This study aimed to investigate patterns of mortality by road transport injury (RTI) in Brazilian municipalities, focused on deaths of motorcyclists, between 2000 and 2018, and their relation with ...population size and economic status.
This was an ecological epidemiological study with a descriptive and analytical nature.
The age-standardized RTI mortality rates were calculated for the Brazilian municipalities, referring to the 3-year periods of 2000/2002 (T1), 2009/2011 (T2), and 2016/2018 (T3). The rates were stratified according to macroregion and population size and were compared in terms of percentage variation from one 3-year period to another. The Moran Global and Local indices were used in the spatial point-pattern analysis of the rates. To verify the association with the gross domestic product (GDP) per capita, the Spearman correlation coefficient was applied.
A decline in RTI mortality rates was found between 2000 and 2018, with the most significant declines observed in municipalities from the South and Southeast regions of Brazil. However, increases were observed among motorcyclists. Clusters of municipalities were detected, which presented high mortality rates among the motorcyclists in the Northeast region and in some states of the North and Midwest regions. The mortality rates showed a negative correlation with the GDP per capita of the Brazilian municipalities.
Although there were decreases in RTI mortality rates between 1990 and 2018, there was a significant increase in deaths among motorcyclists, especially in the Northeast, North, and Midwest regions of the country. Such differences can be explained by unequal growth in the size of the motorcycle fleet in those regions, by less law enforcement capability, and by the implementation of educational actions.
Abstract
Background
This is the first study in Brazil that evaluates the prevalence of low renal function in the Brazilian population and associated factors, using biochemical measures.
Methods
This ...is a cross-sectional household-based epidemiological survey, the National Health Survey (PNS), conducted in 2014 and 2015. The explanatory variables were: sociodemographic characteristics, lifestyles, chronic diseases, anthropometry. The prevalence of kidney filtration rate (KFR) <60 ml / min / 1.73m2 was estimated, using Poisson regression to calculate the Prevalence Ratio Adjusted (RPaj) by age and gender.
Results
The prevalence of low renal function was 6.48% (95% CI 5.88-7.09). After adjusting remained associated: female (RPaj 1.4 CI (95% 1.16-1.68), age 45-59 years was RPaj = 7.3 (95% CI 3.8-14.1), 60 years or older RPaj = 33.6 (95% CI 17.8- 63.4), obesity RP 1.32 (95% CI 1.1-1.7), diabetes PR = 1.4 (95% CI 1.2-1.8), poor / very poor self-rated health PR = 1.5 (95% CI 1.2-1.9).
Conclusions
Renal function <60 ml / min / 1.73m2 was higher in females, increased with age, was associated with obesity, diabetes and poorer health assessment. CKD through biochemical tests and risk and protection factors are essential to support public health policies.
Key messages
The prevalence with laboratory data was 4 times higher than self-reported studies, showing the underreporting of low renal function in Brazil population. The primary care team should request simple biochemical tests, such as creatinine, routinely in the target population, especially the elderly, for prevention and early management of kidney diseases.
Abstract
Congenital Zika syndrome (CZS) is a cluster of malformation, and the mechanisms that lead it are still unclear. Using hypothesis-driven candidate genes and their function in viral ...infections, single-nucleotide polymorphisms (SNPs) were genotyped by quantitative polymerase chain reaction in a sample population from Sergipe State, Brazil. This study shows that rs3775291 SNP at Toll-like receptor 3, which triggers type I interferon antiviral responses in mothers infected by Zika virus during pregnancy, is associated with CZS occurrence (odds ratio OR, 2.19; 95% confidence interval CI, 1.158–4.148). Moreover, rs1799964 SNP at tumor necrosis factor-α gene in CZS babies is associated with severe microcephaly (OR, 2.63; 95% CI, 1.13–6.21).
