Kritična geopolitika obravnava geopolitiko kot diskurzivni postopek, s pomočjo katerega različni akterji prostorizirajo mednarodno politiko. Hitro spreminjanje geopolitičnih razmer so po končani ...hladni vojni Evropsko unijo prisilile k oblikovanju vedno novih prostorizacij evropskega kontinenta. V ospredju le-teh sta širitev Evrope na vzhod in z njo povezano oblikovanje novih meja Evrope.
“Europska izbjeglička/migrantska kriza” geopolitička je oznaka kojom su mediji, politika i šira javnost obilježili dolazak velikog broja izbjeglica u Europsku uniju 2015. i 2016. godine. U članku se ...analizira prostorna raspodjela tražitelja azila u Europskoj uniji od 2011. do 2016. Usredotočuje se na to kako su promjene graničnih režima na vanjskim i unutarnjim granicama Europske unije utjecale na kretanje tražitelja azila i prostornu raspodjelu zahtjeva za azil tijekom »krize«. To skreće pozornost na sve veću važnost militarizacije granica i sekuritizaciju migracijskih tokova na prostornoj raspodjeli podnositelja zahtjeva za azil. Istraživanje se temelji na analizi Eurostat podataka o ukupnom broju podnositelja zahtjeva za azil u državama članicama između 2011. i 2016. Iako promjene u graničnim režimima nisu jedini čimbenik koji utječe na prostornu raspodjelu tražitelja azila tijekom »europske izbjegličke/migrantske krize«, njihovi se učinci mogu iskoristiti kako bi se pokazale granice s kojima se azilanti susreću na svojem putu. Glavni je cilj članka problematizirati upotrebu geografske oznake »Europa«/»europski« u kontekstu »izbjegličke/migrantske krize«. Ta upotreba stvara percepciju jedinstvenoga, bezgraničnog prostora u kojemu pojedinci mogu slobodno izabrati svoje azilno odredište. Diskurs »europska izbjeglička/migrantska kriza« Europsku uniju često predstavlja kao »otvoreni trgovački centar za azil« u kojemu tražitelji azila mogu odabrati bilo koju zemlju domaćina. Članak se suprotstavlja tom pojmu te naglašava ograničenja i učinak koji kontingencija (slučajnost) igra u izboru odredišta azila.
Understanding tumors and their microenvironment are essential for successful and accurate disease diagnosis. Tissue physiology and morphology are altered in tumors compared to healthy tissues, and ...there is a need to monitor tumors and their surrounding tissues, including blood vessels, non‐invasively. This preliminary study utilizes a multimodal optical imaging system combining hyperspectral imaging (HSI) and three‐dimensional (3D) optical profilometry (OP) to capture hyperspectral images and surface shapes of subcutaneously grown murine tumor models. Hyperspectral images are corrected with 3D OP data and analyzed using the inverse‐adding doubling (IAD) method to extract tissue properties such as melanin volume fraction and oxygenation. Blood vessels are segmented using the B‐COSFIRE algorithm from oxygenation maps. From 3D OP data, tumor volumes are calculated and compared to manual measurements using a vernier caliper. Results show that tumors can be distinguished from healthy tissue based on most extracted tissue parameters (p<0.05). Furthermore, blood oxygenation is 50% higher within the blood vessels than in the surrounding tissue, and tumor volumes calculated using 3D OP agree within 26% with manual measurements using a vernier caliper. Results suggest that combining HSI and OP could provide relevant quantitative information about tumors and improve the disease diagnosis.
Optical imaging techniques could monitor tumors and their microenvironment, including blood vessels, non‐invasively. This study uses combined hyperspectral imaging (HSI) and three‐dimensional (3D) optical profilometry (OP) to extract physiological and morphological tissue properties of four different murine tumor models and surrounding healthy tissue in the 430–750 nm spectral band. Furthermore, blood vessels are segmented from the tissue oxygenation maps, and tumor volumes are determined from 3D OP data.
Increased environmental pollution has been suggested as one of the possible causes for increased incidence of neurodegenerative and developmental disorders. Through the environmental pollution, ...everyday consumer products and nanomedical applications, we are also exposed to various nanoparticles (NPs). Specific types of NPs have been shown to be able to cause neural damage in vivo through processes such as disruption of the blood-brain barrier, induction of neuroinflammation, increase in oxidative stress and protein aggregation. In this study, we analysed the influence of PEI-coated magnetic NPs designed for biotechnological applications and industrial SiO
2
, TiO
2
N and TiO
2
P25 NPs on intracellular localization and solubility of fused in farcoma (FUS) and TAR-DNA binding protein 43 (TDP-43) that are important pathological hallmarks of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). SH-SY5Y neuroblastoma cells and B16 mouse melanoma cells were exposed to NPs for 24 h and analysed using confocal microscopy and Western blot. Exposure to 50 μg/ml TiO
2
N and 4 μg/ml PEI NPs in SH-SY5Y cells caused cell toxicity-induced changes in expression in different biochemical/cellular fractions for both FUS and TDP-43 proteins. TiO
2
N induced a drop in nuclear levels of TDP-43 and increase in cytoplasmic levels of FUS, while PEI NPs increased nuclear levels of FUS. Furthermore, TiO
2
N and PEI induced a reduction of FUS and TDP-43 quantity in the less soluble urea fraction. No formation of stress granules was observed. These results demonstrate that TiO
2
N and PEI NPs can affect the behaviour of FUS and TDP-43 proteins; however, the changes were relatively minor compared to pathological changes even for the high NP concentrations (50 μg/ml) used in this study.
Universal Health Services Rogelj, Aljaz; Brezovnik, Bostjan
Lex localis-journal of local self-government,
07/2013, Letnik:
11, Številka:
3
Journal Article
Recenzirano
All EU nationals have the right to health services that are affordable for everyone, under the same conditions. Sector-specific regulations provide that health services are services of general ...interest, that must be implemented through a national legal framework. The state must design the universal health services in a way that respects the principle of public health service affordability for all citizens. In this study, the authors have focused on understanding the legal framework which serves as foundation the regulating universal health services in Slovenia, sector-specific regulations and other acts, and tried to assess the strengths and weaknesses of the Slovenian legal framework. Their efforts have been directed towards studying the legislative framework of the European Union and defining the legal guidelines that establish the legal framework for universal health service creation. Adapted from the source document.
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