Little is known on how the domain and intensity of physical activity (PA) associates with metabolic syndrome (MetS). The aim of this study was to examine associations between PA domains ...(leisure-time, domestic, active transport, total walking and total PA), PA intensities (light, moderate and vigorous) and PA levels with MetS in the general adult population.
Cross-sectional study. Anthropometry, blood biochemistry, 79-item PA-questionnaire, lifestyle and medical history were evaluated in a representative sample of Canary Island adults (n = 6,729). MetS was diagnosed using the harmonized IDF-NHLBI-AHA criteria. T-test and multivariable logistic regression was used to analyse associations between PA domains and intensities with MetS vs. no MetS, controlling for socio-demographic, lifestyle, family antecedents and body mass index (BMI).
For each MET-h/day spent in moderate-vigorous PA intensities, as well as in recreational domain, active transport, total walking and total PA, the odds of MetS decreased between 3-10%. Energy expenditure exclusively in light and domestic PAs was not associated with MetS, however it was important to achieve a total PA level of 3 MET-h/day, which reduced the odds of MetS by 23%. This reduction was blunted in those with more than 2 h/d of TV watching time. A PA level of 3 MET-h/d also nullified the risk of MetS in those with low PA and high TV consumption.
Some types of leisure time PAs may contribute more than others to reducing MetS. Light and domestic PA play a complementary role in enhancing energy expenditure in the general population. TV watching time above 2 h/d counteracted the MetS risk reduction associated with PA level, but PA level also reduced the risk of METs presented by those with a low level of PA and an excess TV watching time. Physical activity explains a greater amount of the variance of MetS than any other factors of lifestyle, education, sex and family history, and substantially mitigates the strong association of age and BMI with MetS.
Conocer la evolución del consumo de tabaco en Canarias durante 2000-2015 según clase social.
Comunidad Autónoma de Canarias.
Cohorte CDC-Canarias con cortes en 2000 (n=6.729), 2008 (n=6.171) y 2015 ...(n=4.705).
Tabaquismo, sexo, edad y clase social.
El consumo disminuyó un 6% (5-7%, p<0,001) en general, siendo más acentuado en el periodo 2000-2008 (5%). La disminución fue mayor en hombres, aunque siguieron fumando más que las mujeres, con una prevalencia del 25% (24-26%) frente al 18% (17-19%, p<0,001). Solo hubo una disminución del consumo en los grupos jóvenes (6% 3-5%; p=0,011) y de edades intermedias (7% 6-8%; p<0,001). En todas las clases sociales se observó una disminución similar, con mayor prevalencia de tabaquismo en la clase alta: 24% (23-25%) en 2015 (p<0,001). Al valorar conjuntamente sexo, edad y clase social, los hombres más jóvenes y de edad intermedia presentaron los mayores descensos de consumo: 8% (7-9%) clase baja y alta, 10% (9-11%) clase media. En la clase social baja, las mujeres más jóvenes continúan fumando más (27%) aunque abandonaron más el consumo (14%), fenómeno que en las de clase media se produjo en edades intermedias.
La evolución del consumo de tabaco en Canarias sigue un patrón similar al conjunto de España. El abandono del consumo de tabaco se ha frenado en el periodo 2008-2015, especialmente en hombres y en clases sociales medias y altas.
To determine the status of tobacco consumption in the Canary Islands during 2000-2015, according to social class.
Canary Islands.
General population cohort, with contacts in 2000 (n=6,729), 2008 (n=6,171) and 2015 (n=4,705).
Smoking, gender, age, and social class.
Consumption decreased by 6% (5-7%, P<.001) in general, being more accentuated in the period 2000-2008 (5%). The decrease was greater in men, although they continued to smoke more than women, with a prevalence of 25% (24-26%) compared to 18% (17-19%, P<.001). A decrease in consumption was only observed in the younger groups (6% 3-5%, P=.011) and intermediate ages (7% 6-8%, P<.001). A similar decrease was observed in all the social classes, but there was a higher prevalence of smoking in the upper class: 24% (23-25%) in 2015 (P<.001). By jointly assessing gender, age, and social class, younger and middle age men had the greatest decreases in consumption: 8% (7-9%) low and upper classes, 10% (9-11%) middle class. In the lower social class, younger women continue to smoke more (27%) although more of them quit smoking (14%), a phenomenon that occurred in the middle class at intermediate ages.
