The future Belle II experiment will employ a computer-farm based data reduction system for the readout of its innermost detector, a DEPFET-technology based silicon detector with pixel readout. A ...large fraction of the background hits can be rejected by defining a set of regions of interest (ROIs) on the pixel detector sensors (PXD) and then recording just the data from the pixels inside the ROI. The ROIs are defined on an event by event basis by extrapolating back onto the PXD the charged tracks detected in the outer trackers (a four-layer double-sided silicon strip detector surrounded by a wire chamber). The tracks are reconstructed in real time on the High Level Trigger (HLT). The pixel detector is then read out based on the ROI information. A demonstrator of this architecture was under beam test earlier this year in DESY (Hamburg, Germany). The demonstrator was operated in an electron beam whose momentum was in the 2-6 GeV/c range with a typical trigger rate of a few kilohertz in a magnetic field of strength up to 1 T. The demonstrator consists of one pixel sensor and four silicon strip sensors arranged in a five-layer configuration mimicking the Belle II vertex detector. The detector readout was a scaled down version of the full Belle II DAQ + HLT chain. The demonstrator was used to detect the particles, reconstruct in real time the trajectories, identify the ROIs on the PXD plane and record the PXD data within. We describe the requirements and the architecture of the final system together with the results obtained with the demonstrator.
Floating strip Micromegas are high-accuracy and discharge insensitive gaseous detectors, able to track single particles at fluxes of 7MHz/cm2 with 100μm resolution. We developed low-material-budget ...detectors with one-dimensional strip readout, suitable for tracking at highest particle rates as encountered in medical ion transmission radiography or inner tracker applications. Recently we additionally developed Kapton-based floating strip Micromegas with two-dimensional strip readout, featuring an overall thickness of 0.011 X0.
These detectors were tested in high-rate proton and carbon-ion beams at the tandem accelerator in Garching and the Heidelberg Ion-Beam Therapy Center, operated with an optimized Ne:CF4 gas mixture. By coupling the Micromegas detectors to a new scintillator based range detector, ion transmission radiographies of PMMA and tissue-equivalent phantoms were acquired. The range detector with 18 layers is read out via wavelength shifting fibers, coupled to a multi-anode photomultiplier.
We present the performance of the Micromegas detectors with respect to timing and single plane track reconstruction using the μTPC method. We discuss the range resolution of the scintillator range telescope and present the image reconstruction capabilities of the combined system.
A sandwich detector composed of scintillator and steel-covered lead layers was introduced in the fixed-target COMPASS experiment at CERN for vetoing events not completely covered by the two-stage ...magnetic spectrometer. Wavelength shifting fibres glued into grooves in the scintillator tiles serve for fast readout. Minimum ionising particles impinging on the 2
m ×2
m detector outside of a central hole, sparing the spectrometer's entry, are detected with a probability of 98%. The response to charged particles and photons is modelled in detail in Monte Carlo calculations. Figures of merit of the veto trigger in 190
GeV/
c
π
−
+
p
(or nucleus) experiments are an enrichment of exclusive events in the recorded data by a factor of 3.5 and a false-veto probability of 1%.
We present a measurement of angular observables and a test of lepton flavor universality in the B→K^{*}ℓ^{+}ℓ^{-} decay, where ℓ is either e or μ. The analysis is performed on a data sample ...corresponding to an integrated luminosity of 711 fb^{-1} containing 772×10^{6} BBover ¯ pairs, collected at the ϒ(4S) resonance with the Belle detector at the asymmetric-energy e^{+}e^{-} collider KEKB. The result is consistent with standard model (SM) expectations, where the largest discrepancy from a SM prediction is observed in the muon modes with a local significance of 2.6σ.
Immunohistochemical investigation.
To determine whether molecules typical of articular cartilage are present in the transverse ligament and whether the ligament may be a target for an autoimmune ...response in rheumatoid arthritis.
In chronic rheumatoid arthritis there is often a marked instability of the atlantoaxial complex, and the transverse ligament can show degenerative changes that compromise its mechanical function. In some rheumatoid patients there can be an autoimmune response to cartilage link protein, aggrecan, and Type II collagen.
Transverse ligaments were removed from 13 cadavers and fixed in 90% methanol. Cryosections were immunolabeled with antibodies against proteoglycans (aggrecan, link protein, and versican), glycosaminoglycans (chondroitin-4-sulfate, chondroitin-6-sulfate, dermatan sulfate, and keratan sulfate), and collagens (Types I, II, III, and VI).
