This study examined the relationship between dietary intake of advanced glycation end products (dAGEs) and depression and sleep quality in young adults.
This study, which included 420 university ...students (F = 80.2 %; M = 19.8 %), is observational and cross-sectional. Dietary AGEs intakes of individuals were taken with a 24-h food consumption record system. Measuring the depression status of the participants was evaluated with the Beck Depression Inventory (BDI), and the assessment of their sleep quality was evaluated with the Pittsburg Sleep Quality Index (PSQI). Individuals' dAGEs intakes were divided into three equal groups (low, medium, and high). The energy was adjusted in all analyzes of dAGEs intake. Study data were analyzed with the SPSS (27.0 version) and GraphPad program (8.0 version).
The BDI and PSQI total score averages of individuals in the high dAGEs intake group were higher than the other groups, and this difference was statistically significant (p < 0.001). There is no significant difference between individuals' dAGEs intakes and energy and macronutrient intakes. Students' dAGEs intake was affected by BDI (β = 0.722, 95 % Cl = 0.639;0.811) and PSQI (β = 0.286, 95 % Cl = 0.179;0.431) scores (p < 0.001). This effect persisted even when various confounding factors were included (age, gender, smoking, body mass index, chronic disease) (p < 0.001).
These data are cross-sectional, which limits the generalizability of results and establishing cause-effect relationships.
There may be an association between dAGEs intake and the development of depression and sleep quality in young adults. Clinical intervention studies using objective measurement methods should be conducted on this issue in the future.
•The BDI score increased as the students' dietary advanced glycation end products increased.•There is a relationship between dietary advanced glycation end products and sleep quality.•The relationship between the feeding pattern and the development of depression is important.•It is important to take a nutritional anamnesis while investigating the secondary causes of the development of depression.
Abstract
Excessive accumulation of advanced glycation end products (AGEs) in the body has been associated with many adverse health conditions. The common point of the pathologies associated at this ...point is oxidative stress and inflammation. Pregnancy is an important period in which many physiological, psychological, and biological changes are experienced. Along with the physiological changes that occur during this period, the mother maintaining an AGE-rich diet may cause an increase in the body's AGE pool and may increase oxidative stress and inflammation, as seen in healthy individuals. Studies have reported the negative effects of maternal AGE levels on maternal and fetal health during pregnancy. Although gestational diabetes, preeclampsia, endothelial dysfunction, and pelvic diseases constitute maternal complications, a number of pathological conditions such as intrauterine growth retardation, premature birth, neural tube defect, neurobehavioral developmental disorders, fetal death, and neonatal asphyxia constitute fetal complications. It is thought that the mechanisms of these complications have not been confirmed yet and more clinical studies are needed on this subject. The possible effects of dietary AGE levels during pregnancy on maternal and fetal health are examined in this review.
Different functional foods with bioactive nutrients are being explored for the management of NAFLD. Whey proteins are rich in bioactive peptides and are suggested to show antioxidant and ...anti-inflammatory effects. We aim to test the hypothesis that the whey protein supplementation following a high fat-high fructose (HFHF) diet would protect against liver damage, inflammation, endotoxemia and steatosis in male Wistar rats. 36 rats were randomized into four groups for 8 weeks as the HFHF diet group, HFHF diet and whey protein isolate (WPI-200mg/kg/day) group (HFHF+WPI), control (C) group, and C+WPI (200mg/kg/day) group. Rats fed with a HFHF diet had higher final body weight compared to C and C+WPI groups (p = 0.002). Thus, WPI showed no significant effects for the body weight of rats with a HFHF diet. On the other hand, the HFHF+WPI group had significantly lower abdominal circumference when compared with the HFHF group (p<0,001). Higher serum CRP levels were observed in the groups with a HFHF diet (p<0,001) and WPI supplementation showed no effects on CRP levels. Whey protein supplementation resulted with lower total liver damage score in HFHF+WPI group compared with the HFHF diet group (p<0,001). Conversely, higher liver damage scores were observed with the C+WPI group compared to C group (p<0,001). HFHF diet resulted with higher expression of TLR-4 in the liver meanwhile WPI supplementation showed no effects on liver TLR-4 expression. We observed higher colon Occludin expression in HFHF+WPI and C+WPI groups compared with HFHF and C groups (p<0,001). Our results showed that, whey protein supplementation might help improve liver damage associated with a high fat-high fructose diet and increase the expression of Occludin in the small intestine and colon.
•BPA exposure were 0.0297 and 0.0507 μg/kg bw/d due to urine creatinine and excretion.•Dietary BPA intake values were 0.1009 and 0.9165 μg/kg bw/day due to 24-HDR and FFQ.•Exposure to BPA was within ...the EFSA's recommended daily intake (4 μg/kg bw/d).•The estimated BPA hazard ratio was within the international references' values.
Bisphenol A (BPA) is an artificial chemical, and one of the significant external routes of daily BPA exposure is diet. Dietary BPA exposure can be calculated by urinary BPA concentration and dietary recall data. This cross-sectional study investigates exclusively breastfeeding women's BPA exposure by urinary total BPA concentration and nutritional records, including the 24 h Dietary Recall (HDR) and Food Frequency Questionnaire (FFQ). In this study, we included exclusively breastfeeding, healthy women volunteers (n = 80; 18–40 years), collected spot-morning urine samples and conducted a comprehensive face-to-face survey. Moreover, the women's urine BPA concentration was adjusted according to their urine creatinine concentrations. We assessed dietary BPA intake with the 24HDR and FFQ. Estimated daily BPA exposure according to urinary output volume and urinary creatinine concentration median values were 0.0507 and 0.06 μg/kg bw/day, respectively. Moreover, dietary BPA daily intake was found to be 0.17 and 0.95 μg/kg bw/day according to 24HDR data and FFQ data. The milk and dairy product group’s and soft drinks group's contributions to the daily intake of BPA were 55.9 % and 25.92 %, respectively. The hazard ratio for BPA exposure was within limits according to references, including US EPA, Health Canada, and EFSA. This study indicates that BPA exposure, based on both total urinary BPA concentration and dietary recall data, was within the recommended daily intake level (4 μg/kg bw/day). However, further studies are required to understand the influence of seasonal, multicentre, and socioeconomic differences on BPA exposure.
