We have investigated chemical sensing properties of three polymeric films (organic and organometallic poly-ynes) by a surface acoustic wave (SAW) and surface transverse wave (STW) sensor, at room ...temperature. The sensor system, consisting of an acoustic two-port resonator operating at 433.92 and 380.8MHz, respectively, has been configured as a frequency oscillator, including an integrated electronic module. The polymeric membranes have been tested, at room temperature, toward gases (NO2, NO, NH3, CO, CH4, SO2, H2S in N2), relative humidity (RH), and vapours (ethanol, acetone, ethyl-acetate) by showing high sensitivity and low selectivity. A comparison of sensing performance of our SAW RH sensors with a commercial hygrometer has been realised. Principal component analysis (PCA) has been applied as pattern recognition technique achieving good separation for the examined vapours, at tested low concentrations.
High throughput screening of the Roche compound collection led to the identification of diaminopyrroloquinazoline series as a novel class of PTP1B inhibitors. Structural modification of ...diaminopyrroloquinazoline series resulted in pyrido2,3-dpyrimidine-2,4-diamine series which was further optimized to give compounds 5 and 24 as potent, selective (except T-cell phosphatase) PTP1B inhibitors with good mouse PK properties.
High throughput screening of the Roche compound collection led to the identification of diaminopyrroloquinazoline series as a novel class of PTP1B inhibitors. Structural modification of diaminopyrroloquinazoline series resulted in pyrido2,3-dpyrimidine-2,4-diamine series which was further optimized to give compounds 5 and 24 as potent, selective (except T-cell phosphatase) PTP1B inhibitors with good mouse PK properties.
A novel series of orally active pyrimido5,4-31,2,4triazine-5,7-diamine-based hypoglycemic agents have been identified. These compounds show non-selective inhibitory properties against a panel of ...protein tyrosine phosphatases including PTP1B. Compounds
12 and
13 display oral glucose lowering effects in
ob/ob mice.
A novel class of orally active pyrimido5,4-31,2,4triazine-5,7-diamine hypoglycemic agents is described. The compounds show inhibitory properties across a panel of tyrosine phosphatases. Compounds
12 and
13 are orally active in
ob/ob mice.
A
bstract
This report details the capabilities of LHCb and its upgrades towards the study of kaons and hyperons. The analyses performed so far are reviewed, elaborating on the prospects for some key ...decay channels, while proposing some new measurements in LHCb to expand its strangeness research program.
The NA62 RICH detector Anzivino, G.; Bucci, F.; Carassiti, V. ...
2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC),
10/2013
Conference Proceeding
The main goal of the NA62 experiment is the measurement of the K + → π + νν̅ branching ratio with a precision better than 10%. One of the key element of NA62 is the Ring Imaging CHerenkov detector ...(RICH). It will identify pions and muons in the momentum range between 15 and 35 GeV/c, with a muon rejection factor better than 10 -2 . The RICH will also measure the particle arrival time with a precision better than 100 ps to disentangle accidental time associations of beam particles with pions and will provide the reference time and a fast signal for the NA62 trigger system. We present the final design of the detector and the status of the construction. Finally, we recall the results of the beam tests of the RICH prototype.
An orientable time-of-flight detector for cosmic rays Iori, M.; Sergi, A.
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
04/2008, Letnik:
588, Številka:
1-2
Journal Article
Recenzirano
Cosmic ray studies, in particular UHECR, can be in general supported by a directional, easily deployable, simple and robust detector. The design of this detector is based on the time of flight ...between two parallel tiles of scintillator, to distinguish particle passing through in opposite directions; by fine time resolution and pretty adjustable acceptance it is possible to select upward(left)/downward(right) cosmic rays. It has been developed for an array of detectors to measure upward τ from Earth-Skimming neutrino events with energy above 108GeV. The properties and performances of the detector are discussed. Test results from a high noise environment are presented.
A single mutation (Val29→Gly) at the subunit interface of a Cu, Zn superoxide dismutase dimer leads to a twofold increase in the second order catalytic rate, when compared to the native enzyme, ...without causing any modification of the structure or the electric field distribution (Stroppolo et al., 2000). To check the role of dynamic processes in this catalytic enhancement, the flexibility of the dimeric protein at the subunit interface region has been probed by the phosphorescence and fluorescence properties of the unique tryptophan residue. Multiple spectroscopic data indicate that Trp83 experiences a very similar, and relatively hydrophobic, environment in both wild-type and mutant protein, whereas its mobility is distinctly more restrained in the latter. Molecular dynamics simulation confirms this result, and provides, at the molecular level, details of the dynamic change felt by tryptophan. Moreover, the simulation shows that the loops surrounding the active site are more flexible in the mutant than in the native enzyme, making the copper more accessible to the incoming substrate, and being thus responsible for the catalytic rate enhancement. Evidence for increased, dynamic copper accessibility also comes from faster copper removal in the mutant by a metal chelator. These results indicate that differences in dynamic, rather than structural, features of the two enzymes are responsible for the observed functional change.
Petrographic, geochemical and isotopic data are reported for the mafic microgranular enclaves occurring in a calc-alkaline Oligocene pluton outcropping near Xanthi town in northern Greece. The ...intrusion is composed of dominant granodiorites with minor tonalites and quartz diorites. Mafic enclaves occur in large swarms concentrated near the margins of the pluton. They have fine-grained porphyritic textures and contain the same minerals as their granodioritic and tonalitic host rocks (Pl, Qtz, Bt, Hb1, Kfs ± Ap, Zrn, Mt, Spn) but in totally different modal proportions. Chemical compositions range from mafic to intermediate and are characterized by higher abundance of Na^sub 2^O) and lower contents of CaO and Sr with respect to an average basaltic magma with a similar SiO^sub 2^ content. The initial Sr isotopic ratios, ranging from 0.7061 to 0.7063, are similar to those of the enclosing rocks (0.7062-0.7063). Field evidence, as well as petrographic and geochemical data, suggests that the analyzed enclaves derived from disruption of synplutonic intrusions of cogenetic mafic magma. The Xanthi pluton could represent ascent of a zoned magma body, with a silicic cap (granodiorite, tonalite, quartz diorite) having intruded first followed by the deeper more mafic levels as syn-intrusive dikes.PUBLICATION ABSTRACT
![7-Phenyl-pyrido[2,3-d]pyrim...](http://api.summon.serialssolutions.com/2.0.0/image/issn/XR4PS5YY4K/0960-894X/small "7-Phenyl-pyrido[2,3-d]pyrimidine-2,4-diamines: Novel and highly selective protein tyrosine phosphatase 1B inhibitors")
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