The objective was to evaluate the chemical composition and in vitro fermentation of spineless cactus of the genus Nopalea, F-21 (Nopalea cochenillifera Dyck), IPA-Sertânia (Nopalea cochenillifera ...Dyck) and Miúda (Nopalea cochenillifera Salm Dyck), in different phenophases. There was no effect (P < 0.05) of the phenological phases of spineless cactus on DM, ash, OM, EE, and CP. Varieties F-21 and Miúda presented higher values of DM and OM, whereas the CP was higher for IPA-Sertânia. The contents of NDF, ADF, and ADL, as well as the fractions of carbohydrates B2 and C were higher in the mature stage, irrespective of the variety. The Miúda variety showed higher levels of NFC and fractions A + B1 and the lower levels of pectin compared to the F-21 and IPA-Sertânia varieties, but not differ of TC to F-21. The volume of gas produced via the degradation of NFC was higher for young phenological phases. The young and intermediate stages showed a higher in vitro digestibility of DM. Based on the results, varieties IPA-Sertânia and Miúda have a high potential for use in animal feed because of their high nutritional quality. Mature cladodes showed a higher fibrous fraction and lower digestibility in all varieties.The objective was to evaluate the chemical composition and in vitro fermentation of spineless cactus of the genus Nopalea, F-21 (Nopalea cochenillifera Dyck), IPA-Sertânia (Nopalea cochenillifera Dyck) and Miúda (Nopalea cochenillifera Salm Dyck), in different phenophases. There was no effect (P < 0.05) of the phenological phases of spineless cactus on DM, ash, OM, EE, and CP. Varieties F-21 and Miúda presented higher values of DM and OM, whereas the CP was higher for IPA-Sertânia. The contents of NDF, ADF, and ADL, as well as the fractions of carbohydrates B2 and C were higher in the mature stage, irrespective of the variety. The Miúda variety showed higher levels of NFC and fractions A + B1 and the lower levels of pectin compared to the F-21 and IPA-Sertânia varieties, but not differ of TC to F-21. The volume of gas produced via the degradation of NFC was higher for young phenological phases. The young and intermediate stages showed a higher in vitro digestibility of DM. Based on the results, varieties IPA-Sertânia and Miúda have a high potential for use in animal feed because of their high nutritional quality. Mature cladodes showed a higher fibrous fraction and lower digestibility in all varieties.
The importance of radiology in modern medicine is acknowledged for its non-invasive diagnostic capabilities, yet the manual formulation of unstructured medical reports poses time constraints and ...error risks. This study addresses the common limitation of Artificial Intelligence applications in medical image captioning, which typically focus on classification problems, lacking detailed information about the patient's condition. Despite advancements in AI-generated medical reports that incorporate descriptive details from X-ray images, which are essential for comprehensive reports, the challenge persists. The proposed solution involves a multimodal model utilizing Computer Vision for image representation and Natural Language Processing for textual report generation. A notable contribution is the innovative use of the Swin Transformer as the image encoder, enabling hierarchical mapping and enhanced model perception without a surge in parameters or computational costs. The model incorporates GPT-2 as the textual decoder, integrating cross-attention layers and bilingual training with datasets in Portuguese PT-BR and English. Promising results are noted in the proposed database with ROUGE-L 0.748, METEOR 0.741, and NIH CHEST X-ray with ROUGE-L 0.404 and METEOR 0.393.
Upright balance control strategies during pregnancy Danna-Dos-Santos, Alessander; Magalhães, Alessandra T.; Silva, Baldomero A. ...
Gait & posture,
October 2018, 2018-10-00, 20181001, Letnik:
66
Journal Article
Recenzirano
•Study focused on investigating how pregnancy affects postural control.•The first trimester of pregnancy showed significantly larger body sway.•At third trimester the center of pressure migrated ...posteriorly.
Morphological and physiological changes during pregnancy are considered to interfere with the mechanisms of postural control and potentially increase the risk of falling. A clear understanding of these mechanisms is important to improve pre-natal care and reduce the fall risk in this population.
This study focused on investigating how pregnancy affects postural control in each trimester of pregnancy by analyzing pelvic inclination and body sway behavior. Our main hypothesis was that balance control and posture would change during pregnancy. More specifically, pregnancy would increase sway amplitude, anterior pelvic tilt, and body sway regularity in time.
