The extent to which plasma HDL concentration regulates reverse cholesterol transport (RCT) is not known. The principal acceptors of unesterified cholesterol (UC) from cultured cells are small ...pre-beta-HDL, which we have shown increase in plasma during intravenous infusion of apolipoprotein A-I/phosphatidylcholine (apoA-I/PC) discs in humans. We have now examined the effects on tissue fluid HDL and RCT. ApoA-I/PC or proapoA-I/PC discs were infused into 16 healthy males. Eleven had been given intravenous radiocholesterol to label tissue pools; in 12 prenodal leg lymph was collected throughout; and in 8 all feces were collected. The rise in small pre-beta-HDL in plasma was associated with increases in 1) pre-beta-HDL concentration in lymph (all subjects), 2) the size of other lymph HDL (four of four subjects), 3) the cholesterol content of lymph lipoproteins relative to plasma lipoproteins (P < 0.01, n = 4), 4) cholesterol-specific radioactivity in lymph (five of nine subjects), 5) plasma lathosterol (P < 0.004, n = 4), 6) plasma cholesterol esterification rate (P < 0.001, n = 4), and 7) fecal bile acid excretion (P < 0.001, n = 8). These results support the hypothesis that small pre-beta-HDL generated in plasma readily cross endothelium into tissue fluid, and thereby promote efflux of UC from peripheral cells. After delivery to the liver, peripheral cholesterol appears to be utilized more for bile acid synthesis than for biliary cholesterol secretion in humans.
The computing infrastructures serving the LHC experiments have been designed to cope at most with the average amount of data recorded. The usage peaks, as already observed in Run-I, may however ...originate large backlogs, thus delaying the completion of the data reconstruction and ultimately the data availability for physics analysis. In order to cope with the production peaks, the LHC experiments are exploring the opportunity to access Cloud resources provided by external partners or commercial providers. In this work we present the proof of concept of the elastic extension of a local analysis facility, specifically the Bologna Tier-3 Grid site, for the LHC experiments hosted at the site, on an external OpenStack infrastructure. We focus on the Cloud Bursting of the Grid site using DynFarm, a newly designed tool that allows the dynamic registration of new worker nodes to LSF. In this approach, the dynamically added worker nodes instantiated on an OpenStack infrastructure are transparently accessed by the LHC Grid tools and at the same time they serve as an extension of the farm for the local usage.
We report on a blinded analysis of low-energy electronic recoil data from the first science run of the XENONnT dark matter experiment. Novel subsystems and the increased 5.9 ton liquid xenon target ...reduced the background in the (1, 30) keV search region to (15.8±1.3) events/(ton×year×keV), the lowest ever achieved in a dark matter detector and ∼5 times lower than in XENON1T. With an exposure of 1.16 ton-years, we observe no excess above background and set stringent new limits on solar axions, an enhanced neutrino magnetic moment, and bosonic dark matter.
We report on a search for nuclear recoil signals from solar B-8 neutrinos elastically scattering off xenon nuclei in XENON1T data, lowering the energy threshold from 2.6 to 1.6 keV. We develop a ...variety of novel techniques to limit the resulting increase in backgrounds near the threshold. No significant B-8 neutrinolike excess is found in an exposure of 0.6 t x y. For the first time, we use the nondetection of solar neutrinos to constrain the light yield from 1-2 keV nuclear recoils in liquid xenon, as well as nonstandard neutrino-quark interactions. Finally, we improve upon world-leading constraints on dark matter-nucleus interactions for dark matter masses between 3 and 11 GeV c(-2) by as much as an order of magnitude.
Delayed single- and few-electron emissions plague dual-phase time projection chambers, limiting their potential to search for light-mass dark matter. This paper examines the origins of these events ...in the XENON1T experiment. Characterization of the intensity of delayed electron backgrounds shows that the resulting emissions are correlated, in time and position, with high-energy events and can effectively be vetoed. In this work we extend previous S2-only analyses down to a single electron. From this analysis, after removing the correlated backgrounds, we observe rates <30 events/(electron×kg×day) in the region of interest spanning 1 to 5 electrons. We derive 90% confidence upper limits for dark matter-electron scattering, first direct limits on the electric dipole, magnetic dipole, and anapole interactions, and bosonic dark matter models, where we exclude new parameter space for dark photons and solar dark photons.
Xenon dual-phase time projection chambers designed to search for weakly interacting massive particles have so far shown a relative energy resolution which degrades with energy above
∼
200 keV due to ...the saturation effects. This has limited their sensitivity in the search for rare events like the neutrinoless double-beta decay of
136
Xe
at its
Q
value,
Q
β
β
≃
2.46
MeV
. For the XENON1T dual-phase time projection chamber, we demonstrate that the relative energy resolution at
1
σ
/
μ
is as low as (
0.80
±
0.02
) % in its one-ton fiducial mass, and for single-site interactions at
Q
β
β
. We also present a new signal correction method to rectify the saturation effects of the signal readout system, resulting in more accurate position reconstruction and indirectly improving the energy resolution. The very good result achieved in XENON1T opens up new windows for the xenon dual-phase dark matter detectors to simultaneously search for other rare events.
Abstract
The selection of low-radioactive construction materials is of utmost importance for the success of low-energy rare event search experiments. Besides radioactive contaminants in the bulk, the ...emanation of radioactive radon atoms from material surfaces attains increasing relevance in the effort to further reduce the background of such experiments. In this work, we present the
$$^{222}$$
222
Rn emanation measurements performed for the XENON1T dark matter experiment. Together with the bulk impurity screening campaign, the results enabled us to select the radio-purest construction materials, targeting a
$$^{222}$$
222
Rn activity concentration of
$$10\,\mathrm{\,}\upmu \mathrm{Bq}/\mathrm{kg}$$
10
μ
Bq
/
kg
in
$$3.2\,\mathrm{t}$$
3.2
t
of xenon. The knowledge of the distribution of the
$$^{222}$$
222
Rn sources allowed us to selectively eliminate problematic components in the course of the experiment. The predictions from the emanation measurements were compared to data of the
$$^{222}$$
222
Rn activity concentration in XENON1T. The final
$$^{222}$$
222
Rn activity concentration of
$$(4.5\pm 0.1)\,\mathrm{\,}\upmu \mathrm{Bq}/\mathrm{kg}$$
(
4.5
±
0.1
)
μ
Bq
/
kg
in the target of XENON1T is the lowest ever achieved in a xenon dark matter experiment.
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