The importance of coastal upwelling systems is widely recognized. However, several aspects of the current and future behaviors of these systems remain uncertain. Fluctuations in temperature because ...of anthropogenic climate change are hypothesized to affect upwelling-favorable winds and coastal upwelling is expected to intensify across all Eastern Boundary Upwelling Systems. To better understand how upwelling may change in the future, it is necessary to develop a more rigorous method of quantifying this phenomenon. In this paper, we use SST data and wind data in a novel method of detecting upwelling signals and quantifying metrics of upwelling intensity, duration, and frequency at four sites within the Benguela Upwelling System. We found that indicators of upwelling are uniformly detected across five SST products for each of the four sites and that the duration of those signals is longer in SST products with higher spatial resolutions. Moreover, the high-resolution SST products are significantly more likely to display upwelling signals at 25 km away from the coast when signals were also detected at the coast. Our findings promote the viability of using SST and wind time series data to detect upwelling signals within coastal upwelling systems. We highlight the importance of high-resolution data products to improve the reliability of such estimates. This study represents an important step towards the development of an objective method for describing the behavior of coastal upwelling systems.
Marine Heatwaves Oliver, Eric C.J; Benthuysen, Jessica A; Darmaraki, Sofia ...
Annual review of marine science,
01/2021, Letnik:
13, Številka:
1
Journal Article
Recenzirano
Ocean temperature variability is a fundamental component of the Earth's climate system, and extremes in this variability affect the health of marine ecosystems around the world. The study of marine ...heatwaves has emerged as a rapidly growing field of research, given notable extreme warm-water events that have occurred against a background trend of global ocean warming. This review summarizes the latest physical and statistical understanding of marine heatwaves based on how they are identified, defined, characterized, and monitored through remotely sensed and in situ data sets. We describe the physical mechanisms that cause marine heatwaves, along with their global distribution, variability, and trends. Finally, we discuss current issues in this developing research area, including considerations related to thechoice of climatological baseline periods in defining extremes and how to communicate findings in the context of societal needs.
Marine cold-spells Schlegel, Robert W.; Darmaraki, Sofia; Benthuysen, Jessica A. ...
Progress in oceanography,
11/2021, Letnik:
198
Journal Article
Recenzirano
Odprti dostop
•A large body of literature exists on extreme cold ocean temperature events.•These events have well documented negative impacts but no consistent definition.•We propose here a definition for use in ...the detection of marine cold-spells (MCSs).•MCSs are decreasing in count, duration, and intensity over most ocean surfaces.•MCSs are increasing in count and duration in the Southern Ocean.
Characterising ocean temperature variability and extremes is fundamental for understanding the thermal bounds in which marine ecosystems have adapted. While there is growing evidence of how marine heatwaves threaten marine ecosystems, prolonged periods of extremely cold ocean temperatures, marine cold-spells, have received less global attention. We synthesize the literature on cold ocean temperature extremes and their ecological impacts and physical mechanisms. Ecological impacts of these events were observed across a range of species and biophysical processes, including mass mortalities, range shifts, marine habitat loss, and altered phenology. The development of marine cold-spells is often due to wind-induced ocean processes, but a range of physical mechanisms are documented in the literature. Given the need for consistent comparison of marine cold-spells, we develop a definition for detecting these events from temperature time series and for classifying them into four categories. This definition is used to consistently detect marine cold-spells globally over the satellite record and to compare the characteristics of notable cold events. Globally, marine cold-spells’ occurrence, duration, and intensity are decreasing, with some areas, such as the Southern Ocean, showing signs of increase over the past 15 years. All marine cold-spell categories are affected by these decreases, with the exception of “IV Extreme” events, which were so rare that there has been little decrease. While decreasing occurrences of marine cold-spells could be viewed as providing a beneficial reduction in cold stress for marine ecosystems, fewer cold spells will alter the temperature regime that marine ecosystems experience and could have important consequences on ecological structure and function.
Marine heatwaves (MHWs) are increasing in duration and intensity at a global scale and are projected to continue to increase due to the anthropogenic warming of the climate. Because MHWs may have ...drastic impacts on fisheries and other marine goods and services, there is a growing interest in understanding the predictability and developing practical predictions of these events. A necessary step toward prediction is to develop a better understanding of the drivers and processes responsible for the development of MHWs. Prior research has shown that air–sea heat flux and ocean advection across sharp thermal gradients are common physical processes governing these anomalous events. In this study we apply various statistical analyses and employ the self-organizing map (SOM) technique to determine specifically which of the many candidate physical processes, informed by a theoretical mixed-layer heat budget, have the most pronounced effect on the onset and/or decline of MHWs on the Northwest Atlantic continental shelf. It was found that latent heat flux is the most common driver of the onset of MHWs. Mixed layer depth (MLD) also strongly modulates the onset of MHWs. During the decay of MHWs, atmospheric forcing does not explain the evolution of the MHWs well, suggesting that oceanic processes are important in the decay of MHWs. The SOM analysis revealed three primary synoptic scale patterns during MHWs: low-pressure cyclonic Autumn-Winter systems, high-pressure anti-cyclonic Spring-Summer blocking, and mild but long-lasting Summer blocking. Our results show that nearly half of past MHWs on the Northwest Atlantic shelf are initiated by positive heat flux anomaly into the ocean, but less than one fifth of MHWs decay due to this process, suggesting that oceanic processes, e.g., advection and mixing are the primary driver for the decay of most MHWs.
