Desiccation of the Sahara since the middle Holocene has eradicated all but a few natural archives recording its transition from a "green Sahara" to the present hyperarid desert. Our continuous ...6000-year paleoenvironmental reconstruction from northern Chad shows progressive drying of the regional terrestrial ecosystem in response to weakening insolation forcing of the African monsoon and abrupt hydrological change in the local aquatic ecosystem controlled by site-specific thresholds. Strong reductions in tropical trees and then Sahelian grassland cover allowed large-scale dust mobilization from 4300 calendar years before the present (cal yr B.P.). Today's desert ecosystem and regional wind regime were established around 2700 cal yr B.P. This gradual rather than abrupt termination of the African Humid Period in the eastern Sahara suggests a relatively weak biogeophysical feedback on climate.
Key Points
Drivers and impacts of Australia's record drought were analyzed
Impacts accumulated and propagated through the water cycle at different rates
Future droughts may not be managed better than ...past ones.
The “Millennium Drought” (2001–2009) can be described as the worst drought on record for southeast Australia. Adaptation to future severe droughts requires insight into the drivers of the drought and its impacts. These were analyzed using climate, water, economic, and remote sensing data combined with biophysical modeling. Prevailing El Niño conditions explained about two thirds of rainfall deficit in east Australia. Results for south Australia were inconclusive; a contribution from global climate change remains plausible but unproven. Natural processes changed the timing and magnitude of soil moisture, streamflow, and groundwater deficits by up to several years, and caused the amplification of rainfall declines in streamflow to be greater than in normal dry years. By design, river management avoided impacts on some categories of water users, but did so by exacerbating the impacts on annual irrigation agriculture and, in particular, river ecosystems. Relative rainfall reductions were amplified 1.5–1.7 times in dryland wheat yields, but the impact was offset by steady increases in cropping area and crop water use efficiency (perhaps partly due to CO2 fertilization). Impacts beyond the agricultural sector occurred (e.g., forestry, tourism, utilities) but were often diffuse and not well quantified. Key causative pathways from physical drought to the degradation of ecological, economic, and social health remain poorly understood and quantified. Combined with the multiple dimensions of multiyear droughts and the specter of climate change, this means future droughts may well break records in ever new ways and not necessarily be managed better than past ones.
We introduce the antibody landscape, a method for the quantitative analysis of antibodymediated immunity to antigenically variable pathogens, achieved by accounting for antigenic variation among ...pathogen strains. We generated antibody landscapes to study immune profiles covering 43 years of influenza A/H3N2 virus evolution for 69 individuals monitored for infection over 6 years and for 225 individuals pre- and postvaccination. Upon infection and vaccination, titers increased broadly, including previously encountered viruses far beyond the extent of cross-reactivity observed after a primary infection. We explored implications for vaccination and found that the use of an antigenically advanced virus had the dual benefit of inducing antibodies against both advanced and previous antigenic clusters. These results indicate that preemptive vaccine updates may improve influenza vaccine efficacy in previously exposed individuals.
We present an Integral Field Unit survey of 73 galaxy clusters and groups with the VIsible Multi Object Spectrograph on the Very Large Telescope. We exploit the data to determine the H α gas dynamics ...on kpc scales to study the feedback processes occurring within the dense cluster cores. We determine the kinematic state of the ionized gas and show that the majority of systems (∼2/3) have relatively ordered velocity fields on kpc scales that are similar to the kinematics of rotating discs and are decoupled from the stellar kinematics of the brightest cluster galaxy. The majority of the H α flux (>50 per cent) is typically associated with these ordered kinematics and most systems show relatively simple morphologies suggesting they have not been disturbed by a recent merger or interaction. Approximately 20 per cent of the sample (13/73) have disturbed morphologies which can typically be attributed to active galactic nuclei activity disrupting the gas. Only one system shows any evidence of an interaction with another cluster member. A spectral analysis of the gas suggests that the ionization of the gas within cluster cores is dominated by non-stellar processes, possibly originating from the intracluster medium itself.
Executive dysfunction, distinct from other cognitive deficits in depression, has been associated with suicidal behavior. However, this dysfunction is not found consistently across samples.
...Medication-free subjects with DSM-IV major depressive episode (major depressive disorder and bipolar type I disorder) and a past history of suicidal behavior (n = 72) were compared to medication-free depressed subjects with no history of suicidal behavior (n = 80) and healthy volunteers (n = 56) on a battery of tests assessing neuropsychological functions typically affected by depression (motor and psychomotor speed, attention, memory) and executive functions reportedly impaired in suicide attempters (abstract/contingent learning, working memory, language fluency, impulse control).
All of the depressed subjects performed worse than healthy volunteers on motor, psychomotor and language fluency tasks. Past suicide attempters, in turn, performed worse than depressed non-attempters on attention and memory/working memory tasks a computerized Stroop task, the Buschke Selective Reminding Task (SRT), the Benton Visual Retention Test (VRT) and an N-back task but not on other executive function measures, including a task associated with ventral prefrontal function (Object Alternation). Deficits were not accounted for by current suicidal ideation or the lethality of past attempts. A small subsample of those using a violent method in their most lethal attempt showed a pattern of poor executive performance.
