We highlight the progress, current status, and open challenges of QCD-driven physics, in theory and in experiment. We discuss how the strong interaction is intimately connected to a broad sweep of ...physical problems, in settings ranging from astrophysics and cosmology to strongly coupled, complex systems in particle and condensed-matter physics, as well as to searches for physics beyond the Standard Model. We also discuss how success in describing the strong interaction impacts other fields, and, in turn, how such subjects can impact studies of the strong interaction. In the course of the work we offer a perspective on the many research streams which flow into and out of QCD, as well as a vision for future developments.
A tax of one-Mexican peso per liter of sugar-sweetened beverage (SSB) came into effect in January 2014 in Mexico as a national health policy to tackle the high overweight and obesity prevalence. ...Previous studies have shown an overall reduction in SSB purchases after the tax implementation. However, it remains unknown whether and to what extent SSB consumers switched to cheaper taxed beverages, attenuating the potential effect of the policy. Our study's objective was to estimate changes in household purchases of taxed SSBs by tertiles of SSB prices (low, middle, and high) in urban areas after the SSB tax implementation in 2014.
Based on purchase data for 2012-2015 from households living in 54 Mexican cities with a population > 50,000 inhabitants, we calculated unit-value SSB prices for the full period and sorted them on a monthly basis to create monthly price tertiles. We merged these price tertiles to household purchases and created average monthly ml/capita/day SSB purchases by price tertile at the city level. We assessed SSB purchase switching patterns before and after the tax implementation through price-tertile stratified linear models. The main variable in the models was a dummy indicator that allowed us to identify the pre-tax period (2012-13) and post-tax period (2014-15). We controlled our models for time trends and contextual economic variables.
In the regression adjusted models, we found a statistically significant purchase reduction ranging between 10.80 and 13.79 ml/capita/day (p-value < 0.001) across taxed beverages from the middle-price SSB after the tax implementation. We observed no statistically significant reductions in purchases of low-price SSBs and high-price SSBs.
Our findings show purchase reductions in the middle-price SSBs, which represents ≈30% of the overall SSB purchases in urban Mexico. Future studies should be conducted to test if the redesign of the current the tax, by either doubling the tax amount or taxing sugar content, might reduce more effectively purchases across all SSBs.
In the liver, clock genes are proposed to drive metabolic rhythms. These gene rhythms are driven by the suprachiasmatic nucleus (SCN) mainly by food intake and via autonomic and hormonal pathways. ...Forced activity during the normal rest phase, induces also food intake, thus neglecting the signals of the SCN, leading to conflicting time signals to target tissues of the SCN. The present study explored in a rodent model of night-work the influence of food during the normal sleep period on the synchrony of gene expression between clock genes and metabolic genes in the liver. Male Wistar rats were exposed to forced activity for 8 h either during the rest phase (day) or during the active phase (night) by using a slow rotating wheel. In this shift work model food intake shifts spontaneously to the forced activity period, therefore the influence of food alone without induced activity was tested in other groups of animals that were fed ad libitum, or fed during their rest or active phase. Rats forced to be active and/or eating during their rest phase, inverted their daily peak of Per1, Bmal1 and Clock and lost the rhythm of Per2 in the liver, moreover NAMPT and metabolic genes such as Pparα lost their rhythm and thus their synchrony with clock genes. We conclude that shift work or food intake in the rest phase leads to desynchronization within the liver, characterized by misaligned temporal patterns of clock genes and metabolic genes. This may be the cause of the development of the metabolic syndrome and obesity in individuals engaged in shift work.
Coastal areas, and thus coastal species, are at increasing risk from human activities. Sections of the coastline of Western Australia are undergoing intense coastal development to fulfil commercial, ...industrial, and recreational requirements. Multiple populations of bottlenose dolphins (
Tursiops aduncus
) occur around this coastline; however, small community sizes and limited genetic exchange rates make them susceptible to anthropogenic pressure. This study investigated the occupancy of dolphins within the Swan–Canning Rivers, an urbanised estuary, with regard to (1) presence/absence, (2) abundance, and (3) duration in terms of time spent in the area. These response variables were related back to environmental conditions (tidal state, tidal height, salinity, temperature), vessel traffic, and dredging activities using generalised additive modelling. Theodolite tracking data revealed high levels of boat traffic at the two sites considered; however, dolphin occurrence was only negatively affected by vessel density at one of these sites. Dolphin occupancy was also significantly influenced by temperature, with possible seasonal effects. No dolphins were sighted on days when backhoe dredging was present; however, low sample sizes limited statistical interpretation. These results highlight the need to consider context in behavioural response studies, in terms of habitat type studied, explanatory variables considered, and response variables selected.
