When a quantum state is subjected to frequent measurements, the time evolution of the quantum state is frozen. This is called the quantum Zeno effect. Here, we observe such an effect by performing ...frequent discrete measurements in a macroscopic quantum system, a superconducting quantum bit. The quantum Zeno effect induced by discrete measurements is similar to the original idea of the quantum Zeno effect. By using a Josephson bifurcation amplifier pulse readout, we have experimentally suppressed the time evolution of Rabi oscillation using projective measurements, and also observed the enhancement of the quantum state holding time by shortening the measurement period time. This is a crucial step to realize quantum information processing using the quantum Zeno effect.
F-box and WD repeat domain-containing 7 (FBXW7) is a cell cycle regulatory gene whose protein product ubiquitinates positive cell cycle regulators such as c-Myc, cyclin E, and c-Jun, thereby acting ...as a tumour-suppressor gene. This study focused on microRNA-223 (miR-223), which is a candidate regulator of FBXW7 mRNA. The aim of this study was to clarify the clinical significance of miR-223 and FBXW7 in oesophageal squamous cell carcinoma (ESCC) patients, and to elucidate the mechanism by which FBXW7 is regulated by miR-223.
The expression levels of miR-223 and the expression of FBXW7 protein was examined using 109 resected specimens to determine the clinicopathological significance. We also investigated the role of miR-223 in the regulation of FBXW7 expression in ESCC cell lines in an in vitro analysis.
We found that miR-223 expression was significantly higher in cancerous tissues than in the corresponding normal tissues. There was a significant inverse relationship between the expression levels of miR-223 and FBXW7 protein. Moreover, patients with high miR-223 expression demonstrated a significantly poorer prognosis than those with low expression. On the basis of a series of gain-of-function and loss-of-function studies in vitro, we identified FBXW7 as a functional downstream target of miR-223.
Our present study indicates that high expression of miR-223 had a significant adverse impact on the survival of ESCC patients through repression of the function of FBXW7.
Abstract Background We conducted a randomized controlled trial (JCOG0212) to determine whether the outcome of mesorectal excision (ME) alone for rectal cancer is not inferior to that of ME with ...lateral lymph node dissection (LLND). The present study focused on male sexual dysfunction after surgery. Method ology: Eligibility criteria included clinical stage II/III rectal cancer, the lower margin of the lesion below the peritoneal reflection, the absence of lateral pelvic lymph node enlargement, and no preoperative radiotherapy. After confirmation of R0 resection by ME, patients were intraoperatively randomized. Questionnaires using the International Index of Erectile Function (IIEF-5) about the sexual function of men were collected before and 1 year after surgery. Sexual dysfunction incidence was defined as the ratio of patients showing sexual dysfunction after surgery relative to the number who had no erectile dysfunction before surgery. Results Among 701 patients enrolled between June 2003 and August 2010, 472 males were included. Among them, 343 (73%) completed preoperative and postoperative questionnaires. According to the study protocol, the incidences of sexual dysfunction in patients who underwent ME alone and ME with LLND were 68% (17/25; 95%CI, 47%–85%) and 79% (23/29; 95%CI, 60%–92%), respectively (p = 0.37). Incidences of sexual dysfunction in patients with no or only mild erectile dysfunction before surgery who underwent ME alone and ME with LLND were 59% (48/81) and 71% (67/95), respectively (p = 0.15). Multivariate analysis identified age as the only risk factor for sexual dysfunction after surgery (p = 0.02). Conclusions LLND may not increase sexual dysfunction incidence after rectal cancer surgery. This incidence is associated with increased age. This trial is registered with ClinicalTrials.gov, number NCT00190541 and University Hospital Medical Information Network Clinical Trials Registry, number C000000034.
We investigate the origin of the fine structure of the energy spectrum of precipitating electrons for the pulsating aurora (PsA) observed by the low‐altitude Reimei satellite. The Reimei satellite ...achieved simultaneous observations of the optical images and precipitating electrons of the PsA from satellite altitude (~620 km) with resolution of 40 ms. The main modulation of precipitation, with a few seconds, and the internal modulations, with a few hertz, that are embedded inside the main modulations are identified above ~3 keV. Moreover, stable precipitations at ~1 keV are found for the PsA. A “precipitation gap” is discovered between two energy bands. We identify the origin of the fine structure of the energy spectrum for the precipitating electrons using the computer simulation on the wave‐particle interaction between electrons and chorus waves. The lower band chorus (LBC) bursts cause the main modulation of energetic electrons, and the generation and collapse of the LBC bursts determines on‐off switching of the PsA. A train of rising tone elements embedded in the LBC bursts drives the internal modulations. A close set of upper band chorus (UBC) waves causes the stable precipitations at ~1 keV. We show that a wave power gap around the half gyrofrequency at the equatorial plane in the magnetosphere between LBC and UBC reduces the loss rate of electrons at the intermediate energy range, forming a gap of precipitating electrons in the ionosphere.
