The Isotope Separation On-Line (ISOL) method for the production of Radioactive Ion Beams (RIB) is attracting significant interest in the worldwide nuclear physics community. Within this context the ...SPES (Selective Production of Exotic Species) RIB facility is now under construction at INFN LNL (Istituto Nazionale di Fisica Nucleare Laboratori Nazionali di Legnaro). This technique is established as one of the main techniques for high intensity and high quality beams production. The SPES facility will produce n-rich isotopes by means of a 40 MeV proton beam, emitted by a cyclotron, impinging on a uranium carbide multi-foil fission target. The aim of this work is to describe the most important results obtained by the study of the on-line behavior of the SPES production target assembly. This target system will produce RIBs at a rate of about 1013 fissions per second, it will be able to dissipate a total power of up to 10 kW, and it is planned to work continuously for 2 week-runs of irradiation. ISOL beams of 24 different elements will be produced, therefore a target and ion source development is ongoing to ensure a great variety of produced isotopes and to improve the beam intensity and purity.
SPES (Selective Production of Exotic Species) is a second generation facility for the production of radioactive ion beams that is going to be commissioned at the Laboratori Nazionali di Legnaro of ...INFN at Legnaro, Padua, Italy. Radioactive neutron-rich isotopes are expected to be produced by nuclear fission induced by a 40 MeV, 200 μA primary proton beam impinging on a
UC
target. The expected reaction rate is about 10
fission/s. Radioactive ion beams are produced using the isotope separation on-line technique. The production of such an amount of radioactive species raises radiological issues throughout the life cycle of the facility. A study of the radioactive contamination of the components of the radioactive ion beam line is performed with the FLUKA Monte Carlo simulation code, under realistic hypotheses for the produced isobaric beams. The present results complete previous studies focused on the radiological impact of the production target irradiation, the residual activation of the primary proton beam line and the radioactive contamination of the ion source complex. The overall ambient dose equivalent rate due to the different radiation sources is calculated at several positions inside the production bunker and at different times after a typical one-year operating period of the facility with the
UC
target at full power. The obtained results and the developed methodology provide the guidelines and the needed tools to plan ordinary and extraordinary interventions as well as final decommissioning of the SPES facility.
The SPES laser ion source has been tested at ISOLDE Offline 2, CERN. A two-step single resonance photo-ionization scheme has been used to ionize gallium atoms in the SPES tantalum hot-cavity ion ...source. The ion beam time structure, laser enhancement of ion yield, and ionization efficiency are investigated in relation to the ion source temperature and ion load. From the time structures, it is inferred that a significant fraction of the extracted ions are generated in the transfer line rather than just in the hot cavity. The effect of the electrostatic axial field on the movement of ions inside the ion source is discussed. Generally, there is an inverse relationship between total ion load and the laser enhancement factor. This dependency is enhanced at lower operating temperature of the ion source. This is explained by the influence of thermionic electron emission and ion density on the transverse laser-ion confinement, and therefore the survival of ions as they drift towards the extraction region of the ion source. At 2200 °C, the nominal temperature for on-line operation of the ion source, the ratio of laser-ionized to surface-ionized gallium was stable around 55 during the measurement campaign, and independent of the total extracted ion current up to the measured value of 1.1 μA. A resonance laser ionization efficiency value of 27.2% for gallium has been measured.
The realization of pulsed-laser diffused, thin n
+
contacts on high purity germanium (HPGe) and their successful segmentation is described. The contacts have been obtained by a laser-induced ...diffusion of Sb atoms, deposited by sputtering on Ge surface, and then segmented by means of a photolithographic technique. Three small prototypes of gamma ray detectors have been implemented, using the same n
+
contact (laser diffused Sb) but with three different geometries and a B implanted p
+
contact. Electrical and detection properties of the prototypes have been characterized, showing low leakage currents and good spectroscopy data with different gamma-ray sources. The stability of the detector performance has also been tested subjecting one of the prototypes to a typical annealing treatment.
.
A new method for the formation of hole-barrier contacts in high purity germanium (HPGe) is described, which consists in the sputter deposition of a Sb film on HPGe, followed by Sb diffusion ...produced through laser annealing of the Ge surface in the melting regime. This process gives rise to a very thin (
≤
100
nm) n-doped layer, as determined by SIMS measurement, while preserving the defect-free morphology of HPGe surface. A small prototype of gamma ray detector with a Sb laser-diffused contact was produced and characterized, showing low leakage currents and good spectroscopy data with different gamma ray sources.
