The large-scale polarization explorer (LSPE) is a cosmology program for the measurement of large-scale curl-like features (B-modes) in the polarization of the cosmic microwave background. Its goal is ...to constrain the background of inflationary gravity waves traveling through the universe at the time of matter-radiation decoupling. The two instruments of LSPE are meant to synergically operate by covering a large portion of the northern microwave sky. LSPE/STRIP is a coherent array of receivers planned to be operated from the Teide Observatory in Tenerife, for the control and characterization of the low-frequency polarized signals of galactic origin; LSPE/SWIPE is a balloon-borne bolometric polarimeter based on 330 large throughput multi-moded detectors, designed to measure the CMB polarization at 150 GHz and to monitor the polarized emission by galactic dust above 200 GHz. The combined performance and the expected level of systematics mitigation will allow LSPE to constrain primordial B-modes down to a tensor/scalar ratio of
10
-
2
. We here report the status of the STRIP pre-commissioning phase and the progress in the characterization of the key subsystems of the SWIPE payload (namely the cryogenic polarization modulation unit and the multi-moded TES pixels) prior to receiver integration.
Synopsis
Objective
The objective of this study is to create and establish a simple and rapid method for lipid evaluation in daily‐use female products, namely lipsticks.
Methodology
This approach uses ...STE‐LDI‐MSI for fast fingerprinting of complex lipids, such as triacylglycerols, phosphoglycerols and simpler structures as free fatty acids.
Results
This work has focused on lipsticks of several brands globally marketed. With no sample preparation, it has demonstrated to readily identify compounds of interest by integrating both full scan and MS/MS data.
Conclusion
A novel and rapid technique for lipid evaluation in lipsticks is presented.
Résumé
Objectif
Créer et mettre en place une méthode simple et rapide pour l'évaluation des lipides dans les produits d'usage quotidien pour femmes, notamment les rouges à lèvres.
Methodologie
Cette approche utilise STE‐LDI‐MSI pour une caractérisation rapide des lipides complexes, tels que les triglycérides, phosphoglycérols et des structures plus simples comme les acides gras libres.
Résultats
Ce travail a porté sur les rouges à lèvres de plusieurs marques commercialisées au niveau mondial. En l'absence de préparation de l'échantillon, il démontré la capacité à identifier facilement les composés d'intérêt en intégrant à la fois l'analyse complète et de données MS / MS.
Conclusion
Une nouvelle technique rapide de l'évaluation des lipides dans les rouges à lèvres est présentée.
A novel and rapid technique for lipid evaluation in lipsticks is presented. This approach uses STE‐LDI‐MSI for fast fingerprinting of complex lipids, such as triacylglycerols, phosphoglycerols and simpler structures as free fatty acids. With no sample preparation, it has demonstrated to readily identify compounds of interest by integrating both full scan and MS/MS data. This work has focused on lipsticks of several brands globally marketed.
The advent of modern high-throughput sequencing has made it possible to generate vast quantities of genomic sequence data. However, the processing of this volume of information, including prediction ...of gene-coding and regulatory sequences remains an important bottleneck in bioinformatics research. In this work, we integrated DNA duplex stability into the repertoire of a Neural Network (NN) capable of predicting promoter regions with augmented accuracy, specificity and sensitivity. We took our method beyond a simplistic analysis based on a single sigma subunit of RNA polymerase, incorporating the six main sigma-subunits of Escherichia coli. This methodology employed successfully re-discovered known promoter sequences recognized by E. coli RNA polymerase subunits σ(24), σ(28), σ(32), σ(38), σ(54) and σ(70), with highlighted accuracies for σ(28)- and σ(54)- dependent promoter sequences (values obtained were 80% and 78.8%, respectively). Furthermore, the discrimination of promoters according to the σ factor made it possible to extract functional commonalities for the genes expressed by each type of promoter. The DNA duplex stability rises as a distinctive feature which improves the recognition and classification of σ(28)- and σ(54)- dependent promoter sequences. The findings presented in this report underscore the usefulness of including DNA biophysical parameters into NN learning algorithms to increase accuracy, specificity and sensitivity in promoter beyond what is accomplished based on sequence alone.