This work presents a new methodology for density prediction of petroleum and derivatives for products' monitoring application. The approach is based on pulse height distribution pattern recognition ...by means of an artificial neural network (ANN). The detection system uses appropriate broad beam geometry, comprised of a 137Cs gamma-ray source and a NaI(Tl) detector diametrically positioned on the other side of the pipe in order measure the transmitted beam. Theoretical models for different materials have been developed using MCNP-X code, which was also used to provide training, test and validation data for the ANN. 88 simulations have been carried out, with density ranging from 0.55 to 1.26gcm−3 in order to cover the most practical situations. Validation tests have included different patterns from those used in the ANN training phase. The results show that the proposed approach may be successfully applied for prediction of density for these types of materials. The density can be automatically predicted without a prior knowledge of the actual material composition.
•The approach is based on pulse height distributions pattern recognition by means of ANN.•Theoretical models for different materials have been developed using MCNP-X code.•The fluid's density can be predicted without knowledge of the material composition.•The detection system uses a 137Cs gamma-ray source and a NaI(Tl) detector in order calculate transmitted beam.
Geographical barriers like mountain ranges impede genetic exchange among populations, promoting diversification. The effectiveness of these barriers in limiting gene flow varies between lineages due ...to each species' dispersal modes and capacities. Our understanding of how the Andes orogeny contributes to species diversification comes from well‐studied vertebrates and a few arthropods and plants, neglecting organisms unable to fly or walk long distances. Some arachnids, such as Gasteracantha cancriformis, have been hypothesized to disperse long distances via ballooning (i.e. using their silk to interact with the wind). Yet, we do not know how the environment and geography shape its genetic diversity. Therefore, we tested whether the Andes contributed to the diversification of G. cancriformis acting as an absolute or semi‐permeable barrier to genetic connectivity between populations of this spider at opposite sides of the mountain range. We sampled thousands of loci across the distribution of the species and implemented population genetics, phylogenetic, and landscape genetic analyses. We identified two genetically distinct groups structured by the Central Andes, and a third less structured group in the Northern Andes that shares ancestry with the previous two. This structure is largely explained by the altitude along the Andes, which decreases in some regions, possibly facilitating cross‐Andean dispersal and gene flow. Our findings support that altitude in the Andes plays a major role in structuring populations in South America, but the strength of this barrier can be overcome by organisms with long‐distance dispersal modes together with altitudinal depressions.
Resumen
Las barreras geográficas como las cordilleras montañosas impiden el intercambio genético entre poblaciones, promoviendo la diversificación. La efectividad de estas barreras para limitar el flujo genético varía entre linajes debido a los modos y capacidades de dispersión de cada especie. Nuestra comprensión de cómo la orogenia de los Andes contribuye a la diversificación de especies proviene de vertebrados y algunos artrópodos y plantas bien estudiados, descuidando a los organismos incapaces de volar o caminar grandes distancias. Se ha hipotetizado que algunas arañas, como Gasteracantha cancriformis, se dispersan a grandes distancias mediante la técnica de “ballooning” (es decir, utilizando su seda para interactuar con el viento). Sin embargo, no sabemos cómo el entorno y la geografía han dado forma a su diversidad genética. Por lo tanto, probamos si los Andes contribuyeron a la diversificación de G. cancriformis actuando como una barrera absoluta o permeable para la conectividad genética entre poblaciones de esta araña en lados opuestos de la cordillera. Muestreamos miles de loci a través de la distribución de la especie e implementamos análisis de genética de poblaciones, filogenéticos y de genética del paisaje. Identificamos dos grupos genéticamente distintos estructurados por los Andes Centrales, y un tercer grupo menos estructurado en los Andes del Norte que comparte ascendencia con los dos anteriores. Esta estructura se explica en gran medida por la altitud a lo largo de los Andes, que disminuye en algunas regiones, posiblemente facilitando la dispersión y el flujo genético a través de los Andes. Nuestros hallazgos apoyan que la altitud en los Andes juega un papel importante en la estructuración de las poblaciones en América del Sur, pero la fuerza de esta barrera puede ser superada por organismos con modos de dispersión a larga distancia junto con depresiones altitudinales.
