ABSTRACT
We perform simulations of giant impacts on to the young Uranus using smoothed particle hydrodynamics (SPH) with over 100 million particles. This 100–1000 × improvement in particle number ...reveals that simulations with below 107 particles fail to converge on even bulk properties such as the post-impact rotation period, or on the detailed erosion of the atmosphere. Higher resolutions appear to determine these large-scale results reliably, but even 108 particles may not be sufficient to study the detailed composition of the debris – finding that almost an order of magnitude more rock is ejected beyond the Roche radius than with 105 particles. We present two software developments that enable this increase in the feasible number of particles. First, we present an algorithm to place any number of particles in a spherical shell such that they all have an SPH density within 1 per cent of the desired value. Particles in model planets built from these nested shells have a root-mean-squared velocity below 1 per cent of the escape speed, which avoids the need for long precursor simulations to produce relaxed initial conditions. Secondly, we develop the hydrodynamics code sph with interdependent fine-grained tasking(swift) for planetary simulations. swift uses task-based parallelism and other modern algorithmic approaches to take full advantage of contemporary supercomputer architectures. Both the particle placement code and swift are publicly released.
Subtilases (SBTs) are serine peptidases that are found in all three domains of life. As compared with homologs in other Eucarya, plant SBTs are more closely related to archaeal and bacterial SBTs, ...with which they share many biochemical and structural features. However, in the course of evolution, functional diversification led to the acquisition of novel, plant-specific functions, resulting in the present-day complexity of the plant SBT family. SBTs are much more numerous in plants than in any other organism, and include enzymes involved in general proteolysis as well as highly specific processing proteases. Most SBTs are targeted to the cell wall, where they contribute to the control of growth and development by regulating the properties of the cell wall and the activity of extracellular signaling molecules. Plant SBTs affect all stages of the life cycle as they contribute to embryogenesis, seed development and germination, cuticle formation and epidermal patterning, vascular development, programmed cell death, organ abscission, senescence, and plant responses to their biotic and abiotic environments. In this article we provide a comprehensive picture of SBT structure and function in plants.
The DEAR (DAPhiNE exotic atom research) experiment measured the energy of x rays emitted in the transitions to the ground state of kaonic hydrogen. The measured values for the shift epsilon and the ...width Gamma of the 1s state due to the K(-)p strong interaction are epsilon(1s)=-193 +/- 37 (stat) +/- 6 (syst) eV and Gamma(1s)=249 +/- 111 (stat) +/- 30 (syst) eV, the most precise values yet obtained. The pattern of the kaonic hydrogen K-series lines, K(alpha), K(beta), and K(gamma), was disentangled for the first time.
Many phenomena in the realm of social cognition and behavior are influenced by the extent to which individuals perceive themselves to be vulnerable to infectious diseases. Existing ...individual-difference measures that might assess this construct are limited in their applicability. This article reports the development and psychometric evaluation of a 15-item perceived vulnerability to disease questionnaire, designed to assess individual differences in chronic concerns about the transmission of infectious diseases. Data from 1539 respondents revealed that the 15 items loaded on two internally consistent subscales. One subscale assesses beliefs about one’s own susceptibility to infectious diseases (Perceived Infectability); the other assesses emotional discomfort in contexts that connote an especially high potential for pathogen transmission (Germ Aversion). Additional analyses provide evidence bearing on the convergent, discriminate, and predictive validity of each subscale.
Abstract
We present adaptive optics assisted integral field spectroscopy of 34 star-forming galaxies at z = 0.8–3.3 selected from the HiZELS narrow-band survey. We measure the kinematics of the ...ionized interstellar medium on ∼1 kpc scales, and show that the galaxies are turbulent, with a median ratio of rotational to dispersion support of V / σ = 0.82 ± 0.13. We combine the dynamics with high-resolution rest-frame optical imaging and extract emission-line rotation curves. We show that high-redshift star-forming galaxies follow a similar power-law trend in specific angular momentum with stellar mass to that of local late-type galaxies. We exploit the high resolution of our data and examine the radial distribution of angular momentum within each galaxy by constructing total angular momentum profiles. Although the stellar mass of a typical star-forming galaxy is expected to grow by a factor ∼8 in the ∼5 Gyr between z ∼ 3.3 and z ∼ 0.8, we show that the internal distribution of angular momentum becomes less centrally concentrated in this period; that is, the angular momentum grows outwards. To interpret our observations, we exploit the EAGLE simulation and trace the angular momentum evolution of star-forming galaxies from z ∼ 3 to z ∼ 0, identifying a similar trend of decreasing angular momentum concentration. This change is attributed to a combination of gas accretion in the outer disc, and feedback that preferentially arises from the central regions of the galaxy. We discuss how the combination of the growing bulge and angular momentum stabilizes the disc and gives rise to the Hubble sequence.