The risk of aquatic invasions in the Arctic is expected to increase with climate warming, greater shipping activity and resource exploitation in the region. Planktonic and benthic marine aquatic ...invasive species (AIS) with the greatest potential for invasion and impact in the Canadian Arctic were identified and the 23 riskiest species were modelled to predict their potential spatial distributions at pan‐Arctic and global scales. Modelling was conducted under present environmental conditions and two intermediate future (2050 and 2100) global warming scenarios. Invasion hotspots—regions of the Arctic where habitat is predicted to be suitable for a high number of potential AIS—were located in Hudson Bay, Northern Grand Banks/Labrador, Chukchi/Eastern Bering seas and Barents/White seas, suggesting that these regions could be more vulnerable to invasions. Globally, both benthic and planktonic organisms showed a future poleward shift in suitable habitat. At a pan‐Arctic scale, all organisms showed suitable habitat gains under future conditions. However, at the global scale, habitat loss was predicted in more tropical regions for some taxa, particularly most planktonic species. Results from the present study can help prioritize management efforts in the face of climate change in the Arctic marine ecosystem. Moreover, this particular approach provides information to identify present and future high‐risk areas for AIS in response to global warming.
Marine aquatic invasive species with the greatest potential for invasion and impact in the Canadian Arctic were identified and modelled to predict their potential spatial distributions at pan‐Arctic and global scales. Modelling for 23 species was conducted under present environmental conditions and two future (2050 and 2100) global warming scenarios. Potential invasion hotspots were identified for Hudson Bay, Northern Grand Banks/Labrador, Chukchi/Eastern Bering seas and Barents/White seas, suggesting that these regions are most vulnerable to invasions. Organisms showed future poleward shifts and overall gains in habitat suitability under future conditions, although some species distributions will likely recede towards the equator.
The rapid environmental changes in aquatic systems as a result of anthropogenic forcings are creating a multitude of challenging conditions for organisms and communities. The need to better ...understand the interaction of environmental stressors now, and in the future, is fundamental to determining the response of ecosystems to these perturbations. This work describes an automated ex situ mesocosm perturbation system that can manipulate several variables of aquatic media in a controlled setting. This perturbation system was deployed in Kongsfjorden (Svalbard); within this system, ambient water from the fjord was heated and mixed with freshwater in a multifactorial design to investigate the response of mixed-kelp communities in mesocosms to projected future Arctic conditions. The system employed an automated dynamic offset scenario in which a nominal temperature increase was programmed as a set value above real-time ambient conditions in order to simulate future warming. A freshening component was applied in a similar manner: a decrease in salinity was coupled to track the temperature offset based on a temperature–salinity relationship in the fjord. The system functioned as an automated mixing manifold that adjusted flow rates of warmed and chilled ambient seawater, with unmanipulated ambient seawater and freshwater delivered as a single source of mixed media to individual mesocosms. These conditions were maintained via continuously measured temperature and salinity in 12 mesocosms (1 control and 3 treatments, all in triplicate) for 54 d. System regulation was robust, as median deviations from nominal conditions were < 0.15 for both temperature (∘C) and salinity across the three replicates per treatment. Regulation further improved during a second deployment that mimicked three marine heat wave scenarios in which a dynamic temperature regulation held median deviations to < 0.036 ∘C from the nominal value for all treatment conditions and replicates. This perturbation system has the potential to be implemented across a wide range of conditions to test single or multi-stressor drivers (e.g., increased temperature, freshening, and high CO2) while maintaining natural variability. The automated and independent control for each experimental unit (if desired) provides a large breadth of versatility with respect to experimental design.
Activation of the phosphoinositide 3-kinase (PI3K) pathway occurs frequently in breast cancer. However, clinical results of single-agent PI3K inhibitors have been modest to date. A combinatorial drug ...screen on multiple PIK3CA mutant cancers with decreased sensitivity to PI3K inhibitors revealed that combined CDK 4/6-PI3K inhibition synergistically reduces cell viability. Laboratory studies revealed that sensitive cancers suppress RB phosphorylation upon treatment with single-agent PI3K inhibitors but cancers with reduced sensitivity fail to do so. Similarly, patients’ tumors that responded to the PI3K inhibitor BYL719 demonstrated suppression of pRB, while nonresponding tumors showed sustained or increased levels of pRB. Importantly, the combination of PI3K and CDK 4/6 inhibitors overcomes intrinsic and adaptive resistance leading to tumor regressions in PIK3CA mutant xenografts.
•Synergy exists between inhibitions of CDK 4/6 and PI3K in PIK3CA mutant breast cancer.•CDK 4/6-PI3K inhibition is effective in several PIK3CA mutant xenograft tumor models.•Failure to suppress pRB correlates with resistance to PI3K inhibitors in patients.
