First and foremost: Margaret Dayhoff's 1966 hypothesis on the origin of proteins is now an accepted model for the emergence of large, globular, functional proteins from short, simple peptides. ...However, the fundamental question of how the first protein(s) emerged still stands. The tools and hypotheses pioneered by Dayhoff, and the over 65 million protein sequences and 12 000 structures known today, enable those who follow in her footsteps to address this question.
Magnetic refrigeration (MR) at room temperature is an emerging technology and shows real potential to enter conventional markets. The principle of MR obeys the magnetocaloric effect (MCE), which is ...based on the effect caused by a magnetic field on the materials that bear the property of varying the magnetic entropy, as well as its temperature, when varying the magnetic field. This article revises the MCE, its theory and thermodynamics. It discusses the properties that must be met by the magnetocaloric materials as well as those most suitable for room temperature MR and those displaying a promising future. Finally, a presentation and description of the Carnot, Brayton, Ericsson, AMR and cascading MR cycles is given with a view to establishing selection criteria based on their performances.
The evolution of the Milky Way disk, which contains most of the stars in the Galaxy, is affected by several phenomena. For example, the bar and the spiral arms of the Milky Way induce radial ...migration of stars
and can trap or scatter stars close to orbital resonances
. External perturbations from satellite galaxies can also have a role, causing dynamical heating of the Galaxy
, ring-like structures in the disk
and correlations between different components of the stellar velocity
. These perturbations can also cause 'phase wrapping' signatures in the disk
, such as arched velocity structures in the motions of stars in the Galactic plane. Some manifestations of these dynamical processes have already been detected, including kinematic substructure in samples of nearby stars
, density asymmetries and velocities across the Galactic disk that differ from the axisymmetric and equilibrium expectations
, especially in the vertical direction
, and signatures of incomplete phase mixing in the disk
. Here we report an analysis of the motions of six million stars in the Milky Way disk. We show that the phase-space distribution contains different substructures with various morphologies, such as snail shells and ridges, when spatial and velocity coordinates are combined. We infer that the disk must have been perturbed between 300 million and 900 million years ago, consistent with estimates of the previous pericentric passage of the Sagittarius dwarf galaxy. Our findings show that the Galactic disk is dynamically young and that modelling it as time-independent and axisymmetric is incorrect.
Anaerobic digestion is a commercial reality for several kinds of waste. Nonetheless, anaerobic digestion of single substrates presents some drawbacks linked to substrate characteristics. Anaerobic ...co-digestion, the simultaneous digestion of two or more substrates, is a feasible option to overcome the drawbacks of mono-digestion and to improve plant׳s economic feasibility. At present, since 50% of the publication has been published in the last two years, anaerobic co-digestion can be considered the most relevant topic within anaerobic digestion research. The aim of this paper is to present a review of the achievements and perspectives of anaerobic co-digestion within the period 2010–2013, which represents a continuation of the previous review made by the authors 3. In the present review, the publications have been classified as for the main substrate, i.e., animal manures, sewage sludge and biowaste. Animal manures stand as the most reported substrate, agro-industrial waste and the organic fraction of the municipal solid waste being the most reported co-substrate. Special emphasis has been made to the effect of the co-digestion over digestate quality, since land application seems to be the best option for digestate recycling. Traditionally, anaerobic co-digestion between sewage sludge and the organic fraction of the municipal solid waste has been the most reported co-digestion mixture. However, between 2010 and 2013 the publications dealing with fats, oils and greases and algae as sludge co-substrate have increased. This is because both co-substrates can be obtained at the same wastewater treatment plant. In contrast, biowaste as a main substrate has not been as studied as manures or sewage sludge. Finally, three interdisciplinary sections have been written for addressing novelty aspects in anaerobic co-digestion, i.e., pre-treatments, microbial dynamics and modeling. However, much effort needs to be done in these later aspects to better understand and predict anaerobic co-digestion.
