proteoglycan content and size suggests that calcification may precede or predispose to disc degeneration in ageing sheep.
A
bstract
The jet angularities are a class of jet substructure observables which characterize the angular and momentum distribution of particles within jets. These observables are sensitive to ...momentum scales ranging from perturbative hard scatterings to nonperturbative fragmentation into final-state hadrons. We report measurements of several groomed and ungroomed jet angularities in pp collisions at
s
= 5
.
02 TeV with the ALICE detector. Jets are reconstructed using charged particle tracks at midrapidity (
|η| <
0
.
9). The anti-
k
T
algorithm is used with jet resolution parameters
R
= 0
.
2 and
R
= 0
.
4 for several transverse momentum
p
T
ch
jet
intervals in the 20–100 GeV/
c
range. Using the jet grooming algorithm Soft Drop, the sensitivity to softer, wide-angle processes, as well as the underlying event, can be reduced in a way which is well-controlled in theoretical calculations. We report the ungroomed jet angularities,
λ
α
, and groomed jet angularities,
λ
α
,g
, to investigate the interplay between perturbative and nonperturbative effects at low jet momenta. Various angular exponent parameters
α
= 1, 1.5, 2, and 3 are used to systematically vary the sensitivity of the observable to collinear and soft radiation. Results are compared to analytical predictions at next-to-leading-logarithmic accuracy, which provide a generally good description of the data in the perturbative regime but exhibit discrepancies in the nonperturbative regime. Moreover, these measurements serve as a baseline for future ones in heavy-ion collisions by providing new insight into the interplay between perturbative and nonperturbative effects in the angular and momentum substructure of jets. They supply crucial guidance on the selection of jet resolution parameter, jet transverse momentum, and angular scaling variable for jet quenching studies.
Kinship systems are conceptually grounded in culturally formulated idea-systems we refer to as kinship terminologies and through which the boundaries, form and structure of human social systems are ...culturally constituted. A terminology, contrary to a long-standing assumption in anthropology, is not based on a prior categorization of genealogical relations, as the latter is derived from the structural logic of the kinship terminology. The terminology structure, formally represented as an algebraic structure, can be generated from primary kin terms in accordance with a hypothesized universal theory of kinship terminology structures. Terminologies differ culturally according to the primary terms and equations used for generating them. This requires a paradigm shift from the received view of genealogy as the primary basis for kin relations to a new paradigm in which kinship incorporates both a kin term space expressed through a culturally constituted idea-system we refer to as a kinship terminology and a genealogical space constructed recursively using parent-child relations. Both of these spaces are grounded in a family space composed of parent-child, spouse and sibling positions. D'un point de vue conceptuel, les systèmes de parenté reposent sur des modes de représentation culturelle que nous appelons terminologies de parenté et à partir desquelles les limites, la forme et la structure des principes d'organisation sociale sont culturellement élaborés. Contrairement à ce que les anthropologues tiennent depuis longtemps pour acquis, une terminologie n'est pas forcément inhérente aux relations généalogiques, ces dernières découlant de la logique structurelle de la terminologie de parenté. La structure de la terminologie, représentée sous une forme algébrique, peut être produite à partir des principaux termes de parenté, suivant un principe supposé universel de structures terminologiques de la parenté. Les terminologies diffèrent, sur le plan culturel, selon les principales expressions et équations utilisées pour les élaborer. Cela implique un changement de paradigme qui nous ferait passer de la généalogie considérée comme fondement essentiel des relations de parenté à un modèle dans lequel la parenté intégrerait à la fois des termes de parenté propres à un système de représentations culturellement constitué auquel nous nous référons dans la terminologie de parenté, et une dimension généalogique élaborée de manière récursive en utilisant les relations parents/enfants. Ces deux domaines sont fondés sur un espace familial comprenant les positions de parents/enfants, conjoints, germains.
