Ruta chalepensis L. (Rutaceae) is used in traditional medicine to treat a wide variety of disorders such as rheumatism, fever, mental disorders, dropsy, neuralgia, menstrual problems, anxiety, and ...epilepsy.
To evaluate and compare the anticonvulsant properties of an aqueous extract and ethyl acetate (AcOEt) fraction of R. chalepensis on pentylenetetrazole (PTZ)-induced seizures and maximal electroshock (MES) test in mice, by analyzing behavior and electroencephalogram (EEG), as well as GABAA receptors involvement.
The effect of an acute administration of different dosage of the aqueous extract (300 or 500 mg/kg) or AcOEt fraction (100, 300, 500 or 1000 mg/kg) of R. chalepensis was explored on two different models of acute seizure induction in mice, the PTZ and maximal electroshock (MES) tests. Behavioral and electrographic effects were quantified. Additionally, the possible involvement of the GABAA receptors was explored in the presence of picrotoxin (a non-competitive antagonist of the GABAA receptor).
AcOEt fraction of R. chalepensis was more efficient than aqueous extract to reduce the incidence of tonic-clonic seizures and mortality in a significant and dose-dependent manner in both the PTZ and MES tests. This anticonvulsant effect was not abolished in the presence of picrotoxin. The EEG spectral power analysis revealed that aqueous extract decreased alpha and beta power, while AcOEt fraction decreased alpha and gamma power confirming previous findings of its depressant effect in the central nervous system. It is important to mention that the highest dosage of the AcOEt (1000 mg/kg) produced a severe suppression or isoelectric EEG activity (EEG flattening), recognized as a comatose state, suggesting a neurotoxic effect at this dosage.
Our data reinforce that depressant and anticonvulsant effects of R. chalepensis depend in part on the presence of constituents from medium polarity. We also found that anticonvulsant effect is not mediated by GABAA receptors. In addition, cautious is emphasized when high doses of this natural product are used in traditional medicine since it might produce neurotoxic effects.
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We describe a likelihood analysis using MasterCode of variants of the MSSM in which the soft supersymmetry-breaking parameters are assumed to have universal values at some scale
M
in
below the ...supersymmetric grand unification scale
M
GUT
, as can occur in mirage mediation and other models. In addition to
M
in
, such ‘sub-GUT’ models have the 4 parameters of the CMSSM, namely a common gaugino mass
m
1
/
2
, a common soft supersymmetry-breaking scalar mass
m
0
, a common trilinear mixing parameter
A
and the ratio of MSSM Higgs vevs
tan
β
, assuming that the Higgs mixing parameter
μ
>
0
. We take into account constraints on strongly- and electroweakly-interacting sparticles from
∼
36
/fb of LHC data at 13 TeV and the LUX and 2017 PICO, XENON1T and PandaX-II searches for dark matter scattering, in addition to the previous LHC and dark matter constraints as well as full sets of flavour and electroweak constraints. We find a preference for
M
in
∼
10
5
to
10
9
GeV
, with
M
in
∼
M
GUT
disfavoured by
Δ
χ
2
∼
3
due to the
BR
(
B
s
,
d
→
μ
+
μ
-
)
constraint. The lower limits on strongly-interacting sparticles are largely determined by LHC searches, and similar to those in the CMSSM. We find a preference for the LSP to be a Bino or Higgsino with
m
χ
~
1
0
∼
1
TeV
, with annihilation via heavy Higgs bosons
H
/
A
and stop coannihilation, or chargino coannihilation, bringing the cold dark matter density into the cosmological range. We find that spin-independent dark matter scattering is likely to be within reach of the planned LUX-Zeplin and XENONnT experiments. We probe the impact of the
(
g
-
2
)
μ
constraint, finding similar results whether or not it is included.
The cause of lung cancer is generally attributed to tobacco smoking. However lung cancer in never smokers accounts for 10 to 25% of all lung cancer cases. Arsenic, asbestos and radon are three ...prominent non-tobacco carcinogens strongly associated with lung cancer. Exposure to these agents can lead to genetic and epigenetic alterations in tumor genomes, impacting genes and pathways involved in lung cancer development. Moreover, these agents not only exhibit unique mechanisms in causing genomic alterations, but also exert deleterious effects through common mechanisms, such as oxidative stress, commonly associated with carcinogenesis. This article provides a comprehensive review of arsenic, asbestos, and radon induced molecular mechanisms responsible for the generation of genetic and epigenetic alterations in lung cancer. A better understanding of the mode of action of these carcinogens will facilitate the prevention and management of lung cancer related to such environmental hazards.