Deficits in specific components of attention control, memory and working memory were associated with suicidal behavior in a sample where non-violent attempt predominated. Broader executive dysfunction in depression may be associated with specific forms of suicidal behavior, rather than suicidal behavior per se.
The molecular basis of antigenic drift was determined for the hemagglutinin (HA) of human influenza A/H3N2 virus. From 1968 to 2003, antigenic change was caused mainly by single amino acid ...substitutions, which occurred at only seven positions in HA immediately adjacent to the receptor binding site. Most of these substitutions were involved in antigenic change more than once. Equivalent positions were responsible for the recent antigenic changes of influenza B and A/H1N1 viruses. Substitution of a single amino acid at one of these positions substantially changed the virus-specific antibody response in infected ferrets. These findings have potentially far-reaching consequences for understanding the evolutionary mechanisms that govern influenza viruses.
Identifying the type and strength of interactions between local anthropogenic and other stressors can help to set achievable management targets for degraded marine ecosystems and support their ...resilience by identifying local actions. We undertook a meta‐analysis, using data from 118 studies to test the hypothesis that ongoing global declines in the dominant habitat along temperate rocky coastlines, forests of canopy‐forming algae and/or their replacement by mat‐forming algae are driven by the nonadditive interactions between local anthropogenic stressors that can be addressed through management actions (fishing, heavy metal pollution, nutrient enrichment and high sediment loads) and other stressors (presence of competitors or grazers, removal of canopy algae, limiting or excessive light, low or high salinity, increasing temperature, high wave exposure and high UV or CO₂), not as easily amenable to management actions. In general, the cumulative effects of local anthropogenic and other stressors had negative effects on the growth and survival of canopy‐forming algae. Conversely, the growth or survival of mat‐forming algae was either unaffected or significantly enhanced by the same pairs of stressors. Contrary to our predictions, the majority of interactions between stressors were additive. There were however synergistic interactions between nutrient enrichment and heavy metals, the presence of competitors, low light and increasing temperature, leading to amplified negative effects on canopy‐forming algae. There were also synergistic interactions between nutrient enrichment and increasing CO₂ and temperature leading to amplified positive effects on mat‐forming algae. Our review of the current literature shows that management of nutrient levels, rather than fishing, heavy metal pollution or high sediment loads, would provide the greatest opportunity for preventing the shift from canopy to mat‐forming algae, particularly in enclosed bays or estuaries because of the higher prevalence of synergistic interactions between nutrient enrichment with other local and global stressors, and as such it should be prioritized.
We report a novel splicing-based pressure-assisted melt-filling technique for creating metallic nanowires in hollow channels in microstructured silica fibers. Wires with diameters as small as 120 nm ...(typical aspect ration 50:1) could be realized at a filling pressure of 300 bar. As an example we investigate a conventional single-mode step-index fiber with a parallel gold nanowire (wire diameter 510 nm) running next to the core. Optical transmission spectra show dips at wavelengths where guided surface plasmon modes on the nanowire phase match to the glass core mode. By monitoring the side-scattered light at narrow breaks in the nanowire, the loss could be estimated. Values as low as 0.7 dB/mm were measured at resonance, corresponding to those of an ultra-long-range eigenmode of the glass-core/nanowire system. By thermal treatment the hollow channel could be collapsed controllably, permitting creation of a conical gold nanowire, the optical properties of which could be monitored by side-scattering. The reproducibility of the technique and the high optical quality of the wires suggest applications in fields such as nonlinear plasmonics, near-field scanning optical microscope tips, cylindrical polarizers, optical sensing and telecommunications.
In this work, the Smooth Particle Hydrodynamics (SPH) method, a Lagrangian mesh-free numerical scheme, is adapted for the first time to resolve thermal–mechanical–material fields in a range of Laser ...Fusion Additive Manufacturing processes. The method is capable of simulating large-deformation, free-surface melting, flow, and re-solidification of metallic materials with complex physics and material geometries. A novel SPH formulation for modeling isothermally-incompressible fluids, which allows for the accurate simulation of thermally-driven, liquid-phase metal expansion/contraction, is presented and verified. Fundamental validation of the methodology is performed via comparison with spot laser welding experiments. The methodology is then used to investigate the specific Additive Manufacturing process of the Selective Laser Melting of Metallic, micro-scale particle beds. The physics of a track deposition process is explored through numerical experiments, and the influence of processing parameters on the quality of the finished melt-track is investigated. The unique abilities of using a Lagrangian mesh-free method, as opposed to mesh-based numerical schemes, to model this process are highlighted. The SPH method is found to be a viable and promising numerical tool for simulating laser fusion driven Additive Manufacturing processes.
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