This paper reports the first differential measurement of the charged-current $\overline{ν}$μ interaction cross section on water with no pions in the final state. The unfolded flux-averaged ...measurement using the T2K off-axis near detector is given in double-differential bins of μ+ momentum and angle. The integrated cross section in a restricted phase space is σ = (1.11 ± 0.18) × 10-38 cm2 per water molecule. Comparisons with several nuclear models are also presented.
We have reported encouraging results of unrelated cord blood transplantation for patients with lymphoid malignancies. Whether those outcomes are comparable to matched unrelated donor transplants ...remains to be defined. We studied 645 adult patients with mature lymphoid malignancies who received an allogeneic unrelated donor transplant using umbilical cord blood (n=104) or mobilized peripheral blood stem cells (n=541) after a reduced-intensity conditioning regimen. Unrelated cord blood recipients had more refractory disease. Median follow-up time was 30 months. Neutrophil engraftment (81% vs. 97%, respectively; P<0.0001) and chronic graft-versus-host disease (26% vs. 52%; P=0.0005) were less frequent after unrelated cord blood than after matched unrelated donor, whereas no differences were observed in grade II-IV acute graft-versus-host disease (29% vs. 32%), non-relapse mortality (29% vs. 28%), and relapse or progression (28% vs. 35%) at 36 months. There were also no significant differences in 2-year progression-free survival (43% vs. 58%, respectively) and overall survival (36% vs. 51%) at 36 months. In a multivariate analysis, no differences were observed in the outcomes between the two stem cell sources except for a higher risk of neutrophil engraftment (hazard ratio=2.12; P<0.0001) and chronic graft-versus-host disease (hazard ratio 2.10; P=0.0002) after matched unrelated donor transplant. In conclusion, there was no difference in final outcomes after transplantation between umbilical cord blood and matched unrelated donor transplant. Umbilical cord blood is a valuable alternative for patients with lymphoid malignancies lacking an HLA-matched donor, being associated with lower risk of chronic graft-versus-host disease.
Summary
Patients with bone marrow failure syndromes (BMFS) who reject a first allogeneic transplant or fail immunosuppressive therapy (IST) have an especially grim prognosis. We report 14 patients ...(eight adults, six children) transplanted with double cord blood transplantation (dUCBT) for BMFS. Neutrophil recovery was observed in eight patients, with full donor chimerism of one unit, and acute GVHD in 10. With a median follow‐up of 23 months, the estimated 2 years overall survival was 80 ± 17% and 33 ± 16% for patients with acquired and inherited BMFS, respectively. Transplantation of two partially HLA‐matched UCB thus enables salvage treatment of high‐risk patients with BMFS.
Objective. Up to now, no validated tools are in use for the assessment of the skin lesions in localized scleroderma (LS). The aim of this study is to evaluate the performance of a new computerized ...skin score (CSS) method for the measurement of circumscribed lesions in LS.
Methods. The study consisted of three phases: set up of the CSS technique, measurement of target lesions of LS patients, assessment of intra- and inter-rater reliability. The CSS technique consists in delimitating the indurate lesion on an adhesive transparent film, transferring it over a cardboard and then calculating the affected area with a specifically created software.
The technique was explained to a panel of 10 physicians with different expertise in LS (three paediatric rheumatologists, two dermatologists, five paediatric residents). All participants, singularly and blindly to the others, examined 10 consecutive patients twice after a time interval of at least 6 h. The intra-observer variability was evaluated by the repeatability coefficient and the inter-rater reliability by the intra-class correlation coefficient (ICC).
Results. The repeatability coefficients were good, ranging between 1.90 and 7.03. The mean values of skin scores were not significantly different among the examiners. The ICC for indurate area calculation were high in both the experts (0.97) and the residents (0.91-0.94).
Conclusions. CSS has shown to be a reliable method to assess the skin lesions in patients with LS. It is reproducible, easy to use and, with the support of the CSS software, applicable worldwide.
