Dye-sensitized solar cells (DSSCs) belong to the group of thin-film solar cells which have been under extensive research for more than two decades due to their low cost, simple preparation ...methodology, low toxicity and ease of production. Still, there is lot of scope for the replacement of current DSSC materials due to their high cost, less abundance, and long-term stability. The efficiency of existing DSSCs reaches up to 12%, using Ru(II) dyes by optimizing material and structural properties which is still less than the efficiency offered by first- and second-generation solar cells, i.e., other thin-film solar cells and Si-based solar cells which offer ~ 20–30% efficiency. This article provides an in-depth review on DSSC construction, operating principle, key problems (low efficiency, low scalability, and low stability), prospective efficient materials, and finally a brief insight to commercialization.
This book presents geological characteristics and evolution of the fold belts and the cratonic areas of the Indian shield. It evaluates the different evolutionary models for each fold belt in light ...of all the currently available information.
In the present investigation, GO was prepared by exfoliation of graphite using modified Hummer's method and then reduced using hydrazine hydrate (reducing agent) to produce rGO. XRD, FESEM, Raman, ...FTIR spectrophotometer and TGA were used for characterization of GO and rGO. XRD images reveal crystalline structure for both GO and rGO. The d‐spacing is observed to be reduced for rGO as compared to that for GO because of removal of oxygen containing functional groups. Raman excitation peaks were obtained for two laser wavelengths 532 and 785 nm. Ratio of intensities of D and G bands (ID/IG) increase for rGO due to increase in order by reduction, implying restoration of the p‐conjugation. The bands are narrower for rGO.TGA thermograms show a higher overall loss of weight for GO in the temperature range 0–1000 °C under N2 flow. Intensity of FTIR peaks of oxide, hydroxyl and alkoxy groups decreases significantly on reduction. FESEM image shows more corrugated surface of rGO as compared to GO. It is expected that this investigation would be useful to develop GO/rGO based gas sensors to detect minute concentration of gases.
Carbon nanotubes (CNT) represent one of the most unique materials in the field of nanotechnology. CNT are the allotrope of carbon having sp2 hybridization. CNT are considered to be rolled-up graphene ...with a nanostructure that can have a length to diameter ratio greater than 1,000,000. CNT can be single-, double-, and multi-walled. CNT have unique mechanical, electrical, and optical properties, all of which have been extensively studied. The novel properties of CNT are their light weight, small size with a high aspect ratio, good tensile strength, and good conducting characteristics, which make them useful for various applications. The present review is focused on the structure, properties, toxicity, synthesis methods, growth mechanism and their applications. Techniques that have been developed to synthesize CNT in sizeable quantities, including arc discharge, laser ablation, chemical vapor deposition, etc., have been explained. The toxic effect of CNT is also presented in a summarized form. Recent CNT applications showing a very promising glimpse into the future of CNT in nanotechnology such as optics, electronics, sensing, mechanical, electrical, storage, and other fields of materials science are presented in the review.
Water is of fundamental importance for life on earth. The synthesis and structure of cell constituents and transport of nutrients into the cells as well as body metabolism depend on water. The ...contaminations present in water disturb the spontaneity of the mechanism and result in long/short-term diseases. The probable contaminations and their possible routes are discussed in the present review. Continued research efforts result in some processes/technologies to remove the contaminations from water. The review includes concepts and potentialities of the technologies in a comprehensible form. It also includes some meaningful hybrid technologies and promising awaited technologies in coming years.
The biological mechanisms that link the development of depression to metabolic disorders such as obesity and diabetes remain obscure. Dopamine- and plasticity-related signalling in mesolimbic reward ...circuitry is implicated in the pathophysiology and aetiology of depression.
To determine the impact of a palatable high-fat diet (HFD) on depressive-like behaviour and biochemical alterations in brain reward circuitry in order to understand the neural processes that may contribute to the development of depression in the context of diet-induced obesity (DIO).
Adult male C57Bl6 mice were placed on a HFD or ingredient-matched, low-fat diet for 12 weeks. At the end of the diet regimen, we assessed anxiety and depressive-like behaviour, corticosterone levels and biochemical changes in the midbrain and limbic brain regions. Nucleus accumbens (NAc), dorsolateral striatum (DLS) and ventral tegmental area dissections were subjected to SDS-PAGE and immunoblotting using antibodies against D1A receptor, D2 receptor, brain-derived neurotrophic factor (BDNF), phospho-DARPP-32(thr75), phospho-CREB and ΔFosB.
HFD mice showed significant decreases in open arm time and centre time activity in elevated plus maze and open field tasks, respectively, and increased immobility (behavioural despair) in the forced swim test. Corticosterone levels following acute restraint stress were substantially elevated in HFD mice. HFD mice had significantly higher D2R, BDNF and ΔFosB, but reduced D1R, protein expression in the NAc. Notably, the expression of BDNF in both the NAc and DLS and phospho-CREB in the DLS was positively correlated with behavioural despair.