Abstract X-linked agammaglobulinemia (XLA) is caused by BTK mutations, patients typically show < 2% of peripheral B cells and reduced levels of all immunoglobulins; they suffer from recurrent ...infections of bacterial origin; however, viral infections, autoimmune-like diseases, and an increased risk of developing gastric cancer are also reported. In this work, we report the BTK mutations and clinical features of 12 patients diagnosed with XLA. Furthermore, a clinical revision is also presented for an additional cohort of previously reported patients with XLA. Four novel mutations were identified, one of these located in the previously reported mutation refractory SH3 domain. Clinical data support previous reports accounting for frequent respiratory, gastrointestinal tract infections and other symptoms such as the occurrence of reactive arthritis in 19.2% of the patients. An equal proportion of patients developed septic arthritis; missense mutations and mutations in SH1, SH2 and PH domains predominated in patients who developed arthritis.
The pMSSM10 after LHC run 1 de Vries, K. J.; Bagnaschi, E. A.; Buchmueller, O. ...
The European physical journal. C, Particles and fields,
09/2015, Letnik:
75, Številka:
9
Journal Article
Recenzirano
Odprti dostop
We present a frequentist analysis of the parameter space of the pMSSM10, in which the following ten soft SUSY-breaking parameters are specified independently at the mean scalar top mass scale
M
SUSY
...≡
m
t
~
1
m
t
~
2
: the gaugino masses
M
1
,
2
,
3
, the first-and second-generation squark masses
m
q
~
1
=
m
q
~
2
, the third-generation squark mass
m
q
~
3
, a common slepton mass
m
ℓ
~
and a common trilinear mixing parameter
A
, as well as the Higgs mixing parameter
μ
, the pseudoscalar Higgs mass
M
A
and
tan
β
, the ratio of the two Higgs vacuum expectation values. We use the MultiNest sampling algorithm with
∼
1.2
×
10
9
points to sample the pMSSM10 parameter space. A dedicated study shows that the sensitivities to strongly interacting sparticle masses of ATLAS and CMS searches for jets, leptons
+
signals depend only weakly on many of the other pMSSM10 parameters. With the aid of the Atom and Scorpion codes, we also implement the LHC searches for electroweakly interacting sparticles and light stops, so as to confront the pMSSM10 parameter space with all relevant SUSY searches. In addition, our analysis includes Higgs mass and rate measurements using the HiggsSignals code, SUSY Higgs exclusion bounds, the measurements of
BR
(
B
s
→
μ
+
μ
-
)
by LHCb and CMS, other
B
-physics observables, electroweak precision observables, the cold dark matter density and the XENON100 and LUX searches for spin-independent dark matter scattering, assuming that the cold dark matter is mainly provided by the lightest neutralino
χ
~
1
0
. We show that the pMSSM10 is able to provide a supersymmetric interpretation of
(
g
-
2
)
μ
, unlike the CMSSM, NUHM1 and NUHM2. As a result, we find (omitting Higgs rates) that the minimum
χ
2
=
20.5
with 18 degrees of freedom (d.o.f.) in the pMSSM10, corresponding to a
χ
2
probability of 30.8 %, to be compared with
χ
2
/
d
.
o
.
f
.
=
32.8
/
24
(
31.1
/
23
)
(
30.3
/
22
)
in the CMSSM (NUHM1) (NUHM2). We display the one-dimensional likelihood functions for sparticle masses, and we show that they may be significantly lighter in the pMSSM10 than in the other models, e.g., the gluino may be as light as
∼
1250
GeV
at the 68 % CL, and squarks, stops, electroweak gauginos and sleptons may be much lighter than in the CMSSM, NUHM1 and NUHM2. We discuss the discovery potential of future LHC runs,
e
+
e
-
colliders and direct detection experiments.
Supersymmetry in light of 1/fb of LHC data Buchmueller, O.; Cavanaugh, R.; De Roeck, A. ...
