Stabilizers are ingredients employed to improve the technological properties of products. The food industry and consumers have recently become interested in the development of natural ingredients. In ...this work, the effects of hydrocolloids from butternut squash (Cucurbita moschata) seeds (HBSS) as stabilizers on the physicochemical, rheological, and sensory properties of natural yogurt were examined. HBSS improved the yogurt’s physical stability and physicochemical properties, decreasing syneresis and modifying the samples’ rheological properties, improving the assessment of sensory characteristics. The samples presented shear thinning behavior characterized by a decrease in viscosity with the increase of the shear rate; nevertheless, the samples showed a two-step yield stress. HBSS is an alternative as a natural stabilizer for the development of microstructured products.
Denture marking (DM) helps identify edentulous people with different methods. Analyzing perceptions and attitudes of denture wearers would enable understanding of the practical aspects, an analysis ...still absent in South America. Fifty‐three individual candidates for removable dentures were instructed on disaster victim identification (DVI) and the usefulness of DM for this purpose. They were physically shown eight DM systems and a questionnaire to which they responded by highlighting preferences in those systems. Although 98.11% did not know that dentures could be marked, only 9.43% denied interest in some type of DM. The 90.57% would mark their dentures with some system, preferring the inclusion of QR codes or a micro SIM card. The proven weaknesses of DVI and propensity for disaster mean this community in Chile is an opportunity to implement DM systems. Obstacles may come not from patients but from their dentists, educational institutions, or a lack of public policies.
Problems of behaviour, communication, and social interaction associated with Autism Spectrum Disorders can overwhelm parents. Disturbances in parents' psychological well-being (anxiety, depression) ...affect adherence to treatment, making it less effective. There is a need to investigate how to increase psychological wellbeing in parents of children with autism.
An 8-week brief training programme using the Mindfulness Parenting (MP) intervention was applied to fourteen parents (6 couples and two mothers). Participants were assigned to one of two groups, both groups received the same treatment but at two different time points. Measures of anxiety (SCAARED), parental stress (PSI-4), autism severity level (AIM) and mindfulness awareness (FFMQ), were assessed.
Analysis indicates that MP training increased mindfulness awareness, increasing non-judgment and reactivity, and consequently, reduced anxiety (parental, general, social), improving parent-child interaction. This improvement did not influence parents' perception of the severity of the disorder.
The small number of participants precludes generalisation of the results. More clinical trials are needed to demonstrate the usefulness of including these programmes in early intervention services, as well as profiles of parents who may potentially benefit from it.
Fire-derived organic matter, often referred to as pyrogenic organic matter (PyOM), is present in the Earth's soil, sediment, atmosphere, and water. We investigated interactions of PyOM with ammonia ...(NH
) gas, which makes up much of the Earth's reactive nitrogen (N) pool. Here we show that PyOM's NH
retention capacity under ambient conditions can exceed 180 mg N g
PyOM-carbon, resulting in a material with a higher N content than any unprocessed plant material and most animal manures. As PyOM is weathered, NH
retention increases sixfold, with more than half of the N retained through chemisorption rather than physisorption. Near-edge X-ray absorption fine structure and nuclear magnetic resonance spectroscopy reveal that a variety of covalent bonds form between NH
-N and PyOM, more than 10% of which contained heterocyclic structures. We estimate that through these mechanisms soil PyOM stocks could retain more than 600-fold annual NH
emissions from agriculture, exerting an important control on global N cycling.
Forward Diffractive Detector control system for Run 3 in the ALICE experiment Mejía Camacho, J.M.; Rodríguez Ramírez, S.A.; Cabanillas Noris, J.C. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
05/2023, Letnik:
1050
Journal Article
Recenzirano
The ALICE experiment went through major upgrades in preparation for Runs 3 and 4 at the CERN LHC, which foresee a significant increase in the data stream rate. To cope with it, a new Computing System ...Online–Offline (O2) was developed by ALICE and several detectors were upgraded. One of these upgrades corresponded to the ALICE Diffractive (AD) detector, which was replaced by the new Forward Diffractive Detector (FDD). A fundamental system that allows for recording of data as well as for the stable and safe operation of the experimental setup is the Detector Control System (DCS). The DCS controls, monitors, and configures detectors’ hardware and their subsystems among which are commercial hardware and specific custom equipment. In this work, we describe the implementation of the DCS of FDD, which was designed and developed using the SCADA commercial software WinCC Open Architecture (WinCC-OA®) and the Joint Controls Project (JCOP) Framework. We also describe the modeling of FDD-DCS as a finite state machine to be integrated into the ALICE Central DCS, and to be operated by DCS shifters in the run control center and, remotely, by detector experts. This new DCS was developed to comply with the new LHC operational standards that allow for processing the increased luminosity due to collisions at a higher energy, and for fulfilling the specific requirements of the ALICE experiment, in order to address the scientific challenges of its physics program.
