The LHCb measurements of certain ratios of decay modes testing lepton flavor nonuniversality might open an exciting world of new physics beyond the standard model. The latest LHCb measurements of RK* ...offer some new insight beyond the previous measurement of RK. We work out the present significance for nonuniversality, and argue that claims of 5σ deviations from the standard model based on all present b→sℓ+ℓ− data including the ratios are misleading and are at present still based on guesstimates of hadronic power corrections in the b→sℓ+ℓ− angular observables. We demonstrate that only a small part of the luminosity of 50 fb−1 foreseen to be accumulated by the LHCb will be needed to offer soon a definite answer to the present question of whether we see a very small glimpse of lepton flavor nonuniversal new physics or not. We also present new predictions for other ratios based on our analysis of the present measurements of the ratios RK(*) and analyze if they are able to differentiate between various new physics options within the effective field theory at present or in the near future.
A
bstract
The well-known problem of the unknown power corrections within QCD improved factorisation leaves the interpretation of the so-called LHCb anomalies in the angular observables of
B
→
K
∗
μ
+
...μ
−
as an open problem. In order to contribute to the question whether they represent a first sign for new physics beyond the Standard Model or a consequence of underestimated hadronic power corrections, we present a direct comparison of two global fits to the data based on the two different assumptions. In addition, we summarise the possible options to resolve this puzzle in the future.
Update on the b → s anomalies Arbey, A.; Hurth, T.; Mahmoudi, F. ...
Physical review. D,
07/2019, Letnik:
100, Številka:
1
Journal Article
Recenzirano
Odprti dostop
We present a brief update of our model-independent analyses of the b → s data presented in the articles published in Phys. Rev. D 96, 095034 (2017) and Phys. Rev. D 98, 095027 (2018) based on new ...data on RK by LHCb, on RK* by Belle, and on Bs,d → μ+μ− by ATLAS.
Human PIWI-interacting RNAs (piRNAs) are known to be expressed in germline cells, functionally silencing LINEs and SINEs. Their expression patterns in somatic tissues are largely uncharted. We ...analyzed 6,260 human piRNA transcriptomes derived from non-malignant and tumour tissues from 11 organs. We discovered that only 273 of the 20,831 known piRNAs are expressed in somatic non-malignant tissues. However, expression patterns of these piRNAs were able to distinguish tissue-of-origin. A total of 522 piRNAs are expressed in corresponding tumour tissues, largely distinguishing tumour from non-malignant tissues in a cancer-type specific manner. Most expressed piRNAs mapped to known transcripts, contrary to "piRNA clusters" reported in germline cells. We showed that piRNA expression can delineate clinical features, such as histological subgroups, disease stages, and survival. PiRNAs common to many cancer types might represent a core gene-set that facilitates cancer growth, while piRNAs unique to individual cancer types likely contribute to cancer-specific biology.
•The interest in developing epigenetic drugs is substantially increasing.•We reviewed the recent epigenetics structure-activity relationships.•Epi-informatics has seen recent advances in databases ...and web servers.•Polypharmacology profiling is a must in the future of epigenetic drug discovery.•We briefly discuss the future directions of epi-informatics.
The ability of epigenetic markers to affect genome function has enabled transformative changes in drug discovery, especially in cancer and other emerging therapeutic areas. Concordant with the introduction of the term ‘epi-informatics’, the size of the epigenetically relevant chemical space has grown substantially and so did the number of applications of cheminformatic methods to epigenetics. Recent progress in epi-informatics has improved our understanding of the structure–epigenetic activity relationships and boosted the development of models predicting novel epigenetic agents. Herein, we review the advances in computational approaches to drug discovery of small molecules with epigenetic modulation profiles, summarize the current chemogenomics data available for epigenetic targets, and provide a perspective on the greater utility of biomedical knowledge mining as a means to advance the epigenetic drug discovery.
Epigenetic drug discovery is gaining growing attention both in industry and academia; ‘epi-informatics’ is an emerging concurrent area of computational research that helps accelerate this effort.