Labeling for aggrecan and link protein was characteristic of the fibrocartilages, but versican was only detected in the fibrous regions. Equally, Types I, III, and VI collagens and keratan, dermatan, and chondroitin-4-sulfates were found throughout the ligament, but labeling for Type II collagen and chondroitin-6-sulfate was restricted to the fibrocartilages.
The presence of molecules typical of articular cartilage (aggrecan, link protein, and Type II collagen) in the transverse ligament explains why it can be a target for destruction in rheumatoid arthritis and also suggests that it is subject to constant compression against the dens rather than only at the extremes of movement.
Many theories of phonology assume that the sound structure of language is made up of
, but there is considerable debate about how much articulatory detail distinctive features encode in long-term ...memory. Laryngeal features such as
provide a unique window into this question: while many languages have two-way contrasts that can be given a simple binary feature account ±VOICE, the precise articulatory details underlying these contrasts can vary significantly across languages. Here, we investigate a series of two-way voicing contrasts in English, Arabic, and Russian, three languages that implement their voicing contrasts very differently at the articulatory-phonetic level. In three event-related potential experiments contrasting English, Arabic, and Russian fricatives along with Russian stops, we observe a consistent pattern of asymmetric mismatch negativity (MMN) effects that is compatible with an articulatorily abstract and cross-linguistically uniform way of marking two-way voicing contrasts, as opposed to an articulatorily precise and cross-linguistically diverse way of encoding them. Regardless of whether a language is theorized to encode VOICE over SPREAD GLOTTIS, the data is consistent with a universal marking of the SPREAD GLOTTIS feature.
Using a data sample of 980 fb−1 of e+e− annihilation data taken with the Belle detector operating at the KEKB asymmetric-energy e+e− collider, we report the results of a study of excited Ξc states ...that decay, via the emission of photons and/or charged pions, into Ξc0 or Ξc+ ground state charmed-strange baryons. We present new measurements of the masses of all members of the Ξc′, Ξc(2645), Ξc(2790), Ξc(2815), and Ξc(2980) isodoublets, measurements of the intrinsic widths of those that decay strongly, and evidence of previously unknown transitions.
The effect of non-esterified myristate (C14:0) or dodecyl sulfate was studied on passive swelling of rat liver mitochondria suspended in hypotonic alkaline KCl medium in the absence of the potassium ...ionophore valinomycin. Both compounds rapidly initiated large-amplitude swelling. However, they failed to initiate swelling when the mitochondria were suspended in hypotonic alkaline sucrose medium. In contrast to myristate or dodecyl sulfate, the non-ionic detergent Triton X-100 initiated swelling of mitochondria in both of the media. The following findings indicate that the inner mitochondrial membrane (IMM) is permeabilized by myristate to K
+ and Cl
− in a specific manner. (i) Swelling initiated by myristate did not respond to cyclosporin A, (ii) the protonophoric uncoupler FCCP was unable to mimic the myristate effect on swelling, and (iii) myristate-induced Cl
−-permeation (measured with KCl medium plus valinomycin) was inhibited by
N,
N′-dicyclohexylcarbodiimide, quinine or ATP. Myristate- or dodecyl sulfate-initiated swelling was paralleled by the lowering of endogenous Mg
2+ content. Both effects, stimulation of swelling and depletion of endogenous Mg
2+ are correlated with each other. Similar effects have been reported previously for the carboxylic divalent cation ionophore calcimycin (A23187). The A23187-induced swelling has identical inhibiting characteristics on Cl
−-permeation with respect to
N,
N′-dicyclohexylcarbodiimide, quinine and ATP as the myristate-stimulated swelling. Therefore, we conclude that non-esterified fatty acids increase the permeability of mitochondria to K
+ and Cl
− at alkaline pH by activating Mg
2+-dependent ion-conducting pathways in IMM.
The COMPASS Collaboration at CERN has measured diffractive dissociation of 190 GeV/c pions into the π(-)π(-)π(+) final state using a stationary hydrogen target. A partial-wave analysis (PWA) was ...performed in bins of 3π mass and four-momentum transfer using the isobar model and the so far largest PWA model consisting of 88 waves. A narrow peak is observed in the f0(980)π channel with spin, parity and C-parity quantum numbers J(PC)=1(++). We present a resonance-model study of a subset of the spin-density matrix selecting 3π states with J(PC)=2(++) and 4(++) decaying into ρ(770)π and with J(PC)=1(++) decaying into f0(980)π. We identify a new a1 meson with mass (1414(-13)(+15)) MeV/c2 and width (153(-23)(+8)) MeV/c2. Within the final states investigated in our analysis, we observe the new a1(1420) decaying only into f0(980)π, suggesting its exotic nature.
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