Abstract
Since the discovery of neutrino oscillations, we know that neutrinos have non-zero mass. However, the absolute neutrino-mass scale remains unknown. Here we report the upper limits on ...effective electron anti-neutrino mass,
m
ν
, from the second physics run of the Karlsruhe Tritium Neutrino experiment. In this experiment,
m
ν
is probed via a high-precision measurement of the tritium
β
-decay spectrum close to its endpoint. This method is independent of any cosmological model and does not rely on assumptions whether the neutrino is a Dirac or Majorana particle. By increasing the source activity and reducing the background with respect to the first physics campaign, we reached a sensitivity on
m
ν
of 0.7 eV
c
–2
at a 90% confidence level (CL). The best fit to the spectral data yields
$${{\mbox{}}}{m}_{\nu }^{2}{{\mbox{}}}$$
m
ν
2
= (0.26 ± 0.34) eV
2
c
–4
, resulting in an upper limit of
m
ν
< 0.9 eV
c
–2
at 90% CL. By combining this result with the first neutrino-mass campaign, we find an upper limit of
m
ν
< 0.8 eV
c
–2
at 90% CL.
IntroductionDegenerative cervical myelopathy (DCM) is the most common cause of spinal cord impairment. Unfortunately, the condition remains poorly recognised and underdiagnosed. To better identify ...patients, screening tests that target individuals at high risk would be helpful. One group in particular known to have a high prevalence of DCM consists of patients with lumbar degenerative disease (LDD), with the combined presentation referred to as tandem stenosis. Given that LDD is one of the most common presentations in neurosurgical practice and primary care, it is the objective of the proposed study to administer a screening test to these patients as well as those with risk factors or symptoms which raise the suspicion of underlying DCM.Methods and analysisA screening test based on clinical signs/symptoms and known risk factors of DCM was designed. Screening will be performed in neurosurgical consultations for patients with LDD or those with any suspicion of myelopathy. Points are attributed based on the presence of signs/symptoms of DCM (eg, Hoffmann sign, hyper-reflexia) and for comorbidities that predispose or are frequently associated with cervical myelopathy (eg, rheumatoid arthritis, carpal tunnel syndrome). Patients with ≥3 points undergo cervical MRI examination. Patients with positive MRIs will be consulted and receive assessment via modified Japanese Orthopedic Association and Neck Disability Index scores, and subsequent clinical management will be based on practice guidelines. An exploratory multivariate analysis of the effectiveness and efficiency of this proposed screening test will be evaluated after positively screening 50 patients for DCM.Ethics and disseminationThis study has received research ethics approval from the Swiss Association of Research Ethics Committees (ID: 2020-02785). The results of this study will be disseminated in a journal targeting physicians commonly encountering patients with LDD.
It is unknown whether decompressive craniectomy improves clinical outcome for people with spontaneous severe deep intracerebral haemorrhage. The SWITCH trial aimed to assess whether decompressive ...craniectomy plus best medical treatment in these patients improves outcome at 6 months compared to best medical treatment alone.
In this multicentre, randomised, open-label, assessor-blinded trial conducted in 42 stroke centres in Austria, Belgium, Finland, France, Germany, the Netherlands, Spain, Sweden, and Switzerland, adults (18–75 years) with a severe intracerebral haemorrhage involving the basal ganglia or thalamus were randomly assigned to receive either decompressive craniectomy plus best medical treatment or best medical treatment alone. The primary outcome was a score of 5–6 on the modified Rankin Scale (mRS) at 180 days, analysed in the intention-to-treat population. This trial is registered with ClincalTrials.gov, NCT02258919, and is completed.
