A model with fermion and scalar fields charged under a Peccei–Queen (PQ) symmetry is proposed. The PQ charges are chosen in such a way that they can reproduce mass matrices with five texture zeros, ...which can generate the fermion masses, the CKM matrix, and the PMNS matrix of the Standard Model (SM). To obtain this result, at least 4 Higgs doublets are needed. As we will see in the manuscript this is a highly non-trivial result since the texture zeros of the mass matrices impose a large number of restrictions. This model shows a route to understand the different scales of the SM by extending it with a multi-Higgs sector and an additional PQ symmetry. Since the PQ charges are not universal, the model predicts flavor-changing neutral currents (FCNC) at the tree level, a feature that constitutes the main source of restrictions on the parameter space. We report the allowed regions by lepton decays and compare them with those coming from the semileptonic decays
K
±
⟶
π
ν
¯
ν
. We also show the excluded regions and the projected bounds of future experiments for the axion–photon coupling as a function of the axion mass and compare it with the parameter space of our model.
Using a conventional bi-planar turbulence-generating grid, we confirm the recent findings (Valente & Vassilicos, Phys. Rev. Lett., vol. 108, 2012, art. 214503) that show there is a turbulence decay ...region close to the generating grid that departs from the ‘classical’ turbulence decay (Comte-Bellot & Corrsin, J. Fluid Mech., vol. 25, 1966, pp. 657–682). In this ‘near-field’ region, the turbulence energy decays more rapidly than in the far-field and it exhibits unusual scaling properties. Based on the velocity decay laws, we show that for our conventional grid, the near-field extends from
$\def \xmlpi #1{}\def \mathsfbi #1{\boldsymbol {\mathsf {#1}}}\let \le =\leqslant \let \leq =\leqslant \let \ge =\geqslant \let \geq =\geqslant \def \Pr {\mathit {Pr}}\def \Fr {\mathit {Fr}}\def \Rey {\mathit {Re}}x/M \sim 6$
to
$x/M \sim 12$
where
$x$
is the downstream distance from the grid and
$M$
is the mesh size. This corresponds to
$1.1 \le x/x* \le 2.3$
where
$x*$
is the wake interaction length scale (Mazellier & Vassilicos, Phys. Fluids, vol. 22, 2010, art. 075101). However, other statistics (velocity derivatives and length-scale ratios) indicate that the extent of the initial period depends on the grid mesh Reynolds number,
$R_M$
, extending further for higher values of
$R_M$
. In the near-field the turbulence approaches isotropy both at the large and small scales but there still is inhomogeneity in the derivative statistics. The derivative skewness also departs from values observed at comparable Reynolds numbers in the far-field decay region, and in other turbulent flows at comparable Reynolds numbers. Two values of
$R_M$
were studied:
$42 \times 10^3$
and
$76 \times 10^3$
.
The Canary Islands' indigenous people have been the subject of substantial archaeological, anthropological, linguistic and genetic research pointing to a most probable North African Berber source. ...However, neither agreement about the exact point of origin nor a model for the indigenous colonization of the islands has been established. To shed light on these questions, we analyzed 48 ancient mitogenomes from 25 archaeological sites from the seven main islands. Most lineages observed in the ancient samples have a Mediterranean distribution, and belong to lineages associated with the Neolithic expansion in the Near East and Europe (T2c, J2a, X3a…). This phylogeographic analysis of Canarian ancient mitogenomes, the first of its kind, shows that some lineages are restricted to Central North Africa (H1cf, J2a2d and T2c1d3), while others have a wider distribution, including both West and Central North Africa, and, in some cases, Europe and the Near East (U6a1a1, U6a7a1, U6b, X3a, U6c1). In addition, we identify four new Canarian-specific lineages (H1e1a9, H4a1e, J2a2d1a and L3b1a12) whose coalescence dates correlate with the estimated time for the colonization of the islands (1st millennia CE). Additionally, we observe an asymmetrical distribution of mtDNA haplogroups in the ancient population, with certain haplogroups appearing more frequently in the islands closer to the continent. This reinforces results based on modern mtDNA and Y-chromosome data, and archaeological evidence suggesting the existence of two distinct migrations. Comparisons between insular populations show that some populations had high genetic diversity, while others were probably affected by genetic drift and/or bottlenecks. In spite of observing interinsular differences in the survival of indigenous lineages, modern populations, with the sole exception of La Gomera, are homogenous across the islands, supporting the theory of extensive human mobility after the European conquest.
Undermining Colombia's peace and environment Salazar, Alejandro; Salazar, Juan F.; Sánchez-Pacheco, Santiago J. ...
Science (American Association for the Advancement of Science),
07/2021, Letnik:
373, Številka:
6552
Journal Article
The endosomal Toll-like receptors （TLRs） TLR3, TLR7, TLR8 and TLR9 are important in sensing foreign nucleic acids encountered by phagocytes. Because TLR8 was initially thought to be non-functional in ...mice, less is known about TLR8 than the genetically and functionally related TLR7. Originally associated with the recognition of single-stranded RNA of viral origin, there is now evidence that human TLR8 is also able to sense bacterial RNA released within phagosomal vacuoles, inducing the production of both nuclear factor （NF）-κB-dependent cytokines and type I interferons （IFNs）, such as IFN-β. The functions of TLR8 extend beyond the recognition of foreign pathogens and include cross-talk with other endosomal TLRs, a process that may also have a role in the generation of autoimmunity.