El estudio de la respuesta al sombreado en especies forrajeras nativas es una estrategia de premejoramiento útil para la selección de los materiales adaptados a los sistemas productivos ...silvopastoriles, predominantes en la ganadería de cría bovina de Argentina. En el presente estudio se evaluaron caracteres agronómicos y ecofisiológicos en entradas de Macroptilium lathyroides del banco de germoplasma “Ing. Agr. José M. Alonso” de la UNL, en condiciones naturales y artificiales de luz y sombra. La respuesta general estuvo asociada a una estrategia de escape al sombreado, donde las plantas elongaron más los tallos y produjeron mayor área foliar en perjuicio de la biomasa radical y foliar. Sin embargo, se identificaron entradas cuya biomasa de tallo y raíz no sufrieron modificaciones significativas bajo sombra. No obstante, la conductividad estomática y la tasa fotosintética se vieron afectadas en todas las entradas en condiciones de sombra, independientemente de la biomasa relativa al testigo.
Prolonged driving is now recognised as one of the main contributing factors to a number of health issues related to professional drivers. Back pain and musculoskeletal disorders are the most frequent ...symptoms and would seem to be directly related to the driving conditions and, in particular, the seating system. SAFEGUARD, a European co-funded research project, has developed two prototype seating systems, one customised for a track and the other for a tractor, with the intention of addressing these problems by the implementation of sensors and actuators that are suited for increasing safety and comfort while driving. The diversity of the options provided by the prototype systems, their complexity and requirement to be used properly has necessitated the development of an advanced user interface (UI). The UI prerequisites are for the efficient handling of the varied seat features, a non-obstructive character for the interface and a natural integration of the operational input/output elements in the cabin interior.
The influenza virus has been a challenge to science due to its ability to withstand new environmental conditions. Taking into account the development of virus sequence databases, computational ...approaches can be helpful to understand virus behavior over time. Furthermore, they can suggest new directions to deal with influenza. This work presents triplet entropy analysis as a potential phylodynamic tool to quantify nucleotide organization of viral sequences. The application of this measure to segments of hemagglutinin (HA) and neuraminidase (NA) of H1N1 and H3N2 virus subtypes has shown some variability effects along timeline, inferring about virus evolution. Sequences were divided by year and compared for virus subtype (H1N1 and H3N2). The nonparametric Mann–Whitney test was used for comparison between groups. Results show that differentiation in entropy precedes differentiation in GC content for both groups. Considering the HA fragment, both triplet entropy as well as GC concentration show intersection in 2009, year of the recent pandemic. Some conclusions about possible flu evolutionary lines were drawn.
•Triplet entropy is applied to infer viral sequence phylodynamics.•Differentiation in entropy precedes differentiation in GC content.•Hemagglutinin triplet entropy shows intersection for H1N1 and H3N2 in the year 2009.
Pancreatic ductal adenocarcinoma (PDAC) is recognized world-wide as an aggressive disease with poor prognosis in patients with or without resection. Further knowledge about the biological mechanisms ...of PDAC is necessary to enable the identification of novel molecular markers and therapeutic targets for early diagnosis and improved treatment. Transcription factors are the final effectors of signaling pathways and regulate a number of cellular functions. Changes in their expression may contribute to cellular transformation and tumor progression. Thus, the aim of the present study was to identify the Master Regulators (MRs) of transcription potentially involved in PDAC disease. To achieve this goal, we utilized microarray data to correlate MR genes with the tumor phenotype. Analyses were performed with RTN, Limma, and Survival packages in the R environment. We identified Tubby-like protein 3 (TULP3) as a MR of transcription in PDAC samples. The prognostic value of TULP3 was assessed in three independent cohort analyses. Our data demonstrated that pancreatic cancer patients exhibiting high transcriptional levels of TULP3 showed a poor overall survival rate. High expression levels of TULP3 may play an essential role in pancreatic cancer progression and possibly lead to a poor clinical outcome. Our results highlight the potential use of TULP3 as a clinical prognostic biomarker for pancreatic adenocarcinoma.
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