Forty women formed four groups: non-pregnant women (NP) and women at their first, second, and third trimester of pregnancy (P1, P2, and P3, respectively). All participants performed (1) postural evaluation of the pelvic inclination using a digital system of postural analysis and (2) instrumented posturography using a force platform to collect the coordinates of the body’s center of pressure (COP) during quiet bipedal stance for 120 s. Kruskal-Wallis H test and post-hoc Mann-Whitney U tests were used to investigate the effects of pregnancy (NP, P1, P2, and P3) on pelvic inclination angle and postural indices computed from the COP signals.
Results revealed significant larger body sway accompanied by a more regular medial-lateral pattern of oscillation and a more synchronized anterior-posterior and medial-lateral sway already at the first trimester of pregnancy. The averaged COP migrated posteriorly at third trimester of pregnancy and the anterior pelvic tilt increased at second and third trimesters.
Our results indicate the existence of changes in posture and balance metrics even at early stages of pregnancy. We suggest the use of posturography as one of screening tools for postural instability and fall risk during pregnancy.
•The construction of a chimeric protein leads to enhanced immune protection against Ascaris infection.•Vaccination with chimeric protein induced greater than 70% reduction in larval load after ...challenge.•Vaccine protection is associated with IgG response and reduced lung inflammation compared to controls.
An estimated 400 million people are infected by parasites of the genus Ascaris and the existing control measures are inefficient. Vaccine development using B cell antigens is a promising strategy for increased protection against this parasite. The present study aimed at developing a chimeric protein capable of conferring protection against infection by Ascaris sp. For this purpose, we performed B-cell epitope predictions on previously described vaccine candidate proteins from Ascaris suum and the corresponding peptides were used to construct a chimeric protein. Female BALB / c mice were immunized subcutaneously in three doses at 10 day intervals with a vaccine formulation comprised of the chimeric protein together with monophosphoryl lipid A (MPLA). Control groups included protein alone, MPLA, or PBS. After challenge infection, animals vaccinated with chimeric protein plus MPLA showed a reduction of 73.54% of larval load in the lung compared to control group animals. Animals immunized with chimeric protein plus MPLA also display higher IgG response and a reduction in lung inflammation. Our study highlights how chimeric proteins containing more than one B cell epitope can enhance immune protection against helminthic infection and offer new approaches to the development of Ascaris vaccines.
The laboratorial diagnosis of leishmaniasis is based on parasitological methods, which are invasive, present high cost, require laboratorial infrastructure and/or trained professionals; as well as by ...immunological methods, which usually present variable sensitivity and/or specificity, such as when they are applied to identify asymptomatic cases and/or mammalian hosts presenting low levels of antileishmanial antibodies. As consequence, new studies aiming to identify more refined antigens to diagnose visceral (VL) and tegumentary (TL) leishmaniasis are urgently necessary. In the present work, the Leishmania eukaryotic elongation factor-1 beta (EF1b) protein, which was identified in L. infantum protein extracts by antibodies in VL patients’ sera, was cloned and its recombinant version (rEF1b) was expressed, purified and tested as a diagnostic marker for VL and TL. The post-therapeutic serological follow-up was also evaluated in treated and untreated VL and TL patients, when anti-rEF1b antibody levels were measured before and after treatment. Results showed that rEF1b was highly sensitive and specific to diagnose symptomatic and asymptomatic canine VL, as well as human TL and VL. In addition, low cross-reactivity was observed when sera from healthy subjects or leishmaniasis-related diseases patients were tested. The serological follow-up showed also that rEF1b-specific antibodies declined significantly after treatment, suggesting that this protein could be also evaluated as a prognostic marker for human leishmaniasis.
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•The eukaryotic elongation factor-1 was tested to diagnose leishmaniasis.•Canine and human serological panels were used in the ELISA experiments.•Sensitivity and specificity values of 100% were found in both sera classes.•The post-treatment serological follow-up specific to protein was evaluated.•Results showed that specific antibodies declined significantly after the end of treatment.
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