The gastrointestinal absorption of aluminum from orally administered aluminum-containing drugs is well documented. Retention of the absorbed aluminum leads to elevated levels of this metal in the ...tissue of patients with renal failure. We studied two groups of dialysis patients who had received equal amounts of the different aluminum-containing phosphate-binders Aludrox and Antiphosphat. It has recently been shown that Antiphosphat releases only a few aluminum ions in an environment of low pH. Consistent with this finding, we found the aluminum levels to be significantly higher in the plasma, bone, and hair of patients who had received Aludrox as phosphate binder. Subjects with normal renal function excreted most of the ingested and absorbed aluminum. No data are available concerning the tissue load of the element in these subjects. We studied two groups of patients with normal renal function who had received antacid drugs prior to neurosurgery on a brain tumor. The first group of patients were treated with an aluminum-rich antacid (Maalox 70); the other group received an aluminum-poor drug (magaldrate) for 10 days prior to the operation. Analysis of the brain-tissue removed revealed twofold higher aluminum levels in the patients who had received Maalox 70. These results indicate that administration of aluminum-containing drugs leads to a tissue load of aluminum in patients with an impaired renal function as well as in those with a normal function. The extent of the aluminum load depends on the aluminum content and the liberation rate of the drug.
An era of exploring the interactions of high-intensity, hard X-rays with matter has begun with the start-up of a hard-X-ray free-electron laser, the Linac Coherent Light Source (LCLS). Understanding ...how electrons in matter respond to ultra-intense X-ray radiation is essential for all applications. Here we reveal the nature of the electronic response in a free atom to unprecedented high-intensity, short-wavelength, high-fluence radiation (respectively 10(18) W cm(-2), 1.5-0.6 nm, approximately 10(5) X-ray photons per A(2)). At this fluence, the neon target inevitably changes during the course of a single femtosecond-duration X-ray pulse-by sequentially ejecting electrons-to produce fully-stripped neon through absorption of six photons. Rapid photoejection of inner-shell electrons produces 'hollow' atoms and an intensity-induced X-ray transparency. Such transparency, due to the presence of inner-shell vacancies, can be induced in all atomic, molecular and condensed matter systems at high intensity. Quantitative comparison with theory allows us to extract LCLS fluence and pulse duration. Our successful modelling of X-ray/atom interactions using a straightforward rate equation approach augurs favourably for extension to complex systems.
We study the dynamics of supermassive black hole binaries embedded in circumbinary gaseous discs, with the smoothed particle hydrodynamics code gadget-2. The subparsec binary (of total mass M and ...mass ratio q= 1/3) has excavated a gap and transfers its angular momentum to the self-gravitating disc (M
disc= 0.2M). We explore the changes of the binary eccentricity, e, by simulating a sequence of binary models that differ in the initial eccentricity e
0 only. In initially low-eccentric binaries, the eccentricity increases with time, while in high-eccentric binaries e declines, indicating the existence of a limiting eccentricity e
crit that is found to fall in the interval 0.6, 0.8. We also present an analytical interpretation for this saturation limit. An important consequence of the existence of e
crit is the detectability of a significant residual eccentricity e
LISA by the proposed gravitational wave detector Laser Interferometer Space Antenna (LISA). It is found that at the moment of entering the LISA frequency domain e
LISA∼ 10−3-10−2, a signature of its earlier coupling with the massive circumbinary disc. We also observe large periodic inflows across the gap, occurring on the binary and disc dynamical time-scales rather than on the viscous time. These periodic changes in the accretion rate (with amplitudes up to ∼100 per cent, depending on the binary eccentricity) can be considered a fingerprint of eccentric subparsec binaries migrating inside a circumbinary disc.
The entatic state denotes a distorted coordination geometry of a complex from its typical arrangement that generates an improvement to its function. The entatic-state principle has been observed to ...apply to copper electron-transfer proteins and it results in a lowering of the reorganization energy of the electron-transfer process. It is thus crucial for a multitude of biochemical processes, but its importance to photoactive complexes is unexplored. Here we study a copper complex-with a specifically designed constraining ligand geometry-that exhibits metal-to-ligand charge-transfer state lifetimes that are very short. The guanidine-quinoline ligand used here acts on the bis(chelated) copper(I) centre, allowing only small structural changes after photoexcitation that result in very fast structural dynamics. The data were collected using a multimethod approach that featured time-resolved ultraviolet-visible, infrared and X-ray absorption and optical emission spectroscopy. Through supporting density functional calculations, we deliver a detailed picture of the structural dynamics in the picosecond-to-nanosecond time range.
