We have collected four cases of supergiant cerebral aneurysm, each greater than 6.0 cm in diameter. Two of these cases were saccular aneurysms of the anterior communicating artery and middle cerebral ...artery, of which the necks were clipped with resection of the aneurysms. Another patient had a fusiform aneurysm of the middle cerebral artery, which was resected accompanied by a reconstructive procedure of cerebral blood flow. The last patient had a fusiform aneurysm of the internal carotid artery. Following internal carotid artery occlusion surgery with superficial temporal artery-middle cerebral artery anastomosis, the aneurysm completely disappeared radiologically within several months.
Cyproheptadine administration has been demonstrated to stimulate appetite. Our previous report demonstrated a depression of blood glucose by cyproheptadine irrespective of circulating insulin level ...in rats. The aim of the present study is to determine the effect of cyproheptadine on blood glucose, serum insulin and serum growth hormone level during, 1) the standard oral glucose tolerance test (OGTT), and during 2) the intravenous glucose tolerance test (IVGTT). The subjects were seven apparently healthy males without family history of diabetes, aged from 23 to 25. Blood samples were drawn from the cubital vein before, and 30, 60, 90, and 120 minutes after oral administration of 50g of glucose. In IVGTT, blood samples were collected before and at 3, 5, 7, 10 minutes and after every ten minute interval until 60 minutes. Time was counted zero at the start of the intravenous injection of 10 g of glucose in 50% aqueous solution. After examining all seven subjects with OGTT and IVGTT to obtain control values, cyproheptadine 8mg per day in tablet form, was administered for seven to ten days until the other OGTT and IVGTT were completed. Results obtained are as follows. Blood glucose levels in subjects under cyproheptadine treatment during OGTT were lower than those of controls. Differences of glucose levels were significant in 60 minutes and 90 minutes during OGTT. Changes in insulin levels, however, in OGTT after administration of cyproheptadine were minimum. 5 subjects on cyproheptadine had serum growth hormone levels lower than the controls in OGTT, but the differences were not significant. In IVGTT cyproheptadine had no effect on serum insulin levels. However, glucose disappearance ratio (K-value) in IVGTT was 1.7±0.1 for the control and 2.6±0.4 for cases with cyproheptadine treatment (p<0.05). These results in combination with our previous report may indicate enhancement of blood glucose utilisation in peripheral tissues irrespective of change in circulating insulin levels in man. The next suggestion from the present study is that cyproheptadine has no effect on the insulin secretory response of the B cell of the islet of Langerhans during IVGTT in which the effect of the gut factor is neglected and insulinogenesis is a result of a direct hyperglycemic stimulus on the B cell.
Digital VIT Signal Generator Naitoh, Hiroshi; Saitoh, Seiichi; Ikeda, Sadayuki ...
The Journal of the Institute of Television Engineers of Japan,
1976, Letnik:
30, Številka:
2
Journal Article
Perinatal and postnatal study of sodium colistin methanesulfonate (CLM) was performed with Wistar strain rats. The dams were given CLM intravenously at doses of 6.25mg, 12.5mg and 25mg/kg from dary ...17 of gestation to the 21st day post partum. Results were given as follows; 1. CLM did not affect general condition, maternal body weight and food consumption in the dams. 2. There was no significant difference between the CLM treated groups and the control group in duration of pregnancy, number of newborns, number of liveborns, number of stillborns, sex ratio and weight of liveborns at delivery. Moreover, no external malformations of liveborns were observed in any treated group. 3. CLM did not affect delivery rate or nursing rate. 4. CLM did not affect postnatal growth, development and differentiation in newborn rats. 5. CLM did not affect postnatal behavior, sensational reflex, spontaneous activity, nerve-muscle ability, learning ability, emotional pattern and reproductive ability in newborn rats. It can be concluded that CLM does not influence the health of dams and postnatal development of their offspring. In this study, the maximum non-effect dose of CLM was 25 mg/kg in rats.
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