Key Points
Fine structure of energy spectrum of pulsating aurora electrons
Two different populations coexisted in the precipitating electrons
Simulation reproduces the fine structure of the energy spectrum
We investigated low-latitude ionospheric scintillation in Indonesia using two GPS receivers installed at Bandung (107.6° E, 6.9° S; magnetic latitude 17.5° S) and Pontianak (109.3° E, 0.02° S; ...magnetic latitude 8.9° S). This study aimed to characterise climatological and directional ionospheric scintillation occurrences, which are useful not only for the physics of ionospheric irregularities but also for practical use in GNSS (global navigation satellite system)-based navigation. We used the deployed instrument's amplitude scintillation (S4 index) data from 2009, 2010, and 2011; the yearly SSN (sunspot-smoothed numbers) were 3.1, 16.5, and 55.9, respectively. In summary, (1) scintillation occurrences in the post-sunset period (18:00-01:00 LT) during equinox months (plasma bubble season) at the two sites can be ascribed to the plasma bubble; (2) using directional analyses of the two sites, we found that the distribution of scintillation occurrences is generally concentrated between the two sites, indicating the average location of the EIA (equatorial ionisation anomaly) crest; (3) scintillation occurrence enhancements for the two sites in field-aligned directions are herein reported for the first time by ground-based observation in a low-latitude region; (4) distribution of scintillation occurrences at Pontianak are concentrated in the southern sky, especially in the southwest direction, which is very likely associated with the plasma bubble tilted westward with increasing latitude; and (5) scintillation occurrence in the post-midnight period in the non-plasma-bubble season is the most intriguing variable occurring between the two sites (i.e. post-midnight scintillations are observed more at Bandung than Pontianak). Most of the post-midnight scintillations observed at Bandung are concentrated in the northern sky, with low elevation angles. This might be due to the amplitude of irregularities in certain directions, which may be effectively enhanced by background density enhancement by the EIA and because satellite-receiver paths are longer in the EIA crest region and in a field-aligned direction.
Nano-structured silicon is an attractive alternative anode material to conventional graphite in lithium-ion batteries. However, the anode designs with higher silicon concentrations remain to be ...commercialized despite recent remarkable progress. One of the most critical issues is the fundamental understanding of the lithium-silicon Coulombic efficiency. Particularly, this is the key to resolve subtle yet accumulatively significant alterations of Coulombic efficiency by various paths of lithium-silicon processes over cycles. Here, we provide quantitative and qualitative insight into how the irreversible behaviors are altered by the processes under amorphous volume changes and hysteretic amorphous-crystalline phase transformations. Repeated latter transformations over cycles, typically featured as a degradation factor, can govern the reversibility behaviors, improving the irreversibility and eventually minimizing cumulative irreversible lithium consumption. This is clearly different from repeated amorphous volume changes with different lithiation depths. The mechanism behind the correlations is elucidated by electrochemical and structural probing.
Relativistic electron microbursts, which are bursty enhancements of the precipitation of relativistic electrons, are often observed by low‐altitude satellite measurements. These microbursts are ...likely to play an important role in high‐energy electron flux loss in the outer radiation belt. Some observations suggest that whistler chorus waves are a cause of relativistic electron microbursts. First, we derived the relativistic time of flight model considering the propagation of whistler mode waves, and then investigated characteristics of the precipitations. We found that relativistic electron precipitation has a positive energy dispersion at low altitude. The duration of electron precipitation by one whistler chorus element decreases when the energy of the precipitated electrons is increased. We then performed three‐dimensional test particle simulation with a newly developed wave‐particle interaction model using realistic plasma parameters in the inner magnetosphere. The test particle simulation showed for the first time that the resonant interactions with whistler chorus elements at high‐latitudes produce bursty enhancements of relativistic electron precipitation, thus confirming the results of the TOF analysis. A few Hz modulations are embedded in the precipitating electron flux variations, which is associated with the repetition period of the whistler chorus elements. The simulation results indicate that microbursts of relativistic electrons of the outer belt are caused by chorus wave‐particle interactions at high latitudes and a series of rising tone elements of chorus waves produce a few Hz modulation of microbursts observed by the SAMPEX satellite.
Key Points
Newly developed GEMSIS‐RBW code that can solve wave‐particle interactions
Energy dispersion of relativistic electron precipitations derived from TOF model
A few Hz modulation of microbursts associated with whistler chorus emissions
Electronic and structural properties of a 3D carbon allotrope made of Hopf-linked graphenes, which we call a Hopfene - a type of topological crystal, are examined by semi-empirical molecular-orbital ...and density-functional-theoretical methods, where band-structure analyses reveal very different properties from those of 2D graphenes. Furthermore, the analyses give an interesting finding that, depending on graphene-sheet spacings, Hopfenes exhibit different band features between primary-type Hopfene with a finite minimum sheet spacing and secondary type with its double-sized spacing. The primary type shows semi-metallic nature and the secondary type exhibits semi-metallic or semiconducting nature at different bands and also has flat bands; these conducting features can be utilised by Fermi-level control. A device application of Hopfenes is also provided.
The idea behind multimetric indices is to integrate information from several metrics to provide a general classification of water bodies without losing the particularities of each individual metric. ...Historically, multimetric indices use information on richness, taxon sensitivity, and taxonomic diversity. Recently, functional and phylogenetic diversity proved to capture different dimensions of biodiversity. Here we asked if these new metrics provide complementary information to classical metrics and should be included in multimetric indices. We used an index construction protocol based on statistical filters to test candidate metrics for range, sensitivity, and redundancy. We used macroinvertebrate data from streams located in a Savanna region of Brazil, encompassing a gradient of impact, to test our ideas. Of 41 candidate metrics, functional dispersion of functional diversity, mean nearest neighbor distance of phylogenetic diversity, and four classical metrics passed the filter selection composing the final multimetric index. Our results indicated that functional and phylogenetic diversity metrics indeed responded to environmental impact and complemented the information provided by classical metrics. We suggest that future indices should consider including new metrics of functional and phylogenetic diversity to properly monitor multiple dimensions of biodiversity.
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