The nonlinear absorption mechanisms of neon atoms to intense, femtosecond kilovolt x rays are investigated. The production of Ne(9+) is observed at x-ray frequencies below the Ne(8+), 1s(2) ...absorption edge and demonstrates a clear quadratic dependence on fluence. Theoretical analysis shows that the production is a combination of the two-photon ionization of Ne(8+) ground state and a high-order sequential process involving single-photon production and ionization of transient excited states on a time scale faster than the Auger decay. We find that the nonlinear direct two-photon ionization cross section is orders of magnitude higher than expected from previous calculations.
In order to study degradation effects of neutrons on plasma-facing materials and joints, actively-cooled beryllium and CFC samples were irradiated in the High Flux Reactor in Petten up to 0.35 dpa at ...350 and 700°C. Later, these samples were tested by means of an electron beam facility under static and cyclic heating conditions. The heat removal efficiency and the thermal fatigue behavior of these samples were compared to those of corresponding non-irradiated samples. A significant increase of surface temperature was observed for all samples, due to a reduced thermal conductivity of the CFC materials after neutron irradiation. This effect is less distinctive for samples irradiated at the higher temperature. Long term fatigue tests with 1000 heating cycles at 15 MW/m
2
did not create any failure of the plasma-facing material or the bond layer of the tested mock-ups. Similar experiments have been performed with brazed beryllium-copper mock-ups. Flat tile mock-ups with an S65 C armor on a CuCrZr heat sink were loaded up to 1000 cycles at a power density of 7 MW/m
2
without detachment of tiles.
Short-wavelength free-electron lasers are now well established as essential and unrivalled sources of ultrabright coherent X-ray radiation. One of the key characteristics of these intense X-ray ...pulses is their expected few-femtosecond duration. No measurement has succeeded so far in directly determining the temporal structure or even the duration of these ultrashort pulses in the few-femtosecond range. Here, by deploying the so-called streaking spectroscopy technique at the Linac Coherent Light Source, we demonstrate a non-invasive scheme for temporal characterization of X-ray pulses with sub-femtosecond resolution. This method is independent of photon energy, decoupled from machine parameters, and provides an upper bound on the X-ray pulse duration. We measured the duration of the shortest X-ray pulses currently available to be on average no longer than 4.4 fs. Analysing the pulse substructure indicates a small percentage of the free-electron laser pulses consisting of individual high-intensity spikes to be on the order of hundreds of attoseconds.
In the decade of the dawn of gravitational wave astronomy, the concept of multimessenger astronomy, combining gravitational wave signals to conventional electromagnetic observation, has attracted the ...attention of the astrophysical community. So far, most of the effort has been focused on ground- and space-based laser interferometer sources, with little attention devoted to the ongoing and upcoming pulsar timing arrays (PTAs). We argue in this paper that PTA sources, being very massive (>108 M⊙) cosmologically nearby (z < 1) black hole binaries (MBHBs), are particularly appealing multimessenger carriers. According to current models for massive black hole formation and evolution, the planned Square Kilometre Array will observe thousands of such massive systems, being able to individually resolve and locate in the sky several of them (maybe up to a hundred). MBHBs form in galaxy mergers, which are usually accompanied by strong inflows of gas in the centre of the merger remnant. By employing a standard model for the evolution of MBHBs in circumbinary discs, with the aid of dedicated numerical simulations, we characterize the gas-binary interplay, identifying possible electromagnetic signatures of the PTA sources. We concentrate our investigation on two particularly promising scenarios in the high-energy domain, namely the detection of X-ray periodic variability and double broad Kα iron lines. Up to several hundreds of periodic X-ray sources with a flux >10−13 erg s−1 cm−2 will be in the reach of upcoming X-ray observatories; in the most optimistic case, a few of them may be already being observed by the MAXI detector placed on the International Space Station. Double relativistic Kα lines may be observable in a handful of low-redshift (z < 0.3) sources by proposed deep X-ray probes, such as Athena. The exact figures depend on the details of the adopted MBHB population and on the properties of the circumbinary discs, but the existence of a sizeable population of sources suitable to multimessenger astronomy is a robust prediction of our investigation.
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