PI3K inhibitors have only modest clinical efficacy in breast cancers with an aberrantly activated PI3K pathway. Vora et al. show that inhibiting CDK 4/6 overcomes intrinsic and adaptive resistance to PI3K inhibitors in these tumors and that reduction of phosphorylated RB is a good biomarker for the response.
Global increases in temperature are altering land-sea temperature gradients.
Bakun (1990)
hypothesized that changes within these gradients will directly affect atmospheric pressure cells associated ...with the development of winds and will consequently impact upwelling patterns within ecologically important Eastern Boundary Upwelling Systems (EBUS). In this study we used daily time series of NOAA Optimally Interpolated sea surface temperature (SST) and ERA 5 reanalysis wind products to calculate a series novel of metrics related to upwelling dynamics. We then use these to objectively describe upwelling signals in terms of their frequency, intensity and duration throughout the four EBUS during summer months over the last 37 years (1982–2019). We found that a decrease (increase) in SST is associated with an increase (decrease) in the number of upwelling “events,” a decrease (increase) in the intensity of upwelling, and an increase (decrease) in the cumulative intensity of upwelling, with differences between EBUS and regions within EBUS. The Humboldt Current is the only EBUS that shows a consistent response from north to south with a general intensification of upwelling. However, we could not provide clear evidence for associated changes in the wind dynamics hypothesized to drive the upwelling dynamics.
Arctic fjords are considered to be one of the ecosystems changing most rapidly in response to climate change. In the Svalbard archipelago, fjords are experiencing a shift in environmental conditions ...due to the Atlantification of Arctic waters and the retreat of sea-terminating glaciers. These environmental changes are predicted to facilitate expansion of large, brown macroalgae, into new ice-free regions. The potential resilience of macroalgal benthic communities in these fjord systems will depend on their response to combined pressures from freshening due to glacial melt, exposure to warmer waters, and increased turbidity from meltwater runoff which reduces light penetration. Current predictions, however, have a limited ability to elucidate the future impacts of multiple-drivers on macroalgal communities with respect to ecosystem function and biogeochemical cycling in Arctic fjords. To assess the impact of these combined future environmental changes on benthic productivity and resilience, we conducted a two-month mesocosm experiment exposing mixed kelp communities to three future conditions comprising increased temperature (+ 3.3 and + 5.3°C), seawater freshening by ∼ 3.0 and ∼ 5.0 units (i.e., salinity of 30 and 28, respectively), and decreased photosynthetically active radiation (PAR, - 25 and - 40 %). Exposure to these combined treatments resulted in non-significant differences in short-term productivity, and a tolerance of the photosynthetic capacity across the treatment conditions. We present the first robust estimates of mixed kelp community production in Kongsfjorden and place a median compensation irradiance of ∼12.5 mmol photons m−2 h−1 as the threshold for positive net community productivity. These results are discussed in the context of ecosystem productivity and biological tolerance of kelp communities in future Arctic fjord systems.
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•Future climate change in Arctic fjord systems manifests as multiple perturbations•Arctic kelp communities were exposed to warming, freshening, and reduced light•Net community production by mixed kelp communities was most affected by light•Model predictions suggest mixed kelp communities are net autotrophic during summer•Summer net productivity by Arctic kelp appears tolerant to future multi-stressors
Following the discovery of NVP-BEZ235, our first dual pan-PI3K/mTOR clinical compound, we sought to identify additional phosphoinositide 3-kinase (PI3K) inhibitors from different chemical classes ...with a different selectivity profile. The key to achieve these objectives was to couple a structure-based design approach with intensive pharmacologic evaluation of selected compounds during the medicinal chemistry optimization process. Here, we report on the biologic characterization of the 2-morpholino pyrimidine derivative pan-PI3K inhibitor NVP-BKM120. This compound inhibits all four class I PI3K isoforms in biochemical assays with at least 50-fold selectivity against other protein kinases. The compound is also active against the most common somatic PI3Kα mutations but does not significantly inhibit the related class III (Vps34) and class IV (mTOR, DNA-PK) PI3K kinases. Consistent with its mechanism of action, NVP-BKM120 decreases the cellular levels of p-Akt in mechanistic models and relevant tumor cell lines, as well as downstream effectors in a concentration-dependent and pathway-specific manner. Tested in a panel of 353 cell lines, NVP-BKM120 exhibited preferential inhibition of tumor cells bearing PIK3CA mutations, in contrast to either KRAS or PTEN mutant models. NVP-BKM120 shows dose-dependent in vivo pharmacodynamic activity as measured by significant inhibition of p-Akt and tumor growth inhibition in mechanistic xenograft models. NVP-BKM120 behaves synergistically when combined with either targeted agents such as MEK or HER2 inhibitors or with cytotoxic agents such as docetaxel or temozolomide. The pharmacological, biologic, and preclinical safety profile of NVP-BKM120 supports its clinical development and the compound is undergoing phase II clinical trials in patients with cancer.