Flavored axions and the flavor problem Giraldo, Yithsbey; Martinez, R.; Rojas, Eduardo ...
The European physical journal. C, Particles and fields,
12/2022, Letnik:
82, Številka:
12
Journal Article
Recenzirano
Odprti dostop
A Peccei-Quinn (PQ) symmetry is proposed, in order to generate in the Standard Model (SM) quark sector a realistic mass matrix ansatz with five texture-zeros. Limiting our analysis to Hermitian mass ...matrices we show that this requires a minimum of 4 Higgs doublets. This model allows assigning values close to 1 for several Yukawa couplings, giving insight into the origin of the mass scales in the SM. Since the PQ charges are non-universal the model features Flavor-Changing Neutral Currents (FCNC) at the tree level. From the analytical expressions for the FCNC we report the allowed region in the parameter space obtained from the measurements of branching ratios of semileptonic meson decays.
Connexins (Cxs) are a family of 21 protein isoforms, eleven of which are expressed in the central nervous system, and they are found in neurons and glia. Cxs form hemichannels (connexons) and ...channels (gap junctions/electric synapses) that permit functional and metabolic coupling between neurons and astrocytes. Altered Cx expression and function is involved in inflammation and neurological diseases. Cxs-based hemichannels and channels have a relevance to seizures and epilepsy in two ways: First, this pathological condition increases the opening probability of hemichannels in glial cells to enable gliotransmitter release, sustaining the inflammatory process and exacerbating seizure generation and epileptogenesis, and second, the opening of channels favors excitability and synchronization through coupled neurons. These biological events highlight the global pathological mechanism of epilepsy, and the therapeutic potential of Cxs-based hemichannels and channels. Therefore, this review describes the role of Cxs in neuroinflammation and epilepsy and examines how the blocking of channels and hemichannels may be therapeutic targets of anti-convulsive and anti-epileptic treatments.
Recent in vitro evidence indicates that astrocytes can modulate synaptic plasticity by releasing neuroactive substances (gliotransmitters). However, whether gliotransmitter release from astrocytes is ...necessary for higher brain function in vivo, particularly for memory, as well as the contribution of connexin (Cx) hemichannels to gliotransmitter release, remain elusive. Here, we microinfused into the rat basolateral amygdala (BLA) TAT‐Cx43L2, a peptide that selectively inhibits Cx43‐hemichannel opening while maintaining synaptic transmission or interastrocyte gap junctional communication. In vivo blockade of Cx43 hemichannels during memory consolidation induced amnesia for auditory fear conditioning, as assessed 24 h after training, without affecting short‐term memory, locomotion, or shock reactivity. The amnesic effect was transitory, specific for memory consolidation, and was confirmed after microinfusion of Gap27, another Cx43‐hemichannel blocker. Learning capacity was recovered after coinfusion of TAT‐Cx43L2 and a mixture of putative gliotransmitters (glutamate, glutamine, lactate, d‐serine, glycine, and ATP). We propose that gliotransmitter release from astrocytes through Cx43 hemichannels is necessary for fear memory consolidation at the BLA. Thus, the present study is the first to demonstrate a physiological role for astroglial Cx43 hemichannels in brain function, making these channels a novel pharmacological target for the treatment of psychiatric disorders, including post‐traumatic stress disorder.—Stehberg, J., Moraga‐Amaro, R., Salazar, C., Becerra, A., Echeverría, C., Orellana, J. A., Bultynck, G., Ponsaerts, R., Leybaert, L., Simon, F., Sáez, J. C., Retamal, M. A. Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala. FASEB J. 26, 3649–3657 (2012). www.fasebj.org
Cerebrospinal fluid opening pressure values are associated with various neurologic diseases; however, numerous factors can modify this measurement. This study aims to describe factors related to ...modifications in opening pressure measurements in pediatric patients. Methods: A retrospective analysis of lumbar punctures in pediatric patients conducted by the neuropediatrics group with institutional standardization. Bivariate and linear regression analyses were performed to determine the association between opening pressure and variables included in the study. Results: 544 events, median age 107 months, median opening pressure 19.7 cm H2O. Bivariate analysis found no association with medication use; anesthetics that increased opening pressure were remifentanil (P = .02) and propofol (P = .05), along with a positive linear correlation between opening pressure and age (P < .0001). Multiple linear regression analysis revealed that age, BMI, male gender, and remifentanil use were associated with an increase in opening pressure, whereas corticosteroid withdrawal was associated with a reduction in opening pressure. There is an interaction between age and headache, with an association with increased opening pressure up to around 140 months. Conclusion: This study identifies factors associated with changes in opening pressure, crucial for estimating normal opening pressure values in children. Headaches, anesthetic use, and corticosteroid withdrawal are confirmed as significant factors.
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