SWITCH had to be stopped early due to lack of funding. Between Oct 6, 2014, and April 4, 2023, 201 individuals were randomly assigned and 197 gave delayed informed consent (96 decompressive craniectomy plus best medical treatment, 101 best medical treatment). 63 (32%) were women and 134 (68%) men, the median age was 61 years (IQR 51–68), and the median haematoma volume 57 mL (IQR 44–74). 42 (44%) of 95 participants assigned to decompressive craniectomy plus best medical treatment and 55 (58%) assigned to best medical treatment alone had an mRS of 5–6 at 180 days (adjusted risk ratio aRR 0·77, 95% CI 0·59 to 1·01, adjusted risk difference aRD −13%, 95% CI −26 to 0, p=0·057). In the per-protocol analysis, 36 (47%) of 77 participants in the decompressive craniectomy plus best medical treatment group and 44 (60%) of 73 in the best medical treatment alone group had an mRS of 5–6 (aRR 0·76, 95% CI 0·58 to 1·00, aRD −15%, 95% CI −28 to 0). Severe adverse events occurred in 42 (41%) of 103 participants receiving decompressive craniectomy plus best medical treatment and 41 (44%) of 94 receiving best medical treatment.
SWITCH provides weak evidence that decompressive craniectomy plus best medical treatment might be superior to best medical treatment alone in people with severe deep intracerebral haemorrhage. The results do not apply to intracerebral haemorrhage in other locations, and survival is associated with severe disability in both groups.
Swiss National Science Foundation, Swiss Heart Foundation, Inselspital Stiftung, and Boehringer Ingelheim.
We report on the dataset, data handling, and detailed analysis techniques of the first neutrino-mass measurement by the Karlsruhe Tritium Neutrino (KATRIN) experiment, which probes the absolute ...neutrino-mass scale via the β -decay kinematics of molecular tritium. The source is highly pure, cryogenic T2 gas. The β electrons are guided along magnetic field lines toward a high-resolution, integrating spectrometer for energy analysis. A silicon detector counts β electrons above the energy threshold of the spectrometer, so that a scan of the thresholds produces a precise measurement of the high-energy spectral tail. After detailed theoretical studies, simulations, and commissioning measurements, extending from the molecular final-state distribution to inelastic scattering in the source to subtleties of the electromagnetic fields, our independent, blind analyses allow us to set an upper limit of 1.1 eV on the neutrino-mass scale at a 90% confidence level. This first result, based on a few weeks of running at a reduced source intensity and dominated by statistical uncertainty, improves on prior limits by nearly a factor of two. This result establishes an analysis framework for future KATRIN measurements, and provides important input to both particle theory and cosmology.
Meropenem, a carbapenem broad-spectrum antibiotic, is regularly used in patients undergoing continuous venovenous hemodiafiltration (CVVHDF). Its disposition was studied over one dosage interval in ...15 patients under CVVHDF on a steady regimen of 500 or 1000 mg every 8 to 12 hours. Meropenem levels were measured in plasma and filtrate-dialysate by high-performance liquid chromatography (HPLC) with UV detection. The mean CVVHDF flow rates were 7.1 +/- 0.9 L/h for blood (mean +/- SD), 0.5 +/- 0.3 L/h for predilution solution, 1.2 +/- 0.3 L/h for countercurrent dialysate, and 1.8 +/- 0.5 L/h for the total filtrate-dialysate. The pharmacokinetic analysis was based both on a noncompartmental approach and on a four-compartment modeling. The mean (coefficient of variation CV) total body clearance, volume of distribution at steady state, and mean residence time were, respectively, 5.0 L/h (46%), 14.3 L (29%), and 4.8 h (36%). The hemodiafiltration clearances calculated from plasma data alone and plasma with filtrate-dialysate data were 1.2 L/h (26%) and 1.6 L/h (39%), respectively. The compartmental model was used to optimize the therapeutic schedule of meropenem, considering reference minimal inhibitory concentration (MIC) of sensitive strains (4 mg/L). The results indicate that two different therapeutic schedules of meropenem are equally applicable to patients receiving CVVHD: either 750 mg tid or 1500 bid.
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