Summary
Background
Over the past several years, hepatitis C therapy has been pegylated interferon and ribavirin based. Although protease inhibitor‐based therapy has enhanced response rates in ...genotype 1, the recent advances in therapy have demonstrated a challenge in genotype 3, a highly prevalent infection globally.
Aim
To provide a comprehensive summary of the literature evaluating the unique characteristics and evolving therapies in genotype 3.
Methods
A structured search in PubMed, the Cochrane Library and EMBASE was performed using defined key words, including only full text papers and s in English.
Results
HCV genotype 3 is more prevalent in Asia and among intra‐venous drug users. Furthermore, it interferes with lipid and glucose metabolism, and the natural history involves a more rapid progression of liver disease and a higher incidence of hepatocellular carcinoma (HCC). New therapies with protease inhibitors have focused on genotype 1 largely and have demonstrated enhanced responses, but have limited activity against genotype 3. Thus far, in clinical trials, NS5B and NS5A inhibitors have performed more poorly in genotype 3, while a cyclophilin inhibitor, alisporivir, has shown promise.
Conclusions
As treatments for HCV have evolved, genotype 3 has become the most difficult to treat. Furthermore, genotype 3 has special characteristics, such as insulin resistance and alterations in lipid metabolism, which may partly explain the lower treatment responses. A great deal of emphasis on advancing therapy is needed in this population that appears to have a more rapid progression of liver disease and a higher incidence of HCC.
This study analyses the measures used to promote renewable energy for electricity generation in the 18 Latin American countries that signed the Paris Agreement, in an electricity demand growth ...context. The Latin American countries have had a remarkable growth in the use of renewable energy for electricity generation. Biomass, wind and solar energy have experienced strong growth, however, their participation in the energy mix remains small. All the studied countries have established renewable energy targets, 16 having adopted at least one promotion measure. The most used measures are tax incentives, mainly through exemptions in income tax, value added or sales tax and on tariffs. Also, most countries are using auction systems, which are replacing the Feed-In Tariff system. The net metering system adoption is also growing in the region. The results of the study show a positive relationship between the most active countries in renewable energy promotion and the performance achieved in the studied years. Therefore active policies are considered necessary for the future development of renewable energies.
•The measures used to promote RE for electricity generation in LA countries are studied.•All the studied countries have established renewable energy targets.•The most used measures are tax incentives and auction systems.•The net metering system adoption is also growing in the region.•More active countries in RE promotion are those with higher performance achieved.
Combining the precise parallaxes and optical photometry delivered by Gaia’s second data release with the photometric catalogues of Pan-STARRS1, 2MASS, and AllWISE, we derived Bayesian stellar ...parameters, distances, and extinctions for 265 million of the 285 million objects brighter than G = 18. Because of the wide wavelength range used, our results substantially improve the accuracy and precision of previous extinction and effective temperature estimates. After cleaning our results for both unreliable input and output data, we retain 137 million stars, for which we achieve a median precision of 5% in distance, 0.20 mag in V-band extinction, and 245 K in effective temperature for G ≤ 14, degrading towards fainter magnitudes (12%, 0.20 mag, and 245 K at G = 16; 16%, 0.23 mag, and 260 K at G = 17, respectively). We find a very good agreement with the asteroseismic surface gravities and distances of 7000 stars in the Kepler, K2-C3, and K2-C6 fields, with stellar parameters from the APOGEE survey, and with distances to star clusters. Our results are available through the ADQL query interface of the Gaia mirror at the Leibniz-Institut für Astrophysik Potsdam (gaia.aip.de) and as binary tables at data.aip.de. As a first application, we provide distance- and extinction-corrected colour-magnitude diagrams, extinction maps as a function of distance, and extensive density maps. These demonstrate the potential of our value-added dataset for mapping the three-dimensional structure of our Galaxy. In particular, we see a clear manifestation of the Galactic bar in the stellar density distributions, an observation that can almost be considered direct imaging of the Galactic bar.