A
bstract
The cross section for coherent photonuclear production of J/
ψ
is presented as a function of the electromagnetic dissociation (EMD) of Pb. The measurement is performed with the ALICE ...detector in ultra-peripheral Pb-Pb collisions at a centre-of-mass energy per nucleon pair of
s
NN
= 5.02 TeV. Cross sections are presented in five different J/
ψ
rapidity ranges within |
y
| < 4, with the J/
ψ
reconstructed via its dilepton decay channels. In some events the J/
ψ
is not accompanied by EMD, while other events do produce neutrons from EMD at beam rapidities either in one or the other beam direction, or in both. The cross sections in a given rapidity range and for different configurations of neutrons from EMD allow for the extraction of the energy dependence of this process in the range 17 <
W
γ
Pb
,
n
< 920 GeV, where
W
γ
Pb
,
n
is the centre-of-mass energy per nucleon of the
γ
Pb system. This range corresponds to a Bjorken-
x
interval spanning about three orders of magnitude: 1.1 × 10
−
5
<
x
< 3.3 × 10
−
2
. In addition to the ultra-peripheral and photonuclear cross sections, the nuclear suppression factor is obtained. These measurements point to a strong depletion of the gluon distribution in Pb nuclei over a broad, previously unexplored, energy range. These results, together with previous ALICE measurements, provide unprecedented information to probe quantum chromodynamics at high energies.
A
bstract
The first measurement of the e
+
e
−
pair production at low lepton pair transverse momentum (
p
T
,
ee
) and low invariant mass (
m
ee
) in non-central Pb–Pb collisions at
s
NN
= 5
.
02 TeV ...at the LHC is presented. The dielectron production is studied with the ALICE detector at midrapidity (
|η
e
| <
0
.
8) as a function of invariant mass (0.4
≤ m
ee
<
2
.
7 GeV/
c
2
) in the 50–70% and 70–90% centrality classes for
p
T
,
ee
<
0.1 GeV/
c
, and as a function of
p
T
,
ee
in three
m
ee
intervals in the most peripheral Pb–Pb collisions. Below a
p
T
,
ee
of 0.1 GeV/
c
, a clear excess of e
+
e
−
pairs is found compared to the expectations from known hadronic sources and predictions of thermal radiation from the medium. The
m
ee
excess spectra are reproduced, within uncertainties, by different predictions of the photon–photon production of dielectrons, where the photons originate from the extremely strong electromagnetic fields generated by the highly Lorentz-contracted Pb nuclei. Lowest-order quantum electrodynamic (QED) calculations, as well as a model that takes into account the impact-parameter dependence of the average transverse momentum of the photons, also provide a good description of the
p
T
,
ee
spectra. The measured
p
T
,
ee
2
of the excess
p
T
,
ee
spectrum in peripheral Pb–Pb collisions is found to be comparable to the values observed previously at RHIC in a similar phase-space region.
This article reports on the inclusive production cross section of several quarkonium states,
J
/
ψ
,
ψ
(
2
S
)
,
Υ
(
1
S
)
,
Υ
(
2
S
)
, and
Υ
(
3
S
)
, measured with the ALICE detector at the LHC, ...in pp collisions at
s
=
5.02
TeV. The analysis is performed in the dimuon decay channel at forward rapidity (
2.5
<
y
<
4
). The integrated cross sections and transverse-momentum (
p
T
) and rapidity (
y
) differential cross sections for
J
/
ψ
,
ψ
(
2
S
)
,
Υ
(
1
S
)
, and the
ψ
(
2
S
)
-to-
J
/
ψ
cross section ratios are presented. The integrated cross sections, assuming unpolarized quarkonia, are:
σ
J
/
ψ
(
p
T
<
20
GeV/c) = 5.88 ± 0.03 ± 0.34
μ
b,
σ
ψ
(
2
S
)
(
p
T
<
12
GeV/c) = 0.87 ± 0.06 ± 0.10
μ
b,
σ
Υ
(
1
S
)
(
p
T
<
15
GeV/c) = 45.5 ± 3.9 ± 3.5 nb,
σ
Υ
(
2
S
)
(
p
T
<
15
GeV/c) = 22.4 ± 3.2 ± 2.7 nb, and
σ
Υ
(
3
S
)
(
p
T
<
15
GeV/c) = 4.9 ± 2.2 ± 1.0 nb, where the first (second) uncertainty is the statistical (systematic) one. For the first time, the cross sections of the three
Υ
states, as well as the
ψ
(
2
S
)
one as a function of
p
T
and
y
, are measured at
s
=
5.02
TeV at forward rapidity. These measurements also significantly extend the
J
/
ψ
p
T
reach and supersede previously published results. A comparison with ALICE measurements in pp collisions at
s
=
2.76
, 7, 8, and 13 TeV is presented and the energy dependence of quarkonium production cross sections is discussed. Finally, the results are compared with the predictions from several production models.