We make a frequentist analysis of the parameter space of the CMSSM and NUHM1, using a Markov Chain Monte Carlo (MCMC) with 95 (221) million points to sample the CMSSM (NUHM1) parameter spaces. Our ...analysis includes the ATLAS search for supersymmetric jets + signals using ∼5/fb of LHC data at 7 TeV, which we apply using PYTHIA and a Delphes implementation that we validate in the relevant parameter regions of the CMSSM and NUHM1. Our analysis also includes the constraint imposed by searches for BR(Bs→μ+μ−) by LHCb, CMS, ATLAS and CDF, and the limit on spin-independent dark matter scattering from 225 live days of XENON100 data. We assume Mh∼125 GeV, and use a full set of electroweak precision and other flavour-physics observables, as well as the cold dark matter density constraint. The ATLAS5/fb constraint has relatively limited effects on the 68 and 95 % CL regions in the (m0,m1/2) planes of the CMSSM and NUHM1. The new BR(Bs→μ+μ−) constraint has greater impacts on these CL regions, and also impacts significantly the 68 and 95 % CL regions in the (MA,tanβ) planes of both models, reducing the best-fit values of tanβ. The recent XENON100 data eliminate the focus-point region in the CMSSM and affect the 68 and 95 % CL regions in the NUHM1. In combination, these new constraints reduce the best-fit values of m0,m1/2 in the CMSSM, and increase the global χ2 from 31.0 to 32.8, reducing the p-value from 12 % to 8.5 %. In the case of the NUHM1, they have little effect on the best-fit values of m0,m1/2, but increase the global χ2 from 28.9 to 31.3, thereby reducing the p-value from 15 % to 9.1 %.
Recently the LHCb collaboration has confirmed the evidence for lepton flavour nonuniversality at the 3.1σ level via an updated measurement of RK. In this work we analyse this evidence within a ...model-independent approach. We make projections for future measurements which indicate that LHCb will be in the position to discover lepton nonuniversality with the Run 3 data in a single observable. We analyse other ratios based on our analysis of the present measurements of the ratios RK(⁎) and analyse if they are able to differentiate between various new physics options within the effective field theory at present or in the near future. We also compare the present deviations in the ratios with NP indications in the angular observables of exclusive b→sℓℓ transitions. Finally, we update our global analysis considering all b→sℓℓ observables altogether, including a 20-parameter fit in connection of a Wilks' test.
The CMSSM and NUHM1 after LHC Run 1 Buchmueller, O.; Cavanaugh, R.; Roeck, A. De ...
The European physical journal. C, Particles and fields,
2014/6, Letnik:
74, Številka:
6
Journal Article
Recenzirano
Odprti dostop
We analyze the impact of data from the full Run 1 of the LHC at 7 and 8 TeV on the CMSSM with
μ
>
0
and
<
0
and the NUHM1 with
μ
>
0
, incorporating the constraints imposed by other experiments such ...as precision electroweak measurements, flavour measurements, the cosmological density of cold dark matter and the direct search for the scattering of dark matter particles in the LUX experiment. We use the following results from the LHC experiments: ATLAS searches for events with
E
/
T
accompanied by jets with the full 7 and 8 TeV data, the ATLAS and CMS measurements of the mass of the Higgs boson, the CMS searches for heavy neutral Higgs bosons and a combination of the LHCb and CMS measurements of
BR
(
B
s
→
μ
+
μ
-
)
and
BR
(
B
d
→
μ
+
μ
-
)
. Our results are based on samplings of the parameter spaces of the CMSSM for both
μ
>
0
and
μ
<
0
and of the NUHM1 for
μ
>
0
with 6.8
×
10
6
, 6.2
×
10
6
and 1.6
×
10
7
points, respectively, obtained using the MultiNest tool. The impact of the Higgs-mass constraint is assessed using FeynHiggs 2.10.0, which provides an improved prediction for the masses of the MSSM Higgs bosons in the region of heavy squark masses. It yields in general larger values of
M
h
than previous versions of FeynHiggs, reducing the pressure on the CMSSM and NUHM1. We find that the global
χ
2
functions for the supersymmetric models vary slowly over most of the parameter spaces allowed by the Higgs-mass and the
E
/
T
searches, with best-fit values that are comparable to the
χ
2
/
dof
for the best Standard Model fit. We provide 95 % CL lower limits on the masses of various sparticles and assess the prospects for observing them during Run 2 of the LHC.
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