The evolution of tobacco consumption in the Canary Islands follows a pattern similar to that of mainland Spain. The abandonment of tobacco consumption has slowed down in the period 2008-2015, especially in men, and middle and upper social classes.
Serum resistin is a pro-inflammatory cytokine that has been described as a risk factor associated with mortality in several clinical sets including type 2 diabetes. Mortality studies in the general ...population are needed to find out the risk of death associated to this cytokine. In a follow-up study of a cohort of adult population (n = 6636) in Spain over a period of fifteen years (447 deaths/102,255 person-years), serum resistin measurements and death records were obtained. The risks of all-cause deaths, and deaths from cardiovascular and oncological diseases were estimated. Hazard ratios (HR) and its confidence intervals (CI) were calculated using multivariable Cox models, adjusting the effect of 11 traditional risk factors. The risk of all-cause mortality among participants exposed to the highest quintile of resistin was always higher than among those in the lowest quintile (HR varied between 1.55 when smoking was the adjusted factor 95% CI 1.17-2.05, and 1.68 when the adjusted factor was physical activity 95% CI 1.27-2.21). The maximally adjusted model, accounting for the effect of all traditional factors, corroborated this higher risk of all-cause mortality among people in the highest resistin quintile (HR = 1.52; 95% CI 1.13-2.05). The effect of resistin was even higher for cardiovascular deaths (HR = 2.14; 95% CI 1.13-4.06), being exceeded only by suffering diabetes (HR = 3.04; 95% CI 1.98-4.69) or previous acute coronary syndrome (HR = 3.67; 95% CI 2.18-6.18). This findings corroborate the role of resistin as a risk factor for all-cause (and cardiovascular) death in the general population.
Resistin is a cytokine related with inflammation and ischemic heart disease. Physical activity (PA) prevents chronic inflammation and ischemic heart disease. We studied the relationship of serum ...concentration of resistin with HDL cholesterol, a known biomarker of PA, and with different measures of PA, in a large sample of the general adult population in the Canary Islands.
Cross-sectional study of 6636 adults recruited randomly. We analyzed the correlation of resistin and HDL cholesterol with PA (as metabolic equivalent level MET), and fitted the results with linear and logistic regression models using adjustment for age, alcohol consumption and smoking.
Mean resistin level was higher in women (p<0.001), correlated inversely with age, HDL cholesterol (p<0.001) and alcohol consumption (p<0.001 in men), and correlated directly with smoking (p<0.001). Resistin correlated inversely with the duration of leisure time PA (p<0.001), leisure time MET (p<0.001) and moderate leisure time PA (p<0.001), with some differences between sexes. Men (OR = 0.78 0.61-0.99; p<0.05) and women (OR = 0.75 0.61-0.92; p<0.01) in the upper quintile of leisure time PA had a lower risk of elevated resistin. In contrast, a high degree of sedentarism was associated with an increased risk elevated resistin in women (OR = 1.24 1.04-1.47; p<0.05 and in men (OR = 1.40 1.01-1.82; p<0.05).
In our sample of the general population, resistin was inversely associated with measures and levels of PA and HDL cholesterol. The association of resistin with PA was stronger than the association of HDL cholesterol with PA, making resistin a potentially useful biomarker of PA.