Over the past decade, there has been appreciable progress
towards modeling the water, energy, and carbon cycles at field scales
(10–100 m) over continental to global extents in Earth system models
...(ESMs). One such approach, named HydroBlocks, accomplishes this task while
maintaining computational efficiency via Hydrologic Response Units (HRUs),
more commonly known as “tiles” in ESMs. In HydroBlocks, these HRUs are
learned via a hierarchical clustering approach from available global
high-resolution environmental data. However, until now there has yet to be
a river routing approach that is able to leverage HydroBlocks' approach to
modeling field-scale heterogeneity; bridging this gap will make it possible
to more formally include riparian zone dynamics, irrigation from surface
water, and interactive floodplains in the model. This paper introduces a
novel dynamic river routing scheme in HydroBlocks that is intertwined with
the modeled field-scale land surface heterogeneity. Each macroscale polygon
(a generalization of the concept of macroscale grid cell) is assigned its
own fine-scale river network that is derived from very high resolution
(∼ 30 m) digital elevation models (DEMs); the inlet–outlet reaches of a domain's
macroscale polygons are then linked to assemble a full domain's river
network. The river dynamics are solved at the reach-level via the kinematic
wave assumption of the Saint-Venant equations. Finally, a two-way coupling
between each HRU and its corresponding fine-scale river reaches is
established. To implement and test the novel approach, a 1.0∘ bounding
box surrounding the Atmospheric Radiation and Measurement (ARM) Southern
Great Plains (SGP) site in northern Oklahoma (United States) is used. The
results show (1) the implementation of the two-way coupling between the land
surface and the river network leads to appreciable differences in the
simulated spatial heterogeneity of the surface energy balance, (2) a limited
number of HRUs (∼ 300 per 0.25∘ cell) are required to
approximate the fully distributed simulation adequately, and (3) the surface
energy balance partitioning is sensitive to the river routing model
parameters. The resulting routing scheme provides an effective and efficient
path forward to enable a two-way coupling between the high-resolution river
networks and state-of-the-art tiling schemes in ESMs.
Background
Beta‐lactams generate different allergenic determinants that induce selective or cross‐reactive drug hypersensitivity reactions (DHRs). We aimed to identify the drugs involved, the ...selectivity of the response, the mechanism, and the value of the different diagnostic tests for establishing a diagnosis in children evaluated for DHRs to beta‐lactams.
Methods
Prospective study evaluating children aged under 16 years reporting DHRs to beta‐lactams. Reactions were classified as immediate and non‐immediate reactions. The workup included sIgE, skin testing, and drug provocation tests (DPTs) for immediate reactions and patch testing and DPTs for non‐immediate ones.
Results
Of the 510 children included, 133 were evaluated for immediate reactions and confirmed in 8.3%. Skin test/in vitro IgE contributed to diagnosing half of the cases. Selective reactions occurred with amoxicillin (63%), followed by common penicillin determinants (27%) and cephalosporins (0.9%).
Among non‐immediate reactions (11.4% of the 377 children evaluated), most required DPTs, 52.7% of which were positive at 6–7 days of drug challenge. Selective reactions were identified with amoxicillin (80%), penicillin G (7.5%), cephalosporins (7.5%), and clavulanic acid (5%). Urticaria and maculopapular exanthema were the most frequent entities.
Conclusions
There were few confirmed cases of either type of reaction. Skin testing proved less valuable in non‐immediate reactions, over half of which would also have been lost in a short DPT protocol. Selective responders to amoxicillin were more likely to have non‐immediate reactions, while clavulanic acid selectivity was exclusive to the non‐immediate typology. Over half the cases with DPTs required 6–7 days of treatment for DHR confirmation.
Cervical cancer is the third female cancer most common worldwide. The carcinogenic process involves an alteration of the mechanisms associated with transcription. Several studies have reported an ...oncogenic role of the polycomb complex subunit, EZH2. However, the role of EZH2 in cervical cancer is unknown. Hence, the objective of this study was to determine the role of EZH2 in transcriptional regulation in cervical cancer. The EZH2 expression and the methylation status of its promoter were analyzed in The Cancer Genome Atlas. The EZH2 enrichment profile was analyzed using chromatin immunoprecipitation with massively parallel DNA sequencing data provided by ENCODE project. The chromatin compartments were identified in the 4D Nucleome Data Portal. The functional annotation was examined in Enrichr. We report that EZH2 expression is increased in cervical cancer which is associated with hypomethylation of its promoter. EZH2 is enriched at promoter and distal intergenic regions. We identified that EZH2 defines chromatin domains enriched with H3K27me3 within repressive compartments in the HeLa-S3 cell line. Additionally, high EZH2 expression is associated with the repression of the senescent phenotype in cervical cancer patients. Our results suggest the participation of EZH2 in the generation of domains with a silencer function in cervical cancer, which regulate the expression of genes associated with cellular senescence.
This paper introduces a systematic approach for water integration in industrial facilities based on properties. New property operators and mixing rules (e.g., for odor and toxicity) are proposed to ...enable the tracking of stream characteristics and the inclusion in an optimization model. Additionally, the dependence of the properties on temperature is accounted for. The thermal effects upon properties are also considered in the proposed water-network model by including cooling and heating. The proposed model for water integration is based on a recycle scheme that includes regeneration processes to improve the stream properties. Furthermore, temperature-adjusting property interceptors are included in the superstructure of the regeneration network to satisfy the temperature constraints in the sinks and also to improve temperature-dependent properties. The applicability of the proposed approach is shown through several case studies, where methodology comparison is made with respect to the ones previously reported in the literature.
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