Background: Osteopontin (OPN) is a glycosylated phosphoprotein found in human tissues and body fluids. OPN in breast milk is thought to play a major role in growth and immune system development in ...early infancy. Here, we investigated maternal factors that may affect concentrations of OPN in breast milk, and the possible associated consequences for the health of neonates. Methods: General characteristics, health status, dietary patterns, and anthropometric measurements of 85 mothers and their babies were recorded antenatally and during postnatal follow-up. Results: The mean concentration of OPN in breast milk was 137.1 ± 56.8 mg/L. Maternal factors including smoking, BMI, birth route, pregnancy weight gain, and energy intake during lactation were associated with OPN levels (p < 0.05). Significant correlations were determined between body weight, length, and head circumference, respectively, and OPN levels after one (r = 0.442, p = < 0.001; r = −0.284, p = < 0.001; r = −0.392, p = < 0.001) and three months (r = 0.501, p = < 0.001; r = −0.450, p = < 0.001; r = −0.498, p = < 0.001) of lactation. A negative relation between fever-related infant hospitalizations from 0–3 months and breast milk OPN levels (r = −0.599, p < 0.001) was identified. Conclusions: OPN concentrations in breast milk differ depending on maternal factors, and these differences can affect the growth and immune system functions of infants. OPN supplementation in infant formula feed may have benefits and should be further investigated.
This study was designed to investigate whether background music genre and volume can alter energy intake, short-term satiety, and mood states in women with normal body weight. Participants (N = 35) ...were tested using a randomized, crossover design consisting of five conditions: the control day on which no music was playing (CON), 60-dB Western classical (60 dB C), 80-dB Western classical (80 dB C), 60-dB rock (60 dB R), and 80-dB rock (80 dB R) music. The four music conditions were from 15 min before lunch and during an ad libitum lunch until the end of the meal. The participants were first asked to report visual analog scale (VAS) scores on sensory outcomes, lunch was served, and the energy intake of the individuals and their profile of mood states (POMS) were measured. Overall, mean VAS scores were similar between the groups on all of the test days (p > .05). Listening to different music genres and volumes did not exert a significant effect on energy intake (p > .05). The only mood state that differed significantly was confusion-bewilderment (p = .017). Neither music genre nor volume influence short-term energy intake and satiety-related VAS outcomes.
Bisphenol A (BPA) is a known endocrine disruptor and free BPA will interact with estrogen. BPA is also fat soluble and will therefore contaminate breast milk. The European Food Safety Authority has ...set a limit for temporary tolerable daily intake of 4 μg/kg body weight/day in breastfeeding infants. The aim of this study was to measure human milk BPA concentrations in Turkish women and thus exclusively breastfed infants’ exposure to BPA.
Healthy, postnatal, exclusively breastfeeding women were recruited and breast milk samples were collected. Free BPA concentration was analyzed in the milk samples using competitive enzyme-linked immunosorbent assay. Participants’ demographic characteristics and nutritional habits were investigated through face-to-face interviews using a detailed questionnaire.
Eighty women participated. Median milk free BPA level was 0.63 μg/L. There was no statistically significant association between maternal body mass index, birth type, parity, infant birth week, infant birth weight, and human milk BPA concentration. Nevertheless, there was a significant association between human milk BPA level and consumption of fast-food and carbonated drinks (p=0.022 and p=0.018, respectively). Exclusively breastfed infants’ mean BPA exposure was 0.0099±0.0079 μg/kg bw/day. There was a moderate negative significant correlation between infant BPA exposure and infant current body weight (r=0.327, p=0.003).
BPA exposure in exclusively breastfed infants was within accepted limits and the current dietary exposure level of infants in this cohort was safe.
The aim of this study was to determine the fatty acid composition and trans fatty acid and fatty acid contents of breast milk in Turkish women and to find the effect of breastfeeding mothers' diet on ...trans fatty acid and fatty acid composition. Mature milk samples obtained from 50 Turkish nursing women were analyzed. Total milk lipids extracts were transmethylated and analyzed by using gas liquid chromatography to determine fatty acids contents. A questionnaire was applied to observe eating habits and 3 days dietary records from mothers were obtained. Daily dietary intake of total energy and nutrients were estimated by using nutrient database. The mean total trans fatty acids contents was 2.13 ± 1.03%. The major sources of trans fatty acids in mothers' diets were margarines-butter (37.0%), bakery products and confectionery (29.6%). Mothers who had high level of trans isomers in their milk consumed significantly higher amounts of these products. Saturated fatty acids, polyunsaturated fatty acids and monounsaturated fatty acids of human milk constituted 40.7 ± 4.7%, 26.9 ± 4.2% and 30.8 ± 0.6% of the total fatty acids, respectively. The levels of fatty acids in human milk may reflect the current diet of the mother as well as the diet consumed early in pregnancy. Margarines, bakery products and confectionery are a major source of trans fatty acids in maternal diet in Turkey.
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