Abstract
The current inhabitants of the Canary Islands have a unique genetic makeup in the European diversity landscape due to the existence of African footprints from recent admixture events, ...especially of North African components (> 20%). The underrepresentation of non-Europeans in genetic studies and the sizable North African ancestry, which is nearly absent from all existing catalogs of worldwide genetic diversity, justify the need to develop CIRdb, a population-specific reference catalog of natural genetic variation in the Canary Islanders. Based on array genotyping of the selected unrelated donors and comparisons against available datasets from European, sub-Saharan, and North African populations, we illustrate the intermediate genetic differentiation of Canary Islanders between Europeans and North Africans and the existence of within-population differences that are likely driven by genetic isolation. Here we describe the overall design and the methods that are being implemented to further develop CIRdb. This resource will help to strengthen the implementation of Precision Medicine in this population by contributing to increase the diversity in genetic studies. Among others, this will translate into improved ability to fine map disease genes and simplify the identification of causal variants and estimate the prevalence of unattended Mendelian diseases.
To analyze the trend of lower extremity major amputations (MA) among patients with type 2 diabetes mellitus (T2DM) in the Regions of Spain from year 2001 until 2015.
Descriptive study of 40,392 MA. ...Data were obtained from the national hospital discharge database in patients with T2DM. The incidence rate was calculated in each Region, in addition to the incidence ratios (IR) between annual incidence and incidence of the year 2001. The length of hospital stay and mortality risks were analyzed using regression models adjusted for sex, age and smoking.
The major amputations incidence rate per 100,000 person-years was 0.48 in Spain; Canary Islands showed the highest incidence (0.81). The trend was a slight decrease or stability of the incidence in all Regions except in the Canary Islands (IR
= 2.0 CI95% = 1.5, 2.6) and in Madrid (IR
= 0.1 CI95% = 0.1, 0.2). Mortality after major amputations was 10% in Spain; Cantabria suffered the highest risk of death 1.7 (CI95% = 1.4; 2.1), p < 0.001 and La Rioja the lowest risk (0.5 CI95% = 0.2; 0.9; p = 0.026). The longest hospital stay was registered in the Canary Islands (CI95% = 11.4;13.3, p < 0.001), and the shortest in the Valencian Community (CI95% = - 7.3; - 5.8), p < 0.001).
MA in T2DM followed a growing trend in the Canary Islands, which diverged from the downward trend in Spain. The variability of mortality and hospital stay, suggest to review the clinical management in some Regions. Sudden incidence decrease in Madrid suggests checking the record procedures of hospital discharges.
Irisin is a myokine that increases with leisure time physical activity (LTPA) and for which a cardiovascular protective role has been postulated. Our aim was to assess this role in the general ...population.
A cross-sectional analysis was performed in a large randomly selected population sample (n=2298 women and 1529 men). Apart from age and sex, we record anthropometrics (blood pressure, heart rate, obesity), lifestyle (LTPA, smoking, alcohol), and biochemical measurements (irisin, lipid profile, insulin resistance). Correlations and regression multivariate models were used to analyze the association of irisin levels with the studied factors.
The variables more strongly and directly associated with irisin, adjusting the studied factors separately in women and men, were HOMA-2 (p=0.043 and p=0.001, respectively) and LTPA (p<0.001 and p=0.001, respectively). Also heart rate inversely (p=0.005 and p=0.002, respectively) and DBP directly (p<0.005 and p=0.045, respectively) were associated to irisin in both sexes. The waist/height ratio (p<0.001) was inversely associated to irisin only in women, and the alcohol drinking was directly associated (p=0.029) only in men.
We provide new findings for irisin, such as its association with DBP and with heart rate; furthermore, in women irisin is associated to abdominal obesity, and in men is associated to the alcohol intake. We also corroborate the association of irisin with LTPA and insulin resistance. The associations detected point towards a protective role of irisin in the maintenance of cardiometabolic health.
Fundamento: Canarias ocupa el primer lugar de España en
mortalidad por cardiopatía isquémica y por diabetes. Sus mujeres son
las primeras en mortalidad por cáncer de mama. El CDC de Canarias
es el ...estudio de una cohorte de población general para analizar
la prevalencia e incidencia de estas enfermedades y la exposición a
sus factores de riesgo (FR) en la población adulta del archipiélago.
