A yet unexplained feature of the tropical wavenumber–frequency spectrum is its parity distribution, i.e., the distribution of power between the meridionally symmetric and antisymmetric components of ...the spectrum. Due to the linearity of the decomposition to symmetric and antisymmetric components and the Fourier analysis, the total spectral power equals the sum of the power contained in each of these two components. However, the spectral power need not be evenly distributed between the two components. Satellite observations and reanalysis data provide ample evidence that the parity distribution of the tropical wavenumber–frequency spectrum is biased toward its symmetric component. Using an intermediate-complexity model of an idealized moist atmosphere, we find that the parity distribution of the tropical spectrum is nearly insensitive to large-scale forcing, including topography, ocean heat fluxes, and land–sea contrast. On the other hand, we find that a small-scale (stochastic) forcing has the capacity to affect the parity distribution at large spatial scales via an upscale (inverse) turbulent energy cascade. These results are qualitatively explained by considering the effects of triad interactions on the parity distribution. According to the proposed mechanism, any bias in the small-scale forcing, symmetric or antisymmetric, leads to symmetric bias in the large-scale spectrum regardless of the source of variability responsible for the onset of the asymmetry. As this process is also associated with the generation of large-scale features in the tropics by small-scale convection, the present study demonstrates that the physical process associated with deep convection leads to a symmetric bias in the tropical spectrum.
The simulated Northern Hemisphere winter stationary wave (SW) field is investigated in 11 Subseasonal-to-Seasonal (S2S) prediction project models. It is shown that while most models considered can ...well simulate the stationary wavenumbers 1 and 2 during the first 2 weeks of integration, they diverge from observations following week 3. Those models with a poor resolution in the stratosphere struggle to simulate the waves, in both the troposphere and the stratosphere, even during the first 2 weeks. Focusing on the tropospheric regions where SWs peak in amplitude reveals that the models generally do a better job in simulating the northwestern Pacific stationary trough, while certain models struggle to simulate the stationary ridges in both western North America and the North Atlantic. In addition, a strong relationship is found between regional biases in the stationary height field and model errors in simulated upward propagation of planetary waves into the stratosphere. In the stratosphere, biases are mostly in wave 2 in those models with high stratospheric resolution, whereas in those models with low resolution in the stratosphere, a wave 1 bias is evident, which leads to a strong bias in the stratospheric mean zonal circulation due to the predominance of wave 1 there. Finally, biases in both amplitude and location of mean tropical convection and the subsequent subtropical downwelling are identified as possible contributors to biases in the regional SW field in the troposphere.
This study evaluates the ability of state-of-the-art subseasonal to seasonal (S2S) forecasting systems to represent and predict the teleconnections of the Madden Julian Oscillations and their effects ...on weather in terms of midlatitude weather patterns and North Atlantic tropical cyclones. This evaluation of forecast systems applies novel diagnostics developed to track teleconnections along their preferred pathways in the troposphere and stratosphere, and to measure the global and regional responses induced by teleconnections across both the Northern and Southern Hemispheres. Results of this study will help the modeling community understand to what extent the potential to predict the weather on S2S time scales is achieved by the current generation of forecasting systems, while informing where to focus further development efforts. The findings of this study will also provide impact modelers and decision makers with a better understanding of the potential of S2S predictions related to MJO teleconnections.
The stratosphere can be a source of predictability for surface weather on timescales of several weeks to months. However, the potential predictive skill gained from stratospheric variability can be ...limited by biases in the representation of stratospheric processes and the coupling of the stratosphere with surface climate in forecast systems. This study provides a first systematic identification of model biases in the stratosphere across a wide range of subseasonal forecast systems. It is found that many of the forecast systems considered exhibit warm global-mean temperature biases from the lower to middle stratosphere, too strong/cold wintertime polar vortices, and too cold extratropical upper-troposphere/lower-stratosphere regions. Furthermore, tropical stratospheric anomalies associated with the Quasi-Biennial Oscillation tend to decay toward each system's climatology with lead time. In the Northern Hemisphere (NH), most systems do not capture the seasonal cycle of extreme-vortex-event probabilities, with an underestimation of sudden stratospheric warming events and an overestimation of strong vortex events in January. In the Southern Hemisphere (SH), springtime interannual variability in the polar vortex is generally underestimated, but the timing of the final breakdown of the polar vortex often happens too early in many of the prediction systems. These stratospheric biases tend to be considerably worse in systems with lower model lid heights. In both hemispheres, most systems with low-top atmospheric models also consistently underestimate the upward wave driving that affects the strength of the stratospheric polar vortex. We expect that the biases identified here will help guide model development for subseasonal-to-seasonal forecast systems and further our understanding of the role of the stratosphere in predictive skill in the troposphere.
While a connection between the El Niño–Southern Oscillation (ENSO) and the Northern Hemisphere wintertime stratospheric polar vortex appears robust in observational studies focusing on the period ...before 1979 and in many modeling studies, this connection is not evident over the past few decades. In this study, the factors that have led to the disappearance of the ENSO‐vortex relationship are assessed by comparing this relationship in observational data and in operational subseasonal forecasting models over the past few decades. For reforecasts initialized in December, the models simulate a significantly weaker vortex during El Niño than La Niña (LN) as occurred before 1979, but no such effect was observed to have occurred. The apparent cause of this is the eastern European and western Siberian height anomalies present during ENSO. The observed LN events were associated with persistent ridging over eastern Europe as compared to El Niño. Although the Subseasonal‐to‐Seasonal models are initialized with this ridge, the ridge quickly dissipates. As ridging over this region enhances wave flux entering the stratosphere, the net effect is no robust stratospheric response to ENSO in the observations despite a North Pacific teleconnection that would, in isolation, lead to less wave flux for LN. The anomalies in the eastern European sector in response to ENSO likely reflect unforced internal atmospheric variability.