The European physical journal. C, Particles and fields,
02/2012, Letnik:
72, Številka:
2
Journal Article
Recenzirano
Odprti dostop
We update previous frequentist analyses of the CMSSM and NUHM1 parameter spaces to include the public results of searches for supersymmetric signals using ∼1/fb of LHC data recorded by ATLAS and CMS ...and ∼0.3/fb of data recorded by LHCb in addition to electroweak precision and B-physics observables. We also include the constraints imposed by the cosmological dark matter density and the XENON100 search for spin-independent dark matter scattering. The LHC data set includes ATLAS and CMS searches for jets +
events and for the heavier MSSM Higgs bosons, and the upper limits on BR(
B
s
→
μ
+
μ
−
) from LHCb and CMS. The absences of jets +
signals in the LHC data favour heavier mass spectra than in our previous analyses of the CMSSM and NUHM1, which may be reconciled with (
g
−2)
μ
if tan
β
∼40, a possibility that is, however, under pressure from heavy Higgs searches and the upper limits on BR(
B
s
→
μ
+
μ
−
). As a result, the
p
-value for the CMSSM fit is reduced to ∼15(38)%, and that for the NUHM1 to ∼16(38)%, to be compared with ∼9(49)% for the Standard Model limit of the CMSSM for the same set of observables (dropping (
g
−2)
μ
), ignoring the dark matter relic density. We discuss the sensitivities of the fits to the (
g
−2)
μ
and BR(
b
→
sγ
) constraints, contrasting fits with and without the (
g
−2)
μ
constraint, and combining the theoretical and experimental errors for BR(
b
→
sγ
) linearly or in quadrature. We present predictions for
, BR(
B
s
→
μ
+
μ
−
),
M
h
and
M
A
, and update predictions for spin-independent dark matter scattering, incorporating the uncertainty in the
π
-nucleon
σ
term
Σ
πN
. Finally, we present predictions based on our fits for the likely thresholds for sparticle pair production in
e
+
e
−
collisions in the CMSSM and NUHM1.
In this work, we have synthesized and characterized yttrium iron garnet nanoparticles doped with cobalt. The X-ray diffraction data showed a single phase, belonging to the cubic structure of ...Y3Fe5O12. Rietveld refinement revealed variation of the angles and interionic distances (Fe3+(a)-O2-Y3+(c) and Fe3+(d)-O2--Y3+(c) when Fe3+ ions are replaced by Co3+ ions in the tetrahedral (d) and octahedral (a) sites of YIG. In addition, the lattice parameter a, decreases from 12.3846 Å to 12.3830 Å with the increasing of cobalt concentration. The analysis by Infrared and Raman spectroscopies has shown a slight stretching at lower wave numbers as the dopant concentration increased. The magnetic measurements confirm the substitution of Fe3+ by Co3+ in the a-sites and d-sites with the reduction of the saturation magnetization from 26.63 emu/g to 24.92 emu/g, for 0.000 ≤ y ≤ 0.030. Changes in the coercive field varying the dopant concentration were related to the particle size and pinning centers existence.
We make frequentist analyses of the CMSSM, NUHM1, VCMSSM and mSUGRA parameter spaces taking into account all the public results of searches for supersymmetry using data from the 2010 LHC run and the ...XENON100 direct search for dark matter scattering. The LHC data set includes ATLAS and CMS searches for
events (with or without leptons) and for the heavier MSSM Higgs bosons, and the upper limit on BR(
B
s
→
μ
+
μ
−
) including data from LHCb as well as CDF and DØ. The absence of signals in the LHC data favours somewhat heavier mass spectra than in our previous analyses of the CMSSM, NUHM1 and VCMSSM, and somewhat smaller dark matter scattering cross sections, all close to or within the pre-LHC 68% CL ranges, but does not impact significantly the favoured regions of the mSUGRA parameter space. We also discuss the impact of the XENON100 constraint on spin-independent dark matter scattering, stressing the importance of taking into account the uncertainty in the
π
-nucleon
σ
term
Σ
πN
, which affects the spin-independent scattering matrix element, and we make predictions for spin-dependent dark matter scattering. Finally, we discuss briefly the potential impact of the updated predictions for sparticle masses in the CMSSM, NUHM1, VCMSSM and mSUGRA on future
e
+
e
−
colliders.
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