Métodos: Estudio prospectivo con muestreo aleatorio en
población general, en el que participaron 6.729 personas entre los
años 2000 y 2005 (edad 18-75 años). Se les realizó antropometría
y se extrajo sangre para almacenamiento de muestras séricas y
genéticas. Mediante cuestionario se recogió: hábitos dietéticos,
actividad física, antecedentes personales y familiares de enfermedad,
exposición a FR laborales o ambientales, tabaquismo, etc.
Resultados: La prevalencia de obesidad es casi del 30%, sin
diferencias entre sexos, pero el sobrepeso afecta más a los varones
(45 vs. 33%; p<0 001), los cuales presentan también mayor
prevalencia de diabetes (12 vs. 10%; p =0 005), hipertensión (43
vs. 33%; p<0 001), ingesta excesiva de alcohol (13 vs. 2%;
p<0 001) y falta de protección solar (46 vs. 18%; p<0 001). En
las mujeres es más frecuente la exposición a bajos niveles de
colesterol HDL (37 vs. 30%; p<0 001) y al sedentarismo (71 vs.
55%; p<0 001). La exposición a los FR estudiados, entre ellos la
pobreza, es mayor en edades avanzadas, salvo el tabaquismo
(26%) que es mayor en edades jóvenes. La estimación de riesgos
relativos de exposición a los factores de riesgo cardiovascular y de
cáncer es más alta en las clases sociales pobres.
Conclusiones: La actual población adulta de Canarias presenta
una elevada prevalencia de exposición a factores de riesgo para
las enfermedades cardiovasculares, la diabetes y el cáncer, destacando
especialmente el sobrepeso, la obesidad y el sedentarismo.
The Canary Island archipelago holds 2.2 million inhabitants and received more than 14 million tourist visitors in 2019. Its volcanic origin and the presence of recent volcanic activity highlight its ...potential geothermal interest for heat production, therefore offering an attractive pathway for a renewable energy supply, not only for power generation and deep geothermal exploitation but also for low-enthalpy heating and cooling production. This work investigates nine touristic infrastructures in the Canary Islands which experienced a transition from conventional heat production systems to shallow geothermal energy (SGE) systems. The SGE systems established consisted in ultra-low temperature district heating and cooling (DHC) micro-networks involving, in most cases, small apartment blocks fed by shallow geothermal plants with an average cooling capacity of 602 kW and a heating capacity of 614 kW. The examination of this transition has exhibited an average saving of 374 MWh, 69,235 € and 280 tCO2 for each installation every year. This work provides evidence of the economical, energetical and environmental advantages of SGE technology in volcanic islands facing both and enormous heating and cooling demand due to tourism, in an energy-dependent system that also faces the challenge of the decarbonization of the heating production sector.
•Nine shallow geothermal systems in Canary Islands were examined.•Transition to shallow geothermal energy resulted in 66% energy savings.•Investments showed return rates higher than 13% for all cases studied.•Emissions savings were 256 tCO2 per installation and year on average.
Hypoxia is involved in the development of chronic inflammatory processes. Under hypoxic conditions HIF1A, VEGF and VEGFR2 are expressed and mediate the course of the resultant disease. The aim of the ...present study was to define the associations between tSNPs in these genes and COPD susceptibility and progression in a Spanish cohort. The T alleles in rs3025020 and rs833070 SNPs (VEGFA gene) were less frequent in the group of COPD cases and were associated with a lower risk of developing the disease (OR = 0.60; 95% CI = 0. 39-0.93; p = 0.023 and OR = 0.60; 95% CI = 0.38-0.96; p = 0.034, respectively) under a dominant model of inheritance. The haplotype in which both SNPs presented the T allele confirmed the association found (OR = 0.02; 95% CI = 0.00 to 0.66; p = 0.03). Moreover, patients with COPD carrying the T allele in homozygosis in rs3025020 SNP showed higher lung function values and this association remained constant during 3 years of follow-up. In conclusion, T allele in rs833070 and rs3025020 may confer a protective effect to COPD susceptibility in a Spanish population and the association of the SNP rs3025020 with lung function may be suggesting a role for VEGF in the progression of the disease.
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