We report measurements by the T2K experiment of the parameters θ23 and Δm322, which govern the disappearance of muon neutrinos and antineutrinos in the three-flavor PMNS neutrino oscillation model at ...T2K's neutrino energy and propagation distance. Utilizing the ability of the experiment to run with either a mainly neutrino or a mainly antineutrino beam, muon-like events from each beam mode are used to measure these parameters separately for neutrino and antineutrino oscillations. Data taken from 1.49×1021 protons on target (POT) in neutrino mode and 1.64 × 1021 POT in antineutrino mode are used. The best-fit values obtained by T2K were sin2 (θ23) = 0.51−0.07+0.06(0.43−0.05+0.21) and Δm322=2.47−0.09+0.08(2.50−0.13+0.18)× 10−3 eV2/c4 for neutrinos (antineutrinos). No significant differences between the values of the parameters describing the disappearance of muon neutrinos and antineutrinos were observed. An analysis using an effective two-flavor neutrino oscillation model where the sine of the mixing angle is allowed to take nonphysical values larger than 1 is also performed to check the consistency of our data with the three-flavor model. Our data were found to be consistent with a physical value for the mixing angle.
The T2K experiment measures muon neutrino disappearance and electron neutrino appearance in accelerator-produced neutrino and antineutrino beams. With an exposure of 14.7 ( 7.6 ) ×1020 protons on ...target in the neutrino (antineutrino) mode, 89 νe candidates and seven anti- νe candidates are observed, while 67.5 and 9.0 are expected for δCP=0 and normal mass ordering. The obtained 2σ confidence interval for the CP -violating phase, δCP , does not include the CP -conserving cases ( δCP=0 , π ). The best-fit values of other parameters are sin2θ23=0.526-0.036+0.032 and Δ m322=2.463-0.070+0.071×10-3 eV2 / c4 .
The ENUBET project is aimed at designing and experimentally demonstrating the concept of monitored neutrino beams. These novel beams are enhanced by an instrumented decay tunnel, whose detectors ...reconstruct large-angle charged leptons produced in the tunnel and give a direct estimate of the neutrino flux at the source. These facilities are thus the ideal tool for high-precision neutrino cross-section measurements at the GeV scale because they offer superior control of beam systematics with respect to existing facilities. In this paper, we present the first end-to-end design of a monitored neutrino beam capable of monitoring lepton production at the single particle level. This goal is achieved by a new focusing system without magnetic horns, a 20 m normal-conducting transfer line for charge and momentum selection, and a 40 m tunnel instrumented with cost-effective particle detectors. Employing such a design, we show that percent precision in cross-section measurements can be achieved at the CERN SPS complex with existing neutrino detectors.
Shashlik calorimeters are sampling calorimeters using wavelength shifting fibers running perpendicularly to the scintillating/absorber plates for the light readout. These devices are cost-effective, ...easy to assemble, and characterized by a good flexibility in terms of energy resolution. On the contrary, the perpendicular optical fiber readout and the resulting fiber bundling to the photosensor pose a strong limitation to the longitudinal segmentation. Recently, the fast development of solid state photosensors allowed for the integration of the readout system directly in the bulk of the calorimeter, opening new possibilities in terms of longitudinal segmentation (SCENTT INFN R &D). In an ultra-compact module every single fiber segment is directly connected to a SiPM; the SiPMs are arranged in arrays on custom PCBs and readout by a fast electronics based on waveform digitizers. This detector technology is the baseline option for ENUBET: a 5 year project (2016-2021) funded by the European Research Council aiming to demonstrate the possibility of a complete instrumentation of the decay tunnel of conventional neutrino beam. This technique allows for a ten-fold reduction on the neutrino flux normalization error. In the talk we will present the results and a detailed performance assessment of the novel ultra-compact design obtained with a prototype of longitudinally segmented shashlik calorimeter, readout with SiPMs embedded in the calorimeter bulk. Tests performed at the CERN PST9 beamline in the 1-5 GeV energy range in November 2016 provided results in terms of linearity, energy resolution and e/\pi discrimination at various beam angles reproducing the grazing incident conditions typical of neutrino beam decay tunnels. We will also present results from a neutron irradiation campaign of our Silicon Photomultipliers at the INFN-LNL CN accelerator allowing to test neutron fluences of O(10^{12/cm^{2}}) using 5 MeV protons on a Be target.
PDF