Regulatory T (Treg) cells control self-tolerance, inflammatory responses and tissue homeostasis. In mature Treg cells, continued expression of FOXP3 maintains lineage identity, while T cell receptor ...(TCR) signaling and interleukin-2 (IL-2)/STAT5 activation support the suppressive effector function of Treg cells, but how these regulators synergize to control Treg cell homeostasis and function remains unclear. Here we show that TCR-activated posttranslational modification by O-linked N-Acetylglucosamine (O-GlcNAc) stabilizes FOXP3 and activates STAT5, thus integrating these critical signaling pathways. O-GlcNAc-deficient Treg cells develop normally but display modestly reduced FOXP3 expression, strongly impaired lineage stability and effector function, and ultimately fatal autoimmunity in mice. Moreover, deficiency in protein O-GlcNAcylation attenuates IL-2/STAT5 signaling, while overexpression of a constitutively active form of STAT5 partially ameliorates Treg cell dysfunction and systemic inflammation in O-GlcNAc deficient mice. Collectively, our data demonstrate that protein O-GlcNAcylation is essential for lineage stability and effector function in Treg cells.
This study presents a method based on gamma-ray densitometry using only one multilayer perceptron artificial neural network (ANN) to identify flow regime and predict volume fraction of gas, water, ...and oil in multiphase flow, simultaneously, making the prediction independent of the flow regime. Two NaI(Tl) detectors to record the transmission and scattering beams and a source with two gamma-ray energies comprise the detection geometry. The spectra of gamma-ray recorded by both detectors were chosen as ANN input data. Stratified, homogeneous, and annular flow regimes with (5 to 95%) various volume fractions were simulated by the MCNP6 code, in order to obtain an adequate data set for training and assessing the generalization capacity of ANN. All three regimes were correctly distinguished for 98% of the investigated patterns and the volume fraction in multiphase systems was predicted with a relative error of less than 5% for the gas and water phases.
•Flow regime information can be used to improve measurement accuracy in the volumetric fluid fraction.•Only one MLP artificial neural network was used to identify flow regime and predict volume fraction of gas, water, and oil.•Volume fractions are predicted independently of the flow regime using gamma-rays with a relative error below 5%.•Stratified, homogeneous, and annular flow regimes were simulated by the MCNP6 code.•Stratified, annular and homogeneous flow regimes were correctly distinguished for 98%.
We report on the measurement of the γp→J/ψp cross section from E_{γ}=11.8 GeV down to the threshold at 8.2 GeV using a tagged photon beam with the GlueX experiment. We find that the total cross ...section falls toward the threshold less steeply than expected from two-gluon exchange models. The differential cross section dσ/dt has an exponential slope of 1.67±0.39 GeV^{-2} at 10.7 GeV average energy. The LHCb pentaquark candidates P_{c}^{+} can be produced in the s channel of this reaction. We see no evidence for them and set model-dependent upper limits on their branching fractions B(P_{c}^{+}→J/ψp) and cross sections σ(γp→P_{c}^{+})×B(P_{c}^{+}→J/ψp).
Health promotion programs are effective at reducing cardiovascular diseases (CVDs). One-time health promotion programs are effective at increasing immediate knowledge gain about CVDs. It is unknown ...if such interventions translate into sustained knowledge gain or actual behavior modifications. We surveyed a group of mostly Latino/Hispanic women who previously participated in a
Por Tu Corazon
even to determine if knowledge gain were sustained after two years and risk reduction behaviors were implemented. Of 125, participants, 56% returned two years later. There was no difference between the knowledge score of the initial post-event survey and the subsequent pre-event survey (78.85 ± 22.55 vs. 75.2 ± 24.01, p = 0.34). Of the 70 participants who returned two years later, 63% reported implementing at least one risk modification. Sustained knowledge gain about CVDs and implementation of risk modifications can be achieved after a single health promotion intervention in a highly motivated group of Latino/Hispanic women.
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