Key Points
The strength of the connection between the Arctic stratospheric vortex and ENSO has weakened in the past few decades
The apparent cause of this was height anomalies over eastern Europe; LN events were associated with persistent ridging as compared to EN
Anomalies in the eastern European sector can modulate the vortex,but this effect likely was not forced by ENSO, rather is internal variability
Theranostic platform integrating diagnostic imaging and therapeutic function into a single system has become a new direction of nanoparticle research. In the process of treatment, therapeutic ...efficacy is monitored. The use of theranostic nanoparticle can add an additional "layer" to keep track on the therapeutic agent such as the pharmacokinetics and biodistribution. In this report, we have developed quantum rod (QR) based formulations for the delivery of small interfering RNAs (siRNAs) to human neuronal cells. PEGlyated QRs with different surface functional groups (amine and maleimide) were designed for selectively down-regulating the dopaminergic signaling pathway which is associated with the drug abuse behavior. We have demonstrated that the DARPP-32 siRNAs were successfully delivered to dopaminergic neuronal (DAN) cells which led to drastic knockdown of specific gene expression by both the electrostatic and covalent bond conjugation regimes. The PEGlyated surface offered high biocompatibilities and negligible cytotoxicities to the QR formulations that may facilitate the in vivo applications of these nanoparticles.
Arrow (1962) showed that a secure monopolist (unconcerned with preemption) has a weaker incentive than would a competitive firm to invest in a patentable process innovation. This paper shows that the ...ranking can be reversed for product innovations. Only the innovator sells the new product, a differentiated substitute for the old. Under alternative market structures considered, the old product is sold only by that same firm (two-product monopoly), only by a different firm (post-innovation duopoly), or in perfect competition. In an asymmetric Hotelling model, the innovation incentive under monopoly is greater than under duopoly if and only if the new product has the higher quality, and is always greater than under perfect competition. Classification-JEL Codes: D4, L1
Fluid shear stress (FSS) from blood flow acting on the endothelium critically regulates vascular morphogenesis, blood pressure, and atherosclerosis 1. FSS applied to endothelial cells (ECs) triggers ...signaling events including opening of ion channels, activation of signaling pathways, and changes in gene expression. Elucidating how ECs sense flow is important for understanding both normal vascular function and disease. EC responses to FSS are mediated in part by a junctional mechanosensory complex consisting of VE-cadherin, PECAM-1, and VEGFR2 2. Previous work suggested that flow increases force on PECAM-1, which initiates signaling 2–4. Deletion of PECAM-1 blocks responses to flow in vitro and flow-dependent vascular remodeling in vivo 2, 5. To understand this process, we developed and validated FRET-based tension sensors for VE-cadherin and PECAM-1 using our previously developed FRET tension biosensor 6. FRET measurements showed that in static culture, VE-cadherin in cell-cell junctions bears significant myosin-dependent tension, whereas there was no detectable tension on VE-cadherin outside of junctions. Onset of shear stress triggered a rapid (<30 s) decrease in tension across VE-cadherin, which paralleled a decrease in total cell-cell junctional tension. Flow triggered a simultaneous increase in tension across junctional PECAM-1, while nonjunctional PECAM-1 was unaffected. Tension on PECAM-1 was mediated by flow-stimulated association with vimentin. These data confirm the prediction that shear increases force on PECAM-1. However, they also argue against the current model of passive transfer of force through the cytoskeleton to the junctions 7, showing instead that flow triggers cytoskeletal remodeling, which alters forces across the junctional receptors.
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•VE-cadherin is under myosin-dependent tension•Flow triggers decreased tension on VE-cadherin by reducing overall contractility•Flow triggers increased tension on PECAM-1 through attachment to vimentin•The data suggest that an unidentified upstream mechanosensor initiates signaling
Arrow (1962) showed that a secure monopolist (unconcerned with preemption) has a weaker incentive than would a competitive firm to invest in a patentable process innovation. This paper shows that the ...ranking can be reversed for product innovations. Only the innovator sells the new product, a differentiated substitute for the old. Under alternative market structures considered, the old product is sold only by that same firm (two-product monopoly), only by a different firm (post-innovation duopoly), or in perfect competition. In an asymmetric Hotelling model, the innovation incentive under monopoly is greater than under duopoly if and only if the new product has the higher quality, and is always greater than under perfect competition.
The molecular mechanisms responsible for the development and progression of atherosclerotic lesions have not been fully established. Here, we investigated the role played by ...endothelial-to-mesenchymal transition (EndMT) and its key regulator FGF receptor 1 (FGFR1) in atherosclerosis. In cultured human endothelial cells, both inflammatory cytokines and oscillatory shear stress reduced endothelial FGFR1 expression and activated TGF-β signaling. We further explored the link between disrupted FGF endothelial signaling and progression of atherosclerosis by introducing endothelial-specific deletion of FGF receptor substrate 2 α (Frs2a) in atherosclerotic (Apoe(-/-)) mice. When placed on a high-fat diet, these double-knockout mice developed atherosclerosis at a much earlier time point compared with that their Apoe(-/-) counterparts, eventually demonstrating an 84% increase in total plaque burden. Moreover, these animals exhibited extensive development of EndMT, deposition of fibronectin, and increased neointima formation. Additionally, we conducted a molecular and morphometric examination of left main coronary arteries from 43 patients with various levels of coronary disease to assess the clinical relevance of these findings. The extent of coronary atherosclerosis in this patient set strongly correlated with loss of endothelial FGFR1 expression, activation of endothelial TGF-β signaling, and the extent of EndMT. These data demonstrate a link between loss of protective endothelial FGFR signaling, development of EndMT, and progression of atherosclerosis.
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