The relationship between the denaturation temperatures of proteins (Tm values) and the living temperatures of their host organisms (environmental temperatures: TENV values) is poorly understood. ...Since different proteins in the same organism may show widely different Tm's, no simple universal relationship between Tm and TENV should hold, other than Tm≥TENV. Yet, when analyzing a set of homologous proteins from different hosts, Tm's are oftentimes found to correlate with TENV's but this correlation is shifted upward on the Tm axis. Supporting this trend, we recently reported Tm's for resurrected Precambrian thioredoxins that mirror a proposed environmental cooling over long geological time, while remaining a shocking ~50°C above the proposed ancestral ocean temperatures. Here, we show that natural selection for protein kinetic stability (denaturation rate) can produce a Tm↔TENV correlation with a large upward shift in Tm. A model for protein stability evolution suggests a link between the Tm shift and the in vivo lifetime of a protein and, more specifically, allows us to estimate ancestral environmental temperatures from experimental denaturation rates for resurrected Precambrian thioredoxins. The TENV values thus obtained match the proposed ancestral ocean cooling, support comparatively high Archaean temperatures, and are consistent with a recent proposal for the environmental temperature (above 75°C) that hosted the last universal common ancestor. More generally, this work provides a framework for understanding how features of protein stability reflect the environmental temperatures of the host organisms.
Context.
The large astrometric and photometric survey performed by the
Gaia
mission allows for a panoptic view of the Galactic disc and its stellar cluster population. Hundreds of stellar clusters ...were only discovered after the latest
Gaia
data release (DR2) and have yet to be characterised.
Aims.
Here we make use of the deep and homogeneous
Gaia
photometry down to
G
= 18 to estimate the distance, age, and interstellar reddening for about 2000 stellar clusters identified with
Gaia
DR2 astrometry. We use these objects to study the structure and evolution of the Galactic disc.
Methods.
We relied on a set of objects with well-determined parameters in the literature to train an artificial neural network to estimate parameters from the
Gaia
photometry of cluster members and their mean parallax.
Results.
We obtain reliable parameters for 1867 clusters. Our catalogue confirms the relative lack of old stellar clusters in the inner disc (with a few notable exceptions). We also quantify and discuss the variation of scale height with cluster age, and we detect the Galactic warp in the distribution of old clusters.
Conclusions.
This work results in a large and homogeneous cluster catalogue, allowing one to trace the structure of the disc out to distances of ∼4 kpc. However, the present sample is still unable to trace the outer spiral arm of the Milky Way, which indicates that the outer disc cluster census might still be incomplete.
Obesity is associated with complications during pregnancy and increased health risks in the newborn. The objective of the present study was to establish possible relationships between gut microbiota, ...body weight, weight gain and biochemical parameters in pregnant women. Fifty pregnant women were classified according to their BMI in normal-weight (n 34) and overweight (n 16) groups. Gut microbiota composition was analysed by quantitative real-time PCR in faeces and biochemical parameters in plasma at 24 weeks of pregnancy. Reduced numbers of Bifidobacterium and Bacteroides and increased numbers of Staphylococcus, Enterobacteriaceae and Escherichia coli were detected in overweight compared with normal-weight pregnant women. E. coli numbers were higher in women with excessive weight gain than in women with normal weight gain during pregnancy, while Bifidobacterium and Akkermansia muciniphila showed an opposite trend. In the whole population, increased total bacteria and Staphylococcus numbers were related to increased plasma cholesterol levels. Increased Bacteroides numbers were related to increased HDL-cholesterol and folic acid levels, and reduced TAG levels. Increased Bifidobacterium numbers were related to increased folic acid levels. Increased Enterobacteriaceae and E. coli numbers were related to increased ferritin and reduced transferrin, while Bifidobacterium levels showed the opposite trend. Therefore, gut microbiota composition is related to body weight, weight gain and metabolic biomarkers during pregnancy, which might be of relevance to the management of the health of women and infants.
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