The LHCb collaboration has redesigned its trigger to enable the full offline detector reconstruction to be performed in real time. Together with the real-time alignment and calibration of the ...detector, and a software infrastructure to make persistent the high-level physics objects produced during real-time processing, this redesign enabled the widespread deployment of real-time analysis during Run 2. We describe the design of the Run 2 trigger and real-time reconstruction, and present data-driven performance measurements for a representative sample of LHCb's physics programme.
Abstract
Background
Severely calcified coronary lesions present a particular challenge for percutaneous coronary intervention.
Aims
The aim of this randomized study was to determine whether coronary ...intravascular lithotripsy (IVL) is non‐inferior to rotational atherectomy (RA) regarding minimal stent area (MSA).
Methods
The randomized, prospective non‐inferiority ROTA.shock trial enrolled 70 patients between July 2019 and November 2021. Patients were randomly (1:1) assigned to undergo either IVL or RA before percutaneous coronary intervention of severely calcified coronary lesions. Optical coherence tomography was performed at the end of the procedure for primary endpoint analysis.
Results
The primary endpoint MSA was lower but non‐inferior after IVL (mean: 6.10 mm
2
, 95% confidence interval 95% CI: 5.32–6.87 mm
2
) versus RA (6.60 mm
2
, 95% CI: 5.66–7.54 mm
2
; difference in MSA: −0.50 mm
2
, 95% CI: −1.52–0.52 mm
2
; non‐inferiority margin: −1.60 mm
2
). Stent expansion was similar (RA: 0.83 ± 0.10 vs. IVL: 0.82 ± 0.11;
p
= 0.79). There were no significant differences regarding contrast media consumption (RA: 183.1 ± 68.8 vs. IVL: 163.3 ± 55.0 mL;
p
= 0.47), radiation dose (RA: 7269 ± 11288 vs. IVL: 5010 ± 4140 cGy cm
2
;
p
= 0.68), and procedure time (RA: 79.5 ± 34.5 vs. IVL: 66.0 ± 19.4 min;
p
= 0.18).
Conclusion
IVL is non‐inferior regarding MSA and results in a similar stent expansion in a random comparison with RA. Procedure time, contrast volume, and dose‐area product do not differ significantly.