Abstract
The ADIGE (Acceleratore Di Ioni a Grande carica Esotici) injector consists of an electrostatic 1+ beam line, equipped with ion sources able to produce a wide variety of beams, coupled to a ...magnetic beam line, where charge multiplication is accomplished by implementing an Electron Cyclotron Resonance (ECR) based charge breeder. The injector is totally integrated in the SPES (Selective Production of Exotic Species) beam line, to allow the post-acceleration of radioactive ions and is now in an advanced phase of installation. The electrostatic 1+beam line has been put into operation and is now producing beams from alkali metals. This contribution concerns the first results of the beam commissioning of this part of the injector, with the description of the initial debug phase and the solutions adopted to ensure a reliable and continuous operation. Preliminary results of the 1+ beam line characterization will be shown, with a comparison between simulated and measured emittances.
Radiopharmaceuticals represent a fundamental tool for nuclear medicine procedures, both for diagnostic and therapeutic purposes. The present work aims to explore the Isotope Separation On-Line (ISOL) ...technique for the production of carrier-free radionuclides for nuclear medicine at SPES, a nuclear physics facility under construction at INFN-LNL. Stable ion beams of strontium, yttrium and iodine were produced using the SPES test bench (Front-End) to simulate the production of 89Sr, 90Y, 125I and 131I and collected with good efficiency on suitable targets.
•The use of ISOL method for radionuclides production is proposed.•ISOL method allows to produce carrier-free radionuclides for nuclear medicine.•Tests with stable ion beams were produced as a proof of concept.•Sodium Chloride is suitable as material for targets for Sr and Y beams.•Activated Carbon can be compacted with PVA to have a solid target for I2 beams.
Axillary lymph node dissection is an established component of the surgical treatment of breast cancer, and is an important procedure in cancer staging; however, it is associated with unpleasant side ...effects. We have investigated a radioactive tracer-guided procedure that facilitates identification, removal, and pathologic examination of the sentinel lymph node (i.e., the lymph node first receiving lymphatic fluid from the area of the breast containing the tumor) to predict the status of the axilla and to assess the safety of foregoing axillary dissection if the sentinel lymph node shows no involvement.
We injected 5-10 MBq of 99mTc-labeled colloidal particles of human albumin peritumorally in 376 consecutive patients with breast cancer who were enrolled at the European Institute of Oncology during the period from March 1996 through March 1998. The sentinel lymph node in each case was visualized by lymphoscintigraphy, and its general location was marked on the overlying skin. During breast surgery, the sentinel lymph node was identified for removal by monitoring the acoustic signal from a hand-held gamma ray-detecting probe. Total axillary dissection was then carried out. The pathologic status of the sentinel lymph node was compared with that of the whole axilla.
The sentinel lymph node was identified in 371 (98.7%) of the 376 patients and accurately predicted the state of the axilla in 359 (95.5%) of the patients, with 12 false-negative findings (6.7%; 95% confidence interval = 3.5%-11.4%) among a total of 180 patients with positive axillary lymph nodes.
Sentinel lymph node biopsy using a gamma ray-detecting probe allows staging of the axilla with high accuracy in patients with primary breast cancer. A randomized trial is necessary to determine whether axillary dissection may be avoided in those patients with an uninvolved sentinel lymph node.
Progress in the design and construction of SPES at INFN-LNL Bisoffi, G.; Prete, G.; Andrighetto, A. ...
Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms,
06/2016, Letnik:
376
Journal Article
Recenzirano
Odprti dostop
INFN-LNL is constructing an ISOL (Isotope Separation On Line) facility delivering neutron rich ion beams at 10AMeV or beyond, making use of the linear accelerator ALPI as the secondary accelerator. ...The facility includes a direct ISOL target based on UCx and able to reach 1013fissions/s. In parallel, an applied physics facility will be developed, with applications in medicine and neutron production. The SPES project is a national facility, approved and funded. Commissioning with the first exotic species is expected in 2019. The primary accelerator is a commercial cyclotron, which will send a 40MeV, 200μA proton beam onto an UCx target, connected to SIS, PIS and LIS ion sources. The extracted beam is purified through a Low Resolution Mass Separator (LMRS, i.e. a Wien filter and a dispersive dipole), a beam cooler and a High Resolution Mass Separator (HRMS) and sent to an ECR charge breeder to boost the exotic beam charge state. The highly charged exotic beam is further separated in a MRMS (Medium Resolution Mass Separator) and injected into a 100% duty cycle RFQ and into the existing superconducting linac ALPI, which will be refurbished and upgraded to be an efficient exotic beam accelerator. The upgrade of ALPI will give ∼10AMeV energy to 132Sn19+, taken as the reference ion beam. The paper presents the status of the design and construction of the SPES facility.
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