A
bstract
The first measurements of elliptic flow of
π
±
, K
±
,
p
+
p
¯
,
K
S
0
,
Λ
+
Λ
¯
,
ϕ
,
Ξ
−
+
Ξ
¯
+
, and
Ω
−
+
Ω
¯
+
using multiparticle cumulants in Pb–Pb collisions at
s
NN
= 5
.
02 TeV ...are resented. Results obtained with two- (
v
2
{2}) and four-particle cumulants (
v
2
{4}) are shown as a function of transverse momentum,
p
T
, for various collision centrality intervals. Combining the data for both
v
2
{2} and
v
2
{4} also allows us to report the first measurements of the mean elliptic flow, elliptic flow fluctuations, and relative elliptic flow fluctuations for various hadron species. These observables probe the event-by-event eccentricity fluctuations in the initial state and the contributions from the dynamic evolution of the expanding quark–gluon plasma. The characteristic features observed in previous
p
T
-differential anisotropic flow measurements for identified hadrons with two-particle correlations, namely the mass ordering at low
p
T
and the approximate scaling with the number of constituent quarks at intermediate
p
T
, are similarly present in the four-particle correlations and the combinations of
v
2
{2} and
v
2
{4}. In addition, a particle species dependence of flow fluctuations is observed that could indicate a significant contribution from final state hadronic interactions. The comparison between experimental measurements and CoLBT model calculations, which combine the various physics processes of hydrodynamics, quark coalescence, and jet fragmentation, illustrates their importance over a wide
p
T
range.
Abstract
In our Galaxy, light antinuclei composed of antiprotons and antineutrons can be produced through high-energy cosmic-ray collisions with the interstellar medium or could also originate from ...the annihilation of dark-matter particles that have not yet been discovered. On Earth, the only way to produce and study antinuclei with high precision is to create them at high-energy particle accelerators. Although the properties of elementary antiparticles have been studied in detail, the knowledge of the interaction of light antinuclei with matter is limited. We determine the disappearance probability of
$^{3}\overline{{{\rm{He}}}$$
3
He
¯
when it encounters matter particles and annihilates or disintegrates within the ALICE detector at the Large Hadron Collider. We extract the inelastic interaction cross section, which is then used as an input to the calculations of the transparency of our Galaxy to the propagation of
$^{3}\overline{{{\rm{He}}}$$
3
He
¯
stemming from dark-matter annihilation and cosmic-ray interactions within the interstellar medium. For a specific dark-matter profile, we estimate a transparency of about 50%, whereas it varies with increasing
$^{3}\overline{{{\rm{He}}}$$
3
He
¯
momentum from 25% to 90% for cosmic-ray sources. The results indicate that
$^{3}\overline{{{\rm{He}}}$$
3
He
¯
nuclei can travel long distances in the Galaxy, and can be used to study cosmic-ray interactions and dark-matter annihilation.
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