Our results demonstrate that chronic consumption of high-fat food and obesity induce plasticity-related changes in reward circuitry that are associated with a depressive-like phenotype. As increases in striatal BDNF and CREB activity are well implicated in depressive behaviour and reward, we suggest these signalling molecules may mediate the effects of high-fat feeding and DIO to promote negative emotional states and depressive-like symptomology.
Specific therapy of ocular infections often requires etiological diagnosis that is a combined effect of observation of characteristic clinical features and microbiological investigations. Clinical ...impression is central to guiding the laboratory investigation, and the aim of laboratory investigation is to confirm or rule out the clinical diagnosis. However, clinical features may vary considerably, and no one clinical feature may be pathognomonic of a particular pathogen. In addition, there may be a racial, geographical, and climatic difference in the distribution and type of causative agents associated with infections. Ophthalmologists have at their disposal in vivo and in vitro methods of diagnosis of ocular infections. The expertise of the clinician and the microbiologist along with the facilities available, determine the success with accurate diagnosis. A wide range of conventional and molecular techniques are available that not only provide rapid diagnosis for known common infections but have the potential to bring to the fore unknown organisms that may be associated with ocular infections.
Summary
Escherichia coli biofilm consists of a bacterial colony embedded in a matrix of extracellular polymeric substances (EPS) which protects the microbes from adverse environmental conditions and ...results in infection. Besides being the major causative agent for recurrent urinary tract infections, E. coli biofilm is also responsible for indwelling medical device‐related infectivity. The cell‐to‐cell communication within the biofilm occurs due to quorum sensors that can modulate the key biochemical players enabling the bacteria to proliferate and intensify the resultant infections. The diversity in structural components of biofilm gets compounded due to the development of antibiotic resistance, hampering its eradication. Conventionally used antimicrobial agents have a restricted range of cellular targets and limited efficacy on biofilms. This emphasizes the need to explore the alternate therapeuticals like anti‐adhesion compounds, phytochemicals, nanomaterials for effective drug delivery to restrict the growth of biofilm. The current review focuses on various aspects of E. coli biofilm development and the possible therapeutic approaches for prevention and treatment of biofilm‐related infections.
Enzymes are extremely complex catalytic structures with immense biological and technological importance. Nevertheless, their widespread environmental implementation faces several challenges, ...including high production costs, low operational stability, and intricate recovery and reusability. Therefore, the de novo design of minimalistic biomolecular nanomaterials that can efficiently mimic the biocatalytic function (bionanozymes) and overcome the limitations of natural enzymes is a critical goal in biomolecular engineering. Here, we report an exceptionally simple yet highly active and robust single amino acid bionanozyme that can catalyze the rapid oxidation of environmentally toxic phenolic contaminates and serves as an ultrasensitive tool to detect biologically important neurotransmitters similar to the laccase enzyme. While inspired by the laccase catalytic site, the substantially simpler copper-coordinated bionanozyme is ∼5400 times more cost-effective, four orders more efficient, and 36 times more sensitive compared to the natural protein. Furthermore, the designed mimic is stable under extreme conditions (pH, ionic strength, temperature, storage time), markedly reusable for several cycles, and displays broad substrate specificity. These findings hold great promise in developing efficient bionanozymes for analytical chemistry, environmental protection, and biotechnology.
A model-based description of the scaling and radial location of turbulent fluctuations in turbulent pipe flow is presented and used to illuminate the scaling behaviour of the very large scale ...motions. The model is derived by treating the nonlinearity in the perturbation equation (involving the Reynolds stress) as an unknown forcing, yielding a linear relationship between the velocity field response and this nonlinearity. We do not assume small perturbations. We examine propagating helical velocity response modes that are harmonic in the wall-parallel directions and in time, permitting comparison of our results to experimental data. The steady component of the velocity field that varies only in the wall-normal direction is identified as the turbulent mean profile. A singular value decomposition of the resolvent identifies the forcing shape that will lead to the largest velocity response at a given wavenumber–frequency combination. The hypothesis that these forcing shapes lead to response modes that will be dominant in turbulent pipe flow is tested by using physical arguments to constrain the range of wavenumbers and frequencies to those actually observed in experiments. An investigation of the most amplified velocity response at a given wavenumber–frequency combination reveals critical-layer-like behaviour reminiscent of the neutrally stable solutions of the Orr–Sommerfeld equation in linearly unstable flow. Two distinct regions in the flow where the influence of viscosity becomes important can be identified, namely wall layers that scale with R+1/2 and critical layers where the propagation velocity is equal to the local mean velocity, one of which scales with R+2/3 in pipe flow. This framework appears to be consistent with several scaling results in wall turbulence and reveals a mechanism by which the effects of viscosity can extend well beyond the immediate vicinity of the wall. The model reproduces inner scaling of the small scales near the wall and an approach to outer scaling in the flow interior. We use our analysis to make a first prediction that the appropriate scaling velocity for the very large scale motions is the centreline velocity, and show that this is in agreement with experimental results. Lastly, we interpret the wall modes as the motion required to meet the wall boundary condition, identifying the interaction between the critical and wall modes as a potential origin for an interaction between the large and small scales that has been observed in recent literature as an amplitude modulation of the near-wall turbulence by the very large scales.
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